DRSC/TRiP Functional Genomics Resources

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Protein Alignment mei-41 and PRKDC

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:NP_008835.5 Gene:PRKDC / 5591 HGNCID:9413 Length:4128 Species:Homo sapiens


Alignment Length:3375 Identity:633/3375 - (18%)
Similarity:1109/3375 - (32%) Gaps:1178/3375 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 SLVRELHNKFQDTFLLWLLNKLAKCLSE-SPDSSECINLQRKILSSCCSNHPKLFERL------- 100
            |.:|:...:....||.|.:.::.....| ||.:::  :|.:::.|  .:.||..|:||       
Human  1023 STLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTK--SLFKRLYS--LALHPNAFKRLGASLAFN 1083

  Fly   101 --------------------VLAYVEA---------------------------IEETHLQLSSL 118
                                ::.|:|:                           ||:.|:.|:..
Human  1084 NIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLNKA 1148

  Fly   119 DLGQLSNERKPAITVRIFRCDVECLQEFDPHCAIEDIK------------VPL----EQADMYAK 167
            ...:|.....|:.::    |.::.::....||.....:            |||    ...:::.|
Human  1149 KKRRLPRGFPPSASL----CLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSPNLWLK 1209

  Fly   168 SLLEVLQHAHHIGYATHGDIF-------------SGSLHQ-ALLILKE--------CDMDTKLAS 210
            .:|:           ..|..|             ||.|.| .||.|:.        |.:|..||:
Human  1210 DVLK-----------EEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLAA 1263

  Fly   211 LNYCHNVLRSQSASSWITNPDVGHYAQLTLEATAIMWSAVAKWLDMGCM---------------- 259
            |. |:|        ::|....||....|..||.:.:..|||.:|:...|                
Human  1264 LE-CYN--------TFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAG 1319

  Fly   260 ---TRQELKRLN------------ITTKLLLEVLHMRARPAHHLGYLLLNEILSLPTAIELDDGL 309
               :.||.:|.|            .||.||      ...|.   |:.||.:.|.....:.:   |
Human  1320 NRTSPQEGERYNYSKCTVVVRIMEFTTTLL------NTSPE---GWKLLKKDLCNTHLMRV---L 1372

  Fly   310 LETLSSYIQGQLEHSVVPLEQLVHLQQLMLSHWHCHPTHLVPILALMGLK---QTEMRSGVVQVL 371
            ::||..  ...:..::..::.:.||..:.:        :|:..|.:...|   :|.:|    :.:
Human  1373 VQTLCE--PASIGFNIGDVQVMAHLPDVCV--------NLMKALKMSPYKDILETHLR----EKI 1423

  Fly   372 TQSLVEILKKEEVLSKDWQ----KLIAILRGFKQLEK------LILSQS---QHKIAEHEGHIDS 423
            |...:|.|....:...|.|    :|.|::...|||.:      ::.|||   .|.:...      
Human  1424 TAQSIEELCAVNLYGPDAQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTE------ 1482

  Fly   424 SVLAMLPLQCEIIKVADTNWNNLSMQLVELESKCSADRRHIHLEICSLLMQITFIRHFLKTQTQH 488
                :|.|..:.|...|..     ..|..|:..|.        ::.|.|:::.|....|    ..
Human  1483 ----LLSLVYKGIAPGDER-----QCLPSLDLSCK--------QLASGLLELAFAFGGL----CE 1526

  Fly   489 QLLAILQRHLKLSYLCAIRLETPSSVHTQMQSFYAQQYMRLFQSEETQEIFCSNLPQLYISGFIK 553
            :|:::|.....|| ..::.....|.:|..    :.:.:..|| ||........||....:     
Human  1527 RLVSLLLNPAVLS-TASLGSSQGSVIHFS----HGEYFYSLF-SETINTELLKNLDLAVL----- 1580

  Fly   554 PEQLMKALPTINNRSGRAQVIRLLL-------CSQPGKLSVFKVKDRIELYCPKC-------RPL 604
              :||::  :::|....:.|:..:|       .:|  |....|:...|..:..||       .||
Human  1581 --ELMQS--SVDNTKMVSAVLNGMLDQSFRERANQ--KHQGLKLATTILQHWKKCDSWWAKDSPL 1639

  Fly   605 PKKLPGIYLGKCKQQLPC-----------PDFSSTNLEMIANDLLFYPDFECIAQHLDLLCFEPN 658
            ..|:..:.|.....|:..           |:..:|.:.::|:..|   |.....|.:.||.|..:
Human  1640 ETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLADTKL---DLHLKGQAVTLLPFFTS 1701

  Fly   659 VILGLLRETEALQKVSVKVIGQLVSA-MRVRSPEF---LEQLANLVLAAIKAMLAKPLTEQNVLQ 719
            :..|.|.|..       :|:.||:.| ..::|.||   ..:..|.|....|.:.|..|::..:| 
Human  1702 LTGGSLEELR-------RVLEQLIVAHFPMQSREFPPGTPRFNNYVDCMKKFLDALELSQSPML- 1758

  Fly   720 QRSMLNVLTAIAHMEDNEIWLFHWFKMTFFFLVHTRSLVAQEAVLAAT---------------EM 769
                |.::|.:...|...: :...|:.:|..:....|.|.|..:|.:.               :.
Human  1759 ----LELMTEVLCREQQHV-MEELFQSSFRRIARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQS 1818

  Fly   770 CASQGLQTIHLWNWYKRDALDLTVRLALNVYLLDGV-----RFTRSLRA-----LTKMLGF---- 820
            ...:.|.|: ||:.    :|| .:|...:..::|.:     |||:...:     :||.:|:    
Human  1819 FVDRSLLTL-LWHC----SLD-ALREFFSTIVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKIL 1877

  Fly   821 -------------------------TCVQE---------------FT---CKYHRLLTAMVLPHC 842
                                     :|:.|               ||   ...::||....|.||
Human  1878 DVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHC 1942

  Fly   843 IVNPLCKGVLVLIAKQMQKHIGTLFS-------------ISFLRIYTHVFLTEEP-ELANSCIEL 893
            ........|:..:..:::.:.|.|||             |...|.|......|.| |.....||:
Human  1943 AAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEI 2007

  Fly   894 VVSCTQ------------SSLQQLMNADVKQTVAELLIYFN------------------------ 922
            .....:            |||..|.::    |::|.:..|:                        
Human  2008 RKEAREAANGDSDGPSYMSSLSYLADS----TLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRR 2068

  Fly   923 ---RNPTF-----------------------------------------VMRSFQSLLQLSIGSL 943
               |:||.                                         |.|...|.::...|.|
Human  2069 REQRDPTVHDDVLELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKL 2133

  Fly   944 EE----------LSSQTANAE--FANFIAERFLG-------------------VITYFESCLSEP 977
            ..          |:....|.|  |..: |:.:|.                   |:....:.||..
Human  2134 GNPIVPLNIRLFLAKLVINTEEVFRPY-AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWT 2197

  Fly   978 SFEKPL---KEETLYS--LGQIMRFVGSQHVTQFRFKIIAMLSFVHTLQEPRLQRICLKIWHIFL 1037
            ....|.   |:|.|.:  |..:|:.|.......||..    |..:.||.|  ..:.||.|.:..:
Human  2198 GLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHN----LEIIKTLVE--CWKDCLSIPYRLI 2256

  Fly  1038 -------------HVVNVQELG-----------PSLGRIVATLQPLLADNESVKQVNDLYEFIIL 1078
                         :.|.:|.||           |..|...:.....|.:|.|..:..::|    .
Human  2257 FEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVY----A 2317

  Fly  1079 RNASMLGTFITDLYFLDRM----ENVSPSIQKCIRRHTAHLDLK---GLAEEENQSPPLVDQLRF 1136
            ..|.:||..:.  |.::|.    |::...:.|.:::|...::.|   .|.:.....|||.|  ||
Human  2318 AAAEVLGLILR--YVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLAD--RF 2378

  Fly  1137 LQK--------H--ITDECLQV---RVYALQHLG------------------------DLFGRRR 1164
            :..        |  :...||:|   ||..:..|.                        |:..:..
Human  2379 MNAVFFLLPKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMM 2443

  Fly  1165 PKLNSTILSELPLEPML-----------EQIVNVLMAGCQHD-----------DSQLQMASAKCL 1207
            |||....|.|| |.|::           ||:.|:||  ..||           |||.....||.:
Human  2444 PKLKPVELREL-LNPVVEFVSHPSTTCREQMYNILM--WIHDNYRDPESETDNDSQEIFKLAKDV 2505

  Fly  1208 GELGAID---------------ASYLPSN--------YNFASPQHLPLNILS--DDFAVLALTSL 1247
            ...|.||               .:.||||        .:..||: :.::.||  .:| :|.:||:
Human  2506 LIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPK-IEVHFLSLATNF-LLEMTSM 2568

  Fly  1248 CRGY------------QFQQNTKHVDS--------FSLAIQETLAICGI---------------- 1276
            ...|            :||:.|  :||        .:....||.|..|.                
Human  2569 SPDYPNPMFEHPLSECEFQEYT--IDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPV 2631

  Fly  1277 -----SPKEQKKVQLWQSLPARMR------QLMEPML-HSCYTC-----VHRPSTCLQQ------ 1318
                 :.::|....|.|:...|..      ...:|:: |:..:.     .|:.|..||:      
Human  2632 AGQIRATQQQHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSV 2696

  Fly  1319 -PLFGSHYSHNYYEEWAFLWASRLIDYLP----------SSGRRHLLSSYKPCIKRDSNMLSTFY 1372
             |.||.               .||  .||          ::||..|| ..:....||...||..|
Human  2697 GPDFGK---------------KRL--GLPGDEVDNKVKGAAGRTDLL-RLRRRFMRDQEKLSLMY 2743

  Fly  1373 PYILLHALLECTTEQRNHIQEEFMAVLQANEESSSSVRGRQELGAIKENAFKQFE----SRKYAA 1433
                          .|..:.|:     :..:|..|.::.:|:...:...:::..:    ..|:::
Human  2744 --------------ARKGVAEQ-----KREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSS 2789

  Fly  1434 GIKPLASTLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGGKPPETIDSNYRKI 1498
            .|.||.:.        :.|.|.:|.:|.:.|...:   |:|..:....|......:.:..::.: 
Human  2790 LITPLQAV--------AQRDPIIAKQLFSSLFSGI---LKEMDKFKTLSEKNNITQKLLQDFNR- 2842

  Fly  1499 HEFLN----LIPKLLVSRASYNCGEYARALSYLESYLEEG------EDKSQRLLEQ--------- 1544
              |||    ..|..:......:| ::|..||...:.:..|      :....||||:         
Human  2843 --FLNTTFSFFPPFVSCIQDISC-QHAALLSLDPAAVSAGCLASLQQPVGIRLLEEALLRLLPAE 2904

  Fly  1545 ------------------FTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQDILVNRLVERQQDMI 1591
                              :..|.::|.|:.:.|.:.|..........:||..|:........:..
Human  2905 LPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFTSEIGTKQITQSALLAEARSDYSEAA 2969

  Fly  1592 TSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADGLWQRLS-DRYSDQCFAECKSELLWRL 1655
            ..|::.|:..|.:..:...|..|                .|:..| |.|:.  .||.||......
Human  2970 KQYDEALNKQDWVDGEPTEAEKD----------------FWELASLDCYNH--LAEWKSLEYCST 3016

  Fly  1656 GSYDEME--ELQSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLEELRSCSAVQQHSYANA 1718
            .|.|...  :|...|.....|   :...|...|.:...||.|..:..|     .:.:.:..:...
Human  3017 ASIDSENPPDLNKIWSEPFYQ---ETYLPYMIRSKLKLLLQGEADQSL-----LTFIDKAMHGEL 3073

  Fly  1719 YDAVLKLHLVHELHCSQELVEKLEQDRD------EDNQEKLMKNY-------FDDWQYRLQIVQP 1770
            ..|:|:||...||    .|:..|:.|.|      ::..:..|:||       ......:||.||.
Human  3074 QKAILELHYSQEL----SLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLTKLQSVQA 3134

  Fly  1771 QVRIQE--SIYSFRRNILAE--LQRRLTDRNHLLPHLKTELARIW-------------------- 1811
            ...|||  |..|.:.|:.::  |:|.|....:..|..|.:...||                    
Human  3135 LTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTP 3199

  Fly  1812 ---LNSAQINRNAGQLQRAQLY--------ILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEE 1865
               .||..::::.....|.::.        ::::.::......|:.|:   ::.:..:||..|:|
Human  3200 LPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSAR---KQNNFSLAMKLLKE 3261

  Fly  1866 --------------------QLSIMRSGCQGNVKQ------------------------LAAEQR 1886
                                :||..||..||..:|                        ||...:
Human  3262 LHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQ 3326

  Fly  1887 HLFFRGKY---------------------------LQAVYSAESMHLCADAVLKYFQ---EAIAV 1921
            ::.....|                           |....|.:|..:.|....:.||   ||:..
Human  3327 NILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQA 3391

  Fly  1922 HRQ-----SESC---------HVQMAQFLEKILEARQGGKSE-PTGEQDDMLINVMVNYAKSLRY 1971
            ..:     |.||         ::.:|.|.::.|...:...|. .:.|.......|:....|:|:.
Human  3392 AEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKL 3456

  Fly  1972 GSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVND 2036
            .|.......|||:.:.....|.:.:         |:|...:::|...|.:..|.|::.|   ..|
Human  3457 NSNEARLKFPRLLQIIERYPEETLS---------LMTKEISSVPCWQFISWISHMVALL---DKD 3509

  Fly  2037 VFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTF-----QKL---- 2092
            ....:::.:.::.:.|||.   ::.|...|::::..|.     |.:..:|..|     .||    
Human  3510 QAVAVQHSVEEITDNYPQA---IVYPFIISSESYSFKD-----TSTGHKNKEFVARIKSKLDQGG 3566

  Fly  2093 -LQDFNSLTERL----------------------MDLTNKEVTLDRTY----------------- 2117
             :|||.:..::|                      ::..|.|...:|.|                 
Human  3567 VIQDFINALDQLSNPELLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRK 3631

  Fly  2118 -----------------------KLSDLD-------TRLSKLCKQP----EFSQILLPFE-KYMQ 2147
                                   ||||.:       .:::|..|.|    |.|..:..|: ::::
Human  3632 FIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLR 3696

  Fly  2148 PTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDV 2212
            ..|.:   ....:|...|        .|...:.|:||.|.|.::.|..:||::.||..|.:::..
Human  3697 NELEI---PGQYDGRGKP--------LPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPF 3750

  Fly  2213 LVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSI 2277
            |||..:|||:|.|:.:...::...|.||:...||.|.:|||:|:|.....||:|||.|..:.:.:
Human  3751 LVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDL 3815

  Fly  2278 CMNLYAQRRLV-------------------MSTRQLQSLAVPLHESIERKREV--FTKQ--LVPA 2319
            .:|..:|....                   ||.:......:.:::...|...|  |.|:  .|||
Human  3816 LLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPA 3880

  Fly  2320 HPPVFQEWLRQRF----ATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVH 2380
                  :.|::.|    .:|.::...|:.:..:.|::.:..:|||:||||..|.:.|...|..:.
Human  3881 ------DLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIG 3939

  Fly  2381 VDFNCLFNQG-ELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRP 2444
            :||...|... :.||.||::|||||...|..|.|:...|.........||..:.:...|.:.:..
Human  3940 IDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDV 4004

  Fly  2445 FVYD-----------------------------------VGAQTRK--GAATAKITKDVQRIADR 2472
            ||.:                                   :....||  ||..|.||.|     :.
Human  4005 FVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCD-----EL 4064

  Fly  2473 LQGHVK-------------------RQQANSIPLSTEGQVNFLINEATKVDNLASMYIGW 2513
            |.||.|                   |.|.....||.|.||..|:::||..:.|...:.||
Human  4065 LLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGW 4124

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 28/152 (18%)
FAT 1653..1985 CDD:280429 83/470 (18%)
PIKKc_ATR 2181..2448 CDD:270625 83/294 (28%)
FATC 2486..2517 CDD:280430 11/28 (39%)
PRKDCNP_008835.5 HEAT 1 288..323
HEAT 2 1004..1040 4/16 (25%)
Interaction with C1D. /evidence=ECO:0000269|PubMed:9679063 1503..1538 8/46 (17%)
Leucine-zipper 1503..1538 8/46 (17%)
TPR 1 1723..1756 8/32 (25%)
NUC194 1816..2202 CDD:400469 60/396 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2050..2073 0/22 (0%)
KIP-binding 2436..3212 166/864 (19%)
FAT 3023..3470 CDD:396714 81/461 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3200..3222 3/21 (14%)
PIKKc_DNA-PK 3719..4015 CDD:270716 83/301 (28%)
FATC 4097..4128 CDD:396715 11/28 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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