DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and Pik3cb

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	NP_083370.2	Gene:	Pik3cb / 74769	MGIID:	1922019	Length:	1064	Species:	Mus musculus

Alignment Length:	1178	Identity:	233/1178 - (19%)
Similarity:	396/1178 - (33%)	Gaps:	344/1178 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1421 NAFKQFESRKYAAGIKPLASTLVSDRKEDSSR----------VPRLAGKLC--AELLD-----FL 1468
            |.....:|..:|.    :..|.|.:..||.:|          |.:|..:.|  ||.||     .:
Mouse    64 NLLMDIDSYMFAC----VNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPAEKLDSKIGVLI 124

  Fly  1469 QRWLREWQRIHGRSTGGKPPETIDSNYRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEE 1533
            .:.|.|:..:       |.|| ::...||:.:|.....:.||..:..:..::.....:..|.||.
Mouse   125 GKGLHEFDAL-------KDPE-VNEFRRKMRKFSEAKIQSLVGLSWIDWLKHTYPPEHEPSVLEN 181

  Fly  1534 GEDKSQRLLEQFTFLVEVY-GSLRDPDSVEGAVQVRSYDMSVT-QDILVNRLVERQQDMITSYEQ 1596
            .|||             :| |.|......|.:..|.|:.:|.. ..|.:|.|..:::..|...|.
Mouse   182 LEDK-------------LYGGKLVVAVHFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGKED 233

  Fly  1597 LLSSTDQMQPDHVRAMIDAYLRDTPKTA-QLIADGLWQRLSDRY-SDQCFAECKSELLWRLGSYD 1659
            ..|..|.:.  .|...::....|.|... |.|.:.:..|....: ..:|   ||.:.::.    .
Mouse   234 EASPCDYVL--QVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVEC---CKIKKMYE----Q 289

  Fly  1660 EMEELQ-------SNWPAQCSQGCLKLRRPLTTRI---------EFD-SLLDGMRESVLEELRSC 1707
            ||..::       ||.|....        |..||:         .|. :|:.|      .:|.:.
Mouse   290 EMIAIEAAINRNSSNLPLPLP--------PKKTRVISHIWDNNNPFQITLVKG------NKLNTE 340

  Fly  1708 SAVQQHSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQV 1772
            ..|:.|..|..:...       ||.|...:..::....|....|:|      ::...:..:....
Mouse   341 ETVKVHVRAGLFHGT-------ELLCKTVVSSEISGKNDHIWNEQL------EFDINICDLPRMA 392

  Fly  1773 RIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSA--QINRNAGQLQRAQLYILKAA 1835
            |:..::|:                  :|..:||:.:...:|.:  |..|.||::.....::
Mouse   393 RLCFAVYA------------------VLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWV---- 435

  Fly  1836 EYQPSGLFIERAKLLWQKGDQVMAM-----NYLEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYL 1895
               .:.:|..:.:|  :.||.::..     :.|||.|:.|.: .|.|.....|...|:.|.....
Mouse   436 ---NTMVFDFKGQL--RSGDVILHSWSSFPDELEEMLNPMGT-VQTNPYAENATALHITFPENKK 494

  Fly  1896 QAVY---------------SAESMHLCAD------AVLKYF-----------QEAIAVHRQSESC 1928
            |..|               |.:|.::.:.      ||||..           .|...:....:.|
Mouse   495 QPCYYPPFDKIIEKAAELASGDSANVSSRGGKKFLAVLKEILDRDPLSQLCENEMDLIWTLRQDC 559

  Fly  1929 HVQMAQFLEKILEARQGGKSEPTGEQDDML----------------INVMVNYAKSLRYG----- 1972
            .....|.|.|:|.:.:..|.|...:...:|                .|....|.:....|
Mouse   560 RENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQM 624

  Fly  1973 -SEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTA---LPTAVFYTVYSQMLSRLCHP 2033
             .|.:.|.:.:|:              ||.|....| :|..:   |..|:......|.|  ..|.
Mouse   625 SDEELSQYLLQLV--------------QVLKYEPFL-DCALSRFLLERALDNRRIGQFL--FWHL 672

  Fly  2034 VNDVFTVLRNVIIKLV-EAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQKLLQDFN 2097
            .::|.|...:|...:: |||.:.|    :.|.|
Mouse   673 RSEVHTPAVSVQFGVILEAYCRGS----VGHMK-------------------------------- 701

  Fly  2098 SLTERLMDLTNKEVTLDRTYKLSDLDTRLSKLCKQPEFSQILLPFEKYMQPTLPLNSDSNSSEGS 2162
             :..:.::..||..||:...||:.:  :||: .|..|.....|....|.:....|.|
Mouse   702 -VLSKQVEALNKLKTLNSLIKLNAV--KLSR-AKGKEAMHTCLKQSAYREALSDLQS-------- 754

  Fly  2163 HLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRC-SDGKD-YDVLVKPKDDLRRD-- 2223
              |.|...:    ..::|:    |....:.|..||..|.... :.|:| ..|:.|..||||:|
Mouse   755 --PLNPCVI----LSELYV----EKCKYMDSKMKPLWLVYSSRAFGEDSVGVIFKNGDDLRQDML 809

  Fly  2224 ----ARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQ 2284
                .|||:.       |.::|....|.|   .|..|...:..||:|
Mouse   810 TLQMLRLMDL-------LWKEAGLDLRML---PYGCLATGDRSGLIE------------------ 846

  Fly  2285 RRLVMSTRQLQSLA-VPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRT 2348
               |:||.  :::| :.|:.|.......|.|.       ....||:: :.:......|...:..:
Mouse   847 ---VVSTS--ETIADIQLNSSNVAATAAFNKD-------ALLNWLKE-YNSGDDLDRAIEEFTLS 898

  Fly  2349 VAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLP--------YPEVVPFRLTH 2405
            .|...:..|:||:||||.:||: .:..|...|:||      |.:|.        ..|.|||.||:
Mouse   899 CAGYCVASYVLGIGDRHSDNIM-VKKTGQLFHIDF------GHILGNFKSKFGIKRERVPFILTY 956

  Fly  2406 NMI--VAMGPLGVE---GSFRKCCEITLRLLKQESKTLMSILRPFVYDVGAQTRKGAATAKITKD 2465
            :.|  :..|..|..   |.||:|||....:|::.....:::.       ......|.......||
Mouse   957 DFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLF-------ALMLTAGLPELTSVKD 1014

  Fly  2466 VQRIADRL 2473
            :|.:.|.|
Mouse  1015 IQYLKDSL 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	68/409 (17%)
		PIKKc_ATR	2181..2448	CDD:270625	69/288 (24%)
		FATC	2486..2517	CDD:280430
Pik3cb	NP_083370.2	PI3K_p85B	35..112	CDD:197539	11/51 (22%)
		PI3K_rbd	174..282	CDD:366310	27/125 (22%)
		C2_PI3K_class_I_beta_delta	318..495	CDD:176075	37/223 (17%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250	404..412		2/7 (29%)
		PI3Ka_I	526..696	CDD:238444	35/186 (19%)
		PI3Kc_IA_beta	700..1061	CDD:270717	93/432 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900