DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-41 and Mtor

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:NP_064393.2 Gene:Mtor / 56717 MGIID:1928394 Length:2549 Species:Mus musculus


Alignment Length:2851 Identity:549/2851 - (19%)
Similarity:997/2851 - (34%) Gaps:882/2851 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 HHI----GYATHGDIFSGSLHQALLILKECDMDTKLASL-NYCHNVLRSQSASSWITNPDVGHYA 236
            |||    ..:...:...|.|..|.||..|....|::... ||..|:|.|       ::|.|...|
Mouse    69 HHIFELVSSSDANERKGGILAIASLIGVEGGNSTRIGRFANYLRNLLPS-------SDPVVMEMA 126

  Fly   237 QLTLEATAIMWSA-VAKWLDMGCMTRQELKRLNITTKLLLEVLHM-RARPAHHLGYLLLNEI-LS 298
            ...:...|:.... .|::::.      |:||       .||.|.. |.....|...|:|.|: :|
Mouse   127 SKAIGRLAMAGDTFTAEYVEF------EVKR-------ALEWLGADRNEGRRHAAVLVLRELAIS 178

  Fly   299 LPTAIELDDGLLETLSSYIQGQLEHSVVPLEQLVHLQQLMLSHWHCHPTHLVPILALMGLKQTEM 363
            :||             .:.|     .|.|.     ...:.::.|.               .:..:
Mouse   179 VPT-------------FFFQ-----QVQPF-----FDNIFVAVWD---------------PKQAI 205

  Fly   364 RSGVVQVLTQSLVEILKKE--EVLSKDWQKLIAILRGFKQLEKLILSQSQHKIAEHEG-HIDSSV 425
            |.|.|..|...|:...::|  |:....|.:     ..|::.||    .....:|:.:| :.|..:
Mouse   206 REGAVAALRACLILTTQREPKEMQKPQWYR-----HTFEEAEK----GFDETLAKEKGMNRDDRI 261

  Fly   426 LAMLPLQCEIIKVADTNWNNLSMQLVELESKCSADRRHIHLEICSLLMQITFIRHFLKTQTQHQL 490
            ...|.:..|:::::......|..::.|:     ..::.:|.:.|..||.                
Mouse   262 HGALLILNELVRISSMEGERLREEMEEI-----TQQQLVHDKYCKDLMG---------------- 305

  Fly   491 LAILQRHLKLSYLCAIRLETPSSVHTQMQSFYAQQYMRLFQSEETQEIFCSNLPQLYIS--GFIK 553
            .....||:           ||   .|..|:...||                  |...:.  |:..
Mouse   306 FGTKPRHI-----------TP---FTSFQAVQPQQ------------------PNALVGLLGYSS 338

  Fly   554 PEQLM--KALPTINNRSGRAQVIRLLLCSQPGKLSVFKVKDRIELYCPKCRPL-PKKLPGIYLGK 615
            |:.||  ...|:                  |.|.::      :|..|  ||.| .:|...:    
Mouse   339 PQGLMGFGTSPS------------------PAKSTL------VESRC--CRDLMEEKFDQV---- 373

  Fly   616 CKQQLPCPDFSSTNLEMIANDLL-----FYPDFECIAQHL-DLLCFEPNVILGLLRETEALQKVS 674
            |:..|.|....::.::|...:||     |.|......|:| |.:    |.:|..::: |..:..:
Mouse   374 CQWVLKCRSSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTM----NHVLSCVKK-EKERTAA 433

  Fly   675 VKVIGQLVSAMRVRSPEFLEQLANLVLAAIK----------------------AMLAK---PLTE 714
            .:.:|.|..|:|.....:|.::.:::.||:.                      :|||:   |..:
Mouse   434 FQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKTVQVDATVFTCISMLARAMGPGIQ 498

  Fly   715 QNVLQ-QRSMLNV-----LTAIAH------------MEDNEIWLFHWFKMTFFFLVHTRSLVAQE 761
            |::.: ...||.|     |||:.:            ::|..:      ||....|:| :.|....
Mouse   499 QDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL------KMLSLVLMH-KPLRHPG 556

  Fly   762 AVLAATEMCASQGLQTIHLWNWYKRDALDLTVRL-ALNVYLLDGVRFTRSLRALTKMLGFTCVQE 825
            .........||.||.|:.    ...|...:|:.| .|..:..:|...|:.:|        .|...
Mouse   557 MPKGLAHQLASPGLTTLP----EASDVASITLALRTLGSFEFEGHSLTQFVR--------HCADH 609

  Fly   826 F--------------TCKYHRLLT---------------------AMVLPHCIV------NP--- 846
            |              ||.  ||||                     |.||...:|      :|   
Mouse   610 FLNSEHKEIRMEAARTCS--RLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIR 672

  Fly   847 LCKGVLVLIAKQMQKHIGTLFSIS--FLRIYTHVFLTEE------------------PELANSCI 891
            .|  ||..:.::...|:....::.  |:.:...||...|                  |.|....|
Mouse   673 YC--VLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLI 735

  Fly   892 ELVVSCTQSSLQQLMNADVKQTVAELLIYFNRNPTFVMRSFQS------LLQLS----------- 939
            :::.....|.:.:     :|:..|.:|.:...|...::|.:..      :|:|.           
Mouse   736 QILTELEHSGIGR-----IKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVI 795

  Fly   940 ---IGSLEELSSQTANAEFANFIAERFLGVITYFE--SCLSEPSFEKPLKEETLYSLGQIMRFVG 999
               :.::.|| :|.:..|...::.|.|:.::...:  |.|::       ::..|::|||::...|
Mouse   796 NNVLATIGEL-AQVSGLEMRKWVDELFIIIMDMLQDSSLLAK-------RQVALWTLGQLVASTG 852

  Fly  1000 --SQHVTQFRFKIIAMLSFVHTLQEPRLQRICLKIWHI------FLHVVNVQELGPSLGRIVATL 1056
              .:...::...:..:|:|:.|.|....:|..:::..:      :.|.||:..:..|......: 
Mouse   853 YVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVS- 916

  Fly  1057 QPLLADNESVKQVNDLYEFIILRNASMLGTFITDLYFLDRMENVSPSI-----------QKCIRR 1110
               |::::|.:..:|.....:|.|   :|....|.::        |::           |.....
Mouse   917 ---LSESKSSQDSSDYSTSEMLVN---MGNLPLDEFY--------PAVSMVALMRIFRDQSLSHH 967

  Fly  1111 HTAHLDLKGLAEEENQSPPLVDQLRFLQKHITDECLQ-------------------VRVYALQHL 1156
            ||.                :|..:.|:.|.:..:|:|                   :|.:..|.|
Mouse   968 HTM----------------VVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQL 1016

  Fly  1157 GDLF----GRRRP-------------KLNSTILSELPLEPMLEQIVNVLMAG------------- 1191
            |.|.    ...||             .:|::|.|.:.|  ::|||| |.:.|             
Mouse  1017 GMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIIL--LIEQIV-VALGGEFKLYLPQLIPHM 1078

  Fly  1192 ---CQHDDSQLQMASAKCLGEL---GAIDASYL-----PSNYNFASPQHLPLNILSDDFAVLALT 1245
               ..||:||.::.|.|.|..:   ||....||     |....|.:|: :||.  |...|:..:.
Mouse  1079 LRVFMHDNSQGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPE-VPLP--SRKAALETVD 1140

  Fly  1246 SLCRGYQFQQNTKHVDSFSLAIQETLAICGISPK-EQKKVQLWQSLP---ARMRQLMEPMLHSCY 1306
            .|.....|      .|..|..|...:.....||: ....:....||.   .:..|:..||::   
Mouse  1141 RLTESLDF------TDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVN--- 1196

  Fly  1307 TCVHRPSTCLQQPLFGSHYSHNYYEEWAFLWASRLIDYLPSSGRRHLLSSYK--PCIKRDSNMLS 1369
                       :.|.....:|..|:    :...|::       :.:.|:..:  |.|.: ..||.
Mouse  1197 -----------KVLVRHRINHQRYD----VLICRIV-------KGYTLADEEEDPLIYQ-HRMLR 1238

  Fly  1370 TFYPYILLHALLECTTEQRNHI-----QEEFMAVLQANEESSSSVRGRQELGAIKENAFKQFES- 1428
            :.....|....:|....::.|:     |:.:.|..:.:::.......|..|..:|:::.....| 
Mouse  1239 SSQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSC 1303

  Fly  1429 RKYAAGIKPLA------------STLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGR 1481
            ...|....|:|            |.|..|::::..|...||  |.::.:..:.:.|.........
Mouse  1304 WALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELA--LTSQDIAEVTQTLLNLAEFMEH 1366

  Fly  1482 STGGKPPETIDSNYRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFT 1546
            |..|..|...|:..            :|:...:..|..||:||.|.|...::|  .:..:||.  
Mouse  1367 SDKGPLPLRDDNGI------------VLLGERAAKCRAYAKALHYKELEFQKG--PTPAILES-- 1415

  Fly  1547 FLVEVYGSLRDPDSVEGAVQVRSYDMSVTQDILVN----RLVERQQDMITSYEQLLSSTDQMQPD 1607
             |:.:...|:.|::..|.::   |.|....::.:.    ..:...:|.:.:|::.: .|::..|:
Mouse  1416 -LISINNKLQQPEAASGVLE---YAMKHFGELEIQATWYEKLHEWEDALVAYDKKM-DTNKEDPE 1475

  Fly  1608 HVRAMIDAYLRDTPKTAQLIADGLWQRLSDRYSDQC--------------FAECKSELLWRLGSY 1658
            .:...:..          |.|.|.|.:|    ..||              .|...:...|.||.:
Mouse  1476 LMLGRMRC----------LEALGEWGQL----HQQCCEKWTLVNDETQAKMARMAAAAAWGLGQW 1526

  Fly  1659 DEMEELQSNWPAQCSQGCLKLRRPLTTRIEFDSL----LDGMRESVLEELRSCSAVQQHSYANAY 1719
            |.|||.....|.....|.. .|..|....:..||    :|..|:.:..||   :|:...||:.||
Mouse  1527 DSMEEYTCMIPRDTHDGAF-YRAVLALHQDLFSLAQQCIDKARDLLDAEL---TAMAGESYSRAY 1587

  Fly  1720 DAVLKLHLVHELHCSQELVE-KLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRR 1783
            .|::..|::.||   :|::: ||..:|.|     :::..   |..|||..|..|...:.|...|.
Mouse  1588 GAMVSCHMLSEL---EEVIQYKLVPERRE-----IIRQI---WWERLQGCQRIVEDWQKILMVRS 1641

  Fly  1784 NILAELQRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPS-------- 1840
            .:::             ||   |..|.||..|.:...:|:|..|...::......||        
Mouse  1642 LVVS-------------PH---EDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLP 1690

  Fly  1841 ----GLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRH-------------- 1887
                .:.....|.:|:...::.|..:::..:..|:...|..:  ...:|:|              
Mouse  1691 TAHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAI--ATEDQQHKQELHKLMARCFLK 1753

  Fly  1888 -----LFFRG-------KYLQAVYSAESMH-------------LCADAVLKYFQEAIAVHRQSES 1927
                 |..:|       |.|| .|||.:.|             :..:|||.|..:..|...:.:.
Mouse  1754 LGEWQLNLQGINESTIPKVLQ-YYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKL 1817

  Fly  1928 CHVQMAQFLEKILEA-----------RQGGKSEPTGEQDD--------------------MLINV 1961
            .|...|........|           .:|..||...|.::                    :|..|
Mouse  1818 RHASGANITNATTAATTAASAAAATSTEGSNSESEAESNENSPTPSPLQKKVTEDLSKTLLLYTV 1882

  Fly  1962 --MVNYAKSLRYGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYS 2024
              :..:.:|:.....:..|...|:::||.|       ......:|:.|.....|:....:..|..
Mouse  1883 PAVQGFFRSISLSRGNNLQDTLRVLTLWFD-------YGHWPDVNEALVEGVKAIQIDTWLQVIP 1940

  Fly  2025 QMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTF 2089
            |:::|:..|...|..::..::..:...:||..::.|....||....|......:|.:....::| 
Mouse  1941 QLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNT- 2004

  Fly  2090 QKLLQDFNSLTERLMDL--------------------------------------------TNKE 2110
              |:|....::|.|:.:                                            |.||
Mouse  2005 --LVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKE 2067

  Fly  2111 VTLDRTY------------------KLSDLD----------TRLSKLCKQPEFSQILLPFEKYMQ 2147
            .:.::.|                  .:.||.          .|:||  :.|:.:.:.|   :|:.
Mouse  2068 TSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISK--QLPQLTSLEL---QYVS 2127

  Fly  2148 PTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDV 2212
            |.|.:..|...:.......||..:.        |.....|:.::.|..:|:|||:..|:|.::..
Mouse  2128 PKLLMCRDLELAVPGTYDPNQPIIR--------IQSIAPSLQVITSKQRPRKLTLMGSNGHEFVF 2184

  Fly  2213 LVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSI 2277
            |:|..:|||:|.|:|:..|||...|..|..:.::.|.|:.|||:|.:...||:.|:|:..:..::
Mouse  2185 LLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL 2249

  Fly  2278 CMNLYAQRRLVMSTRQLQSLAVPL---HESIERKREVF------------TKQLVPAHPPVFQEW 2327
            ..:...:::::::......|.:..   |.::.:|.|||            .|.|          |
Mouse  2250 IRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLL----------W 2304

  Fly  2328 LRQRFATPHS--WYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQG 2390
            |:    :|.|  |::.|..|.|::||||||||||||||||..|::....:|..:|:||...|...
Mouse  2305 LK----SPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVA 2365

  Fly  2391 ELL-PYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYD------ 2448
            ... .:||.:|||||..:..||...|::|::|..|...:.:|::...::|::|..||||      
Mouse  2366 MTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRTTCHTVMEVLREHKDSVMAVLEAFVYDPLLNWR 2430

  Fly  2449 --------------------------------VGAQTRKGAATA--------------------- 2460
                                            :|....|.|.|.                     
Mouse  2431 LMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKAGTTVPESIHSFIGDGLVKPEALNK 2495

  Fly  2461 KITKDVQRIADRLQGHVKRQQANSIPLSTEGQVNFLINEATKVDNLASMYIGWGAF 2516
            |..:.:.|:.|:|.|   |..::...|....||..||.:||..:||...||||..|
Mouse  2496 KAIQIINRVRDKLTG---RDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPF 2548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 18/114 (16%)
FAT 1653..1985 CDD:280429 84/420 (20%)
PIKKc_ATR 2181..2448 CDD:270625 88/284 (31%)
FATC 2486..2517 CDD:280430 14/31 (45%)
MtorNP_064393.2 Interaction with NBN. /evidence=ECO:0000250 1..651 140/757 (18%)
TEL1 363..2549 CDD:227365 470/2411 (19%)
HEAT 16 637..683 8/47 (17%)
HEAT repeat 655..681 CDD:293787 7/27 (26%)
HEAT 17 686..724 5/37 (14%)
HEAT repeat 691..721 CDD:293787 4/29 (14%)
HEAT 18 727..766 8/43 (19%)
HEAT repeat 729..759 CDD:293787 6/34 (18%)
HEAT 19 769..811 6/42 (14%)
HEAT repeat 772..805 CDD:293787 2/32 (6%)
HEAT 20 814..853 8/45 (18%)
HEAT repeat 817..847 CDD:293787 7/36 (19%)
DUF3385 854..1024 CDD:288698 30/200 (15%)
HEAT 21 857..893 5/35 (14%)
HEAT 22 894..942 10/54 (19%)
HEAT 23 943..988 9/68 (13%)
HEAT repeat 955..981 CDD:293787 5/41 (12%)
HEAT 24 989..1027 5/37 (14%)
HEAT repeat 993..1021 CDD:293787 5/27 (19%)
HEAT 25 1029..1068 11/41 (27%)
HEAT repeat 1033..1062 CDD:293787 8/31 (26%)
HEAT 26 1069..1105 7/35 (20%)
HEAT repeat 1073..1099 CDD:293787 7/25 (28%)
HEAT 27 1106..1144 10/40 (25%)
HEAT repeat 1111..1142 CDD:293787 8/33 (24%)
HEAT 28 1145..1188 8/48 (17%)
HEAT repeat 1154..1180 CDD:293787 3/25 (12%)
HEAT 29 1189..1225 8/60 (13%)
HEAT 30 1226..1273 9/47 (19%)
HEAT 31 1274..1311 5/36 (14%)
HEAT 32 1312..1345 8/34 (24%)
TPR 1 1346..1382 5/47 (11%)
TPR 2 1383..1408 8/26 (31%)
TPR 3 1409..1442 8/38 (21%)
TPR 4 1443..1473 3/30 (10%)
TPR 5 1474..1507 8/46 (17%)
TPR 6 1508..1541 9/32 (28%)
TPR 7 1542..1574 7/32 (22%)
TPR 8 1575..1614 15/49 (31%)
TPR 9 1615..1649 10/52 (19%)
TPR 10 1650..1693 9/42 (21%)
TPR 11 1694..1731 5/36 (14%)
TPR 12 1732..1786 11/56 (20%)
TPR 13 1787..1846 8/58 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1825..1867 5/41 (12%)
TPR 14 1898..1930 7/38 (18%)
TPR 15 1931..1970 5/38 (13%)
TPR 16 1971..2005 6/36 (17%)
Sufficient for interaction with the FKBP1A/rapamycin complex 2012..2144 17/136 (13%)
Rapamycin_bind 2015..2112 CDD:285924 8/96 (8%)
PIKKc_TOR 2153..2431 CDD:270713 90/291 (31%)
Interaction with MLST8. /evidence=ECO:0000250 2258..2296 6/37 (16%)
FATC 2518..2549 CDD:280430 14/31 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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