DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and PI4KB

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	XP_011507936.1	Gene:	PI4KB / 5298	HGNCID:	8984	Length:	849	Species:	Homo sapiens

Alignment Length:	1093	Identity:	194/1093 - (17%)
Similarity:	348/1093 - (31%)	Gaps:	414/1093 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1454 PRLAGKLCAELLDFLQRWLREWQRIHGR---STGGKPPET-----IDSNYR-------KIHEFLN 1503
            |.:|.|.|.|:|:       :.:.:||.   |:.|.|.|.     :||..|       :|.|..:
Human    57 PEVAQKACQEVLE-------KVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEED 114

  Fly  1504 LIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVE-----VYGSLRDPDSVEG 1563
            .:...:.|..:.......:..|..:|:|       .||.|...|.:.     :|.| ::|.
Human   115 EMGAAVASGTAKGARRRRQNNSAKQSWL-------LRLFESKLFDISMAISYLYNS-KEPG---- 167

  Fly  1564 AVQVRSYDMSVTQDILVNRL-VERQQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLI 1627
               |::|        :.||| ..|.:|:.....|||:....|..| |...|..|:...
Human   168 ---VQAY--------IGNRLFCFRNEDVDFYLPQLLNMYIHMDED-VGDAIKPYIVHR------- 213

  Fly  1628 ADGLWQRLSDRYSDQCFAECKSELLWRLGSYDEMEELQSNWPAQCSQGCLKLRRPLTTRIEFDSL 1692
                 .|.|..:|.||      .||  ||:|.....:.:.   :.|:| .|||:.:.:    |.|
Human   214 -----CRQSINFSLQC------ALL--LGAYSSDMHISTQ---RHSRG-TKLRKLILS----DEL 257

  Fly  1693 LDGMRESVLEEL-----RSCSAVQQHSYANAYDAVLKLHLVHELH--CSQELVEKLEQDRDEDNQ 1750
            ....|:..|..|     ...|..::....:..||...:.|...|.  .|...||  .:|.:..:.
Human   258 KPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVE--NEDEELSSS 320

  Fly  1751 EKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILA------ELQRRLTD---RNHLLPHLKTE 1806
            .:.:.|.|.. ..||   .|:....:|:.:..:.:..      :.||.:::   .||.||
Human   321 TESIDNSFSS-PVRL---APEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLP----- 376

  Fly  1807 LARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMR 1871
             ||:||.:|..:.:..::...|..:|.:.:..|..:::|                .||
Human   377 -ARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVE----------------VLE------- 417

  Fly  1872 SGCQG----NVKQLAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSESCHVQM 1932
              |:.    :|.....|.|        :::..|.|::..|.           ..|.|
Human   418 --CENFDTTSVPARIPENR--------IRSTRSVENLPECG-----------ITHEQ-------- 453

  Fly  1933 AQFLEKILEARQGGKSEPTGEQDDMLINVMVNYAKSLRYGSEHVYQSMPRLISLWLDTTESSTNT 1997
                                                 |.||   :.::|.     .|..:.:.:.
Human   454 -------------------------------------RAGS---FSTVPN-----YDNDDEAWSV 473

  Fly  1998 EQVKKMN----DLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLW 2058
            :.:.::.    ::.||.|..:         ||            |:|
Human   474 DDIGELQVELPEVHTNSCDNI---------SQ------------FSV------------------ 499

  Fly  2059 MLLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQKLLQDFNSLTERLMDLTNKEVTLDRTYKLSDLD 2123
                                  ||.....:.:.:......:..||.:            :|:...
Human   500 ----------------------DSITSQESKEPVFIAAGDIRRRLSE------------QLAHTP 530

  Fly  2124 TRLSKLCKQPEFSQILLPFEKYMQPTLPLNSDSNSSEGS---HLPANQSTVNWFPYQQIYISGFQ 2185
            |...:..:.|....:..|:::.::         ...|||   |||      ||
Human   531 TAFKRDPEDPSAVALKEPWQEKVR---------RIREGSPYGHLP------NW------------ 568

  Fly  2186 ESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHI 2250
                                  :...|:||..||||::  |:.|.  |.:.|.......:..|.|
Human   569 ----------------------RLLSVIVKCGDDLRQE--LLAFQ--VLKQLQSIWEQERVPLWI 607

  Fly  2251 RTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQ 2315
            :.|.:|..:.:.|::|.:.|                           ||.:|:..::.:......
Human   608 KPYKILVISADSGMIEPVVN---------------------------AVSIHQVKKQSQLSLLDY 645

  Fly  2316 LVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVH 2380
            .:..|...          |..::..|:..::::.|...:|.|:|.:.|||..|||. :..|..:|
Human   646 FLQEHGSY----------TTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILL-DAEGHIIH 699

  Fly  2381 VDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEG---SFRKCCEITLRLLKQESKTLMSIL 2442
            :||..:.:........|...|:||...:..||  |::|   ::.|                |.:|
Human   700 IDFGFILSSSPRNLGFETSAFKLTTEFVDVMG--GLDGDMFNYYK----------------MLML 746

  Fly  2443 RPFVYDVGAQTRKGAATAKITKDVQRIADRLQGHVKRQQANSI--PLSTEGQV 2493
            :..:          ||...:.|.|| |.:.:|...:|...:|.  |:.|..||
Human   747 QGLI----------AARKHMDKVVQ-IVEIMQQGCRRCSGSSPSGPMMTVAQV 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	58/351 (17%)
		PIKKc_ATR	2181..2448	CDD:270625	49/269 (18%)
		FATC	2486..2517	CDD:280430	4/8 (50%)
PI4KB	XP_011507936.1	PI4Kc_III_beta	541..849	CDD:270712	71/368 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900