DRSC/TRiP Functional Genomics Resources

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Protein Alignment mei-41 and pik3c2a

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_005159362.2 Gene:pik3c2a / 571356 ZFINID:ZDB-GENE-030328-39 Length:1691 Species:Danio rerio


Alignment Length:1522 Identity:272/1522 - (17%)
Similarity:493/1522 - (32%) Gaps:476/1522 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1255 QNTKHVDSFSLAIQETLAICGISPKEQKKVQLWQSLPARMRQLMEPMLHSCYTCVHRPSTCLQQP 1319
            |..:..|:|     |.:.:..::.:|.:|:.|..|..|..              :.|||:.|...
Zfish    86 QKKEQKDNF-----EDIDLENLTKEELEKLLLDDSFGANK--------------MTRPSSLLGCN 131

  Fly  1320 LFGSHYSHNYYEEWAFLWASRLIDYLPSSGRRHLLSS----YKPCIKRD--SNMLSTFY------ 1372
            |..|:...:.:...:|.|..     .|:..:..:..|    ..||..::  |..:|.|.      
Zfish   132 LSASYPGGHAFNPSSFHWTP-----TPTHAQTPIFPSAPFAKPPCSFQNGFSPAMSPFIPPTPFL 191

  Fly  1373 -------PYILLHALLECTTEQRNHIQE-----EFMAVLQAN--EESSSSVRGRQELGAIKENA- 1422
                   |..|:::....|.|......:     |::...:::  |..|:||:..:.|....|.. 
Zfish   192 SFTPIQPPAALVYSQPAVTPEMAKLFDKIASTSEYLKNGRSSSMETESASVKSLEPLPQPSEPPN 256

  Fly  1423 FKQFESRKYAAGIKPLASTLVSDRKE-DSSRVPRLAGKLCAELLDFLQR-------WLREWQRIH 1479
            ..:||    ...:.||     :.||| :....|.::.  |    .|::.       |....|..|
Zfish   257 ISRFE----WLDLDPL-----NKRKEVEVEETPAVSS--C----PFIEESGKAKDPWDAVLQDEH 306

  Fly  1480 GRSTGGKPPETIDSNYRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQ 1544
                     ||:|:...|..|..    |....|.:.......::.|...|.....:...:::.:.
Zfish   307 ---------ETVDNGSPKAEEKC----KATQPRRASTGAAVTKSQSLSISSNSTNQSTGKQVNKG 358

  Fly  1545 FTFLVEVYGSLRDPDS--------VEGAVQVRSY----DMSVTQDILVNRLVERQQ---DMITSY 1594
            .|.::..|.:|::.::        .|...::||.    |:|.....:::.::.::.   |...|.
Zfish   359 STNVLSKYSALQEKEAQNLEVVAFCEDISKLRSKFPHDDLSTNPGYVLSPVITQRDAGGDNGGSV 423

  Fly  1595 EQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADGLWQRLSDRYSDQCFAECKSELLWRLGSYD 1659
            :..:..:|..||       ..:..|......|:   :.|.|...:.|....:..|.:|...|..:
Zfish   424 KVSIEISDSQQP-------VTFTCDVTSPVDLL---IMQALCWVHDDLNQVDINSYVLKVCGQEE 478

  Fly  1660 EMEELQSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLEELR-SCSAVQQHSYANAYDAVL 1723
            .::...|....:..|.|.|....:..::.|   |..||..:..... ..|.:....|....:...
Zfish   479 VLQNKHSLGSHEYVQNCRKWESEIKLQLLF---LSTMRRDLARTAEDDISPIDLEKYLGLVERPF 540

  Fly  1724 KLHLVHELHCSQELVEKLEQD--------RDEDNQEKLMKNYFDDWQYRLQIVQPQVR---IQES 1777
            |     |....:.|.|.||..        ::|:||.|.:.|.....: .|.....:|.   |.::
Zfish   541 K-----EAVTREGLAEYLEGFHKQVNLCLQNENNQYKTVDNVVQSVK-NLCCALDEVETPAITDA 599

  Fly  1778 IYSFRRNI----------LAELQRRLTDRN--------------HLLPHLKTELARIWLNS---- 1814
            :...:|::          .||||...|...              .:|.....|||:::|.|    
Zfish   600 VKRLKRSVNLPRTRSPEHYAELQAGATSSGGSANGYSSPVEESLAVLTDAVYELAKLYLQSFCPI 664

  Fly  1815 -------------AQINRNAGQLQRAQL-------------------YILKAAEYQPSGLF--IE 1845
                         ......:|..:..|.                   |::.|..:....||  ::
Zfish   665 SPGFMIEEHKEDERDSKEASGTTEHLQFTLFAVHGIPATWVSSFEKYYLMCALTHNNRNLFKPVQ 729

  Fly  1846 RAK----------LLWQKGDQVMAMNY--------LEEQLSI------------------MRSGC 1874
            ..|          :.|.:     .:|:        ||..||:                  .|.|.
Zfish   730 SKKVGTYKSFFYHIKWDE-----LINFPISVSLLPLEAMLSLSLYGVLSQNANNSPDSNKQRKGP 789

  Fly  1875 Q--GNVKQLAAEQRHLFFRGKYLQAVYSA----------------ESMHLCAD----AVLKYFQE 1917
            :  |.|.....:.|.:..||..|.:::::                |.:.|..|    ||     :
Zfish   790 ELLGKVSMPLFDFRRVLSRGSKLLSLWTSPQALQPGAAGKGRNPTEKIILQVDFPSPAV-----D 849

  Fly  1918 AIAVHRQSESCHVQMAQFLEKILEARQGGKSE-----------PTGEQDDMLINVMVNYAKSLRY 1971
            .:.|..|...|  ...|.|:.:   .|..:||           .....|..|:.....|.:...|
Zfish   850 VLYVGPQENGC--PNPQSLDPL---DQDDRSEIEKLCARASTFGLSRADRQLLWDQRYYCREYEY 909

  Fly  1972 GSEHVYQSMP-----------RLISLW--------LDTTESSTNTEQVKKM---------NDLLT 2008
            ....:..|.|           .|:..|        |:..||.....:|:|:         :|.|.
Zfish   910 SLPKILASAPSWDWGSMGEIHALLHHWPALSPVSALELLESKFADTEVRKVAVSWIQSSSDDELA 974

  Fly  2009 NCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIK--LVEAYPQQSL-----WMLLPHFKS 2066
            :....|..||.:.         ||        |:|.::|  |..|....::     |:|....:.
Zfish   975 DYLPQLVQAVKFE---------CH--------LKNALVKFLLSRALGNVNIAHYLYWLLRDAVQD 1022

  Fly  2067 -AKAHRIKRCKLVL-----TDSRLQNSTFQKLLQDFNSLTERLMDL---TNKEVTLDRTYKLSDL 2122
             |...|.:|...||     |..|.:.....:|:|...:|.|::...   |.:.|.|:...::...
Zfish  1023 PAFGQRYERILCVLLCLCGTGLRAELEKQTRLVQLLGALAEKVRQASSSTRQVVLLEGLERVQSF 1087

  Fly  2123 DTRLSKLCKQPEFSQILLPFEKYMQPTL---PLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGF 2184
            ..:.|  |:.|            :.|:|   .||                         |.:..|
Zfish  1088 FQKNS--CRLP------------ISPSLVAKELN-------------------------IKVCSF 1113

  Fly  2185 QESVLILRSAAKPKKLTIRCSD--GKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRR 2247
                  ..|.|.|.|:.:..:|  |.:.:|:.|..:|||:|...::...::.|...|:.    ..
Zfish  1114 ------FNSNAVPLKIALVNADPLGDEINVMFKVGEDLRQDMLALQMIRIMDRIWLQEG----LD 1168

  Fly  2248 LHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVF 2312
            |.|..:..:...::.|:||.:|:..:.|.|.:. |.    |..:.:.:.||              
Zfish  1169 LRIVNFKCISTGKDKGMVELVPSSETLRKIQVE-YG----VTGSFKDKPLA-------------- 1214

  Fly  2313 TKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGD 2377
                         ||||:.......:.:|...:|.|.|...:..||||:.|||.:||:. ...|.
Zfish  1215 -------------EWLRKYNPAEDEYEKASENFIYTCAGCCVATYILGICDRHNDNIML-RSTGH 1265

  Fly  2378 AVHVDFNCLFNQGELLPYPEVV--------PFRLTHNMIVAMG----PLGVEGSFRKCCEITLRL 2430
            ..|:||      |:.|.:.:::        ||.||.:|...:.    |......|...|.....|
Zfish  1266 MFHIDF------GKFLGHAQMIGSFKRDRAPFVLTSDMAYVINGGERPTSRFQLFVDLCSQAYNL 1324

  Fly  2431 LKQESKTLMSILRPFVYDVGAQTRKGAATAKITKDVQRIADRLQGHVKRQQANSIPLSTEGQVNF 2495
            :::.|...:::|       ...|:.|.......:|::.:.|.||           |.:|:.:...
Zfish  1325 IRKHSNLFLNLL-------SLMTQSGLPELTGVQDLKYVYDALQ-----------PQTTDAEATI 1371

  Fly  2496 LINE---------ATK----VDNLASM 2509
            ....         |||    :.|||.:
Zfish  1372 FFTRLIESSLGSVATKFNFFIHNLAQL 1398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825
FAT 1653..1985 CDD:280429 78/485 (16%)
PIKKc_ATR 2181..2448 CDD:270625 61/280 (22%)
FATC 2486..2517 CDD:280430 8/37 (22%)
pik3c2aXP_005159362.2 Amelogenin <137..207 CDD:330537 11/74 (15%)
PI3K_rbd 420..507 CDD:307097 16/96 (17%)
C2A_PI3K_class_II 681..852 CDD:175979 26/180 (14%)
PI3Ka 872..1038 CDD:320871 34/182 (19%)
PKc_like 1045..1397 CDD:328722 90/457 (20%)
PX_PI3K_C2_alpha 1428..1536 CDD:132822
C2B_PI3K_class_II 1565..1686 CDD:176027
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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