DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-41 and pi4kaa

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_009303356.1 Gene:pi4kaa / 556956 ZFINID:ZDB-GENE-100204-2 Length:2128 Species:Danio rerio


Alignment Length:2209 Identity:394/2209 - (17%)
Similarity:710/2209 - (32%) Gaps:689/2209 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   751 LVHTRSLVAQEAVLAATEMCASQGLQTIHLWNWYK-------RDALDLTVRLA--LNVYLLDGVR 806
            |.|..::|....||.       :||..:   .|.:       |:||.:....:  |...|.|..:
Zfish    70 LQHKDAIVPYLLVLL-------KGLPRV---QWIEESSERKGREALPIAENFSFCLVTVLSDVAQ 124

  Fly   807 FTRSLRA--------LTKMLGFTCV------QEFTCKY------------------HRLLTAMVL 839
            ...|:|.        |.::|..||.      :|:.|||                  ...|.:.:.
Zfish   125 MDESMRIQILEAVMNLIQVLQETCQNIEGQDKEYLCKYTVPCLLGVVRAFGRYSNTEEPLLSKLF 189

  Fly   840 PHCIVNPLCKGVLVLIAKQMQ-KHIGTLFSISFLRIYTHVFLTEEPELANSCIELVVSCTQSSLQ 903
            |..:..|...|....:.::.. ....::...|.|.:.....|..:.. :.|.|....|..::.|.
Zfish   190 PRIVPQPPGTGDGAEVTRRRSFNDFRSILPSSLLTVCQSDTLRRKTS-STSSISQQASPERAGLP 253

  Fly   904 QLMNADVKQTVAELLIYFNR----NPTFVMRSFQSLLQLSIGSLEELSSQTANAEFA-------- 956
            ....:|......|...|...    :|.:...:..|..     |:..|.:.:.|.||.        
Zfish   254 PSSPSDPSAPYFEAASYLPDGSAVDPDYYFSTISSSF-----SVSPLFTGSNNKEFTVPLDLLRQ 313

  Fly   957 ------NFIAERFLGVI---------------TYFESCLSEPSFE---KPLKEETLYSLGQIMRF 997
                  .|::|.|:..:               .|::: .|:|.:.   |.|::...|.....:.|
Zfish   314 LLQMVEQFVSESFMKTLDQAMTEVLEINPTAYLYYKT-FSDPLYVAIFKMLRDSLYYMKDLQVSF 377

  Fly   998 VGSQH---VTQFRF------KIIAMLSFVHT-----------------------LQEPRLQRICL 1030
            |...|   :.||..      :|:..:.::|:                       .:|...:.:|.
Zfish   378 VKEVHDFVLEQFSSSQSELQRILHDVEYLHSELNPLKLRCQANAACVDLMVWAVTEEQGAENLCT 442

  Fly  1031 K--------------IWHIFLHVVNVQELGPSLGRIVATLQPLLADNESVKQVNDLYEFIILRNA 1081
            |              |.|:.|.:..:|.||....|.     |::|.:.::    .|.:|:::   
Zfish   443 KLSEKLQSKTSSKVIIAHMPLLICCLQGLGRLCERF-----PVVAHSVTM----SLRDFLVV--- 495

  Fly  1082 SMLGTFITDLYFLDRMENVSPSIQKCIRRHTAHLDLKG-----LAEEENQS-----------PPL 1130
                              .||.:.|..:.|:.:....|     :..|.:||           |.:
Zfish   496 ------------------PSPVLVKLYKYHSQYTTGAGEIKIHVTNEHSQSTFSSHSSKKSQPSM 542

  Fly  1131 VDQLRFLQKHITDECLQV------------------RVY------------------ALQHLGDL 1159
            .:|||.:..:....||:.                  |:|                  ||.|:...
Zfish   543 YEQLRDISINNICRCLKAGLTMDSVIVEAFLASLSNRLYISQENDKDAHLIPDHTIRALGHIAVA 607

  Fly  1160 FGRRRPKLNSTILSELP---LEP-------MLEQIVNVLMAGCQHDDSQL----QMASAKCLGEL 1210
            . |..|::...||..|.   .:|       :::|:..:::.|.|:...::    |..|.|     
Zfish   608 L-RDTPRVMEPILQILQQKFCQPPSQLDVLIIDQLGCMVITGNQYIYQEVWNLFQQISVK----- 666

  Fly  1211 GAIDASYLPSNYNFASPQHLPLNILSDDFAVLALTSLCRGYQFQQNTKHVDSFSLAIQETLAICG 1275
             |....|...:|.....:|..|.:::      ||.::....|.:|   .||...:.:.|.....|
Zfish   667 -ASSMVYSTKDYKDHGYRHCSLAVIN------ALANIAANLQTEQ---MVDELLVNLLELFVQLG 721

  Fly  1276 ISPKEQKK-------------------------VQLWQSLPA------RMRQLMEPMLHSCYTCV 1309
            :..|...:                         ..|.:.|||      |:::|.....  .|:.|
Zfish   722 LEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTKRLPAIKEAKPRLQKLFRDFW--LYSVV 784

  Fly  1310 HRPSTCLQQPLFGSHYSHNYYEEW-----AFLWASRLIDYLPSSGRRHLLSSYKPCIKRDS---- 1365
            ..         |....|..:.|||     .....|.|:.: ||.........|...:|.|:    
Zfish   785 MG---------FAVEGSGLWPEEWYEGVCEIATKSPLLTF-PSGEPLRSELQYNSALKNDTVTPA 839

  Fly  1366 -------NMLSTFYPYILLHALLE-----CTTEQRNHIQEEFMAVLQANEESSSSVRGR------ 1412
                   .:::...|...:.||:.     .:|...:..:.|:|.||::.|.....|..|      
Zfish   840 ELNDLRGTIINLLDPPPEVAALINKLDFAMSTYLLSVYRLEYMRVLRSQESDRFQVMFRYFEDRA 904

  Fly  1413 ---------QELGAIKENAFKQF--------ESRKYAAGIKPLASTLVSDRKEDSSRVPRLA--- 1457
                     |.:.|:.:..|..|        :::.:...::..|..|:.:......|:.|:|   
Zfish   905 IQKDKSGMMQCVIAVGDKVFDVFLQMMADKAKTKAHEEELESHAQFLLVNFNHIHKRIRRVADKY 969

  Fly  1458 --------------GKLCAELLDFLQRW-LREWQRIHGRSTGGKPPETI-DSNYR----KIHEFL 1502
                          |::...:||.||.. |.....||    ..:|...| |:.||    ..:|..
Zfish   970 LSGLAETFPHLLWSGRVLRTMLDILQTLSLSLSADIH----KDQPYYDIPDTPYRITVPDTYEAR 1030

  Fly  1503 NLIPKLLVSRASYNCGEYAR-----ALSYLESYLEEGEDKSQRL---LEQFTFLVEVYGSL---- 1555
            ..|.|...:|    |||..:     |.|..:|:|:|..:|.|..   |.|.|.|.....|:    
Zfish  1031 ESIVKDFAAR----CGEILKEAMKWAPSVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFA 1091

  Fly  1556 ---RDPDSVEGAVQVRSYDMSVTQDI--------LVNRLVERQQDMITSYEQLLSSTDQMQPDHV 1609
               |...|: |..|:......|.:|.        |.||.......|| .:.:...||..:....:
Zfish  1092 GYNRQSTSL-GTTQLTERPACVKKDYSNFMASLNLRNRYAGEVAGMI-HFSEATRSTSDLNKLMI 1154

  Fly  1610 RAMIDAYLRDTPK---------TAQLIADGLWQRL-------------SDRYSDQCFAECKSELL 1652
            |.|.:|.....|:         .|.||:...|..|             ::...:...|..:..|.
Zfish  1155 RQMNEALDGGQPEAFTEALFKMAALLISSREWDPLLLHHLCWSPLKMFTENGMETAIACWEWLLA 1219

  Fly  1653 WRLG-SYDEMEELQSNW-------------------PAQCSQGCLKLRRP------------LTT 1685
            .|.| ....|.|:...|                   |...|:....:..|            |..
Zfish  1220 GRTGVEVPFMREMAGAWQMTVDLKMGLFSDAQLEADPLAASEESQPIPCPPDVTPHYIWIEFLVQ 1284

  Fly  1686 RIEFD--SLLDGMR--ESVLEELRSCSAVQQHSYANAYDA---------VLKLHLVHELHCSQEL 1737
            |.|..  |..|.:.  .|:|:...|.:.....|..|.:.|         .|.|.|:|....:...
Zfish  1285 RFEIAKYSSADQVEIFGSLLQRSLSLNVGSPKSSLNRHVAAIGPRFRLLTLGLSLLHSDVVTNAT 1349

  Fly  1738 VEKLEQDRDEDNQEKLMKNYFDDWQYRLQI-VQPQVRIQESIYSFRRNILAELQRRLTDRNHLLP 1801
            :..:       .:||:....||.:....:. .|...|::|.| |......|.:   |:|:.:|..
Zfish  1350 IRNV-------LREKIYSTAFDYFSVASKFPTQGDKRLREDI-SIMIRFYASI---LSDKKYLGA 1403

  Fly  1802 HLKTELARIWLNSAQINRNAGQL------QRAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAM 1860
            .|......:..|..|.:.:||..      ..:.:.||...:...:.|.:..|         ....
Zfish  1404 SLLVPPGELGANPPQSSLSAGIFGSLIVSSTSPISILNNQDPSLNSLSVMNA---------TDPR 1459

  Fly  1861 NYLEEQLSIMRSGCQG--------------------NVKQLAAEQRHLFF--RGKYLQAVYSAES 1903
            |.::..:...:...||                    :.|.....|.|.::  |...|.|:.::|.
Zfish  1460 NNMDMTVGSRQQSAQGWINTYPLSSGMSTTSKKSGMSKKSNRGTQLHKYYMKRRTLLLALLASEI 1524

  Fly  1904 MHLCADAVLKYFQ----EAIAVHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQDDMLINVMVN 1964
            ..|..     ::.    :.:|:..: :|....::.:..|.:..        |.:|....:|:..:
Zfish  1525 ERLST-----WYNPLSTQELAIPTE-QSVETSISNWRSKYINL--------TEKQWKDNVNLAWS 1575

  Fly  1965 YAKSL------RY-GSEHVYQSMPRLISLWLDTTESSTNTEQVK-------------KMNDLLTN 2009
            .|..|      |: .::.:...:.||:.  ||....|...|.||             :::.:|..
Zfish  1576 IAPYLALQLPARFKNADAIVAEVTRLVR--LDPGAVSDVPEAVKFLVTWHTIDADSPELSHILCW 1638

  Fly  2010 CCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAH---- 2070
            .....||.:.|  :|.|...  ||:...:.|      |::.::|..::...:|....|..:    
Zfish  1639 APADPPTGLSY--FSSMYPP--HPLTAQYGV------KVLRSFPPDAILFYIPQIVQALRYDKMG 1693

  Fly  2071 --------RIKRCKLVL--------TDSRLQNSTFQKLLQDFNSLTERLMDLTNKEVTLDRTYKL 2119
                    ..::.:|:.        |:..|.....|| ..|...|.|::::    |:|...:...
Zfish  1694 YVREYILWAAQKSQLLAHQFIWNMKTNIFLDEEGHQK-DPDIGELLEQMVE----EITHSLSGPA 1753

  Fly  2120 SDLDTR-LSKLCKQPEFSQILLPFEK---YMQPTLPLNSDSNSSEGSHLPANQSTV-------NW 2173
            .|...| .....|....|.|:.|..|   ..:..|...|:.....|.:||:|...:       :.
Zfish  1754 KDFYQREFDFFNKITNVSAIIKPVPKGDERKRACLKALSEIKVQPGCYLPSNPEAIVLDIDYKSG 1818

  Fly  2174 FPYQQI----YISGFQESVLILR-SAAKPKKLTIRC-SDGKD--------------YDVLVKPKD 2218
            .|.|..    |::.|:    :.| ..::.:|..:|| ||.:|              ...:.|..|
Zfish  1819 TPMQSAAKAPYLAKFK----VKRCGVSELEKEGLRCPSDSQDEGDESSLTAQRVCWQAAIFKVGD 1879

  Fly  2219 DLRRDARLMEFNGLVK---RYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASY----RS 2276
            |.|:|...::..||.|   :.:..|       |.:..|.|:.....||::|.:|:..|.    |.
Zfish  1880 DCRQDMLALQIIGLFKNIFQLVGLD-------LFVFPYRVVATAPGCGVIECIPDCKSRDQLGRQ 1937

  Fly  2277 ICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEA 2341
            ....:|                           :.|..|........||              :|
Zfish  1938 TDFGMY---------------------------DYFRNQYGDESTLAFQ--------------KA 1961

  Fly  2342 RNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQ---GELLPYPEVVPFRL 2403
            |..:||::|..|::.::|.:.|||..||:. :..|..:|:||..:|..   |.|...|::   :|
Zfish  1962 RYNFIRSMAAYSLLLFLLQIKDRHNGNIML-DSKGHLIHIDFGFMFESSPGGNLGWEPDI---KL 2022

  Fly  2404 THNMIVAMGPLGVEGSFRKCCEITLR---LLKQESKTLMSILRPFVYDVGAQTRKGAATAKITK 2464
            |..|::.||.......|:...|:.:|   .::.....::|:: ..:.|.|....:| .|.|:.|
Zfish  2023 TDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLV-TLMLDTGLPCFRG-QTIKLLK 2084

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 28/182 (15%)
FAT 1653..1985 CDD:280429 67/416 (16%)
PIKKc_ATR 2181..2448 CDD:270625 60/295 (20%)
FATC 2486..2517 CDD:280430
pi4kaaXP_009303356.1 PI4Ka 1573..1748 CDD:238443 34/191 (18%)
PI4Kc_III_alpha 1809..2127 CDD:270711 69/334 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.