DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-41 and atr

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_696163.5 Gene:atr / 567770 ZFINID:ZDB-GENE-070912-458 Length:2633 Species:Danio rerio


Alignment Length:2868 Identity:732/2868 - (25%)
Similarity:1246/2868 - (43%) Gaps:650/2868 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 QEPSLISCSLVRELHNKFQDTFLLWLLNKLAKCLSESPDSSECINL----QRKILSS-------- 88
            |:|..|.|..:..:   ..|..::.|  :|.|..|..|   .|:.|    |..|.||        
Zfish    30 QKPRQILCQFIDRI---LTDVDVVAL--ELCKKSSSEP---ACVMLLDFVQHIIKSSSLMFINPA 86

  Fly    89 CCSNHPK------------LFERLV-LAYVEAIEETHLQLSSLDLGQLSNER-KPAITVRIFRCD 139
            |.|:|.|            :..||: :|.....|:.|:::||:....|...| |..:...:|..:
Zfish    87 CLSDHFKNSENSCTDFTKWIINRLLRIAACPECEDLHMKISSVICSLLHLFRAKAPVVFSLFSTE 151

  Fly   140 VECLQEFDPHCAIEDIKVPLEQADMYAKSLLEVLQHAHHIGYATHGDIFSGSLHQALLILKECDM 204
            :.||        |:|:                           .|.::.:....|..::::...:
Zfish   152 LICL--------IQDL---------------------------VHKNLMTRPSPQWPVVVERFSI 181

  Fly   205 DTKLASLNYCHNVLRSQSASSW----------ITNPDVGHYAQLTLEATAIMWSAVAKWLDMGCM 259
            .:..:::.....:|:..|.||.          :|:...|.:..   ....|:|.:....|..|  
Zfish   182 KSGESAVYLTPTILQLSSLSSTQALLATSLRVLTDVIQGLFFP---REVGIIWDSTCLMLSNG-- 241

  Fly   260 TRQELKRLNITTKLLLEVLHMRARPAHH---LGYLLLNEILSLPTAIELDDGLLETLSSYIQGQL 321
             ..:||.:::.  ||..::.:...|..|   .....|:.:.|||.   .|:..|...|...| ||
Zfish   242 -SPKLKAVSMV--LLTRIVTLGGFPEDHSQPFFSAFLHVLDSLPA---FDESELGVFSREFQ-QL 299

  Fly   322 EHSVVPLE-------QLVHLQQLMLSHWHCHPTHLVPILALMGLKQTEMRSGVVQVLT------- 372
            ...:...|       :.|||..||.     ....||.|.||..||..|:::.:.:|..       
Zfish   300 SRCIFQHEEGAHSRFERVHLNMLME-----RLEKLVVIGALEHLKVKEVKATLCEVFCFILGFVP 359

  Fly   373 ---QSLVEILKKEEVLSKDWQKLIAILRGFKQLEKLILSQSQHKIAEHEGHI-----DSSVLAML 429
               :..::|.|         :::.||.   |.|.|.|.::.||: ...||::     ..::.||.
Zfish   360 PGYECALQIRK---------ERVAAIC---KALIKTIGTKDQHE-QSLEGYLYAALKTDAIAAMQ 411

  Fly   430 PLQCEIIKVADTNW---------NNLSM--QL----------VELESK--------CSAD----- 460
            .:|..:...||...         .|||:  ||          |:::|:        |..:     
Zfish   412 DVQASVSDPADPRMYEEELPAKRPNLSLPTQLRSRDKTQPMQVDMKSRSEVWAAVDCRLEELLTQ 476

  Fly   461 -RRHIHLEICSLLMQITFIRHFLKTQTQHQLLAILQRHLKLSYLCAIR----------LETPSSV 514
             |.|...:..|.:..:..|.|.....::|.|.. .||..|.|....:.          .:...|.
Zfish   477 MRNHTVSQCVSAVQGLAVIFHLAALCSEHSLKG-PQRGEKSSESSVVAQLIWLKPQMLAQVVESC 540

  Fly   515 HTQMQSFYAQQYMR---------------LFQSEETQEIFCSNLPQLYISGFIKPEQ-------- 556
            .|.:.:.|.::::.               |..:.|:.:.|..|:..|....::....        
Zfish   541 RTVLANNYNEEHLEHLVEGIVRILDAVLYLSTNSESDKSFHRNICALLSVPWVLEHSSQSVYQTA 605

  Fly   557 --------LMKALPTINNRSGRAQVIRLL------LCSQPGKLSVFK------------------ 589
                    |.:.|..:.|...||..:.||      :|.. .:.||::                  
Zfish   606 SFPASLIALSQKLAPVYNAQTRAHCVFLLAPLSKSVCGD-WRSSVYRWALQSKSEAERASAVRGF 669

  Fly   590 --------VK----------DRIELYCPKCRPLPKKLPGI--YLGKC---------------KQQ 619
                    ||          :|::   .....:..:|.||  .|..|               ..|
Zfish   670 PILLHQLGVKSNSLIHEALLNRLQ---DSSTEVKTELAGITGQLACCLSESSQLQFPQETMPSHQ 731

  Fly   620 LPC-----PDFSSTNLEMIANDLL------------------FYPDFECIAQHLDLLCFEP---- 657
            |.|     .||.|:....|...:|                  |..:...:.:|:||...:|    
Zfish   732 LLCSGLSISDFHSSQTSSIGTSILTPFLQLLKPVEDMKVKQAFIKNIRHLFKHVDLGNTDPDTKA 796

  Fly   658 --NVILGLLRETEALQKVSVKVIGQ------------------LVSAMR--------VRSPEFLE 694
              |.::.|:.:.:  |:|.: :.||                  |||.::        .|:.|...
Zfish   797 LVNALVNLIEDPD--QEVRI-MFGQNIKNLLEFWNGNGFLKELLVSRLKEAYTNAKTSRNNELKN 858

  Fly   695 QL------------ANLVLAAIKAMLAKPLTEQNVLQQRSMLNVLTAIAHMEDNEIWLFHWFKMT 747
            .|            .|||..|:..:|...|::.|.:...:...: .|:|...|.::       .:
Zfish   859 TLILTTGEIGRAAEGNLVSFALLRLLHCLLSKSNPVSVAAYTEI-QALATCRDLKL-------QS 915

  Fly   748 FF---------FLV---HTRSLVAQEAVLAATEMCASQGLQ--TIHLWNWYKRD-ALDLTVRLAL 797
            ||         |||   |:|.:.|    |..|...:|:.||  ..|     :|: |||:...:| 
Zfish   916 FFSQYRNPICQFLVESLHSRHVTA----LRCTPDQSSEALQEEAAH-----QRELALDILSHVA- 970

  Fly   798 NVYLLDGVRFTRSL-RALTKMLGFTCVQEFTCKYHRLLTAMVLPHCIVNPLCKGVLVLIAKQMQK 861
              ::.|.....|.| |.|..:|.|...:                   .:|....::..||||:..
Zfish   971 --HVFDFPDLNRFLNRTLQVLLPFLAAK-------------------ASPTASALIRTIAKQLNV 1014

  Fly   862 HIGTLFSISFLRIYTHVFLTEEPELANSCIELVVSCTQSSLQQLMNADVKQTVAELLIYFNRNPT 926
            :...:...:|..|::|               ||.||::..|::..:....:|..||       .:
Zfish  1015 NRREMLINNFKYIFSH---------------LVCSCSKEELERAFHYLKNETEIEL-------GS 1057

  Fly   927 FVMRSFQSL---LQLSIG--------SLEELSSQTANAE-------------FANFIAERFLGVI 967
            .:.:.||.|   |.|.:|        .|..|:|..::.:             .|:::..:.||::
Zfish  1058 LLRQDFQGLHNELLLRLGEHYQQVFNGLAILASFASSDDPYQGPREITTPGCMADYLQPKLLGIL 1122

  Fly   968 TYFE-SCLSEPSFEKPLKEETLYSLGQIMRFVGSQHVTQFRFKIIAMLSFVHTLQEPRLQRICLK 1031
            .:|. ..||..:.||..|:..|.||..:|:.:|.:|::..|.|::..|. .....:.....:|.:
Zfish  1123 AFFNMQLLSSSAGEKEKKKMALNSLMSLMKLMGPKHISSVRVKMMTTLR-TGLRYKDDFPELCCR 1186

  Fly  1032 IWHIFLHVVNVQELGPSLGRIVATLQPLLADNESVKQVNDLYEFIILRNASMLGTFITDLYFL-D 1095
            .|..|:..::...|||.|..::..|.||::...  |:...:..::|:.|...:..|:.::||| |
Zfish  1187 TWDCFVRCLDPSYLGPLLSHVIVALLPLISIQP--KETAVIMHYLIVENREEVQDFLHEIYFLPD 1249

  Fly  1096 RMENVSPSIQKCIRRHTAHLDLKGLAEEENQSPPLVDQLRFLQKHITDECLQVRVYALQHLGDLF 1160
            ..|      .|.|     |..|:...::.::|..:...|:...:.|..|.:.||::||..|.::.
Zfish  1250 HPE------LKII-----HKVLQDYRKQTSKSTDMQAALQLSMRAIQHENVDVRIHALTSLKEMI 1303

  Fly  1161 GRRRPKLNSTILSELPLEPMLEQIVNVLMAGCQHDDSQLQMASAKCLGELGAIDASYLPSNYNFA 1225
            .:.:..|...:|....:||::.|:|.||:.|||..:::.::...:|||||||||...|  :.:.|
Zfish  1304 YKNQDALLKHVLDSEMVEPVISQLVTVLLRGCQDVNTEARLLCGECLGELGAIDPGRL--DLSPA 1366

  Fly  1226 SPQHLPLNILS--DD--FAVLALTSLCRGY-QFQQNTKHVDSFSLAIQETLAI--CGISPKEQKK 1283
            ..|......:|  ||  ||...||.|.|.: .:..:.:..|:.:.|:||.|::  |.....:...
Zfish  1367 DTQGTGSTFVSGIDDPNFAYELLTELTRAFLAYADDVRAQDAAAYAMQELLSLFECREGRTDSSG 1431

  Fly  1284 VQLWQSLPARMRQLMEPMLHSCYTCVHRPS--TCLQQPLF----GSHYSHNYYEEWAFLWASRLI 1342
            .:||:..|.::::::||.|::.|....:..  :.|::|::    ||.:|     :|:..||.   
Zfish  1432 RRLWRRFPEQVQEILEPHLNTRYKSSQKVVNWSKLKKPIYLSSRGSKFS-----DWSATWAG--- 1488

  Fly  1343 DYLPSSGRRHLLSSYKPC----IKRDSNMLSTFYPYILLHALLECTTEQRNHIQEEFMAVLQANE 1403
             ||.|..|..|......|    ||.|..:.....|:||::.|:.||.|::..:.||.||||:   
Zfish  1489 -YLISKVRHELAGKVFNCCSFIIKHDYKVTIYLLPHILVYVLIGCTQEEQREVTEEIMAVLK--- 1549

  Fly  1404 ESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPLASTLVSDRKEDSSRVPRLAGKLCAELLDFL 1468
                  .|...|..::|||                            |.:.:|:.:....:||.|
Zfish  1550 ------EGDPRLVRLQENA----------------------------SSLSQLSTQTVFSMLDHL 1580

  Fly  1469 QRWLR------EWQRIHGRSTGGKPPET--IDSNYRKIHEFLNLIPKLLVSRASYNCGEYARALS 1525
            .:|.|      ...:..|::...:||.|  .:|.|:.:..|||.||:.::::||:....|.||:.
Zfish  1581 TQWSRHKLQTLSTNKRTGKNAREQPPATGPENSEYQSVVAFLNSIPQDVLAKASFRSRAYTRAVM 1645

  Fly  1526 YLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQDILVNRLVERQQDM 1590
            :.||::.|   |.|.:.:..:||..:|.::.:||.|.|...:|..:.|:.:.||.:..:...::.
Zfish  1646 HFESFIRE---KKQNIQDHLSFLQTLYAAMHEPDGVRGVNALRKEEPSLREQILEHESIGLLRES 1707

  Fly  1591 ITSYEQLLSSTDQMQPD---HVRAMIDAYLR-------DTPKTAQLIADGLWQRLSDRYSDQCFA 1645
            ...|::.:    |::||   |...::::.|.       .|.....|.:...|:...:.|      
Zfish  1708 TACYDRAI----QLEPDQLAHYHGVMNSMLGLGQLSTVITQVNGVLASRPRWKSDLNAY------ 1762

  Fly  1646 ECKSELLWRLGSYDEMEEL------QSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLEEL 1704
              :.|..|:|..:|.:|:.      .|.|..:..|..|..::. .:...::.|....:|.|:.  
Zfish  1763 --RVEAAWKLSKWDLVEDYLASDCKSSTWGVRLGQMLLAAKKQ-DSEAFYEKLKIARKEQVVP-- 1822

  Fly  1705 RSCSAVQQHSYANAYDAVLKLHLVHEL-HCSQEL-VEKLEQDRDEDNQEKLMKNYFDDWQYRLQI 1767
            .|.::.:..:|...|:.:::||::.|| |...|| .|..|..|.:..:.||      :|...|.:
Zfish  1823 LSAASFECGTYQRGYEYIVRLHMLCELEHVFTELQKESSEAGRSKKPEPKL------NWDAHLLM 1881

  Fly  1768 VQPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYIL 1832
            .|...|.:|.:.:.||.:|: |.:..:        .:.::...||.||::.|.||..|.|...:|
Zfish  1882 TQNSFRAKEPVLALRRALLS-LSKGSS--------CEEQVGECWLQSARVARRAGHHQTAFNALL 1937

  Fly  1833 KAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQ---------GNVKQLAAEQRHL 1888
            .|.....|.||||:||.||.|||       :.:.|.:::.|.|         .:.|::..:...:
Zfish  1938 NAENSHLSELFIEKAKWLWSKGD-------VHQALIVLQKGVQQCFPDDQTLTDPKRIQVKGNAM 1995

  Fly  1889 FFRGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSEPTGE 1953
            ...|:|::...:.||     :|::|.:::...:..:.|..:..:|::.:|::......|.|..|.
Zfish  1996 LLVGRYMEETANFES-----NAIMKTYKDVTTLLPEWEDGNFYLAKYYDKVMPMVTDNKLERQGN 2055

  Fly  1954 QDDMLINVMVNY-AKSLRYGSEHVYQSMPRLISLWLD------TTESSTNTEQVK------KMND 2005
                ||..:|.| .|:|::|::::||:|||:::||||      ..|.:..:::|:      |:|.
Zfish  2056 ----LIRYIVTYFGKALQFGNQYIYQAMPRMLTLWLDFGAKVYEFEKAGRSDRVQMRTELTKINS 2116

  Fly  2006 LLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAH 2070
            ::::..:.|....|.|.:||::||:||..|:||.||..::.|:..|||||::||:....||:...
Zfish  2117 VISDHTSNLSPYQFLTAFSQLISRICHSSNEVFAVLMEIVAKVFLAYPQQAMWMMTAVSKSSYPT 2181

  Fly  2071 RIKRCKLVLTDSRLQNSTFQKLLQDFNSLTERLMDLTNKEVT-LDRTYKLSDLDTRLSKLCKQPE 2134
            |:.|||.:|..:...|.:|.|.:.|.|.||::|::|.||.|. ...|..:|.....|.||.::|.
Zfish  2182 RMNRCKEILKKAISLNDSFMKFIGDANRLTDKLLELGNKPVDGNSSTLSMSVHFKMLKKLVEEPT 2246

  Fly  2135 FSQILLPFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKK 2199
            |||||:|.:..:.||||....:|....:           ||...:|:|||.::|.||.|..||||
Zfish  2247 FSQILIPLQSVLIPTLPSTGGANPKHDA-----------FPGHWVYLSGFDDTVEILASLQKPKK 2300

  Fly  2200 LTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGL 2264
            ::::.||||.|.::.|||||||:|.||||||.|:.:.|.:||.:|:|.|.||||||:|.|||||:
Zfish  2301 ISLKGSDGKFYTMMCKPKDDLRKDCRLMEFNCLINKSLRKDAESRRRDLRIRTYAVIPLNEECGI 2365

  Fly  2265 VEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLR 2329
            :||:...|..|.|...||.::.:.:|..:|:.|.:|.....:.|.::....|...|||||.||..
Zfish  2366 IEWVNKTAGLRHILTKLYKEKGIYVSGTELKKLILPKTAPFQEKLKLHKDVLCARHPPVFHEWFL 2430

  Fly  2330 QRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLP 2394
            :.|..|.|||.:|:.|.|:.||||||||||||||||||||||....|:.||||||||||:||...
Zfish  2431 RTFPDPTSWYNSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFD 2495

  Fly  2395 YPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYD---VGAQTRKG 2456
            .|||||||||.||:.||||:|.||.||:.||:.|||::.:.:.|||:|:.|::|   ..::..||
Zfish  2496 VPEVVPFRLTQNMVHAMGPMGTEGLFRQACEVILRLMRDQREPLMSVLKTFLHDPLVEWSKPVKG 2560

  Fly  2457 AATAKITKD-----------VQRIADRLQGHVK-RQQANSIPLSTEGQVNFLINEATKVDNLASM 2509
            .:..::.:.           |..|..||||.:| |.:...:|||.||.|::||.|||..:.|..|
Zfish  2561 FSKTQVNESGEILNEKAKTHVLDIEQRLQGVIKNRNKVMGLPLSIEGHVHYLIQEATDDNLLCMM 2625

  Fly  2510 YIGWGAFL 2517
            |:|||.:|
Zfish  2626 YLGWGPYL 2633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 27/105 (26%)
FAT 1653..1985 CDD:280429 86/349 (25%)
PIKKc_ATR 2181..2448 CDD:270625 142/266 (53%)
FATC 2486..2517 CDD:280430 17/30 (57%)
atrXP_696163.5 HEAT repeat 683..715 CDD:293787 6/34 (18%)
HEAT repeat 753..780 CDD:293787 2/26 (8%)
HEAT repeat 794..823 CDD:293787 6/31 (19%)
UME 1110..1216 CDD:214825 28/106 (26%)
HEAT repeat 1275..1301 CDD:293787 8/25 (32%)
HEAT repeat 1324..1353 CDD:293787 10/28 (36%)
FAT 1760..2084 CDD:280429 88/365 (24%)
TEL1 <2125..2633 CDD:227365 231/518 (45%)
PIKKc_ATR 2282..2556 CDD:270625 143/273 (52%)
FATC 2602..2633 CDD:280430 17/30 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170578996
Domainoid 1 1.000 272 1.000 Domainoid score I1757
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 745 1.000 Inparanoid score I562
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 1 1.000 - - FOG0004409
OrthoInspector 1 1.000 - - oto39995
orthoMCL 1 0.900 - - OOG6_102609
Panther 1 1.100 - - LDO PTHR11139
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2044
SonicParanoid 1 1.000 - - X3128
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1211.930

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