DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and ATR

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	XP_011511226.1	Gene:	ATR / 545	HGNCID:	882	Length:	2646	Species:	Homo sapiens

Alignment Length:	2721	Identity:	700/2721 - (25%)
Similarity:	1204/2721 - (44%)	Gaps:	563/2721 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LLWLLNKLAKCLSESPDSSECINLQ---RKILSSCCSNHPKLFE------RLVLAYVEAIEETHL 113
            |||.:.              |:.|:   .||.|...|...:||:      :....:..:..|...
Human   228 LLWQIG--------------CVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLK 278

  Fly   114 QLSSLDLGQLSNERKP--AITVRIFRCDVECLQEFDP---HCAIEDIKVPLE-------QADMYA 166
            .|..:|..||....:|  .:...:|..:.|..:..:|   :..:|.:.|..|       ::|:..
Human   279 HLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLK 343

  Fly   167 KSLLEVLQHAHHIGYATHGDIFSGSLHQALLILKECDMDTKLASLNYCH---NVLRSQSASSWIT 228
            .:|..:||  :.:.:...|       :::.|.::      |:...|.|.   :||..:..:.::.
Human   344 AALCHLLQ--YFLKFVPAG-------YESALQVR------KVYVRNICKALLDVLGIEVDAEYLL 393

  Fly   229 NPDVGHYAQLTLEATAIMWSAVAKWLDMGCMTRQE----------LKRLNITTKL---------L 274
            .|   .||.|.:|:..|:       .::.|.|:||          .||..:::.|         .
Human   394 GP---LYAALKMESMEII-------EEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQT 448

  Fly   275 LEVLHMRARPAHHLGYLLLNEILSLPTAIELDDGLLETLSSYIQGQLEHSVVPLEQLVHLQQLML 339
            .|:.|:.......|...|..:..||..::|. .||...:...::|     :..:.||..|..:..
Human   449 EEIKHVDMNQKSILWSALKQKAESLQISLEY-SGLKNPVIEMLEG-----IAVVLQLTALCTVHC 507

  Fly   340 SH--WHCHPTHLVPILALMGLKQTEMRSGVVQVLTQSLVEILKKEEVLSKDWQKLIAILRGFKQL 402
            ||  .:|..           .|..:.:|              ||:..:...|..|....:..|..
Human   508 SHQNMNCRT-----------FKDCQHKS--------------KKKPSVVITWMSLDFYTKVLKSC 547

  Fly   403 EKLILSQSQHKIAEHEGHIDSSVLAMLPLQCEIIKVADTNWNNLSMQLVELESKCSADRRHIHLE 467
            ..|:  :|..|: :.|..||           :::|:.|.        |:.::...|.: .||..:
Human   548 RSLL--ESVQKL-DLEATID-----------KVVKIYDA--------LIYMQVNSSFE-DHILED 589

  Fly   468 ICSL--------------LMQITFIRHFL----------KTQTQHQ---LLAILQRHLKLSYLCA 505
            :|.:              |...||..:.|          ..|.|.:   ||.:..|.:.|.:..|
Human   590 LCGMLSLPWIYSHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTA 654

  Fly   506 IRLETPSSVHTQMQSFYAQQYMRLFQSEETQEIFCSNLPQLYI------SGFIKPEQLMKALPTI 564
            :......|.|..:::.....:..|.|.:.:    |:.:|::.|      |..:|.|
Human   655 VYNWALQSSHEVIRASCVSGFFILLQQQNS----CNRVPKILIDKVKDDSDIVKKE--------- 706

  Fly   565 NNRSGRAQVIRLLLCSQPGKLSV-------FKVKDRIELYCPK------------------CRPL 604
                 .|.::..|:|:..|...:       |.....::|:|..                  |:|
Human   707 -----FASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKP- 765

  Fly   605 PKKLPGIYLGKCKQQLPCPDFSSTNLEMIANDLLFYPDFECIAQHLDLLCFEPNVILGLLRETEA 669
                   :|...|:::|.|           ..|.|..:...:.:|||            .||.|.
Human   766 -------FLFLLKKKIPSP-----------VKLAFIDNLHHLCKHLD------------FREDET 800

  Fly   670 LQKVSVKVIGQLVSAMRVRSPEFLEQLANLVLAAIKAMLAKPLTEQNVLQQRSMLNVLTAIAHME 734
            ..|.   |:|.|::.|  ..|:  :.:.......||.:|....:|...:::..:|.:..|..|.:
Human   801 DVKA---VLGTLLNLM--EDPD--KDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTHAQ 858

  Fly   735 ---DNEIWLFHWFKMTF-----------------FFLVH-TRSLVAQEAVL---AATEMCASQGL 775
               :||:      |.|.                 |.|:| ...|:::.|.:   |.||:.|....
Human   859 ISRNNEL------KDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKSASVSGAAYTEIRALVAA 917

  Fly   776 QTIHL---WNWYKRDALDLTV------------------------------RLALNVYLLDGVRF 807
            :::.|   ::.||:......|                              .:|||
Human   918 KSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMALN--------- 973

  Fly   808 TRSLRALTKMLGFTCVQEFTCKYHRLLTAMVLPHCI--VNPLCKGVLVLIAKQMQKHIGTLFSIS 870
              :|..:..:..|..:..|..:..::|    ||...  .:|....::..:.||:..:...:...:
Human   974 --TLSEIANVFDFPDLNRFLTRTLQVL----LPDLAAKASPAASALIRTLGKQLNVNRREILINN 1032

  Fly   871 FLRIYTHVFLTEEPELANSCIELVVSCTQSSLQQLMNADVKQTVAELLIYFNRNPTFVMRSFQSL 935
            |..|::|               ||.||::..|::.::....:|..||       .:.:.:.||.|
Human  1033 FKYIFSH---------------LVCSCSKDELERALHYLKNETEIEL-------GSLLRQDFQGL 1075

  Fly   936 ---LQLSIG--------SLEELSSQTANAE-------------FANFIAERFLGVITYFESCLSE 976
               |.|.||        .|..|:|..::.:             .|:::..:.||::.:|...|..
Human  1076 HNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLS 1140

  Fly   977 PSFEKPLKEETLYSLGQIMRFVGSQHVTQFRFKIIAM----LSFVHTLQEPRLQRICLKIWHIFL 1037
            .|.....|:..|.||..:|:.:|.:||:..|.|::..    |.|.....|     :|.:.|..|:
Human  1141 SSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPE-----LCCRAWDCFV 1200

  Fly  1038 HVVNVQELGPSLGRIVATLQPLLADNESVKQVNDLYEFIILRNASMLGTFITDLYFLDRMENVSP 1102
            ..::...||..|..::..|.||:  :...|:...::.::|:.|...:..|:.::|||..    .|
Human  1201 RCLDHACLGSLLSHVIVALLPLI--HIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPD----HP 1259

  Fly  1103 SIQKCIRRHTAHLDLKGLAEEENQSPPLVDQLRFLQKHITDECLQVRVYALQHLGDLFGRRRPKL 1167
            .::|      ....|:...:|.::|..|...|:...|.|..|.:.||::||..|.:...:.:.||
Human  1260 ELKK------IKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKL 1318

  Fly  1168 NSTILSELPLEPMLEQIVNVLMAGCQHDDSQLQMASAKCLGELGAIDASYLPSNYNFASPQH--- 1229
            .........:||::.|:|.||:.|||..:||.::...:|||||||||    |...:|::.:.
Human  1319 IKYATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAID----PGRLDFSTTETQGK 1379

  Fly  1230 -----LPLNILSDDFAVLALTSLCRGY-QFQQNTKHVDSFSLAIQETLAI--CGISPKEQKKVQL 1286
                 :...:....||...|..|.|.| .:..|::..||.:.||||.|:|  |..........||
Human  1380 DFTFVIETGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGHQL 1444

  Fly  1287 WQSLPARMRQLMEPMLHSCYTCVHRPS--TCLQQPLFGSHYSHNYYEEWAFLWASRLIDYLPSSG 1349
            |:..|..:|:::||.|::.|....:.:  :.:::|::.|....| :.||:..||.    ||.:..
Human  1445 WRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSN-FAEWSASWAG----YLITKV 1504

  Fly  1350 RRHLLSSYKPC----IKRDSNMLSTFYPYILLHALLECTTEQRNHIQEEFMAVLQANEESSSSVR 1410
            |..|.|....|    :|.|..:.....|:||::.||.|..|.:..:..|.||||:.:::
Human  1505 RHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDDQ------ 1563

  Fly  1411 GRQELGAIKENAFKQFESRKYAAGIKPLASTLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLR-E 1474
                                :....:.:||.|.           :|:.:....:||.|.:|.| :
Human  1564 --------------------HTINTQDIASDLC-----------QLSTQTVFSMLDHLTQWARHK 1597

  Fly  1475 WQRI------HGRSTGGKPP---ETID-SNYRKIHEFLNLIPKLLVSRASYNCGEYARALSYLES 1529
            :|.:      |.:|...|..   .|:| .:|:.:..||:|||:..::.||:....|.||:.:.||
Human  1598 FQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFES 1662

  Fly  1530 YLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQDILVNRLVERQQDMITSY 1594
            ::.|   |.|.:.|...||.::|.::.:||.|.|...:|..:.|:.:.||.:..:...:|....|
Human  1663 FITE---KKQNIQEHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACY 1724

  Fly  1595 EQLLSSTDQMQPDH-------VRAMIDAYLRDTPKTAQLIADGLWQRLSDRYSDQCFAECKSELL 1652
            ::.:    |::||.       |::|:......|..|.   .:|:....|: ::|: ....:.|..
Human  1725 DRAI----QLEPDQIIHYHGVVKSMLGLGQLSTVITQ---VNGVHANRSE-WTDE-LNTYRVEAA 1780

  Fly  1653 WRLGSYDEMEEL------QSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLEELRSCSAVQ 1711
            |:|..:|.:|..      .:.|..:..|..|..::...|.. :|||.....|.::.  .|.::.:
Human  1781 WKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDITAF-YDSLKLVRAEQIVP--LSAASFE 1842

  Fly  1712 QHSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRIQE 1776
            :.||...|:.:::||::.||..|   ::.|.|....|:.::...|    |..||::.|...|.:|
Human  1843 RGSYQRGYEYIVRLHMLCELEHS---IKPLFQHSPGDSSQEDSLN----WVARLEMTQNSYRAKE 1900

  Fly  1777 SIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSG 1841
            .|.:.||.:|: |.:|        |.....:...||.||::.|.||..|.|...:|.|.|.:.:.
Human  1901 PILALRRALLS-LNKR--------PDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAE 1956

  Fly  1842 LFIERAKLLWQKGDQVMAMNYLEE--QLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQAVYSAESM 1904
            |::||||.||.|||...|:..|::  :|....:......|.:....|.:...|::::...:.||
Human  1957 LYVERAKWLWSKGDVHQALIVLQKGVELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFES- 2020

  Fly  1905 HLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQDDMLINVMVNYAKSL 1969
                :|::|.:::..|...:.|..|..:|::.:|::......|.|   :|.|::..:::::.:||
Human  2021 ----NAIMKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKME---KQGDLIRYIVLHFGRSL 2078

  Fly  1970 RYGSEHVYQSMPRLISLWLD------TTESSTNTEQVKKMNDL------LTNCCTALPTAVFYTV 2022
            :||::.:||||||:::||||      ..|.:..:::|:..|||      :|.....|....|.|.
Human  2079 QYGNQFIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTA 2143

  Fly  2023 YSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNS 2087
            :||::||:||..::||.||..:|.|:..|||||::||:....||:...|:.|||.:|..:.....
Human  2144 FSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKK 2208

  Fly  2088 TFQKLLQDFNSLTERLMDLTNKEVT-LDRTYKLSDLDTRLSKLCKQPEFSQILLPFEKYMQPTLP 2151
            :.:|.:.|...||::|::|.||.|. ...|..:|.....|.||.::..||:||:|.:..|.||||
Human  2209 SLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLP 2273

  Fly  2152 LNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKP 2216
            ....::::..||.|        ||....||:||.:.|.||.|..||||::::.||||.|.::.||
Human  2274 SILGTHANHASHEP--------FPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKP 2330

  Fly  2217 KDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNL 2281
            |||||:|.||||||.|:.:.|.:||.:|:|.||||||||:|.|:|||::||:.|.|..|.|...|
Human  2331 KDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKL 2395

  Fly  2282 YAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYI 2346
            |.::.:.|:.::|:...:|...::..|.:||.:.|:|.|||:|.||..:.|..|.|||.:|:.|.
Human  2396 YKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYC 2460

  Fly  2347 RTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAM 2411
            |:.||||||||||||||||||||||....|:.||||||||||:||....||:|||||||||:..|
Human  2461 RSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGM 2525

  Fly  2412 GPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYD---VGAQTRKGAATA-----------KI 2462
            ||:|.||.||:.||:|:||::.:.:.|||:|:.|::|   ..::..||.:.|           |.
Human  2526 GPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKA 2590

  Fly  2463 TKDVQRIADRLQGHVK-RQQANSIPLSTEGQVNFLINEATKVDNLASMYIGWGAFL 2517
            ...|..|..||||.:| |.:...:|||.||.|::||.|||..:.|..||:||..::
Human  2591 KTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 2646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825	27/108 (25%)
		FAT	1653..1985	CDD:280429	89/339 (26%)
		PIKKc_ATR	2181..2448	CDD:270625	143/266 (54%)
		FATC	2486..2517	CDD:280430	16/30 (53%)
ATR	XP_011511226.1	UME	1119..1224	CDD:214825	28/111 (25%)
		FAT	1773..2094	CDD:280429	90/347 (26%)
		TEL1	<2135..2646	CDD:227365	231/518 (45%)
		PIKKc_ATR	2295..2569	CDD:270625	144/273 (53%)
		FATC	2615..2646	CDD:280430	16/30 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145609
Domainoid	1	1.000	290	1.000	Domainoid score	I1571
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	771	1.000	Inparanoid score	I535
Isobase	1	0.950	-	0.85977	Normalized mean entropy	S4341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10493at33208
OrthoFinder	1	1.000	-	-		FOG0004409
OrthoInspector	1	1.000	-	-		oto88762
orthoMCL	1	0.900	-	-		OOG6_102609
Panther	1	1.100	-	-	LDO	PTHR11139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.710