Protein Alignment mei-41 and pi4kab

DIOPT Version :9

• Sequence 1: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Sequence 2: NP_001106813.1
• Gene: pi4kab / 793349
• ZFINID: ZDB-GENE-080220-34
• Length: 1099
• Species: Danio rerio
• Alignment Length: 1172
• Identity: 223/1172 - (19%)
• Similarity: 389/1172 - (33%)
• Gaps: 426/1172 - (36%)

  Fly  1407 SSVRGRQELGAIKENAFKQF-ESRKYAAGIKPLASTLVSD--RKEDSSRVPRLAGKLCAELLDFL 1468
            |.::|...:..::|||.::. ||...|........||:||  :|:..||.     ::...::|.:
Zfish    44 SLLKGLPRVQWVEENAGRKCKESLPMAENFSFCLVTLLSDVAQKDPESRT-----QILEAIMDVM 103

  Fly  1469 QRWLREWQ------RIH----------------GRST-------------GGKPP--------ET 1490
            |..|...|      ::|                ||.:             |..||        ||
Zfish   104 QSLLEICQTPENHDKVHLCRFVVPCLLGVARAFGRYSNADEPLLCQLFPRGAPPPATPVRGSVET 168

  Fly  1491 IDSNYRKIHEFLNLIPKLLV------------------SRASYN------CGEYARALSYLE-SY 1530
            .....|..::|.:::|..|:                  ::||.:      |...|....|.| ||
Zfish   169 EGIRRRSFNDFRSILPSSLLTVCQSDTLRRKSTATNLDAQASPDRGGPSPCSPTAPGPQYFEGSY 233

  Fly  1531 LEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMS------------VTQDILVNRL 1583
            |.|                   ||..:||.....|. .|:.||            |..::| .||
Zfish   234 LSE-------------------GSAVNPDYYFTTVS-SSFSMSPLFSGASGPEINVPLELL-RRL 277

  Fly  1584 VERQQDMITSYEQLLSSTDQM--QPDHVRAMIDAY---------------LRDTPKTAQLIADGL 1631
            ::..:..::  :..|.|.|.:  :.....|.:|.:               ||||....:.:..|.
Zfish   278 LQMVKQFVS--DSFLKSLDAVVTEVTEANAGVDLFYKGFSDPLYVSMFKMLRDTLYYMKDVHAGF 340

  Fly  1632 WQRLSDRYSDQCFAECKSEL------------------------------LWRLGSYDEM----- 1661
            .:.:.|...:| |:..:|||                              :|.:  .||.
Zfish   341 VKEVHDFVLEQ-FSSSQSELQRVLHEERLPGEASPLKLRCHANAACVDLMVWAV--KDEQGAENL 402

  Fly  1662 -----EELQSNWPAQ-----------CSQGCLKL--RRPLTTRIEFDSLLDGM--RESVLEELRS 1706
                 |:|||...::           |.||..:|  |.|:.......||.|.:  ..:||.:|
Zfish   403 CTKLSEKLQSKTSSKVIIAHMPLLICCLQGLGRLCERFPVIAHSASLSLKDFLVVPSAVLIKL-- 465

  Fly  1707 CSAVQQHSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDEDNQEKLMKNYFDDWQYRL----QI 1767
               .:.||..::....:|:::.:| | ||..:..|...:|:.:..:.:::...|...|.    ..
Zfish   466 ---YKYHSQCSSGAGGIKINVTNE-H-SQSSLNLLSSRKDQPSMYEQLRDISIDNICRCLKAGLT 525

  Fly  1768 VQPQVRIQESIYSFRRNILAELQRRL-----TDRN-HLLP-HLKTELARIWLNSAQINRNAGQLQ 1825
            :.|.:     :.:|    ||.|..||     .|:. ||:| |....|..|    |...|::.::.
Zfish   526 MDPVI-----VEAF----LASLSNRLYISQENDKEAHLIPDHTIRALGHI----AVAMRDSPKVM 577

  Fly  1826 RAQLYILKAAEYQPSG----LFIERAKLLWQKGDQVMAMNY--LEEQLSIMRSGCQGNVKQLAAE 1884
            ...|.||:....||..    |.|::...:...|:|.:....  |.:|:|:..|    ||
Zfish   578 EPILQILQQKFCQPPSPLDVLIIDQLGCMIITGNQYIYQEVWNLFQQISVKAS----NV------ 632

  Fly  1885 QRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSE 1949
                         ||||          .|.:::....|     |.:.:...|..|....||   |
Zfish   633 -------------VYSA----------TKDYKDHGYRH-----CSLAVINALANIAANLQG---E 666

  Fly  1950 PTGEQDDMLINVMVNYAKSLRYGSEHVYQSMPRLISLWLD---TTESSTNTEQVKKMNDLLTNCC 2011
            |.  .|::|:|::..:                  :.|.|:   ..|.:::.....|.:....|..
Zfish   667 PL--VDELLVNLLELF------------------VQLGLEGKRACERASDKGPALKASSSAGNLG 711

  Fly  2012 TALPTAVFYTVYSQMLSRLCHPVND-------------VFTVLRNVIIKLVEAYPQQSLWM---- 2059
            ..:|...       :|:|...|:.:             :::|:....::....:|::  |.
Zfish   712 VLIPVIA-------VLTRRLPPIKEAKPRLQKLFRDFWLYSVVMGFAVEGSGLWPEE--WYEGVC 767

  Fly  2060 -------LLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQKL-LQDFNSLTERLMD-------LTNK 2109
                   ||. |.|.:..|.:    :..:|.|:|.|.... |.|..|....|:|       |.||
Zfish   768 EIATKSPLLT-FPSGEPLRSE----LQYNSALKNDTVTPAELSDLRSTIINLLDPSPEAAALINK 827

  Fly  2110 EVTLDRTYKLSDLDTRLSKLCKQPEFSQILLPFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWF 2174
            ......||.||.......::....:..:..:.|..:....:..:.
Zfish   828 LDFAMCTYLLSVYRLEYMRMLHSNDADRFQVMFRYFEDKAIQKDK-------------------- 872

  Fly  2175 PYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLV-----KPK-----DDLRRDAR--LM 2227
                   ||..:.|:              |...|.::|.:     |||     ::|.|.|:  |:
Zfish   873 -------SGMMQCVI--------------CVGDKVFEVFLQMMAEKPKTKEHEEELERHAQFLLV 916

  Fly  2228 EFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTR 2292
            .||...||.         ||:..:..:        ||.|..|:|         |::.|.|.....
Zfish   917 NFNHTHKRI---------RRVADKYLS--------GLAETFPHL---------LWSGRVLKTMLD 955

  Fly  2293 QLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGY 2357
            .||:|::.|...|.:.:..:.   :|..|        .|...|.: :|||.:.::..|  :..|.
Zfish   956 ILQTLSLSLSADIHKDQPYYD---IPDTP--------YRITVPDT-HEARESIVKDFA--ARCGE 1006

  Fly  2358 IL 2359
            ||
Zfish  1007 IL 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	77/373 (21%)
		PIKKc_ATR	2181..2448	CDD:270625	43/191 (23%)
		FATC	2486..2517	CDD:280430
pi4kab	NP_001106813.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900