DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and fwd

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster

Alignment Length:	1098	Identity:	196/1098 - (17%)
Similarity:	364/1098 - (33%)	Gaps:	321/1098 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1581 NRLVERQQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADGLWQRLSDRYSDQCFA 1645
            |.:....|.:|.::|:..::..:.||||...:   .|..:|.....:...|.:..:|       .
  Fly   725 NAIFRTAQSIIENHEKKNAAKQKEQPDHSGTV---SLVGSPNGGSSVPQDLVKSPTD-------I 779

  Fly  1646 ECKSELLWRLGSYDEM--------------------EELQSN-----WPAQCSQGCLKLR-RPLT 1684
            ..|.|....|.|...:                    |.|.:|     .|.......||:: |.|.
  Fly   780 SKKKEFFSLLTSSSSIKAAAAAAANSAASTPPATPTEALAANSNSKLQPLSDPSADLKVKERTLN 844

  Fly  1685 TRIEFDSLLDGMRESVLEELRSCSAVQQ-HSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDED 1748
            .|:..||      |.....|..||::.. |........|:|..:..:...|..|      .:.|.
  Fly   845 LRLPGDS------EGSEGALTKCSSINSIHKLKLPVPGVVKYFISEKAPVSDVL------QKPEK 897

  Fly  1749 NQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQRRL-----TDRNHLLPHL----- 1803
            .|..|:: :|:...:.:...     :....||....:|:.:..::     .:.:..:|.|
  Fly   898 GQSGLLR-FFESPVFNIHFA-----VHYLFYSKEPGVLSFIGNKIFSFPDQEVDLYIPQLVVMYI 956

  Fly  1804 -KTELARIWLNSAQIN-RNAGQLQRAQLYILKAAEYQPSGL-----FIERAKLLWQKGDQVMAMN 1861
             ..|||.:......|. |.:.......|::|:|..||...|     ...::||...| :......
  Fly   957 QMDELAEVLDPYLTIRCRKSVDFSLKCLWLLEAYNYQVDSLGNSHNSSRKSKLALMK-EIFSKRE 1020

  Fly  1862 YLEEQLSIMRSGCQG-------NVKQLAAEQRH----------LFFRG---------KYLQAVYS 1900
            :.:.|..:..:|..|       :|..||.:..|          ..||.         .|.|..|:
  Fly  1021 HKQTQNDLKSAGTGGLHVGEPRSVVALAKKTHHRSQSDATVLLADFRSPHTLSISHRMYQQPPYT 1085

  Fly  1901 AESM-----HLCADAVLKYFQEAIAVHRQSESC------HVQMAQFL-EKILEARQGGKSEPTGE 1953
            .:::     .||       ..:..:.|.....|      ..|:...| ::.|.:....|:.|..|
  Fly  1086 TQTLPTTPAKLC-------LGDLTSGHAFDNGCTCFETVRGQVNGLLGQRTLCSCGAPKTSPQKE 1143

  Fly  1954 QDDMLINVMVNYAKSLRYGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAV 2018
            ....|:||..|                   ::.|....|.::    ..:|:..|.|  ..||..|
  Fly  1144 FMKALMNVGKN-------------------LTSWPSKAEKTS----ALRMSLNLIN--KNLPARV 1183

  Fly  2019 FYTVYSQMLSRLCHPVNDVFTVLRN----------VIIKLVEAYPQQSLWMLLP---HFKSAK-- 2068
            :..:||.:...:.....:...||.:          .::::.:.|....:..::|   |.||.:
  Fly  1184 WLPLYSDIPHHVVRITEEKTAVLNSKDKTPYIIYVEVVEIPDIYTSPLIPKMMPSLRHTKSEEHL 1248

  Fly  2069 ------AHRIKRCKLVLTDSRLQNST---------------------------------FQK--- 2091
                  :|:...|....:.|..|..|                                 ||:
  Fly  1249 DGSCLNSHQHLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQEDDV 1313

  Fly  2092 LLQDFNSLTERLMDLTNKEVTLDRTYKLSDLDTRLSKLCKQPEFSQILLPF--EKYMQPTLPLN- 2153
            ..|:.:.:|.:.:::.          |:|:.||          .|||.|..  .:...|.:..|
  Fly  1314 WSQEEDEITAQYLNMR----------KVSERDT----------ISQISLDSCDSRDQGPPVVFNI 1358

  Fly  2154 -----------SDSNSSEGSHLPANQSTV----NWFPYQQIYISGFQESVLILRSAAKPKKLTIR 2203
                       |..|:...|:.|.:.|..    .|           .|...::|.::....|
  Fly  1359 GDVRLRHCSNLSCENTKSFSNDPEDPSAAALKEPW-----------HEKEKLIRESSPYGHL--- 1409

  Fly  2204 CSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWL 2268
             |:.:....:||..||||::....:...:.|....::    |..|.:|.|.::..:.:.||:|.:
  Fly  1410 -SNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEE----QVDLWVRPYKIVCLSNDSGLIEPI 1469

  Fly  2269 PNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFA 2333
            .|..|...|..|         |.:.|                              :|:....:.
  Fly  1470 LNTVSLHQIKKN---------SNKSL------------------------------KEYFIDEYG 1495

  Fly  2334 TP--HSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLF-----NQGE 2391
            :|  .|:..|:..::::.|...::.|:|.:.|||..|||| ..:|..:|:||..:.     |.|.
  Fly  1496 SPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILF-HSDGHIIHIDFGFILSISPKNLGF 1559

  Fly  2392 LLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYDVGAQTRKG 2456
                 |..||:||...:..||....| .:|:..::.|..:....|.:..|:. ||..:.:.....
  Fly  1560 -----EQSPFKLTPEFVEVMGGTSSE-HWREFNKLLLVGMMSARKHMDRIIN-FVEIMRSNAHLP 1617

  Fly  2457 AATAKITKDVQRIADRLQGHVKRQQANSIPLSTEGQVNFLINEATKVDNLAS-MYIGW 2513
            ......:..||.:..|...::..|:       .|.:|..|:.::.|  :|:: :|.|:
  Fly  1618 CFKNGCSGTVQNLRKRFHMNLTEQE-------MERKVEQLVQDSLK--SLSTKLYDGY 1666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	71/413 (17%)
		PIKKc_ATR	2181..2448	CDD:270625	58/273 (21%)
		FATC	2486..2517	CDD:280430	7/29 (24%)
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	71/357 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900