DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and zgc:158659

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	XP_005170630.1	Gene:	zgc:158659 / 791141	ZFINID:	ZDB-GENE-070112-492	Length:	1070	Species:	Danio rerio

Alignment Length:	1238	Identity:	222/1238 - (17%)
Similarity:	391/1238 - (31%)	Gaps:	439/1238 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1415 LGAIKENAFKQFESRKYAAGIKPL-------------ASTLVSDRKEDSSRVPRLAG-KLCAELL 1465
            |.:||:..|.  |:|||     ||             ..|..::|:|......||.. :|...:|
Zfish    42 LTSIKQQLFS--EARKY-----PLYHLLQEESCYIFVGVTQEAEREEFYDETRRLCDLRLFHPIL 99

  Fly  1466 DFLQRWLREWQRIHGRSTG---GKP---------PETIDSNYRKIHEFLNLIPKLLVSRASYNCG 1518
            ..::......::|..|..|   |.|         ||..|  :|:  ..|::..:.:..|.  ..|
Zfish   100 KVIEPLGNREEKILNREIGFAIGMPICEFELVKDPEVQD--FRR--NILSVCREAVEERE--GGG 158

  Fly  1519 EYARALSYLESYLEEGEDKSQRL---LEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQDILV 1580
            .:.:||......:|...|..|.:   |::...:|.::..:...:|.:      .|.:.:..|.|.
Zfish   159 AHTQALYVYPPNVESSPDLPQHIYSKLDKGRLIVTIWVIVSPSNSKQ------KYTLKIAHDSLP 217

  Fly  1581 NRLV-----ERQQDMITSYEQLLSSTDQMQPDHVRA----------------------------- 1611
            .:|:     ::.:.|..|.:||.....:.|..::..
Zfish   218 EQLIAEAIRKKTRSMHLSAQQLRLCVQEYQGQYILKVCGCDEYFLEKYPLSQYKYIRSCITLCRL 282

  Fly  1612 --------------------MIDAYLRDTPKTAQLIADG-------LWQ---------------R 1634
                                |..:|.|.||:.:.....|       ||.               .
Zfish   283 PHLMLVSKDSLYSQLPSSGFMAPSYSRRTPQPSPCPGGGDPGSPRSLWAFNTHLRVRLLCATYVN 347

  Fly  1635 LSDRYSDQCFAECKSELLWRLGSYDEMEELQSNWPAQ---CSQGCLKLRRPLTTR-IEFDSLLDG 1695
            ::.|..|:.:.        |.|.|...|.|..|...|   ||       .|.... :.:|..|..
Zfish   348 VNIRDIDKIYV--------RTGIYHGGEPLCDNVNTQRVPCS-------NPRWNEWLSYDIYLTD 397

  Fly  1696 MRESVLEELRSCS------AVQQH-----SYANAYD-------AVLKLHLVHELHCSQELVEKLE 1742
            :..|....|..||      |.::|     ...|.:|       ..:.|.|....|..::|:..:.
Zfish   398 VPRSARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYKDTLVSGKVALGLWPVPHGLEDLLNPIG 462

  Fly  1743 QDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRIQE----SI-----YSFRRNIL------------ 1786
            ......|:|.........|..:..:...:.:|:|    ||     ||:...:.
Zfish   463 VSGSNPNKETPCVELEFPWFNQTVVFPDEQQIEEHANWSISRELGYSYCLGLSSRLACDSSISQA 527

  Fly  1787 -AELQRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIERAKLL 1850
             ||..|.|..|:.|....:.|...:|              |.:.|.:...|..|        |||
Zfish   528 DAEQLRTLCSRDPLYELSEQEKDFLW--------------RHRHYCVNIPESLP--------KLL 570

  Fly  1851 ----WQKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQAVYSAESMHL--C-- 1907
                |...|:|..:..|.:...:|:                            ...|:.|  |
Zfish   571 LSVKWNSRDEVSQIYCLLKDWPLMQ----------------------------PESSLELLDCNF 607

  Fly  1908 ADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQDDMLINVMVNYAKSLRYG 1972
            .|.:::.|         :..|.:|                    |..||.|...::...:.|:|
Zfish   608 PDPMVREF---------ALRCLIQ--------------------GLTDDKLSQYLLQLVQVLKY- 642

  Fly  1973 SEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDV 2037
              .:|...|  ::.:|           :||   .|||  ..:....|:.:.|:|.::
Zfish   643 --EMYLDNP--LARFL-----------IKK---ALTN--QRIGHFFFWHLKSEMHNK-------- 679

  Fly  2038 FTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQKLLQDFNSLTER 2102
             ||.|...: |:||:                   .:.|.:.|.....|.....||:    :||:.
Zfish   680 -TVSRRFGL-LLEAF-------------------CRACGMYLKHLNRQVEAMDKLV----NLTDT 719

  Fly  2103 LMDLTNKEVTLDRTYKLSDLDTRLSKLCK---QPEFSQILLPFEKYMQPTLPLNSDSNSSEGSHL 2164
            |     |:...|.|.|     |::..|.:   :|::.:.|   :.::.|..|::...|..
Zfish   720 L-----KQEKKDETQK-----TQMKFLVEHMSRPDYMEAL---QGFVSPLNPVHQLGNLR----- 766

  Fly  2165 PANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSD------GKDYDVLVKPKDDLRRD 2223
                                .|...|:.||.:|..|.....|      ..:.:::.|..||||:|
Zfish   767 --------------------LEECRIMSSAKRPLWLNWENPDIMSELLFTNNEIIFKNGDDLRQD 811

  Fly  2224 ARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLV 2288
            ...::...:::. :.|:.....|.|   .|..|...:..||:|.:.|
Zfish   812 MLTLQIIKIMEN-IWQNQGLDLRML---PYGCLSIGDCVGLIEVVKN------------------ 854

  Fly  2289 MSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMS 2353
                        .|..::.:.:...|..:..:......|:|.| ....::..|.:.:.|:.|...
Zfish   855 ------------SHTIMQIQCKGGLKGALQFNSNTLHHWIRDR-NKGEAYDRAIDLFTRSCAGYC 906

  Fly  2354 MVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYP--------EVVPFRLTHNMIVA 2410
            :..:|||:||||..||:..| ||...|:||      |..|.:.        |.|||.||.:.::.
Zfish   907 VATFILGIGDRHNSNIMVKE-NGQLFHIDF------GHFLDHKKKKFGYKRERVPFVLTQDFLIV 964

  Fly  2411 MGPLGVE--------GSFRKCCEITLRLLKQESKTLMSILRPFV---------YDVGAQTRKGAA 2458
            :.. ||:        ..|::.|......::|.:...:::....:         :|..|..||..|
Zfish   965 ISK-GVQECTKTKEFERFQEMCYKAYLAIRQHASLFINLFSLLLGCGMPELQSFDDIAYLRKTLA 1028

  Fly  2459 TAK 2461
            ..|
Zfish  1029 LEK 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	68/383 (18%)
		PIKKc_ATR	2181..2448	CDD:270625	58/297 (20%)
		FATC	2486..2517	CDD:280430
zgc:158659	XP_005170630.1	PI3K_p85B	32..107	CDD:280372	17/71 (24%)
		PI3K_rbd	173..292	CDD:279173	14/124 (11%)
		C2_PI3K_class_I_alpha	327..486	CDD:176043	31/173 (18%)
		PI3Ka_I	528..697	CDD:238444	50/297 (17%)
		PKc_like	696..1065	CDD:304357	83/421 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900