Protein Alignment mei-41 and PIK3C2G

DIOPT Version :9

• Sequence 1: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Sequence 2: XP_016874959.1
• Gene: PIK3C2G / 5288
• HGNCID: 8973
• Length: 1492
• Species: Homo sapiens
• Alignment Length: 1199
• Identity: 225/1199 - (18%)
• Similarity: 412/1199 - (34%)
• Gaps: 325/1199 - (27%)

  Fly  1397 AVLQANEESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPLASTLVSD--RKEDSSR------- 1452
            ::|..:..|...:...:||.....|....|||     .|.|..|:..||  .||::.|
Human   142 SILAPSFTSLDKINLEKELENENHNYHIGFES-----SIPPTNSSFSSDFMPKEENKRSGHVNIV 201

  Fly  1453 ---VPRLAGKLCAELLDFLQRWLREWQR-IHGRSTGGKPPETIDSNYRKIHEFLNLIPKLL---- 1509
               :..|.|.|...:      |...||: |.......:..|...|:...:..|.|.:.|:.
Human   202 EPSLMLLKGSLQPGM------WESTWQKNIESIGCSIQLVEVPQSSNTSLASFCNKVKKIRERYH 260

  Fly  1510 VSRASYNCGEY---ARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQ----- 1566
            .:..::|.|:.   ..|..|             :|..:..|.:.::        ::.:.|
Human   261 AADVNFNSGKIWSTTTAFPY-------------QLFSKTKFNIHIF--------IDNSTQPLHFM 304

  Fly  1567 -VRSYDMSVTQDILVNRLVERQQDMITSYEQLLS---STDQMQPDHV----------RAMIDAYL 1617
             ..:|   :.:|::...|.....|.:...:.:||   |.:.:|.||.          :::|..:|
Human   305 PCANY---LVKDLIAEILHFCTNDQLLPKDHILSVCGSEEFLQNDHCLGSHKMFQKDKSVIQLHL 366

  Fly  1618 RDTPKTAQLIADGLWQRLSDRYSDQCFAECKSELLWRLGSYDEMEELQSNWPAQCSQGCLKLRRP 1682
            :.:.:     |.|...|..:....|.:             .:::.|....|  :.|:.||
Human   367 QKSRE-----APGKLSRKHEEDHSQFY-------------LNQLLEFMHIW--KVSRQCL----- 406

  Fly  1683 LTTRIEFDSLLDGMRE------SVLEELRS-CSAVQQHSYANAYDAVLKLHLV-----HELHCSQ 1735
            ||...::|..|..:.:      :::||::. ||.:.........|||.:|.|:     ...:.|.
Human   407 LTLIRKYDFHLKYLLKTQENVYNIIEEVKKICSVLGCVETKQITDAVNELSLILQRKGENFYQSS 471

  Fly  1736 E-----LVEKLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRIQESIYS----FRRNILAELQR 1791
            |     |:||:..:                             :..|||.    :..:..|:.|.
Human   472 ETSAKGLIEKVTTE-----------------------------LSTSIYQLINVYCNSFYADFQP 507

  Fly  1792 RLTDR--NHLLPHLKTELA----------RIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFI 1844
            ....|  ::|.|.|.:.|:          ..|::|.:.......|..|...:.:...|:.    |
Human   508 VNVPRCTSYLNPGLPSHLSFTVYAAHNIPETWVHSYKAFSFTCWLTYAGKKLCQVRNYRN----I 568

  Fly  1845 ERAKLL-----WQKGDQVMAMNYLEEQLSIMRS----------GCQGNVKQLAA--------EQR 1886
            ...||.     |.:     .:|:..|..|:.|.          .|..|...|.|        :::
Human   569 PDKKLFFFLVNWNE-----TINFPLEIKSLPRESMLTVKLFGIACATNNANLLAWTCLPLFPKEK 628

  Fly  1887 HLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIA-------------VHRQSESCHVQMAQFLEK 1938
            .:.....:...:.|...:.:....|....|.:..             :...||.....:.:.|::
Human   629 SILGSMLFSMTLQSEPPVEMITPGVWDVSQPSPVTLQIDFPATGWEYMKPDSEENRSNLEEPLKE 693

  Fly  1939 ILE--ARQGGKSEPTGEQDDMLINVMVNYAKSLRYGSEHVYQSMPRLISL---WLDTTESSTNT- 1997
            .::  ||...|..|.     :|......|....|:...:...|:|.::..   |.:.|.|..:|
Human   694 CIKHIARLSQKQTPL-----LLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTI 753

  Fly  1998 ------EQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYP--- 2053
                  .|..:...|||   ::.|......|..|.|..|   :||   .|...:.:||:|..
Human   754 LRRWTFSQPLEALGLLT---SSFPDQEIRKVAVQQLDNL---LND---ELLEYLPQLVQAVKFEW 809

  Fly  2054 --QQSLWMLLPH--FKSAK-AHRIKRCKLVLTDSRLQNSTFQKLLQDFNSLT-ERLMDLTNKEVT 2112
              :..|..||.|  .:|.: |||:........:.....|.:||||....... :.|.|..:||..
Human   810 NLESPLVQLLLHRSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQK 874

  Fly  2113 LDRTYKLSDLDTRLSKLC---KQPEFSQILLPFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWF 2174
            |.:.  |.|:..|:....   :|....:.:...|::.|       |.|:   .|||.|.:
Human   875 LIKI--LGDIGERVKSASDHQRQEVLKKEIGRLEEFFQ-------DVNT---CHLPLNPA----- 922

  Fly  2175 PYQQIYISGF-QESVLILRSAAKPKKLTIRCSD--GKDYDVLVKPKDDLRRDARLMEFNGLVKRY 2236
                :.|.|. .::.....|.|.|.|:|...::  ||:..::.|..||||:|..:::...::...
Human   923 ----LCIKGIDHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNI 983

  Fly  2237 LHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPL 2301
            ..|:....|..:    |..|...::.|||:.:|:..:...|              .:...|..||
Human   984 WLQEGLDMQMII----YRCLSTGKDQGLVQMVPDAVTLAKI--------------HRHSGLIGPL 1030

  Fly  2302 HESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHG 2366
            .|:..:|                  |..|.......:.:|...:..:.|...:|.:|||:.|||.
Human  1031 KENTIKK------------------WFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHN 1077

  Fly  2367 ENILFAEGNGDAVHVDFNCLFNQGELLPYPEV--------VPFRLTHNM--IVAMG---PLGVEG 2418
            :||:..: :|...|:||      |:.|.:.:.        .||..|..|  .:..|   |...:.
Human  1078 DNIMLTK-SGHMFHIDF------GKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQD 1135

  Fly  2419 SFRKCCEITLRLLKQESKTLMSILRPFVY 2447
            ....||. ...::::.|:.|:::|...:|
Human  1136 FVELCCR-AYNIIRKHSQLLLNLLEMMLY 1163

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	65/402 (16%)
		PIKKc_ATR	2181..2448	CDD:270625	60/283 (21%)
		FATC	2486..2517	CDD:280430
PIK3C2G	XP_016874959.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900