DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and pik3ca

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	XP_009304451.1	Gene:	pik3ca / 561737	ZFINID:	ZDB-GENE-130409-1	Length:	1069	Species:	Danio rerio

Alignment Length:	1335	Identity:	245/1335 - (18%)
Similarity:	422/1335 - (31%)	Gaps:	519/1335 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1346 PSSGRR---HLLSSYKPCIKRDSNMLSTFYPYILLHAL--------LECTTEQRNHIQEEFMAVL 1399
            ||||..   ||:.                 |.||:..|        |||..|
Zfish     5 PSSGELWGIHLMP-----------------PRILVDCLLPNGMILTLECLRE------------- 39

  Fly  1400 QANEESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPL-------------ASTLVSDRKE--D 1449
                         ..|..||...||  |:|||     ||             :.|..::|:|  |
Zfish    40 -------------ATLITIKHELFK--EARKY-----PLHHLLQEETSYIFVSVTQEAEREEFYD 84

  Fly  1450 SSRVPRLAGKLCAELLDFLQRWL--------REWQRIHGRSTG---GKP---------PETIDSN 1494
            .:|      :||.  |...|.:|        || ::|..|..|   |.|         ||..|
Zfish    85 ETR------RLCD--LRLFQPFLKVIEPVGNRE-EKILNREIGFAIGMPVCEFDLVKDPEVQD-- 138

  Fly  1495 YRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPD 1559
            :|:  ..||:....:..|.:  .|.::|||......:|...:..:          .:||.| |..
Zfish   139 FRR--NILNVCKDSVELRDA--SGAHSRALYVYPPNVESSPELPK----------HIYGKL-DKG 188

  Fly  1560 SVEGAVQV--------RSYDMSVTQD-----ILVNRLVERQQDMITSYEQLLSSTDQMQPDHVRA 1611
            .:...:.|        :.|.:.:..|     ::...:.::.:.|:.|.|||.....:.|..::..
Zfish   189 QIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSAEQLKMCVQEYQGKYILK 253

  Fly  1612 M--IDAYLRD------------------TPKTAQLIADGLWQRL-SDRYSDQCFA---------- 1645
            :  .|.||.:                  .|....:..|.|:.:| .|.::...::
Zfish   254 VCGCDEYLLEKYPISQYKYVRSCIMLGRLPNLMLMSKDSLYSQLPMDNFTMPSYSRRISTATPYM 318

  Fly  1646 --ECKSELLW----------------------------RLGSYDEMEELQSNWPAQ---CSQGCL 1677
              |..::.||                            |.|.|...|:|..|...|   ||
Zfish   319 NGEASTKSLWTINSTLRIRVLCATYVNVNIRDIDKIYVRTGIYHGGEQLCDNVNTQRVPCS---- 379

  Fly  1678 KLRRPLTTR-IEFDSLLDGMRESVLEELRSCS------AVQQH-----SYANAYD-------AVL 1723
               .|.... :.:|..:..:..:....|..||      |.::|     ...|.:|       ..:
Zfish   380 ---NPRWNEWLTYDMYIPDIPRAARLCLSICSVKGRKGAKEEHCPLAWGNVNLFDYTHTLVSGKM 441

  Fly  1724 KLHLVHELHCSQELVEKLEQDRDEDNQE----KLMKNYFD---------------DWQYRLQIVQ 1769
            .|:|....|..::|:..:.......|:|    :|..:||.               :|....::..
Zfish   442 ALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDYFSSPVKFPDMATIEDHANWIISREMGY 506

  Fly  1770 PQVRIQESIYSFRRNILAELQ----RRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLY 1830
            ...:..:|....|.:.:.|..    |:|.:|:.|....:.|...:|              |.:.|
Zfish   507 NYCQSGQSSRVARDHAMTEADIEQLRQLGNRDPLSEITEQEKDFLW--------------RHRQY 557

  Fly  1831 ILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYL 1895
            .:...|..|..|...:    |...|:|..|..|.                            |..
Zfish   558 CVNIPEILPKILLAVK----WNSRDEVAQMYCLL----------------------------KDW 590

  Fly  1896 QAVYSAESMHL--C--ADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQDD 1956
            .|:...::|.|  |  .|.:::.|                ..:.|||.|             .||
Zfish   591 PAIKPEQAMELLDCNYPDPMIRDF----------------AVRCLEKYL-------------TDD 626

  Fly  1957 MLINVMVNYAKSLRYGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYT 2021
            .|...::...:.|:| .:::...:.|.:               :||   .|||  ..:....|:.
Zfish   627 KLSQYLIQLVQVLKY-EQYLDNPLVRFL---------------LKK---ALTN--QRIGHFFFWH 670

  Fly  2022 VYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQN 2086
            :.|:|.::   .|:..|.:       |:|:|                   .:.|.:.|.....|.
Zfish   671 LKSEMHNK---TVSQRFGL-------LLESY-------------------CRACGMYLKHLSRQV 706

  Fly  2087 STFQKLLQDFNSLTERLMDLTNKEVTLDRTYKLSDLDTRLSKLCKQ---PEFSQILLPFEKYMQP 2148
            ...:||:    :||:.|     |:...|.|.|:     ::..|.:|   |::...|..|
Zfish   707 EAMEKLI----NLTDIL-----KQEKKDETQKV-----QMKFLVEQMRRPDYMDALQNF------ 751

  Fly  2149 TLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQ-ESVLILRSAAKPKKLTIRCSD------ 2206
            |.|||           ||:|            :...: |...|:.||.:|..|.....|
Zfish   752 TSPLN-----------PAHQ------------LGNLRLEDCRIMSSAKRPLWLNWENPDIMSELL 793

  Fly  2207 GKDYDVLVKPKDDLRRD------ARLME----FNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEE 2261
            .::.:::.|..||||:|      .|:||    ..||..|.|              .|..|...:.
Zfish   794 FQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRML--------------PYGCLSIGDC 844

  Fly  2262 CGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQE 2326
            .||:|                    :|.|:          |..::.:.:...|..:..:.....:
Zfish   845 VGLIE--------------------VVRSS----------HTIMQIQCKGGLKGALQFNSTTLHQ 879

  Fly  2327 WLRQRFATPHSWYE-ARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQG 2390
            ||:.:  .....|: |.:.:.|:.|...:..:|||:||||..||: .:.:|...|:||      |
Zfish   880 WLKDK--NKGEMYDMAIDLFTRSCAGYCVATFILGIGDRHNSNIM-VKDDGQLFHIDF------G 935

  Fly  2391 ELLPYP--------EVVPFRLTHNMIVAMGPLGVE--------GSFRKCCEITLRLLKQESKTLM 2439
            ..|.:.        |.|||.||.:.::.:...|.:        ..|::.|......::|.:...:
Zfish   936 HFLDHKKKKFGYKRERVPFVLTQDFLIVISKGGTQECTKTREFERFQEMCYKAYLAIRQHANLFI 1000

  Fly  2440 SILRPFV---------YDVGAQTRKGAATAKITKD 2465
            ::....:         :|..|..||..|..|..::
Zfish  1001 NLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQE 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	65/408 (16%)
		PIKKc_ATR	2181..2448	CDD:270625	60/309 (19%)
		FATC	2486..2517	CDD:280430
pik3ca	XP_009304451.1	PI3K_p85B	31..108	CDD:197539	25/117 (21%)
		PI3K_rbd	173..292	CDD:307097	17/129 (13%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	29/165 (18%)
		PI3Ka_I	529..696	CDD:238444	46/291 (16%)
		PKc_like	695..1065	CDD:328722	90/437 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900