DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and PIK3CA

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	NP_006209.2	Gene:	PIK3CA / 5290	HGNCID:	8975	Length:	1068	Species:	Homo sapiens

Alignment Length:	1321	Identity:	247/1321 - (18%)
Similarity:	415/1321 - (31%)	Gaps:	492/1321 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1346 PSSGRR---HLLSSYKPCIKRDSNMLSTFYPYILLHALLECTTEQRNHIQEEFMAVLQANEESSS 1407
            ||||..   ||:.                 |.||:..||          ....:..|:...|::
Human     5 PSSGELWGIHLMP-----------------PRILVECLL----------PNGMIVTLECLREAT- 41

  Fly  1408 SVRGRQELGAIKENAFKQFESRKYAAGIKPL-------------ASTLVSDRKE--DSSRVPRLA 1457
                   |..||...||  |:|||     ||             :.|..::|:|  |.:|
Human    42 -------LITIKHELFK--EARKY-----PLHQLLQDESSYIFVSVTQEAEREEFFDETR----- 87

  Fly  1458 GKLCAELLDFLQRWL--------REWQRIHGRSTG---GKP---------PETIDSNYRKIHEFL 1502
             :||.  |...|.:|        || ::|..|..|   |.|         ||..|  :|:  ..|
Human    88 -RLCD--LRLFQPFLKVIEPVGNRE-EKILNREIGFAIGMPVCEFDMVKDPEVQD--FRR--NIL 144

  Fly  1503 NLIPKLL--------VSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPD 1559
            |:..:.:        .|||.|.......:...|..::....||.|        ::.|...:..|:
Human   145 NVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQ--------IIVVIWVIVSPN 201

  Fly  1560 SVEGAVQVRSYDMSVTQDILVNRLVERQQDMITSYEQL----------------------LSSTD 1602
            :.:....::.....|.:.::...:.::.:.|:.|.|||                      |....
Human   202 NDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYP 266

  Fly  1603 QMQPDHVRAMIDAYLRDTPKTAQLIADGLWQRLSDRYSDQCF-----------------AECKSE 1650
            ..|..::|:.|  .|...|....:..:.|:.:|    ...||                 .|..::
Human   267 LSQYKYIRSCI--MLGRMPNLMLMAKESLYSQL----PMDCFTMPSYSRRISTATPYMNGETSTK 325

  Fly  1651 LLW----------------------------RLGSYDEMEELQSNWPAQ---CSQGCLKLRRPLT 1684
            .||                            |.|.|...|.|..|...|   ||       .|..
Human   326 SLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCS-------NPRW 383

  Fly  1685 TR-IEFDSLLDGMRESVLEELRSCS------AVQQH-----SYANAYD-------AVLKLHLVHE 1730
            .. :.:|..:..:..:....|..||      |.::|     ...|.:|       ..:.|:|...
Human   384 NEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPV 448

  Fly  1731 LHCSQELVEKLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRI----------QESIYSFRRNI 1785
            .|..::|:..:.......|:|........|| :...:..|.:.:          :|:.:|:..
Human   449 PHGLEDLLNPIGVTGSNPNKETPCLELEFDW-FSSVVKFPDMSVIEEHANWSVSREAGFSYSH-- 510

  Fly  1786 LAELQRRLTDRNHLLPHLKTELARIWLN---SAQINRNAGQLQRAQLYILKAAEYQPSGLFIERA 1847
             |.|..||...|.|..:.|.:|..|...   |....:....|...:.|.:...|..|
Human   511 -AGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILP-------- 566

  Fly  1848 KLL----WQKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQAVYSAESMHL-- 1906
            |||    |...|:|..|..|.                            |....:...::|.|
Human   567 KLLLSVKWNSRDEVAQMYCLV----------------------------KDWPPIKPEQAMELLD 603

  Fly  1907 C--ADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQDDMLINVMVNYAKSL 1969
            |  .|.:::.|                ..:.|||.|             .||.|...::...:.|
Human   604 CNYPDPMVRGF----------------AVRCLEKYL-------------TDDKLSQYLIQLVQVL 639

  Fly  1970 RYGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPV 2034
            :|     .|.:..|:..:|           :||   .|||  ..:....|:.:.|:|.::   .|
Human   640 KY-----EQYLDNLLVRFL-----------LKK---ALTN--QRIGHFFFWHLKSEMHNK---TV 680

  Fly  2035 NDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQKLLQDFNSL 2099
            :..|.:       |:|:|                   .:.|.:.|.....|....:||:    :|
Human   681 SQRFGL-------LLESY-------------------CRACGMYLKHLNRQVEAMEKLI----NL 715

  Fly  2100 TERLMDLTNKEVTLDRTYKLSDLDTRLSKLCKQ---PEFSQILLPFEKYMQPTLPLNSDSNSSEG 2161
            |:.|     |:...|.|.|:     ::..|.:|   |:|...|..|      ..|||
Human   716 TDIL-----KQEKKDETQKV-----QMKFLVEQMRRPDFMDALQGF------LSPLN-------- 756

  Fly  2162 SHLPANQSTVNWFPYQQIYISGFQ-ESVLILRSAAKPKKLTIRCSD------GKDYDVLVKPKDD 2219
               ||:|            :...: |...|:.||.:|..|.....|      .::.:::.|..||
Human   757 ---PAHQ------------LGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDD 806

  Fly  2220 LRRD------ARLME----FNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASY 2274
            ||:|      .|:||    ..||..|.|              .|..|...:..||:|.:.|
Human   807 LRQDMLTLQIIRIMENIWQNQGLDLRML--------------PYGCLSIGDCVGLIEVVRN---- 853

  Fly  2275 RSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWY 2339
                                      .|..::.:.:...|..:..:.....:||:.:  .....|
Human   854 --------------------------SHTIMQIQCKGGLKGALQFNSHTLHQWLKDK--NKGEIY 890

  Fly  2340 EAR-NTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYP------- 2396
            :|. :.:.|:.|...:..:|||:||||..||: .:.:|...|:||      |..|.:.
Human   891 DAAIDLFTRSCAGYCVATFILGIGDRHNSNIM-VKDDGQLFHIDF------GHFLDHKKKKFGYK 948

  Fly  2397 -EVVPFRLTHNMIVAMGPLGVEGS-------FRKCCEITLRLLKQESKTLMSILRPFV------- 2446
             |.|||.||.:.::.:.....|.:       |::.|......::|.:...:::....:
Human   949 RERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPEL 1013

  Fly  2447 --YDVGAQTRKGAATAKITKD 2465
              :|..|..||..|..|..::
Human  1014 QSFDDIAYIRKTLALDKTEQE 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	69/402 (17%)
		PIKKc_ATR	2181..2448	CDD:270625	59/308 (19%)
		FATC	2486..2517	CDD:280430
PIK3CA	NP_006209.2	PI3K_p85B	32..107	CDD:396665	23/97 (24%)
		PI3K_rbd	173..292	CDD:197540	18/128 (14%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	28/166 (17%)
		PI3Ka_I	525..696	CDD:238444	47/285 (16%)
		PI3Kc_IA_alpha	695..1064	CDD:270719	89/436 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900