DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-41 and smg1

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_009297728.1 Gene:smg1 / 569810 ZFINID:ZDB-GENE-061013-767 Length:3641 Species:Danio rerio


Alignment Length:2560 Identity:497/2560 - (19%)
Similarity:846/2560 - (33%) Gaps:896/2560 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   676 KVIGQLVSAMRVRSPEFLEQLANLVLAA--IKAMLAKPLTEQNVLQQRSMLNVLTAIAHMEDNEI 738
            |.:||.:....|.:.....|..|..||.  ::....:||...   ::..:.|:|...:..:|.|.
Zfish    95 KSLGQELRINDVTTDITTFQHGNRALATKDMRKSQDRPLAHS---EESRLANLLRRASREDDRER 156

  Fly   739 WLFHWFKMTFFFLVHTRSLVA---------------------------QEAVLAATEMCASQGLQ 776
            .| ...|....|:||:.:.|.                           |||......:||:...:
Zfish   157 RL-ATMKQMKEFIVHSENKVVLVKQLDSILSTLNDILNESSKLLQELRQEAAWCLGLLCAALSYE 220

  Fly   777 TIHLWNWYKRDALDLTVRLALNVYLLDGVRFTRSLRALTKMLGFTCVQEFT-CKYHRLLTAMVLP 840
            ...::.|.   .|..:|.....|.||..|...::|....:...|:.|.:.. .....:|..:..|
Zfish   221 AERIFKWM---FLKFSVSTKDEVKLLYLVAVHKALETAGEKKAFSAVMQLVMSNLQSILENLDTP 282

  Fly   841 HCIVNPLCKGV-LVLIAKQMQKHIGTLFSISF-----LRIYTHVFLTEEPELANSCIELVVSCTQ 899
            ..    ||:.| .:|:..:...||   ||.:|     :.:..|:..|::..|...     ||...
Zfish   283 EL----LCQSVKCILLVARCYPHI---FSTNFRDTVDILVGWHIDHTQKHSLTQQ-----VSGWL 335

  Fly   900 SSLQQLMNADV-------------KQTVAELLIYFNRN---------PTFVMRSFQSLLQL---- 938
            .||:|...||:             .:..||.|.:....         ||..:....:||::    
Zfish   336 QSLEQFWVADLAFSTTLLGQFLEDMEAYAEDLSHVVSGESGDEDIPPPTVSLPKLAALLRVFSTV 400

  Fly   939 --SIGS-LEELSSQTANAEFANFIAERFLGVIT------YFESCLSEPSFEKPLKEETLYSL--- 991
              |||. ...:........:...:..|.|..:|      :.|:.|:..:       |.:..|   
Zfish   401 VHSIGERFNPIRGPPITEAYVTDVLNRVLACVTTAKQVFFSEAVLTAGN-------ECVCVLLVS 458

  Fly   992 ----GQIMRFVGSQHVTQ----------FRFKIIAML-------------SFVHTLQEPRLQRIC 1029
                ||::..|.|..:.|          :...::.:|             |||..|..|:...:.
Zfish   459 IDLGGQLIDAVISYGLDQLNCCQNCGPEYSLSVLTLLTLVVDQINTKLPASFVEKLLAPKSHLLE 523

  Fly  1030 LK-------------IWHIFLHVVNVQELGPS----LGRIVATLQPLLA-----------DNESV 1066
            |:             ::|..|.:.|:..|..:    ||.:...|..||:           .:.:.
Zfish   524 LRFHREREVMAAAHGVYHAVLSLKNIPILEAAYKLVLGEMGCALNSLLSPLGLPDACPHIQHPAF 588

  Fly  1067 KQVN---DLYEFIILRNASMLGTFITDLYFLDRMENVSPSIQKCIRRH--TAHLDLKGLAEEENQ 1126
            .|:|   :..||:::.|.|.|.|.......|..|..:||::...:.::  ..|.||.       .
Zfish   589 SQLNFSPERAEFVLIFNLSALTTIGNTKNSLIGMWALSPTVFALLSQNLVIVHSDLA-------V 646

  Fly  1127 SPPLVDQ--LRFLQKHIT--DECLQ------------------VRVYALQHLGDLFGRRRPKLNS 1169
            ..|.|..  |..|..|.|  |..:.                  |.....:|...|.     .|..
Zfish   647 HHPAVQYAVLYTLYSHCTRHDHFISSSLSSSSPSLFDGAVISTVTTATKRHFSTLL-----NLLG 706

  Fly  1170 TILSELPLEPMLEQIVNVLMAGCQHDDSQLQMASAKCLGELGAIDASYLPSNYNFASPQHLPLNI 1234
            .:||:..|.|...:::.....     :..|.|..::....|.:     |||...|.  :.|..|.
Zfish   707 MLLSKDHLNPEARRLLLTWSL-----EVALMMKKSETYAPLFS-----LPSFLKFC--KGLLANS 759

  Fly  1235 LSDDFAVLALTSLCRGYQFQQ-NTKHVDSFSLA---IQETLAICGISPKEQKKVQLWQSLPARMR 1295
            |::|      |::|    .|. |:..|.|.||.   :|..:.:|        :|||..| ..|:|
Zfish   760 LNED------TTIC----LQACNSLQVLSSSLTMELLQRCVDVC--------RVQLVHS-AVRVR 805

  Fly  1296 QLMEPMLHSCYTCVHRPSTCLQQPL---FGSHYSHNYYEEWAFLWASRLIDYLPSS--------- 1348
            |....:|.|.             |:   ..|.:||:..:|.: |...|.:..:||:         
Zfish   806 QAFGKLLRSV-------------PMHVALSSAHSHSEIKEIS-LAIRRHMSKVPSNTFHPQDFSD 856

  Fly  1349 -------GRRH-------LLSSYKPC---IKRDSNMLSTFYPYILLHALLECTTEQRNHIQEEFM 1396
                   |..|       |...|..|   .|:||.|:    |..||..  |....|        .
Zfish   857 LIGFILYGTVHRGGKEPWLERLYHSCQRLEKKDSAMV----PRALLKT--EAVLWQ--------W 907

  Fly  1397 AVLQANEESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPLASTLVSDRKE----------DSS 1451
            ||.:|.:.:..| :.|..||. .::.|:..|..     |:.||:..::..:|          :..
Zfish   908 AVWEAAQFTVLS-KLRTPLGR-AQDTFQTIEGM-----IRSLAAHSLNTEQELSQWSGGESDEGH 965

  Fly  1452 RVPRLAGKLCAELLDFLQRWLREWQRIHG-RSTGGKPPETID----SNYRKIHEFLNLIPKLLVS 1511
            ...:|...|..:.|:.|::.:  :....| .|....||:.|.    :|.:...::|..| :|.:.
Zfish   966 HTNQLRLALLLQFLENLEKLM--YNAYEGCASALTAPPKGIRTFFYTNRQTCQDWLTRI-RLALM 1027

  Fly  1512 RASYNCGEYARALSYLESYLEEGEDKSQRLLEQ---FTFLVEVYGSLRDPDSVEG----AVQVRS 1569
            |.....|:.|..:.:....|.|.::.|.:..|.   .|.|||....||.|::::|    ::....
Zfish  1028 RVGLLSGQPAVTVRHGFDLLTEIKNSSTQGPEMEVPVTMLVEALCELRCPEAIQGLAAWSLANTG 1092

  Fly  1570 YDMSVTQDILVNRLVERQQDMITSYEQL-------------------LSSTDQMQPDHV------ 1609
            ..|.....:.:....:.::..:...|||                   |:.|:...|.|.      
Zfish  1093 KSMGWLSSVALQAEGKFEKAALEYQEQLCAVTGMDCSIKVFDRSLLKLTGTNTSSPKHTSSGEGR 1157

  Fly  1610 ---------------------------------------RAMIDAYLRDTPKTAQLIADGLWQRL 1635
                                                   .:|::.....:..:..|..|..:.|.
Zfish  1158 KTVLLKSSECSPEVLNFLANKACECYVALSDWESVQEWQASMMNLKKNSSSSSVNLKTDFNYIRA 1222

  Fly  1636 SDRYSDQCFAECKSEL---------LWRLGSYDEMEELQSNWPAQCSQGCLKLRRPLTTRI---- 1687
            ..|:.:..|.||:::|         |....:.|:: :|:...||..|....:|::.:..::    
Zfish  1223 MSRFEEGDFTECRAQLELLPGDDYGLLNSTTKDKI-DLKRLLPAVLSPDPSELQKAIEVQLLRSA 1286

  Fly  1688 ----------------EFDSLLDGMRESVLEELRSCSAVQQHSYANAYDAVLKLHLVHELHCSQE 1736
                            ..|:|:..::::.    |.|....:.|.....|::..|..: :|||:..
Zfish  1287 VGAISATNHEQDQKVASSDTLVKYLKQTG----RICLGPLRLSTLTLSDSLPTLSTL-QLHCANS 1346

  Fly  1737 LVEKLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQRRLTDRNHLLP 1801
            |...|.....||....|......  ..:.|.|||.:.... ..:|:|....:|:...:.      
Zfish  1347 LENSLCNQHPEDCLIPLFSEALT--TCKQQDVQPWLHALR-YTTFQREFFQKLKGSSSP------ 1402

  Fly  1802 HLKTELARIWLNSAQINRNAGQLQRA-QLYIL--KAAEYQPSG---------------------- 1841
             :.:.|..:.|.:.:..|..|.:..| :|..|  |.|.....|                      
Zfish  1403 -VDSHLMELCLTAVKFARKQGNIALATRLLSLCSKPAMSDTEGQDLVQSFRQLSLEGTVGEKWGP 1466

  Fly  1842 -LFIERAKLLWQKGDQVMAMNYLEE-QLSIMRSG------CQGNV---KQLAAEQRHL------- 1888
             |.||:||:|:..|..|.||..|.. .||...||      |:..:   |.|.|:.:.|       
Zfish  1467 ELEIEKAKVLFAAGQSVSAMEMLSSCALSYCHSGKCELAACRSVLTLCKWLLADWKDLTPQLKMV 1531

  Fly  1889 -----------------------------------------------FFRGKY-----LQAVYSA 1901
                                                           |..|:.     .||...|
Zfish  1532 VKKNSGSTSLSTLSKNISGLLELPLEDQGMPHITTETTVSVGVGEPDFVLGQLYQLSTTQAPEVA 1596

  Fly  1902 ESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQ--FLEKILEARQGGKSE--------------- 1949
            :|....|....::.::.:....|.|...:.:.:  .:|::|.|   |.|:               
Zfish  1597 KSWAALASWAYRWGRKVVDNASQGEGVPLLLGEKKEIEELLPA---GTSDEDKETIFGILGQAMC 1658

  Fly  1950 -PTG-------------EQDDM-------------------------LINV---MVN-----YAK 1967
             |.|             ::|||                         ||.|   :|:     |..
Zfish  1659 RPAGIQDEDMALQNEEDDEDDMVDVIGRQLLGACPWLSDVEDTVTDGLIGVWRRVVDRIFSLYRV 1723

  Fly  1968 S---------LRYGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDL----------------L 2007
            |         |..|...:.:..|:|:   |:...|..:::.|..|..|                |
Zfish  1724 SCRAYFTFLKLNAGQVPIDEDDPKLL---LNNQNSKQSSDDVIVMATLRLLRLLVKHAGELREGL 1785

  Fly  2008 TNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLL-------PHF- 2064
            .:...:.|||.:..:..|:.|||.||                |||.:||:..||       ||. 
Zfish  1786 EHGLASTPTAPWRGIIPQLFSRLNHP----------------EAYIRQSICSLLCRVAQDSPHLI 1834

  Fly  2065 -------------------------------------------------KSAKAHRIKRCKLVLT 2080
                                                             .|.::.|.:...:..:
Zfish  1835 LYPAIVGSISLGGEAQTAGNKLPSSLPTLLGNMQGEGLCGGESETGSGPTSQESSRGEEMVMYSS 1899

  Fly  2081 -DSRLQNSTFQKLLQDFNS-------------------------------------LTERLMDLT 2107
             |..:....:.|::...:|                                     :..|:..|.
Zfish  1900 EDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVGELRRVTLLWDELWLGVLQQQHMHVLRRIQQLE 1964

  Fly  2108 N--KEV----TLDRTYKLSDLDTRLSKLCKQPEF----------SQILLPFEKYMQPTL------ 2150
            :  |.|    ||.:..|::.:..:.|.|.|...|          :....|.|::.|.|.      
Zfish  1965 DEVKRVQNNNTLRKDEKVAIMREKHSALMKPVVFALDHVRSITAAPAETPHEEWFQETYGDAIHN 2029

  Fly  2151 -------PLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQ----------------------- 2185
                   |||           |||.:: :|.|::||.:|..|                       
Zfish  2030 ALERLRSPLN-----------PANPAS-SWVPFKQIMLSLQQRAQKRASYLLRLDEISPRLTAMA 2082

  Fly  2186 ----------------------ESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLME 2228
                                  .::.||.:..|||||....|||::|..|.|..:||..|.|:|:
Zfish  2083 NTEMALPGEVSATDAVTIQSVGNTITILPTKTKPKKLYFLGSDGRNYPYLFKGLEDLHLDERIMQ 2147

  Fly  2229 F----NGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWL----PNLASYRSICMNLYAQR 2285
            |    |.:..:...|::|    |...|.|:|.|.....||::|:    |....|:.     :.||
Zfish  2148 FLSIVNTMFTKVNQQESP----RFQARHYSVTPLGTRSGLIQWVDGATPLFGLYKR-----WQQR 2203

  Fly  2286 RLVM-------STRQLQSL-------------------AVPLHESIERK-------REVFTKQLV 2317
            ..|:       |.:|.|:|                   ||.|...:.|:       |:|. ::|:
Zfish  2204 EAVVQAQKAQDSFQQPQNLPMVPRPSELYYSKISPALKAVGLSLDVSRRDWPLSVMRDVL-RELM 2267

  Fly  2318 PAHPP-VFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHV 2381
            .|.|| :..:.|.....||..|:....||.|:.|||||||||:||||||.:|:|.....|:.||:
Zfish  2268 EATPPNLLAKELWCSCTTPSEWWSVTQTYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHI 2332

  Fly  2382 DFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFV 2446
            |:|..|.:|:.|..||.||||:|||:..|:|..||||.||..||..::::::..:||:::|..||
Zfish  2333 DYNVCFEKGKSLRVPEKVPFRMTHNIETALGVTGVEGIFRLSCEQVVQIMRRGRETLLTLLEAFV 2397

  Fly  2447 YDV--------------------GAQTRKGAATAKITKDV------QRIAD-RLQGHVKRQQANS 2484
            ||.                    |.|.....:..::.:|:      .|:|: ::.....|.:...
Zfish  2398 YDPLVDWTAGGEVGFAGAVYGGGGQQAENKQSKREMERDITRSLFSSRVAEIKVNWFKNRDEMTG 2462

  Fly  2485 IPLSTEGQVNFLIN---EATKVDNL 2506
            :....|..|:..:|   :.|:|:.:
Zfish  2463 VLPQLEEAVDEYLNLQEQLTQVEKV 2487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 26/157 (17%)
FAT 1653..1985 CDD:280429 87/519 (17%)
PIKKc_ATR 2181..2448 CDD:270625 107/353 (30%)
FATC 2486..2517 CDD:280430 5/24 (21%)
smg1XP_009297728.1 HEAT repeat 143..173 CDD:293787 9/30 (30%)
HEAT repeat 183..216 CDD:293787 4/32 (13%)
HEAT repeat 223..254 CDD:293787 8/33 (24%)
SMG1 622..1231 CDD:292413 128/689 (19%)
PIKKc_SMG1 2100..2406 CDD:270714 107/315 (34%)
FATC 3611..3640 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.