DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and pi4kb

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	XP_005158276.1	Gene:	pi4kb / 563201	ZFINID:	ZDB-GENE-061013-96	Length:	850	Species:	Danio rerio

Alignment Length:	1069	Identity:	178/1069 - (16%)
Similarity:	339/1069 - (31%)	Gaps:	428/1069 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1432 AAGIKPLAST----------------LVSDRKEDSSRV--PRLAGKLCAELLDFLQRWLREWQRI 1478
            ::|..||.|:                ::|:...:.|.|  ..:|.|.|.|:|..: ::|:....:
Zfish    35 SSGPHPLTSSSPSTSEGLPTSSPPLDVISEGLGELSLVIDTEVAKKACQEVLQKV-KFLKGDGEV 98

  Fly  1479 HGRST---------------GGKPPETIDSNYRKIHEFLNLIPKLLVSRASYNCGEYARALSYLE 1528
            ...|:               ||:||:..:.....|        |.:..|...|..:.:..|...|
Zfish    99 SSASSEPILANGTAHPEANDGGQPPKISEEEVEPI--------KSVRRRQKNNSSKQSWLLRLFE 155

  Fly  1529 SYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQDILVNRLVE-RQQDMIT 1592
            |          :|.:....:..:|.| ::|.       |::|        :.|||.. |.:|:..
Zfish   156 S----------KLFDISMAISYLYNS-KEPG-------VQAY--------IGNRLFSFRNEDVDF 194

  Fly  1593 SYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADGLWQ-RLSDRYSDQCFAECKSELLWRLG 1656
            ...|||:....|..| |...|..|:             ::: |.|..:|.||        .|.||
Zfish   195 YLPQLLNMYIHMDED-VGDAIKPYV-------------VYRCRQSINFSLQC--------AWLLG 237

  Fly  1657 SYDEMEELQSNWPAQCSQGCLKLR--------RPLTTRIEFDSLLDGMRESVLE-------ELRS 1706
            :|.....:.:.   :.|:| .|||        :|.:.||         |..|.:       .|..
Zfish   238 AYSSDMHISTQ---RHSRG-TKLRKLILSDELKPSSQRI---------RREVPQPPPPYPPPLHH 289

  Fly  1707 CSAVQQHSYA--------NAYDAVLKLHLVHELHCSQELVEKLEQDRDEDNQEKLMKNYFDDWQY 1763
            ...:.:||.:        :..||.:.:.|...|..:.. ..|:|..:|||     :.:..|..:.
Zfish   290 GPGMSEHSLSPSKRTHQRSKSDATVSISLSSNLKRTAS-NPKVETSQDED-----LSSSSDSLEL 348

  Fly  1764 RLQI---VQPQVRIQESIYSFRRNILA------ELQRRLTD---RNHLLPHLKTELARIWLNSAQ 1816
            ....   :.||....:|:....:.:..      :.||.:::   .||.||      ||:||.:|.
Zfish   349 EAGTPVRLTPQREFIKSLMGIGKRLATLPTKEQKTQRLISELSLLNHKLP------ARVWLPTAA 407

  Fly  1817 INRNAGQLQRAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQGNVKQL 1881
            .:.:..::...|..:|.:.:..|..:::|                .||         |: |.:..
Zfish   408 FDHHVVRVPHTQAVVLNSKDKAPYLIYVE----------------VLE---------CE-NFETS 446

  Fly  1882 AAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGG 1946
            :...|   .....:::..|.|::..|.
Zfish   447 SVPVR---IPETQIRSTRSVENLPDCG-------------------------------------- 470

  Fly  1947 KSEPTGEQDDMLINVMVNYAKSLRYGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMN----DLL 2007
               .|.:|.....:.:.||                       |..:.:.:.:.:.::.    ::.
Zfish   471 ---ITPDQRASSFSTVPNY-----------------------DNDDEAWSVDDIGELQVELPEIH 509

  Fly  2008 TNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRI 2072
            ||.|..:         ||            |:|
Zfish   510 TNSCDNI---------SQ------------FSV-------------------------------- 521

  Fly  2073 KRCKLVLTDSRLQNSTFQKLLQDFNSLTERLMDLTNKEVTLDRTYKLSDLDTRLSKLCKQPEFSQ 2137
                    ||.....:.:.:......:..||.:            :|:...|...|..:.|....
Zfish   522 --------DSITSQESKEPIFIAAGDIRRRLSE------------QLAHTPTTFRKDPEDPSAVA 566

  Fly  2138 ILLPFEKYMQPTLPLNSDSNSSEGS---HLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKK 2199
            :..|:::.::         ...|||   |||      ||
Zfish   567 LKEPWQEKVR---------RIREGSPYGHLP------NW-------------------------- 590

  Fly  2200 LTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRR--LHIRTYAVLPFNEEC 2262
                    :...|:||..||||::  |:.:..|.:..:..:    |.|  |.|:.|.:|..:.:.
Zfish   591 --------RLLSVIVKCGDDLRQE--LLAYQVLKQLQIIWE----QERVPLWIKPYKILVISSDS 641

  Fly  2263 GLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEW 2327
            |::|.:.|                           ||.:|: ::::.::           :..::
Zfish   642 GMIEPVVN---------------------------AVSIHQ-VKKQSQL-----------LLLDY 667

  Fly  2328 LRQ---RFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQ 2389
            .||   .|.| ..:..|:..::::.|...::.|:|.:.|||..|||. :..|..:|:||..:.:.
Zfish   668 FRQEHGNFNT-EEFLTAQRNFVQSCAGYCLICYLLQVKDRHNGNILL-DSEGHIIHIDFGFILSS 730

  Fly  2390 GELLPYPEVVPFRLTHNMIVAMGPLGVEG 2418
            .......|...|:||...:..||  |::|
Zfish   731 SPRNLGFETSAFKLTSEFVDVMG--GLDG 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	57/366 (16%)
		PIKKc_ATR	2181..2448	CDD:270625	47/243 (19%)
		FATC	2486..2517	CDD:280430
pi4kb	XP_005158276.1	PI4Kc_III_beta	563..850	CDD:270712	56/293 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900