Protein Alignment mei-41 and PIK3CG

DIOPT Version :9

• Sequence 1: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Sequence 2: NP_001269355.1
• Gene: PIK3CG / 5294
• HGNCID: 8978
• Length: 1102
• Species: Homo sapiens
• Alignment Length: 1142
• Identity: 223/1142 - (19%)
• Similarity: 398/1142 - (34%)
• Gaps: 348/1142 - (30%)

  Fly  1472 LREWQRIHGRSTGGKPPETIDSNYRKIHEFLNLIPKLLVSR--ASYNCGEYARALSYLESYLEEG 1534
            ||.|:..| ||.|            :||         ||.|  .|.....:.|.|:.|..|  :.
Human   122 LRYWKATH-RSPG------------QIH---------LVQRHPPSEESQAFQRQLTALIGY--DV 162

  Fly  1535 EDKSQRLLEQFTF---------LVEVYGSLRDPDSVEGAVQVRSYDMS--VTQDILVNRLVERQQ 1588
            .|.|....::..|         :.||  :.|||         :.|.|.  ||...|...|.::..
Human   163 TDVSNVHDDELEFTRRGLVTPRMAEV--ASRDP---------KLYAMHPWVTSKPLPEYLWKKIA 216

  Fly  1589 D---MITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADGLWQRLSDRYSDQCFAECKSE 1650
            :   .|..:....|.|.::.||           |||..   |....:.:::.:.|.....|.:||
Human   217 NNCIFIVIHRSTTSQTIKVSPD-----------DTPGA---ILQSFFTKMAKKKSLMDIPESQSE 267

  Fly  1651 --LLWRLGSYDE-------MEELQSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLEELR- 1705
              .:.|:...||       ::..|  |...|          |....|...:||...:..|:|:|
Human   268 QDFVLRVCGRDEYLVGETPIKNFQ--WVRHC----------LKNGEEIHVVLDTPPDPALDEVRK 320

  Fly  1706 -------SCSAVQQHSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDEDNQEKLMKNYFD-DWQ 1762
                   .|:.|      ..|...|.:|                   .:|::.....:.:| |.:
Human   321 EEWPLVDDCTGV------TGYHEQLTIH-------------------GKDHESVFTVSLWDCDRK 360

  Fly  1763 YRLQI------VQPQ-----VRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLN-SA 1815
            :|::|      |.|:     |.::.:| ...:.:|.  |||.:.:    |..:..|..:||. |.
Human   361 FRVKIRGIDIPVLPRNTDLTVFVEANI-QHGQQVLC--QRRTSPK----PFTEEVLWNVWLEFSI 418

  Fly  1816 QI-NRNAGQLQRAQLYI-------LKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMRS 1872
            :| :...|.|...|:|.       .||:...||.....:.:||:.
Human   419 KIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYY-------------------- 463

  Fly  1873 GCQGNVKQLAAEQRHLFFRGKYL------------QAVYSAESM----------HLCADAVLKYF 1915
                 |..|..:.|.|..||:|:            |..::|:.:          .:....:|..:
Human   464 -----VNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNY 523

  Fly  1916 QEAIAVHR-------QSESCHVQMAQFLEKILEARQGGKSEP----TGEQDDMLINVMVNYAK-- 1967
            ...||:.:       :.:....:|...|.|.|||...  ::|    |.|..::|.:......|
Human   524 CHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIA--TDPLNPLTAEDKELLWHFRYESLKHP 586

  Fly  1968 --------SLRYGSEHV----YQSMPRLISLW-------------LDTTESSTNTE--QVKKM-- 2003
                    |:::|.:.:    ||.:.|. .:|             ||...|..|..  .|:|:
Human   587 KAYPKLFSSVKWGQQEIVAKTYQLLARR-EVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLES 650

  Fly  2004 ---NDLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFK 2065
               :|:|......:....|...:...|:|        |.:.|.:..|.:..:   ..|.|
Human   651 LEDDDVLHYLLQLVQAVKFEPYHDSALAR--------FLLKRGLRNKRIGHF---LFWFL----- 699

  Fly  2066 SAKAHRIKRCKLVLTDSRLQNSTFQKLLQDF--NSLTERLMDLTNKEVTLDRTYKLSDLDTRLSK 2128
                      :..:..||.....|..:|:.:  ...|..|.|.|.:...::...|:: ||.:...
Human   700 ----------RSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVT-LDIKSLS 753

  Fly  2129 LCKQPEFSQILLPFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVL---- 2189
            ..|....||::...::.::          :.:.|.||.:        ::..|..|.:...|
Human   754 AEKYDVSSQVISQLKQKLE----------NLQNSQLPES--------FRVPYDPGLKAGALAIEK 800

  Fly  2190 --ILRSAAKPKKLTIRCSD-----GKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRR 2247
              ::.|..||..|..:|:|     .:...::.|..||||:|..:::    :.|.:..........
Human   801 CKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQ----ILRIMESIWETESLD 861

  Fly  2248 LHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVF 2312
            |.:..|..:...::.|::|.:.:..:...|      |:..|.:|...:.
Human   862 LCLLPYGCISTGDKIGMIEIVKDATTIAKI------QQSTVGNTGAFKD---------------- 904

  Fly  2313 TKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGD 2377
                     .|...||:::..|...:..|...::.:.|...:..::||:||||.:||:..| .|:
Human   905 ---------EVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITE-TGN 959

  Fly  2378 AVHVDF-NCLFNQGELLPY-PEVVPFRLTHNMIVAMGPLGVEGS--FRKCCEITLR--LLKQESK 2436
            ..|:|| :.|.|....|.. .|.|||.||.:.:..||..|.:.|  |:|..:|.::  |..:...
Human   960 LFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHT 1024

  Fly  2437 TLMSILRPFVYDVGAQTRKGAATAKITKDVQRIADRL 2473
            .|:.||    :.:...|.....|:|  :|::.|.|.|
Human  1025 NLLIIL----FSMMLMTGMPQLTSK--EDIEYIRDAL 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	75/414 (18%)
		PIKKc_ATR	2181..2448	CDD:270625	62/283 (22%)
		FATC	2486..2517	CDD:280430
PIK3CG	NP_001269355.1	PI3K_rbd	203..312	CDD:197540	26/134 (19%)
		C2_PI3K_class_I_gamma	350..527	CDD:176044	38/208 (18%)
		PI3Ka_I	549..725	CDD:238444	36/204 (18%)
		PI3Kc_IB_gamma	729..1095	CDD:270627	82/388 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900