DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-41 and PI4KA

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:NP_477352.3 Gene:PI4KA / 5297 HGNCID:8983 Length:2102 Species:Homo sapiens


Alignment Length:2506 Identity:453/2506 - (18%)
Similarity:797/2506 - (31%) Gaps:818/2506 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   317 IQGQLEHS--VVP-LEQLVHLQQLMLSHWHCHPTH----------------LVPILALMGLKQTE 362
            |:..|:|.  ||| |.:|  |:.|...:|....|.                ||.:|:.:..:...
Human    86 IESDLQHKDCVVPYLLRL--LKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPS 148

  Fly   363 MRSGVVQVLTQSL---------VEILKKEEVLSKDWQKLIAILRGF---KQLEKLILSQSQHKIA 415
            :|..:::||.|.|         :||..||.:.......||.|.|.|   ..:|:.:||:...||.
Human   149 LRDEILEVLLQVLHVLLGMCQALEIQDKEYLCKYAIPCLIGISRAFGRYSNMEESLLSKLFPKIP 213

  Fly   416 EH--------EG-----------HIDSSVLAMLPLQCE--IIKVADTNWNNLSMQLVE------- 452
            .|        ||           .:.|::|.:    |:  .:|...::.:::|....|       
Human   214 PHSLRVLEELEGVRRRSFNDFRSILPSNLLTV----CQEGTLKRKTSSVSSISQVSPERGMPPPS 274

  Fly   453 ---------LESKCSADRRHIHLE-----------ICSLLMQITFIRHFLKTQTQHQLLAILQRH 497
                     .|:.|..|...:..|           :..|...:|:....:..:...:||.::::.
Human   275 SPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKI 339

  Fly   498 LK------LSYLCAIRLETPSSVHTQMQSFYAQQYMRLFQSEETQEIFCSNLPQLYISGFIKPEQ 556
            ::      |..:.|..:|...|......||....|:.:|:.......:..:||    :.|:| |.
Human   340 VEEAVLKSLDAIVASVMEANPSADLYYTSFSDPLYLTMFKMLRDTLYYMKDLP----TSFVK-EI 399

  Fly   557 LMKALPTINNRSGRAQVI-----RL--------LLCSQPG---KLSVFKVKDR--IELYCPKCRP 603
            ....|...|...|..|.|     |:        |.|....   .|.|:.|||.  .|..|.|   
Human   400 HDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIK--- 461

  Fly   604 LPKKLPGIYLGKCKQQLPCPDFSSTNLEMIANDLLFYPDFECIAQHLDLLCFE------------ 656
            |.:||.                |.|:.::|...|   |...|..|.|..||..            
Human   462 LSEKLQ----------------SKTSSKVIIAHL---PLLICCLQGLGRLCERFPVVVHSVTPSL 507

  Fly   657 ------PNVILGLLRE------TEALQKVSVKVIGQ-LVSAMRVRS-----PEFLEQLANLVLAA 703
                  |:.:|..|.:      |.|...:.:.|..: ..|.:.|.|     |...|||.::.:..
Human   508 RDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISVTNEHSESTLNVMSGKKSQPSMYEQLRDIAIDN 572

  Fly   704 IKAMLAKPLTEQNVLQQRSMLNVLTAIAHMEDNEIWLFHWFKMTFFFLVHTRSLVAQEAVLAATE 768
            |...|...||...|:.:                          .|...:..|..::||:...|  
Human   573 ICRCLKAGLTVDPVIVE--------------------------AFLASLSNRLYISQESDKDA-- 609

  Fly   769 MCASQGLQTIHLWNWYKRDALDLTVRLALNVYLLDGVRFTRSLRALTKMLG--FTCVQEFTCKYH 831
                      ||       ..|.|:|...::.:        :||...|::.  ...:|:..|:..
Human   610 ----------HL-------IPDHTIRALGHIAV--------ALRDTPKVMEPILQILQQKFCQPP 649

  Fly   832 RLLTAMVLPHCIVNPLCKGVLVLIAKQMQKHIGTLFSISFLRIYTHVF-LTEEPELANSCIELVV 895
            ..|..:::...       |.||:...|.              ||..|: |.::           :
Human   650 SPLDVLIIDQL-------GCLVITGNQY--------------IYQEVWNLFQQ-----------I 682

  Fly   896 SCTQSSLQQLMNADVKQTVAELLIYFNRNPTFVMRSFQSLLQLSIGSLEELSSQTANAEFANFIA 960
            |...||:......|.|.                    ......|:..:..|::..||.:..:.:.
Human   683 SVKASSVVYSATKDYKD--------------------HGYRHCSLAVINALANIAANIQDEHLVD 727

  Fly   961 ERFLGVITYFESC------LSEPSFEKPLKEETLYSLGQIMRFVGSQHVTQFRFKIIAMLS-FVH 1018
            |..:.::..|...      .||.:.||          |..::...|.........:||:|: .:.
Human   728 ELLMNLLELFVQLGLEGKRASERASEK----------GPALKASSSAGNLGVLIPVIAVLTRRLP 782

  Fly  1019 TLQE--PRLQRICLKIWHIFLHVVNVQELGPSLGR--------IVATLQPLLA-----DNESVKQ 1068
            .::|  ||||::....| ::..::.....|..|..        .:||..|||.     ...||.|
Human   783 PIKEAKPRLQKLFRDFW-LYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQ 846

  Fly  1069 VNDLYEFIILRNASMLGTFITDLYFLDRMENVSPSIQKCIRRHTAHL----DLKGLAEEENQSPP 1129
            .|...:...:..|.:.....|.:..||....||..|.|.....:.:|    .|:.:....:..| 
Human   847 YNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDP- 910

  Fly  1130 LVDQLRFLQKHITDECLQVRVYALQH-------------LGDLFGRRRPKLNSTILSELPLEPML 1181
              |:.:.:..:..|:.:|.....:..             |..:..:.:.|.|         |..|
Human   911 --DRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKEN---------EEEL 964

  Fly  1182 EQIVNVLMAGCQHDDSQLQMASAKCLGELGAIDASYLPSNYNFASPQHLPLN--ILSDDFAVLAL 1244
            |:....|:....|...:::..:.|.|.  |.:|.  .|         ||..:  :|.....:|..
Human   965 ERHAQFLLVNFNHIHKRIRRVADKYLS--GLVDK--FP---------HLLWSGTVLKTMLDILQT 1016

  Fly  1245 TSLCRGYQFQQNTKHVD----SFSLAIQET-----------LAICGISPKEQKKVQLWQSLPARM 1294
            .||.......::..:.|    .:.:.:.:|           .|.||:..:|..|   |  .|...
Human  1017 LSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMK---W--APTVT 1076

  Fly  1295 RQLMEPMLHSCYTCV-----HRPSTCLQQPLFGSHYSHNYYEEWAFLWASRLIDYLPSSGRRHLL 1354
            :..::..|:.....|     |.......:.:.  |:: .|.::...|.|::|             
Human  1077 KSHLQEYLNKHQNWVSGLSQHTGLAMATESIL--HFA-GYNKQNTTLGATQL------------- 1125

  Fly  1355 SSYKP-CIKRD-SNMLSTFYPYILLHALLECTTEQRNHIQEEFMAVLQ----ANEESSSSVRGRQ 1413
             |.:| |:|:| ||.:::.              ..||....|...:::    ..:.|..:....|
Human  1126 -SERPACVKKDYSNFMASL--------------NLRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQ 1175

  Fly  1414 ELGAIKENAFKQFESRKYAAGIKPLASTLVSDRKEDSSRVPRLAGKLCAELLDFLQRW--LREWQ 1476
            :|    .:|..:...:.|...:..|.:.|:|.:..|    |:|...||         |  ||.:.
Human  1176 DL----HSALDRSHPQHYTQAMFKLTAMLISSKDCD----PQLLHHLC---------WGPLRMFN 1223

  Fly  1477 RIHGRSTGGKPPETIDSNYRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRL 1541
            . ||..|                              :..|.|:..|          |:|.    
Human  1224 E-HGMET------------------------------ALACWEWLLA----------GKDG---- 1243

  Fly  1542 LEQFTFLVEVYGSLR-----------------DPDSVEGAVQVRSYDMSVTQD-ILVNRLVER-- 1586
             .:..|:.|:.|:..                 ||.:...|.|.:.....||.. |.::.||:|  
Human  1244 -VEVPFMREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFE 1307

  Fly  1587 -----QQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADGLWQRLSDRYSDQCFAE 1646
                 ..|.:..:..||..:..:.....:..::.::.......:|:..||....:|...:.....
Human  1308 IAKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRN 1372

  Fly  1647 CKSELLWRLGSYDEMEELQSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVL---------E 1702
            ...|.:     |....:..|..|...:||..:||..::..|:|.:.:...::.:.         :
Human  1373 VLREKI-----YSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQ 1432

  Fly  1703 ELRSCSAVQQHSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDEDNQEKLMKNYFDDWQYRLQI 1767
            :.||...:...|...|....:.   .:.|......:.|......:.|:...:..|          
Human  1433 DTRSNLDITVGSRQQATQGWIN---TYPLSSGMSTISKKSGMSKKTNRGSQLHKY---------- 1484

  Fly  1768 VQPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARI--WLN--SA------QINRNAG 1822
                       |..||.:|..|             |.||:.|:  |.|  ||      |...|:.
Human  1485 -----------YMKRRTLLLSL-------------LATEIERLITWYNPLSAPELELDQAGENSV 1525

  Fly  1823 QLQRAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQ--GN-------- 1877
            ...|::...|...:::      :...|.|.      ...||..||.......:  ||        
Human  1526 ANWRSKYISLSEKQWK------DNVNLAWS------ISPYLAVQLPARFKNTEAIGNEVTRLVRL 1578

  Fly  1878 -----------VKQL---------AAEQRHL-------------FFRGKY----LQAVYSAESMH 1905
                       :|.|         |.|..|:             :|...|    |.|.|..:.:.
Human  1579 DPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLR 1643

  Fly  1906 -LCADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQDDMLINVMVNYAKSL 1969
             ...||:|.|..:.:...|..:..:|:     |.||.|  ..||:....|  .:.|:..|.    
Human  1644 SFPPDAILFYIPQIVQALRYDKMGYVR-----EYILWA--ASKSQLLAHQ--FIWNMKTNI---- 1695

  Fly  1970 RYGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPV 2034
             |..|..:|..|.:..| ||        :.|:::...|:.     |...||           ...
Human  1696 -YLDEEGHQKDPDIGDL-LD--------QLVEEITGSLSG-----PAKDFY-----------QRE 1734

  Fly  2035 NDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQKLLQDFNSL 2099
            .|.|..:.|| ..:::.||:..             .|.|.|...|::.::|...:..        
Human  1735 FDFFNKITNV-SAIIKPYPKGD-------------ERKKACLSALSEVKVQPGCYLP-------- 1777

  Fly  2100 TERLMDLTNKE-VTLDRTYKLSDLDTRLSKLCKQPEFSQILLPFEKYMQPTLPLNSDSNSSEGSH 2163
                   :|.| :.||..||..   |.:....|.|..::                          
Human  1778 -------SNPEAIVLDIDYKSG---TPMQSAAKAPYLAK-------------------------- 1806

  Fly  2164 LPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCS----DGKDYD---VLVKPKDDLR 2221
                      |..::..:|..::..|..||.::.:     ||    ||:...   .:.|..||.|
Human  1807 ----------FKVKRCGVSELEKEGLRCRSDSEDE-----CSTQEADGQKISWQAAIFKVGDDCR 1856

  Fly  2222 RDARLMEFNGLVK---RYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASY----RSICM 2279
            :|...::...|.|   :.:..|       |.:..|.|:.....||::|.:|:..|.    |....
Human  1857 QDMLALQIIDLFKNIFQLVGLD-------LFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDF 1914

  Fly  2280 NLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNT 2344
            .:|                           :.||:|........||              :||..
Human  1915 GMY---------------------------DYFTRQYGDESTLAFQ--------------QARYN 1938

  Fly  2345 YIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQ---GELLPYPEVVPFRLTHN 2406
            :||::|..|::.::|.:.|||..||:. :..|..:|:||..:|..   |.|...|::   :||..
Human  1939 FIRSMAAYSLLLFLLQIKDRHNGNIML-DKKGHIIHIDFGFMFESSPGGNLGWEPDI---KLTDE 1999

  Fly  2407 MIVAMGPLGVEGSFRKCCEITLR---LLKQESKTLMSILRPFVYDVGAQTRKGAATAKITKDVQR 2468
            |::.||.......|:...|:.:|   .::.....::|:: ..:.|.|....:| .|.|:.|  .|
Human  2000 MVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLV-TLMLDTGLPCFRG-QTIKLLK--HR 2060

  Fly  2469 IADRLQGHVKRQQANSIPLSTEGQVNFLINEATKVD 2504
            .:..:   .:|:.||.|....  |..||.|.:...|
Human  2061 FSPNM---TEREAANFIMKVI--QSCFLSNRSRTYD 2091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 22/121 (18%)
FAT 1653..1985 CDD:280429 71/398 (18%)
PIKKc_ATR 2181..2448 CDD:270625 60/286 (21%)
FATC 2486..2517 CDD:280430 5/19 (26%)
PI4KANP_477352.3 PI4Ka 1547..1722 CDD:238443 40/203 (20%)
PI4Kc_III_alpha 1783..2101 CDD:270711 84/414 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.