DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-41 and Mtor

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:NP_063971.1 Gene:Mtor / 56718 RGDID:68371 Length:2549 Species:Rattus norvegicus


Alignment Length:2852 Identity:545/2852 - (19%)
Similarity:992/2852 - (34%) Gaps:884/2852 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 HHI----GYATHGDIFSGSLHQALLILKECDMDTKLASL-NYCHNVLRSQSASSWITNPDVGHYA 236
            |||    ..:...:...|.|..|.||..|....|::... ||..|:|.|       ::|.|...|
  Rat    69 HHIFELVSSSDANERKGGILAIASLIGVEGGNSTRIGRFANYLRNLLPS-------SDPVVMEMA 126

  Fly   237 QLTLEATAIMWSA-VAKWLDMGCMTRQELKRLNITTKLLLEVLHM-RARPAHHLGYLLLNEI-LS 298
            ...:...|:.... .|::::.      |:||       .||.|.. |.....|...|:|.|: :|
  Rat   127 SKAIGRLAMAGDTFTAEYVEF------EVKR-------ALEWLGADRNEGRRHAAVLVLRELAIS 178

  Fly   299 LPTAIELDDGLLETLSSYIQGQLEHSVVPLEQLVHLQQLMLSHWHCHPTHLVPILALMGLKQTEM 363
            :||             .:.|     .|.|.     ...:.::.|.               .:..:
  Rat   179 VPT-------------FFFQ-----QVQPF-----FDNIFVAVWD---------------PKQAI 205

  Fly   364 RSGVVQVLTQSLVEILKKE--EVLSKDWQKLIAILRGFKQLEKLILSQSQHKIAEHEG-HIDSSV 425
            |.|.|..|...|:...::|  |:....|.:     ..|::.||    .....:|:.:| :.|..:
  Rat   206 REGAVAALRACLILTTQREPKEMQKPQWYR-----HTFEEAEK----GFDETLAKEKGMNRDDRI 261

  Fly   426 LAMLPLQCEIIKVADTNWNNLSMQLVELESKCSADRRHIHLEICSLLMQITFIRHFLKTQTQHQL 490
            ...|.:..|:::::......|..::.|:     ..::.:|.:.|..||.                
  Rat   262 HGALLILNELVRISSMEGERLREEMEEI-----TQQQLVHDKYCKDLMG---------------- 305

  Fly   491 LAILQRHLKLSYLCAIRLETPSSVHTQMQSFYAQQYMRLFQSEETQEIFCSNLPQLYISGFIKPE 555
            .....||:                 |...||.|                            ::|:
  Rat   306 FGTKPRHI-----------------TPFTSFQA----------------------------VQPQ 325

  Fly   556 QLMKALPTINNRSGRAQVIRLLLCSQPGKLSVFKVKDRIELYCPKCRPL-PKKLPGIYLGKCKQQ 619
            | ..||..:...|....::.......|.|.::      :|..|  ||.| .:|...:    |:..
  Rat   326 Q-SNALVGLLGYSSHQGLMGFGASPSPTKSTL------VESRC--CRDLMEEKFDQV----CQWV 377

  Fly   620 LPCPDFSSTNLEMIANDLL-----FYPDFECIAQHL-DLLCFEPNVILGLLRETEALQKVSVKVI 678
            |.|....::.::|...:||     |.|......|:| |.:    |.:|..::: |..:..:.:.:
  Rat   378 LKCRSSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTM----NHVLSCVKK-EKERTAAFQAL 437

  Fly   679 GQLVSAMRVRSPEFLEQLANLVLAAIK----------------------AMLAK---PLTEQNVL 718
            |.|..|:|.....:|.::.:::.||:.                      :|||:   |..:|::.
  Rat   438 GLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKTVQVDATVFTCISMLARAMGPGIQQDIK 502

  Fly   719 Q-QRSMLNV-----LTAIAH------------MEDNEIWLFHWFKMTFFFLVHTRSLVAQEAVLA 765
            : ...||.|     |||:.:            ::|..:      ||....|:| :.|........
  Rat   503 ELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL------KMLSLVLMH-KPLRHPGMPKG 560

  Fly   766 ATEMCASQGLQTIHLWNWYKRDALDLTVRL-ALNVYLLDGVRFTRSLRALTKMLGFTCVQEF--- 826
            .....||.||.|:.    ...|...:|:.| .|..:..:|...|:.:|        .|...|   
  Rat   561 LAHQLASPGLTTLP----EASDVASITLALRTLGSFEFEGHSLTQFVR--------HCADHFLNS 613

  Fly   827 -----------TCKYHRLLT---------------------AMVLPHCIV------NP---LCKG 850
                       ||.  ||||                     |.||...:|      :|   .|  
  Rat   614 EHKEIRMEAARTCS--RLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYC-- 674

  Fly   851 VLVLIAKQMQKHIGTLFSIS--FLRIYTHVFLTEE------------------PELANSCIELVV 895
            ||..:.::...|:....::.  |:.:...||...|                  |.|....|:::.
  Rat   675 VLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILT 739

  Fly   896 SCTQSSLQQLMNADVKQTVAELLIYFNRNPTFVMRSFQS------LLQLS--------------I 940
            ....|.:.:     :|:..|.:|.:...|...::|.:..      :|:|.              :
  Rat   740 ELEHSGIGR-----IKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVL 799

  Fly   941 GSLEELSSQTANAEFANFIAERFLGVITYFE--SCLSEPSFEKPLKEETLYSLGQIMRFVG--SQ 1001
            .::.|| :|.:..|...::.|.|:.::...:  |.|::       ::..|::|||::...|  .:
  Rat   800 ATIGEL-AQVSGLEMRKWVDELFVIIMDMLQDSSLLAK-------RQVALWTLGQLVASTGYVVE 856

  Fly  1002 HVTQFRFKIIAMLSFVHTLQEPRLQRICLKIWHI------FLHVVNVQELGPSLGRIVATLQPLL 1060
            ...::...:..:|:|:.|.|....:|..:::..:      :.|.||:..:..|......:    |
  Rat   857 PYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVS----L 917

  Fly  1061 ADNESVKQVNDLYEFIILRNASMLGTFITDLYFLDRMENVSPSI-----------QKCIRRHTAH 1114
            ::::|.:..:|.....:|.|   :|....|.::        |::           |.....||. 
  Rat   918 SESKSSQDSSDYSTSEMLVN---MGNLPLDEFY--------PAVSMVALMRIFRDQSLSHHHTM- 970

  Fly  1115 LDLKGLAEEENQSPPLVDQLRFLQKHITDECLQ-------------------VRVYALQHLGDLF 1160
                           :|..:.|:.|.:..:|:|                   :|.:..|.||.|.
  Rat   971 ---------------VVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV 1020

  Fly  1161 ----GRRRP-------------KLNSTILSELPLEPMLEQIVNVLMAG----------------C 1192
                ...||             .:|::|.|.:.|  ::|||| |.:.|                .
  Rat  1021 SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIIL--LIEQIV-VALGGEFKLYLPQLIPHMLRVF 1082

  Fly  1193 QHDDSQLQMASAKCLGEL---GAIDASYL-----PSNYNFASPQHLPLNILSDDFAVLALTSLCR 1249
            .||:||.::.|.|.|..:   ||....||     |....|.:|: :||.  |...|:..:..|..
  Rat  1083 MHDNSQGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPE-VPLP--SRKAALETVDRLTE 1144

  Fly  1250 GYQFQQNTKHVDSFSLAIQETLAICGISPK-EQKKVQLWQSLP---ARMRQLMEPMLHSCYTCVH 1310
            ...|      .|..|..|...:.....||: ....:....||.   .:..|:..||::       
  Rat  1145 SLDF------TDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVN------- 1196

  Fly  1311 RPSTCLQQPLFGSHYSHNYYEEWAFLWASRLIDYLPSSGRRHLLSSYK--PCIKRDSNMLSTFYP 1373
                   :.|.....:|..|:    :...|::       :.:.|:..:  |.|.: ..||.:...
  Rat  1197 -------KVLVRHRINHQRYD----VLICRIV-------KGYTLADEEEDPLIYQ-HRMLRSSQG 1242

  Fly  1374 YILLHALLECTTEQRNHI-----QEEFMAVLQANEESSSSVRGRQELGAIKENAFKQFES-RKYA 1432
            ..|....:|....::.|:     |:.:.|..:.:::.......|..|..:|:::.....| ...|
  Rat  1243 DALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALA 1307

  Fly  1433 AGIKPLA------------STLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGG 1485
            ....|:|            |.|..|::::..|...||  |.::.:..:.:.|.........|..|
  Rat  1308 QAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELA--LTSQDIAEVTQTLLNLAEFMEHSDKG 1370

  Fly  1486 KPPETIDSNYRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVE 1550
            ..|...|:..            :|:...:..|..||:||.|.|...::|  .:..:||.   |:.
  Rat  1371 PLPLRDDNGI------------VLLGERAAKCRAYAKALHYKELEFQKG--PTPAILES---LIS 1418

  Fly  1551 VYGSLRDPDSVEGAVQVRSYDMSVTQDILVN----RLVERQQDMITSYEQLLSSTDQMQPDHVRA 1611
            :...|:.|::..|.::   |.|....::.:.    ..:...:|.:.:|::.:.:.          
  Rat  1419 INNKLQQPEAASGVLE---YAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTN---------- 1470

  Fly  1612 MIDAYLRDTP-----KTAQLIADGLWQRLSDRYSDQC--------------FAECKSELLWRLGS 1657
                  :|.|     :...|.|.|.|.:|    ..||              .|...:...|.||.
  Rat  1471 ------KDDPELMLGRMRCLEALGEWGQL----HQQCCEKWTLVNDETQAKMARMAAAAAWGLGQ 1525

  Fly  1658 YDEMEELQSNWPAQCSQGCLKLRRPLTTRIEFDSL----LDGMRESVLEELRSCSAVQQHSYANA 1718
            :|.|||.....|.....|.. .|..|....:..||    :|..|:.:..||   :|:...||:.|
  Rat  1526 WDSMEEYTCMIPRDTHDGAF-YRAVLALHQDLFSLAQQCIDKARDLLDAEL---TAMAGESYSRA 1586

  Fly  1719 YDAVLKLHLVHELHCSQELVE-KLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFR 1782
            |.|::..|::.||   :|::: ||..:|.|     :::..   |..|||..|..|...:.|...|
  Rat  1587 YGAMVSCHMLSEL---EEVIQYKLVPERRE-----IIRQI---WWERLQGCQRIVEDWQKILMVR 1640

  Fly  1783 RNILAELQRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPS------- 1840
            ..:::             ||   |..|.||..|.:...:|:|..|...::......||       
  Rat  1641 SLVVS-------------PH---EDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPL 1689

  Fly  1841 -----GLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRH------------- 1887
                 .:.....|.:|:...::.|..:::..:..|:...|..:  ...:|:|             
  Rat  1690 PTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAI--ATEDQQHKQELHKLMARCFL 1752

  Fly  1888 ------LFFRG-------KYLQAVYSAESMH-------------LCADAVLKYFQEAIAVHRQSE 1926
                  |..:|       |.|| .|||.:.|             :..:|||.|..:..|...:.:
  Rat  1753 KLGEWQLNLQGINESTIPKVLQ-YYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKK 1816

  Fly  1927 SCHVQMAQFLEKILEA-----------RQGGKSEPTGEQDD--------------------MLIN 1960
            ..|...|........|           .:|..||...|.::                    :|..
  Rat  1817 LRHASGANITNATTTATTAASAAAATSTEGSNSESEAESNESSPTPSPLQKKVTEDLSKTLLLYT 1881

  Fly  1961 V--MVNYAKSLRYGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVY 2023
            |  :..:.:|:.....:..|...|:::||.|       ......:|:.|.....|:....:..|.
  Rat  1882 VPAVQGFFRSISLSRGNNLQDTLRVLTLWFD-------YGHWPDVNEALVEGVKAIQIDTWLQVI 1939

  Fly  2024 SQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNST 2088
            .|:::|:..|...|..::..::..:...:||..::.|....||....|......:|.:....::|
  Rat  1940 PQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNT 2004

  Fly  2089 FQKLLQDFNSLTERLMDL--------------------------------------------TNK 2109
               |:|....::|.|:.:                                            |.|
  Rat  2005 ---LVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLK 2066

  Fly  2110 EVTLDRTY------------------KLSDLD----------TRLSKLCKQPEFSQILLPFEKYM 2146
            |.:.::.|                  .:.||.          .|:||  :.|:.:.:.|   :|:
  Rat  2067 ETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISK--QLPQLTSLEL---QYV 2126

  Fly  2147 QPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYD 2211
            .|.|.:..|...:.......||..:.        |.....|:.::.|..:|:|||:..|:|.::.
  Rat  2127 SPKLLMCRDLELAVPGTYDPNQPIIR--------IQSIAPSLQVITSKQRPRKLTLMGSNGHEFV 2183

  Fly  2212 VLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRS 2276
            .|:|..:|||:|.|:|:..|||...|..|..:.::.|.|:.|||:|.:...||:.|:|:..:..:
  Rat  2184 FLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHA 2248

  Fly  2277 ICMNLYAQRRLVMSTRQLQSLAVPL---HESIERKREVF------------TKQLVPAHPPVFQE 2326
            :..:...:::::::......|.:..   |.::.:|.|||            .|.|          
  Rat  2249 LIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLL---------- 2303

  Fly  2327 WLRQRFATPHS--WYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQ 2389
            ||:    :|.|  |::.|..|.|::||||||||||||||||..|::....:|..:|:||...|..
  Rat  2304 WLK----SPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEV 2364

  Fly  2390 GELL-PYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYD----- 2448
            .... .:||.:|||||..:..||...|::|::|..|...:.:|::...::|::|..||||     
  Rat  2365 AMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRTTCHTVMEVLREHKDSVMAVLEAFVYDPLLNW 2429

  Fly  2449 ---------------------------------VGAQTRKGAATA-------------------- 2460
                                             :|....|...|.                    
  Rat  2430 RLMDTNAKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALN 2494

  Fly  2461 -KITKDVQRIADRLQGHVKRQQANSIPLSTEGQVNFLINEATKVDNLASMYIGWGAF 2516
             |..:.:.|:.|:|.|   |..::...|....||..||.:||..:||...||||..|
  Rat  2495 KKAIQIINRVRDKLTG---RDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPF 2548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 18/114 (16%)
FAT 1653..1985 CDD:280429 84/420 (20%)
PIKKc_ATR 2181..2448 CDD:270625 88/284 (31%)
FATC 2486..2517 CDD:280430 14/31 (45%)
MtorNP_063971.1 HEAT repeat 993..1021 CDD:293787 5/27 (19%)
HEAT 25 1029..1068 11/41 (27%)
HEAT repeat 1033..1062 CDD:293787 8/31 (26%)
HEAT 26 1069..1105 7/35 (20%)
HEAT repeat 1073..1099 CDD:293787 7/25 (28%)
HEAT 27 1106..1144 10/40 (25%)
HEAT repeat 1111..1142 CDD:293787 8/33 (24%)
HEAT 28 1145..1188 8/48 (17%)
HEAT repeat 1154..1180 CDD:293787 3/25 (12%)
HEAT 29 1189..1225 8/60 (13%)
HEAT 30 1226..1273 9/47 (19%)
HEAT 31 1274..1311 5/36 (14%)
HEAT 32 1312..1345 8/34 (24%)
TPR 1 1346..1382 5/47 (11%)
TPR 2 1383..1408 8/26 (31%)
TPR 3 1409..1442 8/38 (21%)
TPR 4 1443..1473 2/45 (4%)
TPR 5 1474..1507 8/36 (22%)
TPR 6 1508..1541 9/32 (28%)
TPR 7 1542..1574 7/32 (22%)
TPR 8 1575..1614 15/49 (31%)
TPR 9 1615..1649 10/52 (19%)
TPR 10 1650..1693 9/42 (21%)
TPR 11 1694..1731 5/36 (14%)
TPR 12 1732..1786 11/56 (20%)
TPR 13 1787..1846 8/58 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1812..1867 7/54 (13%)
TPR 14 1898..1930 7/38 (18%)
TPR 15 1931..1970 5/38 (13%)
TPR 16 1971..2005 6/36 (17%)
Sufficient for interaction with the FKBP1A/rapamycin complex. /evidence=ECO:0000250 2012..2144 17/136 (13%)
Rapamycin_bind 2015..2112 CDD:285924 8/96 (8%)
PIKKc_TOR 2153..2431 CDD:270713 90/291 (31%)
Interaction with MLST8. /evidence=ECO:0000250 2258..2296 6/37 (16%)
FATC 2518..2549 CDD:280430 14/31 (45%)
Interaction with NBN. /evidence=ECO:0000250 1..651 137/753 (18%)
TEL1 363..2549 CDD:227365 469/2416 (19%)
HEAT 16 637..683 8/47 (17%)
HEAT repeat 655..681 CDD:293787 7/27 (26%)
HEAT 17 686..724 5/37 (14%)
HEAT repeat 691..721 CDD:293787 4/29 (14%)
HEAT 18 727..766 8/43 (19%)
HEAT repeat 729..759 CDD:293787 6/34 (18%)
HEAT 19 769..811 6/42 (14%)
HEAT repeat 772..805 CDD:293787 2/32 (6%)
HEAT 20 814..853 8/45 (18%)
HEAT repeat 817..847 CDD:293787 7/36 (19%)
DUF3385 854..1024 CDD:288698 30/200 (15%)
HEAT 21 857..893 5/35 (14%)
HEAT 22 894..942 10/54 (19%)
HEAT 23 943..988 9/68 (13%)
HEAT repeat 955..981 CDD:293787 5/41 (12%)
HEAT 24 989..1027 5/37 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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