Protein Alignment mei-41 and tefu

DIOPT Version :9

• Sequence 1: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Sequence 2: NP_001036712.1
• Gene: tefu / 41839
• FlyBaseID: FBgn0045035
• Length: 2767
• Species: Drosophila melanogaster
• Alignment Length: 2863
• Identity: 587/2863 - (20%)
• Similarity: 1042/2863 - (36%)
• Gaps: 846/2863 - (29%)

  Fly     7 DMWKLLYNHVNR------NVSNFSGVYSVIEDI--------------LCQEPSLISCSLVRE--- 48
            |:|..::..:.:      ||:|:....:.:.:|              ||     ::..|.:|
  Fly   399 DVWLAIFTEILQLSSVILNVANYQMALTTVAEIMQMYGNAKNLRNLRLC-----LAHLLTKEQEL 458

  Fly    49 LHNK-FQDTFL--LW--LLNKLAKCLSESPDSSECINLQRKILSSCCSNHPKLFERLVLAYVEAI 108
            ||:| .::.||  ||  :.|:|   :||:..:||.|. :::::......|.||.::|
  Fly   459 LHSKSIREDFLGELWSQMANQL---ISETTTNSEEIK-EKQLVLQMLIRHNKLNQKL-------- 511

  Fly   109 EETHLQLSSLDLGQLSNERKPAITVR-IFRCDVECLQ-----EFDPHCA---------------- 151
              :...|:::...::....:...|:| ||....:|.|     :.:|..|
  Fly   512 --SSTLLNNIISNEMLKRNECLATIREIFIHADKCGQDKASADLEPIIAWAYGSADRFIAAQMIH 574

  Fly   152 -IEDIKVPLEQADMYAKSLLEVL--------QHAHHIGYATHGDIFSGSLHQALLILKECDMDTK 207
             |:.|...| |||.:|.|::..|        ..:.||..:|..::.:...::.|:...: |..|.
  Fly   575 NIDSIDAQL-QADTFAISIINFLDVQQLRQISQSEHIVPSTERNLLAYKYNEQLICFDK-DYATP 637

  Fly   208 LASLNYCHNVLRSQSASSWI-TNPDVGHYAQLTLEATAIMWSAVAKWLDMGCMTRQELKRLNITT 271
            ..|:.:    ::|::.:..| :|.|                          |:.|
  Fly   638 FESITH----IQSETKNCLIQSNYD--------------------------CLMR---------- 662

  Fly   272 KLLLEVLHMRARPAHHLGYLLLNEILSLPTAIELDDGLLETLSSYIQGQLEHSVVPLEQLVHLQQ 336
                           .|.:.:..|  :.|.||      ::.|:|.::     .:..:|:|:|.:.
  Fly   663 ---------------GLNFEIAKE--NKPAAI------IKNLNSLLK-----LICTMERLLHYKV 699

  Fly   337 LML-SHWHCHPTHLVPILALMGLK----QTEMRSGVVQVLTQS-LVEILKKEEVLSKDWQKLIAI 395
            ... ::..|      |::..:||.    :.::::...::|.:| |.|||:.|          |.:
  Fly   700 FDADTYTGC------PLIKRIGLYLSHIEFQLKANGAEILDKSDLPEILRLE----------IYV 748

  Fly   396 LRGFKQLEKLILSQSQHKIAEHEGHIDSSVLAMLPLQCEIIKVADTNWNNLSMQLVELESKCSAD 460
            |..|:  ..|:|..          :::...:.||   .|.:..|      |.:..::.|....||
  Fly   749 LDVFR--TNLVLLD----------YLERQPIEML---VEFVGAA------LKLHSMQRERSVDAD 792

  Fly   461 RRHIHLEICSLLMQITFIRHFLKTQTQHQLLAILQRH-------LKLSYLCAIRLETPSS-VHTQ 517
            ...|.....::|..:...........:|.:...::.|       .|:...|....|..|| :.::
  Fly   793 HGTITRLCLNILAGLCAYNSHRDEAFEHIVKVTMRWHPQDVLIVTKMLCSCQTISEASSSWLVSK 857

  Fly   518 MQSFYAQQYMRLFQSEETQEIFCSNLPQLYISGFIKPEQLMKALPTINNRSGRAQVIRLLLCSQP 582
            :::.:.|.:    |..|..:....::|.::.....|...|...|..:|:      ::|:.:....
  Fly   858 LKTLFQQHH----QDAELMDKVVQHMPTIFYFVRHKENHLDDMLMALNS------LLRIAIKKSY 912

  Fly   583 GKLSVFKVKDRIELYCPKCRPLPKKLPGIYLGK-----CKQQ---LPCPDFSSTNLEMIANDLLF 639
            ......|:...:.|...:|       |.|||.:     ||..   :..|........:....:|.
  Fly   913 TSNLTAKIVRCVGLIAQRC-------PDIYLLENFAVICKSTAKFITMPTLEVRFATLFTFTILL 970

  Fly   640 YPDFECIAQ--------HLDLLCFEPNVILGLLRET----EALQKVSVKVIGQLVSAMRVRSPEF 692
              :..|:..        |.| .|.|....:...:.|    :|:|..:..:: |::.|:.:|| .|
  Fly   971 --ESNCVTSDAIGHSRTHWD-FCQELYESIEFKKLTYNNEDAIQNSNALIV-QMLIAIFLRS-SF 1030

  Fly   693 LEQLANLVLAAIKAML----AKPLTEQNVLQQRSMLNVLTAIAHMED--------NEIWLFHW-- 743
            .:::      |:|.:|    .:.|||:..:..:||     :..|.:.        ..|.|.||
  Fly  1031 HQEI------ALKELLHHCALRRLTEREFISLQSM-----SSCHRQTVRDLIRPFAAILLHHWSS 1084

  Fly   744 -----FKMTFFFLVHTRS---------LVAQEAVLAATEMCASQGLQTIHLWNWYKRDALDLTVR 794
                 .|..:|....|:|         ::|...:...||.              .:|.:..::..
  Fly  1085 KRWPISKFPYFLCYSTKSEFRKTHASEIMAYTFLYGKTED--------------IERCSKSISEE 1135

  Fly   795 LALNV---YLL---------DGVRFTRSLRALTKMLGFTCVQEFTCKYHRLLTAMVLPHCIVNPL 847
            |||.:   :||         :|..|...|:.|::.|.::.:.         .|.:.|.   ::.|
  Fly  1136 LALPILASFLLIKNSSCSESEGQNFKEHLQLLSENLSYSQLN---------ATDVDLD---LDIL 1188

  Fly   848 CKGVLVL-IAKQMQKHIGTL---------FSISFLRIYTHVFLTEEPELANSCIELVVSCTQSSL 902
            |..:.:| ..::|.:..|:|         :|:|...::..:....:||:..|        ..|.:
  Fly  1189 CYVISMLHDPQEMMRLFGSLAICNRTASWYSLSGESLFKCLNFHIDPEMRPS--------MDSRI 1245

  Fly   903 QQLMNADVKQTVAELLIYFNRNPTFVMRSFQSLLQLSIGSLEELSSQTANAEFANFIAERFLGVI 967
            |.:.....|.: ..|:..|.|..|                         |...|:|.::......
  Fly  1246 QSMTTLQTKHS-RVLVDIFGRLKT-------------------------NCYSASFSSQALHDFF 1284

  Fly   968 TYFESCLSEPSFEKPLKEETLYSLGQIMRFVGSQHVTQFRFKIIAMLSFV-----HTLQEPRLQR 1027
            .|.|  :::..::...|.||:              |||..|.:..:..||     || :..|:|.
  Fly  1285 LYCE--VADAVYDAARKNETI--------------VTQCSFFVRDIWFFVVRLLIHT-KFIRVQM 1332

  Fly  1028 ICLKIWHIFL--HVVNVQELGPSLGRIVATLQ--PLLADNESVKQVNDLYEFIILRNAS---MLG 1085
            ..|....:.|  |...:.:.....|.|...|.  .|..:.:.|::........||.:..   .|.
  Fly  1333 AALTFLELLLNKHNFRLDDYQNHFGDIAKLLSNFQLCCEAKEVREKTMSIVMYILESKKGHINLN 1397

  Fly  1086 TFI---TDLYFLDRMENVSPSIQKCIRRHTAHLDLKGLAEEENQSPPLVDQ------LR-FLQKH 1140
            :|:   ||..|                       ||.|.|:...|.|.:|:      || ||...
  Fly  1398 SFLEETTDCEF-----------------------LKPLREDCKSSQPNIDRADVANYLRSFLLSP 1439

  Fly  1141 ITDECLQVRVYALQHLGDLFGRRRPKLNSTILSELPLEPMLEQIVNVL--MAGCQHDDSQLQMAS 1203
            ..:....:|.|..:|        :.|:...       |.:|..::|.|  |....|:.: ..:.|
  Fly  1440 TPERLRDLRTYIAEH--------KDKVQEH-------EKLLFGVINKLIQMTRDAHNKT-TSIDS 1488

  Fly  1204 AKCLGELGAIDASYLPSNYNFASPQHLPLNILSDDFAVLALTSLCRGYQFQQNTKHVDSFSLAIQ 1268
            .|||.::|.:..|.:  :|.|.:           ||....          :.|.:.:::| |.:
  Fly  1489 LKCLAQIGPLKISTV--SYYFQT-----------DFEAFE----------KSNGEPMEAF-LGV- 1528

  Fly  1269 ETLAICGISPKEQKKVQLWQSLPARMRQLMEPMLHSCYTCVHRPSTCLQQPLFGSHYSHNYYEEW 1333
                :|             .||...:.| .:|..|.....|
  Fly  1529 ----VC-------------HSLDTSLFQ-FDPKTHEGLVSV------------------------ 1551

  Fly  1334 AFLWASRLIDYLPSSGRRHLLSSYKPC-IKRDSNMLSTFYPYILLHALLECTTEQRNHIQEEFMA 1397
                |.::::..|.|   :::..||.. |..|.:..|||     ||     :.:|...|  ::::
  Fly  1552 ----AIQVVNSKPGS---NIMERYKNLRIFADKSTASTF-----LH-----SNKQIRRI--DWLS 1597

  Fly  1398 VLQANEESSSSVRGRQELGAIKENAFKQFESRKYA----AGIKPLASTLVSDRK----------- 1447
            :|:|.:..|            .|.....|.|:.:.    .|...||:|..:..|
  Fly  1598 ILKATKSLS------------YEPWMCAFVSKVFQMCGWLGFDKLAATSFAFAKTCLLPFIKLLL 1650

  Fly  1448 EDS-SRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGGKP-PETIDSNYRKIHEFLNL------ 1504
            |:| ..|..|     :::||:.         ..|.::...| .:.|..|.|.|.:||::
  Fly  1651 ENSLEHVESL-----SQMLDYF---------FEGFTSSTAPNSQEIFRNKRAIKKFLHICEYIRI 1701

  Fly  1505 -----IPKLL--VSRASYNCGEYARALSYLESYLEEGEDKSQR-LLEQFTF---LVEVYGSLRDP 1558
                 ||..|  |..||.:|..|..::.|||.:......||:. .|:...|   ..:.|.|:...
  Fly  1702 FNNWTIPINLSNVVMASNHCQAYFLSIMYLELWACSESPKSKADFLDNECFQDGAKKAYESIGCL 1766

  Fly  1559 DSVEGAVQ-VRSYDMSVTQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHV-RAMIDAYLRDTP 1621
            |::.|.|. :||            ||     |.:.....|  ||..::.||: ||
  Fly  1767 DAIPGFVNPMRS------------RL-----DFLGHGSNL--STILLESDHLDRA---------- 1802

  Fly  1622 KTAQLIAD-----GLWQRLSDRYSDQCFAECKS--------ELLWRLGSYDEMEELQSNWPAQCS 1673
             :.||..|     |||.          ||:.:.        |:.||||.:|.:.:.:........
  Fly  1803 -SGQLCIDIMKGNGLWS----------FAKLQQHQNIEPDYEIFWRLGQWDSLTDPKHQQNQTVV 1856

  Fly  1674 QGCLKLRRPLTTRIEFDSLLD-GMRESVLEELRSCSAVQQHSYANAYDAVLKLHLVHELHCSQEL 1737
            :..|.|.:.. .|..|.:|.. |.|    ||..|.||::|     ||..|..:.:...:.|.|.:
  Fly  1857 RTSLDLEQEF-KRHHFVALRSIGQR----EEENSLSAIEQ-----AYSCVRDILMEISVECLQSV 1911

  Fly  1738 VE------KLEQ-----------DRDEDNQEKLMKNYFDDWQYRLQ-----------IVQPQVR- 1773
            .:      .|:|           ..|..:..|:    |..||..|:           ::..|:.
  Fly  1912 YKYLTWLCSLQQAEDFCQIQFGTQLDPASTTKI----FRKWQTELELKYGNFSCKEYVIAHQIAL 1972

  Fly  1774 ----------------------------IQESIYSFRRNILAELQRRLTDRNHLLPHLKTEL-AR 1809
                                        |:|...:.:.|:.|:....|.:    ||:::..: ..
  Fly  1973 LKLAGTRASRRMSEFYQKDPISTYLMKGIEECKSAGKLNLAAKYTATLRE----LPNIRESIKIS 2033

  Fly  1810 IWLNSAQINRNAGQLQRAQL---YILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMR 1871
            :.|..|:||...|..|.|:.   |:....|:.   ..::|...|..:|:.::..|  .|.||.::
  Fly  2034 VLLEDAEINLKMGNQQIAKAILDYVTNNNEFV---YCVQRVPALRMQGEFLLDCN--AETLSWVQ 2093

  Fly  1872 SGCQGNV----------KQLAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYF-QEAIAVHRQS 1925
            |....|.          :|..:|:....|....|.| |:::........:.||. :|...:|
  Fly  2094 SHKFNNSLKLIDDFVQHRQTLSEKYRDIFDWHQLDA-YASKQRTAAYATIAKYADREYQQLH--- 2154

  Fly  1926 ESCHVQMAQFLEKILEA-RQGGKSEPTGE-QDDMLINV--------------------------- 1961
            :..|.|..|.|:.|:|. ||..:.....| ||..:|:|
  Fly  2155 DYRHSQEYQTLKDIIEQNRQTAEKVTQRENQDRRVISVQMKRYASLDEQQLNQIEEKLTEYLRLA 2219

  Fly  1962 MVNYAKSLRYGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQM 2026
            :.||....|..|.....::.|:||||.....|....|.:|  :::||     :|:..|....:|:
  Fly  2220 LTNYMAYCRLDSGFSSAAIYRIISLWFTNATSKQCQECIK--DEILT-----VPSYKFICAANQL 2277

  Fly  2027 LSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLP----HF--KSAKAHRIKRCKLVLTDSRLQ 2085
            .:||......:...|.:::::..:.:|..:.:.|.|    |.  :::...|....:.::.....:
  Fly  2278 TARLNSKNTSLLKGLTDLLVQCGKDHPYHTFYQLYPLVFAHLDGENSNTERSGIARKIIAMICEK 2342

  Fly  2086 NSTFQKLLQDFNSLTERLMDLTNKEVTLD-RTYKLSDLDTRLSKLCKQPEFSQILLPFEKYMQPT 2149
            |.|..:..:...||...|:...|:..|.| |....|..:.:..|:.:....:.:..|..:.  |.
  Fly  2343 NGTAGECSKQLESLLPALITFANEGKTNDNRPVSDSVRNKQFDKVRRWRNLNAVHCPTLEL--PV 2405

  Fly  2150 LPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLV 2214
            :|      |.|.|.:    |.|.| ..:.....|..          .|.|:...|||||....||
  Fly  2406 MP------SKEYSII----SVVKW-TNETTQCGGLN----------APVKIMCVCSDGKIRAQLV 2449

  Fly  2215 KPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNL-------- 2271
            |.|||||:||.:.:..|:|...|:||:...:|:|.:|||.|.|.:...|::||..|.
  Fly  2450 KGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLV 2514

  Fly  2272 --------ASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWL 2328
                    |.||....|....|:|  |:..|:|   |     :..|....|::.....|||..:|
  Fly  2515 VEGKGGAHARYRPNDWNNNKCRKL--SSDHLKS---P-----KETRYAIYKKICENIKPVFHYFL 2569

  Fly  2329 RQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELL 2393
            .::|..|..|:|.|..|..:||..|||||:|||||||.:|||..:...:.:|:||...|.||::.
  Fly  2570 LEKFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQ 2634

  Fly  2394 PYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYDV----GAQTR 2454
            ..||.||||||.:.:..||..|.:|.|.|.||.|:.:|::......:||...:||.    |...:
  Fly  2635 TTPETVPFRLTRDFVAPMGICGTKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGVLKK 2699

  Fly  2455 KGAATAKITKDVQRIADR----LQGHVKRQQANSI-PLSTEGQVNFLINEATKVDNLASMYIGWG 2514
            |.:......:.|..:|.|    :|..:..::|.:: ..:.|.||..||||||...||..::.||.
  Fly  2700 KQSPQQSGEESVNLVAQRALLLVQNKLDGREAGTMGDSNVEAQVERLINEATLPSNLCMLFPGWD 2764

  Fly  2515 AFL 2517
            ..|
  Fly  2765 PHL 2767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825	23/113 (20%)
		FAT	1653..1985	CDD:280429	85/433 (20%)
		PIKKc_ATR	2181..2448	CDD:270625	99/282 (35%)
		FATC	2486..2517	CDD:280430	13/30 (43%)
tefu	NP_001036712.1	FAT	1829..2170	CDD:280429	73/367 (20%)
		PIKKc_ATM	2416..2696	CDD:270715	103/300 (34%)
		FATC	2739..2767	CDD:280430	13/27 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464449
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10493at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950