DRSC/TRiP Functional Genomics Resources

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Protein Alignment mei-41 and PIK3CD

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_016856965.1 Gene:PIK3CD / 5293 HGNCID:8977 Length:1103 Species:Homo sapiens


Alignment Length:1238 Identity:239/1238 - (19%)
Similarity:411/1238 - (33%) Gaps:399/1238 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1448 EDSSRVPRLAGKLC--AELLDFLQRWLREWQRIHGRSTGGKPPETIDSNY-----RKIHEFLNLI 1505
            ||..|      :||  ...|..|:...||..|:         .:.|:|..     :.:|||.:|.
Human    83 EDEQR------RLCDVQPFLPVLRLVAREGDRV---------KKLINSQISLLIGKGLHEFDSLC 132

  Fly  1506 -PKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRL----LEQFTFLVEVY--------GSLRD 1557
             |::...||.. |           .:.||...:.|:|    ..|::|.:::.        |:||.
Human   133 DPEVNDFRAKM-C-----------QFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRL 185

  Fly  1558 PD-------SVEGAVQVRSYDMSVTQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHVRAMIDA 1615
            |:       ..||:.:..::.:| |:|:.:..:....:...|.:.|.|..    ||:.....::.
Human   186 PNRALLVNVKFEGSEESFTFQVS-TKDVPLALMACALRKKATVFRQPLVE----QPEDYTLQVNG 245

  Fly  1616 ---YLRDTPKTAQL------IADGLWQRLSDRYSDQCFAECKSELLWRLGSYDEMEELQSNWPAQ 1671
               ||..:....|.      :..||...|:..:|....|               |.:.|||...|
Human   246 RHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILA---------------MRDEQSNPAPQ 295

  Fly  1672 CSQGCLK----------------LRRPLTTRIEFDSLLDGMRESVLEELR-------------SC 1707
            ..:...|                |.:|.  |||   |:.|.:.:..|.::             .|
Human   296 VQKPRAKPPPIPAKKPSSVSLWSLEQPF--RIE---LIQGSKVNADERMKLVVQAGLFHGNEMLC 355

  Fly  1708 SAVQQHSYANAYDAVLKLHLVHELH-CS-----------QELVEKLEQDRDEDNQEK-------- 1752
            ..|.....:...:.|.|..|..::: |.           ..::||.::.|....:.|        
Human   356 KTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW 420

  Fly  1753 ---LMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNS 1814
               ::.:|.|           |::..|...                  ::.|.:..|...:...:
Human   421 ANLMLFDYKD-----------QLKTGERCL------------------YMWPSVPDEKGELLNPT 456

  Fly  1815 AQINRNAGQLQRAQLYI-----------LKAAEYQPSGLFIE----RAKLLWQKGDQVMAMNYLE 1864
            ..:..|......|.|.|           ..|.|..|.|:.:.    |.:|||             
Human   457 GTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKLPGGMLLASREWRPELLW------------- 508

  Fly  1865 EQLSIMRSGCQGNV--KQLAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSES 1927
                 ||...:.:.  :.:......|......:||...||...|.         :.:.:.|.||.
Human   509 -----MRLHAEDSAPSRMIGVAMPGLGVLPGLVQAPGDAECSRLL---------QILELGRHSEC 559

  Fly  1928 CHVQMAQFLE--KILEARQGGKSEPTGEQDDMLINVMVNYAKSLRYG-SEHVYQSMPR--LISLW 1987
            .||...:.|:  :|||.|  |..|....:.|::        ..||:. .||..:::.|  |::.|
Human   560 VHVTEEEQLQLREILERR--GSGELYEHEKDLV--------WKLRHEVQEHFPEALARLLLVTKW 614

  Fly  1988 LDTTESSTNTEQVKKMNDLLTNCCT--ALPTAVFYTVYSQMLSRL---------CHPVNDVFTVL 2041
                   ...|.|.:|..||   |:  .||          :||.|         ||..:.....|
Human   615 -------NKHEDVAQMLYLL---CSWPELP----------VLSALELLDFSFPDCHVGSFAIKSL 659

  Fly  2042 RNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLV--LTDSRLQNS----------------- 2087
            |    ||.:   .:....||...:..|......|:|.  |.|..|.|.                 
Human   660 R----KLTD---DELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVP 717

  Fly  2088 ----TFQKLLQDF-NSLTERLMDLTNKEVTLDRTYKLSDLDTRLSKLCKQPEFSQIL---LPFEK 2144
                .|..:|:.: ...|..:..|..:...|.:...|:|.....|:...:|:..:::   :..|.
Human   718 SVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEA 782

  Fly  2145 YMQPTLPLNSDSNSSEGSHL--PANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSD- 2206
            |::..            |||  |.:.||:    ..::.:    |....:.|..||  |.|..|: 
Human   783 YLEAL------------SHLQSPLDPSTL----LAEVCV----EQCTFMDSKMKP--LWIMYSNE 825

  Fly  2207 ----GKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIR--TYAVLPFNEECGLV 2265
                |....::.|..||||:|...::...|:      |...:|..|.:|  .|..||..:..||:
Human   826 EAGSGGSVGIIFKNGDDLRQDMLTLQMIQLM------DVLWKQEGLDLRMTPYGCLPTGDRTGLI 884

  Fly  2266 EWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQ 2330
            |                    :|:.:..:.:  :.|::|.......|.|.       ....||:.
Human   885 E--------------------VVLRSDTIAN--IQLNKSNMAATAAFNKD-------ALLNWLKS 920

  Fly  2331 RFATP-HSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLP 2394
            :  .| .:...|...:..:.|...:..|:||:||||.:||:..| :|...|:||      |..|.
Human   921 K--NPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRE-SGQLFHIDF------GHFLG 976

  Fly  2395 --------YPEVVPFRLTHNMIVAMGPLGVEGS-----FRKCCEITLRLLKQESKTLMSILRPFV 2446
                    ..|.|||.||::.:..:.......|     ||..||....:|::....       |:
Human   977 NFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLL-------FL 1034

  Fly  2447 YDVGAQTRKGAATAKITKDVQRIADRLQ---------GHVKRQQANSIPLSTEGQVNFLINEATK 2502
            :........|......:||:|.:.|.|.         .|.:.:...::..|.:.:||:|.:..:|
Human  1035 HLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSK 1099

  Fly  2503 VDN 2505
             ||
Human  1100 -DN 1101

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825
FAT 1653..1985 CDD:280429 69/405 (17%)
PIKKc_ATR 2181..2448 CDD:270625 64/287 (22%)
FATC 2486..2517 CDD:280430 7/20 (35%)
PIK3CDXP_016856965.1 PI3K_p85B 32..107 CDD:308030 9/29 (31%)
PI3K_rbd 175..281 CDD:307097 21/110 (19%)
C2_PI3K_class_I_beta_delta 314..481 CDD:176075 28/200 (14%)
PI3Ka 562..743 CDD:214537 46/217 (21%)
PI3Kc_IA_delta 735..1101 CDD:270718 91/439 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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