DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and pik3c2b

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	XP_003199535.1	Gene:	pik3c2b / 567938	ZFINID:	ZDB-GENE-050309-145	Length:	1587	Species:	Danio rerio

Alignment Length:	1216	Identity:	229/1216 - (18%)
Similarity:	400/1216 - (32%)	Gaps:	373/1216 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1482 STGGKPP-------ETIDSNYRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQ 1539
            |.|.:|.       :..:....::..|.:::..|   |::|.|.:|::...::.|.....::..|
Zfish   258 SLGSRPNGFGYELFQVSEERDEEVAAFCHVLDLL---RSAYPCNDYSKNSGFVWSPCVAQDELQQ 319

  Fly  1540 RLLEQFTFLVEVYGS-LRDPDSVEGAVQVRSYDMSVTQDILVNRLV---ERQQDMITSYEQLLSS 1600
            .|  ..:..|.||.. .|:|.:.       |.|.|.|.|:|:.:.:   ....|||...:.||..
Zfish   320 GL--GVSIKVTVYSDHFREPLTF-------SCDGSSTIDLLIYQTLCYAHDDLDMIDVDDYLLKI 375

  Fly  1601 TDQMQPDHVRAMIDAYLRDTPKTAQLIADGLWQRLSDRYSDQCFA-ECKSELLWRLGSYDEMEEL 1664
            ..|.:          :|::|...|           |..|..||.. :....|:....|...||..
Zfish   376 CSQAE----------FLKNTQTLA-----------SFEYIQQCLKFDWDIRLILTKRSSVNMELA 419

  Fly  1665 QS----NWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLEELRSCSAVQQHSYANAY---DAV 1722
            ::    :.|:..:...|...||:             :::|.:|..:......|:.|.::   :..
Zfish   420 RTTEDDDTPSTMNHSILLQERPI-------------KQTVTKEALTLLLDTFHNEAESFLLSEVE 471

  Fly  1723 LKLHLVHELHCSQELVEKLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRN--- 1784
            |.||:...:...:.|...|......|....|  |.......||   ||:|:...|:.:.:.|
Zfish   472 LPLHVERLVQSVKALCTSLAAVETPDITAAL--NQLPACPCRL---QPKVQKDVSVLAKKENRVA 531

  Fly  1785 ILAELQRRLTD-----------RNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQ 1838
            |:.:|...:.|           ..|.:||.....|.|        :.||.:.....:.:.||
Zfish   532 IVEKLTAAILDLVELYCSTFNANFHTMPHSSRSTAPI--------QEAGMVTNVLSFSVYAA--- 585

  Fly  1839 PSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQAVYSAES 1903
                  .|..:.|       |.:|  |...:..|...|.| :|.|.|
Zfish   586 ------HRVPITW-------AASY--ENFFLSCSLTHGGV-ELCAPQ------------------ 616

  Fly  1904 MHLCADAVLKYFQEAIAVHRQSESCHVQMAQF-----LEKILEAR----QGGKSEPTGEQDDMLI 1959
             |....:|.||... :.|..|.....||:.|.     |...|.|.    .||..|.:.::..:
Zfish   617 -HTSKQSVSKYLFH-LVVWDQRVCFPVQINQLPRESQLTVTLYATPLPPPGGAEEKSKQKRSI-- 677

  Fly  1960 NVMVNYAKSLRYGSEHVYQSMPRLISLWLDTTESS---TNTEQVKKMNDLLTNCCTALPTAVFYT 2021
             ..:.:.....:...||.....:|:.||..|..|.   ::|....:.:.::..  ...||:.|..
Zfish   678 -ESLGWVTMPLFNFRHVLTCGRKLLGLWPSTPGSGNARSSTPNFSQPDSVILQ--VDFPTSSFEV 739

  Fly  2022 VYS-----------------QMLSRLCHPV----------------------------------- 2034
            .:|                 |:..|..|.|
Zfish   740 RFSTPAPAEFSPQYEFSHLDQVSQRQLHDVLHKKSLFWLSPEDRRLLWEKRYFCHVEASRLPLVL 804

  Fly  2035 -----------NDVFTVLR--------NVIIKLVEAYPQQSL------WM----------LLPHF 2064
                       .|::.:||        :.:..|...:|.|..      ||          .||..
Zfish   805 ASAPSWEWACLPDIYALLRQWGCMNHLDALGLLNATFPDQECRRTAVQWMDSISDPELLDFLPQL 869

  Fly  2065 KSAKAHRIKRCKLVLTDSRLQNSTFQKLLQD-------FNSLTERLMDLTNKEVTLDRTYKLSDL 2122
            ..|..:   .|.|   ||.|.....::.:.|       |..|.:.|.|   .:.::...|.|:.|
Zfish   870 VQALKY---ECYL---DSHLVRFLLRRAIGDVRIAHYLFWLLKDTLQD---SQFSVRYQYLLAAL 925

  Fly  2123 DTRLSKLC-----KQPEFSQ------ILLPFEKYMQPTLPLNSDSNSSEG-------------SH 2163
                  ||     .:.||.:      :|....:.::...|.:..:...||             ..
Zfish   926 ------LCCSGRGLREEFDRQCWLVNVLAKVAQRVREASPSSRQAILREGLDDVKQFFSINSSCR 984

  Fly  2164 LPANQSTVNWFPYQQIYISGFQ-ESVLILRSAAKPKKLTIRCSD--GKDYDVLVKPKDDLRRDAR 2225
            ||.|..         :.:.|.. :|.....|.|.|.||:.:..|  |.:.:|:.|..||||:|..
Zfish   985 LPLNPG---------LLVKGINIQSCSYFNSNAVPLKLSFQNQDHLGDNINVIFKAGDDLRQDML 1040

  Fly  2226 LMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMS 2290
            .::...::.:...|:. ...|.:..|.::.   ....|:||.:|:..:.|.|.:     ...|..
Zfish  1041 TLQIIRIMNKIWVQEG-LDMRMVIFRCFST---GRGRGMVEMIPSAETLRKIQV-----EHGVTG 1096

  Fly  2291 TRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMV 2355
            :.:.:.||                           :||::...|...:.:|...:|.:.|...:.
Zfish  1097 SFKDRPLA---------------------------DWLQKHNPTEEEYEKAVENFIYSCAGCCVA 1134

  Fly  2356 GYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPEV--------VPFRLTHNMIVAMG 2412
            .||||:.|||.:||:. :.:|...|:||      |:.|.:.::        .||..|.:|...:.
Zfish  1135 TYILGICDRHNDNIML-KTSGHMFHIDF------GKFLGHAQMFGNIKRDRAPFVFTSDMAYVIN 1192

  Fly  2413 PLGVEGSFR------KCCEITLRLLKQESKTLMSILRPFVYDVGAQTRKGAATAKITKDVQRIAD 2471
            . |.:.|.|      .|||...| :::.:...:::|       |.....|........|::.:.|
Zfish  1193 G-GDKPSSRFHDFVDLCCEAYNR-IRKHAHLFLNLL-------GLMLSSGIPELSDVDDLKYVYD 1248

  Fly  2472 RLQGHVKRQQA--------NSIPLSTEGQVNFLINEATKVDNLASM 2509
            .|:.|.....|        .|...|...::||.|:      |||.|
Zfish  1249 ALRPHESEADATMHFTRLIESSLGSVATKLNFFIH------NLAQM 1288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	67/361 (19%)
		PIKKc_ATR	2181..2448	CDD:270625	61/283 (22%)
		FATC	2486..2517	CDD:280430	8/24 (33%)
pik3c2b	XP_003199535.1	PI3K_rbd	322..413	CDD:295323	25/118 (21%)
		C2A_PI3K_class_II	569..741	CDD:175979	41/215 (19%)
		PI3Ka	763..928	CDD:294194	28/179 (16%)
		PI3Kc_C2_beta	934..1287	CDD:119421	84/419 (20%)
		PX_domain	1317..1425	CDD:295365
		C2B_PI3K_class_II	1458..1579	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900