DRSC/TRiP Functional Genomics Resources

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Protein Alignment mei-41 and Atr

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_003750609.1 Gene:Atr / 685055 RGDID:1305796 Length:2636 Species:Rattus norvegicus


Alignment Length:2802 Identity:725/2802 - (25%)
Similarity:1234/2802 - (44%) Gaps:619/2802 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LLYNHVNRN-----------VSNFSGVYSVIEDILCQEPS-----------LISCSLVRELHNKF 53
            |:|.| .||           ||.|  :..:.|.:.|.:|:           .|..:|:..|.:..
  Rat   159 LIYLH-KRNAVGDVMEWPVVVSRF--LSRLDEHMGCLQPAPLQFMNMQNVEFIEVTLLMVLIHIV 220

  Fly    54 QDTF------LLWLLNKLAKCLSESPDSSECINLQR---KILSSCCSNHPKLFE----------R 99
            ...|      |||.:.              |..|:.   ||.|...|...:|||          .
  Rat   221 PTVFFRRQELLLWQIG--------------CALLEHGSPKIRSLAISLLTELFELGGLPAQPAST 271

  Fly   100 LVLAYVEAIEETHLQLSSLDLGQLSNERKP--AITVRIFRCDVECLQEFDP---HCAIEDIKVPL 159
            ....::|.::    .|..:|..||....:|  .:...:|..:.|..:..:|   :..:|.::|..
  Rat   272 FFSLFLELLQ----HLIGMDADQLKLYEEPLSKLVKTLFPFEAEAYRNIEPVYLNVLLEKLRVMF 332

  Fly   160 E-------QADMYAKSLLEVLQHAHHIGYATHGDIFSGSLHQALLILKECDMDTKLASLNYCH-- 215
            |       ::|:...:|..:||:     :.|    |..:.:::.|.::      |:...:.|.  
  Rat   333 EDRVLMRLKSDLLKAALCHLLQY-----FLT----FVPAGYESALQVR------KVYVTDICRAL 382

  Fly   216 -NVLRSQSASSWITNPDVGHYAQLTLEATAIMWSAVAKWLDMGCMTRQE----------LKRLNI 269
             :||..|:...::..|   .||.|.:|:|.|:..       :.|..:||          .||..:
  Rat   383 VDVLGVQTHVGYLLGP---FYAALKMESTEIIER-------IQCQAQQENLRGSNDGVSPKRRRL 437

  Fly   270 TTKLLL---------EVLHMRARPAHHLGYLLLNEILSLPTAIELDDGLLETLSSYIQGQLEHSV 325
            ::.|..         |:.|:.......|..:|..:..||..::|.             |.|::||
  Rat   438 SSSLSSYKRPSRQSEEINHVDMDKKSILWNVLKQKAESLQISLEC-------------GTLKNSV 489

  Fly   326 V-PLEQL-VHLQQLMLSHWHC-------HPTHLVPILALMGLKQTEMRSGVVQVLTQSLVEILKK 381
            . .||.: :.||...|...||       |           ..|..:.:              .||
  Rat   490 AEALEGITIVLQLTALCTVHCSHQDMDGH-----------NAKDCQHK--------------YKK 529

  Fly   382 EEVLSKDWQKLIAILRGFKQLEKLILSQSQHKIAEHEGHIDSSVLAMLPLQCEIIKVADTNWNNL 446
            :..:...|..|....:..|..:.|:.|..:|::   |..|||           ::::.|.     
  Rat   530 KPPVVITWMSLDFYTKVLKSCKSLLESVQKHEL---ELVIDS-----------VVRIYDA----- 575

  Fly   447 SMQLVELESKCSADRRHIHLEICSL--------------LMQITFIRHFLK----------TQTQ 487
               |:.::.| |:.:.|:..|:|.:              |...||..:.|:          .|.|
  Rat   576 ---LMYIQVK-SSFQDHVLEELCGMLSLPWIYSYSDDNSLKMTTFATNLLRLSQRVWESYSPQAQ 636

  Fly   488 HQ---LLAILQRHLKLSYLCAIRLETPSSVHTQMQSFYAQQYMRLFQSEETQEIFCSNLPQLYI- 548
            .|   ||.:..:.:.|.:...:......|.|..:::...:.:..|.|.|.:    |:.:|::.| 
  Rat   637 SQCVFLLTLFPKRIFLDWRTTVYNWALKSSHEVIRTSCVKGFFILLQQENS----CNQIPKMLID 697

  Fly   549 -----SGFIKPEQLMKALPTINNRSGRAQVIRLLLCSQPGKL-----SVFKVKDRIELYCPK--- 600
                 |..:|.|              .|.|:..|:|:..|..     ||......::|:|..   
  Rat   698 RVKDDSHVVKKE--------------FASVLGQLVCTLHGMFYLTSSSVEPFFGPVDLFCKNLKA 748

  Fly   601 ---------------CRPLPKKLPGIYLGKCKQQLPCPDFSSTNLEMIANDLLFYPDFECIAQHL 650
                           |:|        :|....:..|.|           ..|.|..:...:.:||
  Rat   749 TSQHECSSSQVKASVCKP--------FLFLLTKNTPSP-----------VKLAFIDNLHHLCKHL 794

  Fly   651 DLLCFEPNVILGLLRETEALQKVSVK-VIGQLVSAMRVRSPEFLEQLANLVLAAIKAMLAKPLTE 714
            |   |:.:       |||      || |:|.|::.|  ..|:...::|  ....||.:|....:|
  Rat   795 D---FQED-------ETE------VKAVLGTLLNLM--EDPDKDVRIA--FSGNIKYILESLNSE 839

  Fly   715 QNVLQQRSMLNVLTAIAHME---DNEIWLFHWFKMTF-----------------FFLVH-TRSLV 758
            ...:::..:|.:..|..|.:   .||:      |.|.                 |.|:| ...|:
  Rat   840 DGFIKELFVLRMKEAYTHAQISRSNEL------KDTLILTTGDIGRAAKGDLIPFALLHLLHCLL 898

  Fly   759 AQEAVL---AATEMCASQGLQTIHLWNW---YKRDALDLTV------------------------ 793
            ::.|.:   |.||:.|....:::.|.|:   ||:......|                        
  Rat   899 SKSASVSGAAYTEIRALVAAKSVKLQNFFSQYKKPICQFLVESLHSSQMTALPSTPCQTAEMRKQ 963

  Fly   794 ------RLALNVYLLDGVRFTRSLRALTKMLGFTCVQEFTCKYHRLLTAMVLPHCI--VNPLCKG 850
                  .:|||           :|..:..:..|..:..|..:..::|    ||...  .:|....
  Rat   964 HVAHHREMALN-----------TLSEIANVFDFPDLNRFLTRTLQVL----LPDLAAKASPAASA 1013

  Fly   851 VLVLIAKQMQKHIGTLFSISFLRIYTHVFLTEEPELANSCIELVVSCTQSSLQQLMNADVKQTVA 915
            ::..:.||:..:...:...:|..|::|               ||.||::..|::.::....:|..
  Rat  1014 LIRTLGKQLNVNRREILINNFKYIFSH---------------LVCSCSKDELERALHYLKNETEI 1063

  Fly   916 ELLIYFNRNPTFVMRSFQSL---LQLSIG--------SLEELSSQTANAE-------------FA 956
            ||       .:.:.:.||.|   |.|.||        .|..|:|..::.:             .|
  Rat  1064 EL-------GSLLRQDFQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDITSPELMA 1121

  Fly   957 NFIAERFLGVITYFESCLSEPSFEKPLKEETLYSLGQIMRFVGSQHVTQFRFKIIAM----LSFV 1017
            :::..:.||::.:|...|...|.....|:..|.||..:|:.:|.:||:..|.|::..    |.|.
  Rat  1122 DYLQPKLLGILAFFNMQLLSSSVGIEDKKMALTSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFK 1186

  Fly  1018 HTLQEPRLQRICLKIWHIFLHVVNVQELGPSLGRIVATLQPLLADNESVKQVNDLYEFIILRNAS 1082
            ....|     :|.:.|..|:..::...|||.|..::..|.||:  ....|:...::.::|:.|..
  Rat  1187 DDFPE-----LCCRAWDCFVRCLDHAYLGPLLSHVIVALLPLI--QMQPKETAAIFHYLIIENRV 1244

  Fly  1083 MLGTFITDLYFL---DRMENVSPSIQKCIRRHTAHLDLKGLAEEENQSPPLVDQLRFLQKHITDE 1144
            .:..|:.::|||   ..:|.:...:|:             ..:|.::|..|...|:...|.|..|
  Rat  1245 AVQDFLHEIYFLPDHPELEKIKAVLQE-------------YRKETSESTDLQTTLQLSMKAIQHE 1296

  Fly  1145 CLQVRVYALQHLGDLFGRRRPKLNSTILSELPLEPMLEQIVNVLMAGCQHDDSQLQMASAKCLGE 1209
            .:.||::||..|.:...:.:.||.........:||::.|:|.|::.|||..:||.::...:||||
  Rat  1297 NVDVRIHALTSLKETLYKNQEKLIKYATDSETVEPVISQLVTVILKGCQDANSQARLLCGECLGE 1361

  Fly  1210 LGAIDASYLPSNYNFASPQ------HLPLNILSDDFAVLALTSLCRGY-QFQQNTKHVDSFSLAI 1267
            |||||    |...:|::.:      .....:....||...|..|.|.| .:..|::..||.:.||
  Rat  1362 LGAID----PGRLDFSTTETQGKDFTFVTGVEDLSFAYGLLMELTRAYLAYADNSRAQDSAAYAI 1422

  Fly  1268 QETLAI--CGISPKEQKKVQLWQSLPARMRQLMEPMLHSCYTCVHRPS--TCLQQPLFGSHYSHN 1328
            ||.|:|  |..........|||:..|..:|:::||.|::.|....:.:  :.:.:|::.|...:|
  Rat  1423 QELLSIYDCREMQSNGPGHQLWKRFPEHVREILEPHLNTRYKSSQKSTDWSGVTKPIYLSKLGNN 1487

  Fly  1329 YYEEWAFLWASRLIDYLPSSGRRHLLSSYKPC----IKRDSNMLSTFYPYILLHALLECTTEQRN 1389
             :.||:..||.    ||.:..|.:|.|....|    :|.|..:.....|:||::.||.|:.|.:.
  Rat  1488 -FAEWSSSWAG----YLITKVRDNLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCSQEDQQ 1547

  Fly  1390 HIQEEFMAVLQANEESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPLASTLVSDRKEDSSRVP 1454
            .:..|.||||:.:::.:.|.                                     ::.:|.:.
  Rat  1548 EVYAEIMAVLKHDDQHAIST-------------------------------------QDSASDLC 1575

  Fly  1455 RLAGKLCAELLDFLQRWLR-EWQRIHGRSTGGKPPETIDS----NYRKIHEFLNLIPKLLVSRAS 1514
            :|:.:....:||.|.:|.| ::|.::........|:.:.|    :|:.:..||:|||:..::.||
  Rat  1576 QLSTQTVFSMLDHLTQWARHKFQALNAEKLAQNKPKGVSSVNFEDYQSVTRFLDLIPQDTLAVAS 1640

  Fly  1515 YNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQDIL 1579
            :....|.||:.:.||::.|   |.|.:.:...||.::|.::.:||.|.|...:|..:.|:.:.||
  Rat  1641 FRSKAYTRAVMHFESFITE---KKQNIQKHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQIL 1702

  Fly  1580 VNRLVERQQDMITSYEQLLSSTDQMQPDH-------VRAMIDAYLRDTPKTAQLIADGLWQRLSD 1637
            .:..:...:|....|::.:    |::||.       |::|:......|..|.   .:|:....|:
  Rat  1703 EHESIGLLRDATACYDRAI----QLEPDQIIHYHGVVKSMLGLGQLSTVITQ---VNGVHANRSE 1760

  Fly  1638 RYSDQCFAECKSELLWRLGSYDEMEEL------QSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGM 1696
             ::|: ....:.|..|:|..:|.:|..      .:.|..:..|..|..::..||.. :|:|....
  Rat  1761 -WTDE-LNTYRVEAAWKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDTTAF-YDTLKLVR 1822

  Fly  1697 RESVLEELRSCSAVQQHSYANAYDAVLKLHLVHEL-HCSQELVEKLEQDRDEDNQEKLMKNYFDD 1760
            .|.::.  .|.::.::.||...|:.:::||::.|| |..:.|..|.  ..|..|::.|      :
  Rat  1823 AEQIVP--LSAASFERGSYQRGYEFIVRLHMLCELEHSLKPLFHKF--PGDSCNEDSL------N 1877

  Fly  1761 WQYRLQIVQPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQ 1825
            |..||::.|...|.:|.|.:.||.:|: |.:|        |.....:...||.||::.|.||..|
  Rat  1878 WAARLEMTQNSYRAKEPILALRRALLS-LNKR--------PDYNEMVGECWLQSARVARKAGHHQ 1933

  Fly  1826 RAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRHLFF 1890
            .|...:|.|.|.:.:.|::||||.||.|||...|:..|::.:.:    |....|. ..|.:|:..
  Rat  1934 TAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGVEL----CFPENKS-PTESKHMLI 1993

  Fly  1891 RGK--YLQAVYSAESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSEPTGE 1953
            .|:  .|...:..|:.:..::|::|.:::......:.|..|..:|::.:|::......|.|   :
  Rat  1994 HGRATLLVGRFMEETANFESNAIMKKYKDVTLFLPEWEDGHFYLAKYYDKLMPMVTDNKME---K 2055

  Fly  1954 QDDMLINVMVNYAKSLRYGSEHVYQSMPRLISLWLDTTESSTNTEQ------------VKKMNDL 2006
            |.|::..:::::.:||:||::.:||||||::|||||....:...|:            :.|:|.:
  Rat  2056 QGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLSLWLDFGAKAYEWEKGGRSDRLQMRNDLAKINSV 2120

  Fly  2007 LTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHR 2071
            ||.....|....|.|.:||::||:||..::||.||..:|.|:..|||||::||:....||:...|
  Rat  2121 LTEHTNRLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMR 2185

  Fly  2072 IKRCKLVLTDSRLQNSTFQKLLQDFNSLTERLMDLTNKEVT-LDRTYKLSDLDTRLSKLCKQPEF 2135
            :.|||.:||.:.....:.:|.:.|...||::|::|.||.|. .:.|..:|.....|.||.:.|.|
  Rat  2186 VNRCKEILTKAIHMKKSLEKFVGDATRLTDKLLELCNKSVDGSNSTLSMSTHFKMLKKLVEDPTF 2250

  Fly  2136 SQILLPFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKL 2200
            |:||:|.:..|.||||      |..|:|  ||...   ||....|::||.:.|.||.|..||||:
  Rat  2251 SEILIPLQSVMIPTLP------SILGAH--ANHDP---FPGHWAYLAGFDDVVEILSSLQKPKKI 2304

  Fly  2201 TIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLV 2265
            :::.||||.|.::.|||||||:|.||||||.|:.:.|.:||.:|:|.||||||||:|.|:|||::
  Rat  2305 SLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLNDECGII 2369

  Fly  2266 EWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQ 2330
            ||:.|.|..|.|...||.::.:.|:.::|:...:|...::..|.:||.:.|:|.|||||.||..:
  Rat  2370 EWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFQEILLPRHPPVFHEWFLR 2434

  Fly  2331 RFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPY 2395
            .|..|.|||.:|:.|.|:.||||||||||||||||||||||....|:.||||||||||:||....
  Rat  2435 TFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFEV 2499

  Fly  2396 PEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYD---VGAQTRKGA 2457
            ||:|||||||||:..|||:|.||.||:.||:||||::.:.:.|||:|:.|::|   ..::..||.
  Rat  2500 PEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTLRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGH 2564

  Fly  2458 ATA-----------KITKDVQRIADRLQGHVK-RQQANSIPLSTEGQVNFLINEATKVDNLASMY 2510
            :.|           |....|..|..||||.:| |.:...:|||.||.|::||.|||..:.|..||
  Rat  2565 SKAPPNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMY 2629

  Fly  2511 IGWGAFL 2517
            :||..::
  Rat  2630 LGWTPYM 2636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 28/108 (26%)
FAT 1653..1985 CDD:280429 90/340 (26%)
PIKKc_ATR 2181..2448 CDD:270625 144/266 (54%)
FATC 2486..2517 CDD:280430 16/30 (53%)
AtrXP_003750609.1 UME 1120..1226 CDD:214825 29/112 (26%)
FAT 1766..2087 CDD:280429 91/348 (26%)
TEL1 <2118..2636 CDD:227365 239/528 (45%)
PIKKc_ATR 2285..2559 CDD:270625 145/273 (53%)
FATC 2605..2636 CDD:280430 16/30 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166339300
Domainoid 1 1.000 291 1.000 Domainoid score I1472
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 780 1.000 Inparanoid score I499
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 1 1.000 - - FOG0004409
OrthoInspector 1 1.000 - - oto95896
orthoMCL 1 0.900 - - OOG6_102609
Panther 1 1.100 - - LDO PTHR11139
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X3128
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.760

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