Protein Alignment mei-41 and ATM

DIOPT Version :9

• Sequence 1: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Sequence 2: NP_000042.3
• Gene: ATM / 472
• HGNCID: 795
• Length: 3056
• Species: Homo sapiens
• Alignment Length: 3093
• Identity: 592/3093 - (19%)
• Similarity: 1069/3093 - (34%)
• Gaps: 1013/3093 - (32%)

  Fly     9 WKLLYNHVNRNVSNFSGV--YSVIEDILCQEP-SLISCSLVRELHNKFQDTFLLWLLNKL----- 65
            |:::.:|:.::.::|..|  ..:...::.:.| ||.:|.|          :.||.:|::|
Human   393 WEVIKDHLQKSQNDFDLVPWLQIATQLISKYPASLPNCEL----------SPLLMILSQLLPQQR 447

  Fly    66 --------AKCLSESPDSSECINLQRKILSSCCSNHPKLFERLVLAYVEAIEETHLQLSSLDL-- 120
                    .:||:|   .:.|.:.:..:.||..|:..||:.::.......|....:|..:..|
Human   448 HGERTPYVLRCLTE---VALCQDKRSNLESSQKSDLLKLWNKIWCITFRGISSEQIQAENFGLLG 509

  Fly   121 -------------------GQLSNERKPAI--------------TVRI----FRCDVE------- 141
                               |.......||:              ||::    ..|:|.
Human   510 AIIQGSLVEVDREFWKLFTGSACRPSCPAVCCLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKE 574

  Fly   142 -----------------------CLQEFDPHCAIEDIKVPLEQADMYAKSLLEVLQHA----HH- 178
                                   .|....||..:|.|.|.|...:  .|:.:...|..    ||
Human   575 SIMKWLLFYQLEGDLENSTEVPPILHSNFPHLVLEKILVSLTMKN--CKAAMNFFQSVPECEHHQ 637

  Fly   179 -----IGYATHGDIFSGSLHQA---LLILKECDMDTKLASLNY-CHNVLRS-------------- 220
                 :.::...::|..:....   |.|::||.::...:|:.: .|..|:.
Human   638 KDKEELSFSEVEELFLQTTFDKMDFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLL 702

  Fly   221 QSASSWITNPDVGHYAQLTLEATAIMWSAVAKWLDMGCMTRQELKRLNI--TTKLLLE------- 276
            .:.||.|||      ::..:..:.::...:..:..||.:..:|..:..:  ..|.|::
Human   703 NNYSSEITN------SETLVRCSRLLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESIT 761

  Fly   277 VLHMRARPAHHLGYL----------------------------------LLNEIL----SLPTAI 303
            :...:......:|.|                                  |:|:|.    ||.:.|
Human   762 LFKNKTNEEFRIGSLRNMMQLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFI 826

  Fly   304 E--LDDGLLETLSSYIQGQLEHSVVPLEQLVHLQQLMLSHWHCHPTHLVPILALMGLKQTEMRSG 366
            :  .|.|.:|::.....|.|    :.:|     .|..::.::.:|...|......|..|:.:  |
Human   827 KKPFDRGEVESMEDDTNGNL----MEVE-----DQSSMNLFNDYPDSSVSDANEPGESQSTI--G 880

  Fly   367 VVQVLTQSLVEILKKEEVLSKDWQKLIAI-----------LRGFKQLEKLILSQSQHKIAEHEGH 420
            .:..|.:   |.|.|:::|..|..|.:.:           .|......||::.
Human   881 AINPLAE---EYLSKQDLLFLDMLKFLCLCVTTAQTNTVSFRAADIRRKLLML------------ 930

  Fly   421 IDSSVL-----AMLPLQCEIIKVADTNWNNLSMQ-----LVELESKCSADRRHIHLEICSLLMQI 475
            ||||.|     ..|.:...::|........|.|:     |..|.:.||..||  ..::|..:  :
Human   931 IDSSTLEPTKSLHLHMYLMLLKELPGEEYPLPMEDVLELLKPLSNVCSLYRR--DQDVCKTI--L 991

  Fly   476 TFIRHFLKT------------QTQHQLLAILQR--HL--KLSYLCAIRLETPSSVHTQMQSFYAQ 524
            ..:.|.:|.            ..|.|.|.::..  ||  :..|:.::|:...:.:.|.::   |.
Human   992 NHVLHVVKNLGQSNMDSENTRDAQGQFLTVIGAFWHLTKERKYIFSVRMALVNCLKTLLE---AD 1053

  Fly   525 QYMR------LFQSEETQEIFCSNLPQLYISGFIKPEQLMKALPTINN--RSGRAQVIRLLLCSQ 581
            .|.:      :.:.....|:|...|...:      .:..|.|..:||.  :..:....|||
Human  1054 PYSKWAILNVMGKDFPVNEVFTQFLADNH------HQVRMLAAESINRLFQDTKGDSSRLL---- 1108

  Fly   582 PGKLSVFKVKDRIELYCPKCRPLPKKLPGIYLGKCKQQLPCPDFSSTNLEMIANDLLFYPDFECI 646
                                :.||.||         ||
Human  1109 --------------------KALPLKL---------QQ--------------------------- 1117

  Fly   647 AQHLDLLCFEPNVILGLLRETEALQKVSVKVIGQLVSAMRVRSPEFLEQLAN---LVLAAIKAML 708
                  ..||.    ..|:..|.::::|          ....:||.|:::.|   ::|..|..:|
Human  1118 ------TAFEN----AYLKAQEGMREMS----------HSAENPETLDEIYNRKSVLLTLIAVVL 1162

  Fly   709 A-KPLTE------------QNVLQQRSMLNVLTAIAHMEDNEIWLFHWFKMTFFFLVHTRSLVAQ 760
            : .|:.|            :|.|:...:..||..::.       .|.:.::..|...|...||.:
Human  1163 SCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSE-------TFGYRRLEDFMASHLDYLVLE 1220

  Fly   761 EAVLAATEMCASQGLQTIHLWNWYKRDALDLTVRLALNVYLLDGVRFTRSLRALTKMLGFTCVQE 825
            ...|..||                               |.|....|.        :|.:|.:::
Human  1221 WLNLQDTE-------------------------------YNLSSFPFI--------LLNYTNIED 1246

  Fly   826 FTCKYHRLLTAMVLPHCIVNPLCKGVLVLIAKQMQKHIGTLFSISFLRIYTHVF----------- 879
            |    :|....:::||.::......| ..||.|:|:...:|.:..|.:|..::.
Human  1247 F----YRSCYKVLIPHLVIRSHFDEV-KSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDS 1306

  Fly   880 -LTEEPELANSCIELVVS--CTQSSLQQLMNADVKQTVAELLIYFNRNPTFVMRSFQSLLQLSIG 941
             :.::.|.|....:::.|  .....:..|..:::.:.|.|||:..:....
Human  1307 GMAQQRETATKVYDMLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPAN--------------- 1356

  Fly   942 SLEELSSQTANAEFANFIAERFLGVITYFESCLSEPSFEKPLKEETLYSLGQIMRFVGSQHVTQF 1006
                 ||.:.:.:..:|..:        .:...:.|.|...:.:.|       ..::.:.|.|:.
Human  1357 -----SSASQSTDLCDFSGD--------LDPAPNPPHFPSHVIKAT-------FAYISNCHKTKL 1401

  Fly  1007 RFKIIAMLSFVHTLQEPRLQRIC---------------LKIWHIF-------------------- 1036
            : .|:.:||......:..|..||               |||:|:|
Human  1402 K-SILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVL 1465

  Fly  1037 -------LHVVNVQELGPS-----------------------------------LGRIVATLQPL 1059
                   :|.:|.:   ||                                   |..||.||.||
Human  1466 RDVIYTLIHYINQR---PSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPL 1527

  Fly  1060 LADNESV-KQVNDLYEFIILRNASMLGTFITDLYFLDRMENVSPSIQKCIRRHTAHLDLK----- 1118
            :.:...| |||.||.:::::.|......:|| :..||...:           |....||:
Human  1528 VYEQVEVQKQVLDLLKYLVIDNKDNENLYIT-IKLLDPFPD-----------HVVFKDLRITQQK 1580

  Fly  1119 --------GLAEEENQSPPLVDQLRFLQKHITDECLQVRVYALQHLGDLFGRRRPKLNSTILSEL 1175
                    .|.||.|         .||...:.|.....|:..|:.|     ||:.:|:...:.::
Human  1581 IKYSRGPFSLLEEIN---------HFLSVSVYDALPLTRLEGLKDL-----RRQLELHKDQMVDI 1631

  Fly  1176 -------PLEP-MLEQIVNVL----MAGCQHDDSQLQMASAKCLGELGAIDASYLPSNYNFASPQ 1228
                   |.:. |::.:||:|    ||.....:.::..|...||||:|.||.|.:...::..:..
Human  1632 MRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASY 1696

  Fly  1229 HLPLNILSD---DFAVLALTSLCRGYQFQQNTKHVDSFSLAIQETLAICGISPKEQKKV------ 1284
            ...|.:..|   .:..:.||.|       .||...|  .:.::.....|      .|.:
Human  1697 TKALKLFEDKELQWTFIMLTYL-------NNTLVED--CVKVRSAAVTC------LKNILATKTG 1746

  Fly  1285 -QLWQSLPARMRQLMEPMLHSCYTCVHRPS--TCLQQPLFGSHYSHNYYEE------WAFL---- 1336
             ..|:.    .:...:|||  .|....|.|  ..|:.|.|.   ..|.:|.      |..|
Human  1747 HSFWEI----YKMTTDPML--AYLQPFRTSRKKFLEVPRFD---KENPFEGLDDINLWIPLSENH 1802

  Fly  1337 --WASRL-IDYLPSSGRR-HLLSSYKPCIKRDSNMLSTFYPYILLHALLECTTEQ-RN----HIQ 1392
              |...| ..:|.|.|.: .:|...||..:..::...|..||::...||:.|.|. ||    |:|
Human  1803 DIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQ 1867

  Fly  1393 EEFMAVLQANEESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPLASTLVSDRKEDSSRVPRLA 1457
            ..|.:.|:...::|.|.. ...|.:..|:.|:                 ...|:|...:.:
Human  1868 GFFTSCLRHFSQTSRSTT-PANLDSESEHFFR-----------------CCLDKKSQRTML---- 1910

  Fly  1458 GKLCAELLDFLQRWLREWQRIHGRSTGGKPPETIDSNYRKIHEFLNLIPKLLVSRASYNCGEYAR 1522
                 .::|:::|     |:.....|.......:|.||            |.|::.:.:|..:..
Human  1911 -----AVVDYMRR-----QKRPSSGTIFNDAFWLDLNY------------LEVAKVAQSCAAHFT 1953

  Fly  1523 ALSYLESYLEEG--EDKSQRLL-----EQFT-------------------FLVEVYGSLRDPDSV 1561
            ||.|.|.|.::.  :|:.:|.|     .|.|                   .|:|:|.|:.:|||:
Human  1954 ALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSL 2018

  Fly  1562 EGA---------VQVRSYDMS-------VTQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHVR 1610
            .|.         .::|:|:..       ||.|:      |......|....::.:...:...|:
Human  2019 YGCGGGKMLQPITRLRTYEHEAMWGKALVTYDL------ETAIPSSTRQAGIIQALQNLGLCHI- 2076

  Fly  1611 AMIDAYLRD--------TPKTAQLIADGLWQRLSDRYSDQCFAECKS-------ELLWRLGSYDE 1660
              :..||:.        .|:..:|.....|:.:.   .|.|.:..|.       |.|     |:.
Human  2077 --LSVYLKGLDYENKDWCPELEELHYQAAWRNMQ---WDHCTSVSKEVEGTSYHESL-----YNA 2131

  Fly  1661 MEELQSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLEELRSCSAVQQHSYANAYDAVLKL 1725
            ::.|:..                    ||.:..:.::.:.::|:.........|..:.|..:.:|
Human  2132 LQSLRDR--------------------EFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRL 2176

  Fly  1726 HLVHELHCSQELVEKLEQDRDEDNQEKLMKNYFDDWQYRLQIVQ-PQVRIQESIYSFRRNILAEL 1789
            ..:.||....||..:....|.       :...:..||...|::: .....||.|.:.|..||..|
Human  2177 QAIGELESIGELFSRSVTHRQ-------LSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEIL 2234

  Fly  1790 QRRLTDRNH-------LLPHL--KTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIE 1845
            ..:..|.:.       |..||  .:.|||.:.|:....|...|:::........:|:|     :|
Human  2235 MEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQ-----LE 2294

  Fly  1846 RAKLLWQKGDQVMAMNYLEEQLSIMRSGCQGNVKQL--------------AAE---QRHLFFRGK 1893
            .|::.|.|.:|.:|::.|::.:..:.:.|..|...|              .||   :........
Human  2295 EAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQT 2359

  Fly  1894 YLQAV------YSAESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLE--------------- 1937
            ||:..      |..||.....:..:|.|   :::.|.|::.:.::..:::
Human  2360 YLEKAVEVAGNYDGESSDELRNGKMKAF---LSLARFSDTQYQRIENYMKSSEFENKQALLKRAK 2421

  Fly  1938 ---------KILEARQGGKSEPTGEQDDM------------LINVMVNYAKSLRYGSEH---VYQ 1978
                     ||...|...|.:...|.|::            |...:.||...|..|.||   |:
Human  2422 EEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVF- 2485

  Fly  1979 SMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRL---------CHPV 2034
               ||.||||:.:       .|.::|.::......:||..|..:..|:.:|:         .|
Human  2486 ---RLCSLWLENS-------GVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFH-- 2538

  Fly  2035 NDVFTVLRNVIIKLVEAYPQQSLWMLL-------PHF--KSAKAHRIKRCKLV------LTDSRL 2084
                .||.|:|.::...:|..:|:::|       ..|  |...|.|.:..|.|      |.:.|.
Human  2539 ----EVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRT 2599

  Fly  2085 Q---------NSTFQKLLQDFNSLTERLMDLTNKEVTLDRTYKLS---DLDTRLSKLCKQPEFSQ 2137
            :         .|...::::...:|.:..:.|.|.:.|..:|.:..   ..|..::||..
Human  2600 EAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKN------ 2658

  Fly  2138 ILLPFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTI 2202
                .|..:.||:.:..|.....|:               .:.|..|:....:......||.:..
Human  2659 ----LEDVVVPTMEIKVDHTGEYGN---------------LVTIQSFKAEFRLAGGVNLPKIIDC 2704

  Fly  2203 RCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEW 2267
            ..||||:...|||.:||||:||.:.:...:....|.::...|:|:|.|.||.|:|.::..|::||
Human  2705 VGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW 2769

  Fly  2268 LPNLA---------------SYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLV 2317
            .....               .||....:.:..::.:|..::         :|.|.|.||| ..:.
Human  2770 CTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQK---------KSFEEKYEVF-MDVC 2824

  Fly  2318 PAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVD 2382
            ....|||:.:..::|..|..|:|.|..|.|:||..|:|||||||||||.:|||..|.:.:.||:|
Human  2825 QNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHID 2889

  Fly  2383 FNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVY 2447
            ....|.||::||.||.||||||.:::..||..||||.||:|||.|:.:::...:||::|:...:|
Human  2890 LGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLY 2954

  Fly  2448 D------------VGAQTRKGAAT---------------------AKITKDVQRIADRLQGHVKR 2479
            |            :..|.|....|                     ....|..:|:..|||..:|.
Human  2955 DPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKG 3019

  Fly  2480 QQANSIPLSTEGQVNFLINEATKVDNLASMYIGWGAFL 2517
            .:..:: ||..||||.||.:|....||:.::.||.|::
Human  3020 VEEGTV-LSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825	27/181 (15%)
		FAT	1653..1985	CDD:280429	72/403 (18%)
		PIKKc_ATR	2181..2448	CDD:270625	97/281 (35%)
		FATC	2486..2517	CDD:280430	14/30 (47%)
ATM	NP_000042.3	TAN	8..165	CDD:402988
		Interaction with ABL1. /evidence=ECO:0000269|PubMed:9168117	1373..1382		1/8 (13%)
		FAT	2097..2489	CDD:396714	79/438 (18%)
		PIKKc_ATM	2683..2962	CDD:270715	99/288 (34%)
		FATC	3026..3055	CDD:396715	13/28 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10493at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920