DRSC/TRiP Functional Genomics Resources

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Protein Alignment mei-41 and Pi3K92E

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:NP_001262770.1 Gene:Pi3K92E / 42446 FlyBaseID:FBgn0015279 Length:1088 Species:Drosophila melanogaster


Alignment Length:1187 Identity:222/1187 - (18%)
Similarity:411/1187 - (34%) Gaps:352/1187 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1474 EWQRIHGRSTGGKPPETIDSNYR--KIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEEGED 1536
            |:| ::|.||....|.| |...|  ::..:..::          :.||.....|:...|      
  Fly    92 EYQ-VYGISTFNIEPYT-DETKRLSEVQPYFGIL----------SLGERTDTTSFSSDY------ 138

  Fly  1537 KSQRLLEQFTFLVE-VYGSLRDPDSVEGAVQVRSYDMSVTQDILVNRLVER-----QQDMITSYE 1595
                   :.|.:|. :.|:..|.:...|:.::..:.:.:|| ...|..:||     ||.::..:.
  Fly   139 -------ELTKMVNGMIGTTFDHNRTHGSPEIDDFRLYMTQ-TCDNIELERSAYTWQQRLLYEHP 195

  Fly  1596 QLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIA----DGLWQRLSDRYSDQCFAECKSELLWRLG 1656
            ..|:::.:| |:.:|.      |...:|..::.    |.....||....|..|:..:|.|     
  Fly   196 LRLANSTKM-PELIRE------RHPTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTL----- 248

  Fly  1657 SYDEMEELQSNWPAQCSQGCLKLRRPLTTRIEFDSLLDG---MRESVLEELRSCSAVQQHSYANA 1718
              .:|...|.....:.|...||    ::.|.|:  ||..   ::...::|:.|.|||......:.
  Fly   249 --QKMNRSQMKMNDRTSDYILK----VSGRDEY--LLGDYPLIQFLYIQEMLSDSAVPNVVLQSV 305

  Fly  1719 YDAVLKLHLVHELHCSQELVEK--LEQDRDEDNQEKL-----MKNYFDDWQYRLQIVQP------ 1770
            |.  |:.::.|  |..|.:|.|  |.:.|.....:.:     |.|||   |..|..:..      
  Fly   306 YR--LESYINH--HNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNYF---QLTLHSISNVNFDKT 363

  Fly  1771 ---QVRIQESIYSFRRNILAELQRRLTDR----------NHLLPHLKTELARIWLNSAQINRNAG 1822
               :|.:...:|...:.:.|:   |.||.          |.|:.....::           ||..
  Fly   364 RALKVGVHVCLYHGDKKLCAQ---RSTDSPNGNFDTFLFNDLVMDFDIQM-----------RNLP 414

  Fly  1823 QLQRAQLYILKAAEYQPSGLFIERAK------------LLWQKGDQVMAMNYLEEQLSIMRSGCQ 1875
            ::.|..:.|.:..:       :.|:|            :.:.|.........:.:...|:|:|  
  Fly   415 RMTRLCIVIFEVTK-------MSRSKKSSNNKDIALKDVPYNKNPLAWVNTTIFDHKDILRTG-- 470

  Fly  1876 GNVKQLAAEQRHLFFRGKYLQAVYSAESMH------------LCADAVLKYFQEAI-AVHRQSES 1927
                      ||..:...|...:.|.|..|            .||...|.:..... .|...||.
  Fly   471 ----------RHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEE 525

  Fly  1928 CHVQMAQFLEKI--LEARQGGKSEPTGEQDDMLINVMVNYAKSLRYGSEHVYQSMPR-LISLWLD 1989
            ..:|.|...|::  |:.:..|..:|..|    |..:|.||.     |.:.:|:.:.: ..::|  
  Fly   526 VVLQYAADREQVNRLQRQLAGPEKPIKE----LKELMANYT-----GLDKIYEMVDQDRNAIW-- 579

  Fly  1990 TTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCH--------PVNDVFTVLRNVII 2046
                       ::.||:|..    ||         :.||.|.|        .|.|::.:|:...:
  Fly   580 -----------ERRNDILRE----LP---------EELSILLHCVYWKERDDVADMWYLLKQWPL 620

  Fly  2047 KLVEAYPQQSLWMLLPHFKSAKAHRIK-RCKLVLTDSRLQNSTFQKLLQDFNS-----------L 2099
            ..:|    :||.:|...:......|.. ||...|.|..|.....| |:|....           |
  Fly   621 ISIE----RSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQ-LVQAIKHESYLESDLVVFL 680

  Fly  2100 TERLMDLTNKEV------TLDRTYKLSDLDTRLSKL-------CKQ---PEFSQILLPFEKYMQP 2148
            .||.  |.|:.:      .|....:...:.||...|       ||.   |...|:.: .||..|.
  Fly   681 LERA--LRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHV-LEKLKQG 742

  Fly  2149 TLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCS-------- 2205
            :|.....|.....:.|             |.::.. |.:..:.::...|...:.|||        
  Fly   743 SLIAKKGSKEKVKTML-------------QDFLRD-QRNSAVFQNIQNPLNPSFRCSGVTPDRCK 793

  Fly  2206 --DGK----------------DYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRT 2252
              |.|                |..::.|..||||:|...::...::.:...:|  ....|::|  
  Fly   794 VMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRD--GMDFRMNI-- 854

  Fly  2253 YAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLV 2317
            |..:...:..|::|                       ..|..:::|     :|::::.:|: ...
  Fly   855 YNCISMEKSLGMIE-----------------------VVRHAETIA-----NIQKEKGMFS-ATS 890

  Fly  2318 PAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVD 2382
            |........||::.........:|.|.:..:.|...:..|:||:.|||.:||: .:.||...|:|
  Fly   891 PFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIM-VKRNGQLFHID 954

  Fly  2383 FNCLFNQGELLPY--------PEVVPFRLTHNMIVAMGPLGVEG----------SFRKCCEITLR 2429
            |      |.:|.:        .|.|||.|||:.:..:.    :|          .|::.||....
  Fly   955 F------GHILGHFKEKLGVRRERVPFVLTHDFVYVIN----KGFNDRESKEFCHFQELCERAFL 1009

  Fly  2430 LLKQESKTLMSILRPFVYDVGAQTRKGAATAKITKDVQRIADRL---------QGHVKRQQANSI 2485
            :|::....::|:....:       ..|.......||:..:.:.|         :.|.:.:.:.::
  Fly  1010 VLRKHGCLILSLFSMMI-------STGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEAL 1067

  Fly  2486 PLSTEGQVNFLINEATK 2502
            ..|.:..:|:..:..:|
  Fly  1068 ANSWKTSLNWASHNFSK 1084

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825
FAT 1653..1985 CDD:280429 72/388 (19%)
PIKKc_ATR 2181..2448 CDD:270625 58/310 (19%)
FATC 2486..2517 CDD:280430 3/17 (18%)
Pi3K92ENP_001262770.1 PI3K_p85B 56..132 CDD:295322 11/51 (22%)
PI3K_rbd 200..307 CDD:197540 26/126 (21%)
C2_PI3K_class_I_beta_delta 339..517 CDD:176075 33/213 (15%)
PI3Ka_I 552..723 CDD:238444 42/212 (20%)
PI3Kc_I 727..1084 CDD:270709 74/422 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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