DRSC/TRiP Functional Genomics Resources

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Protein Alignment mei-41 and pik3cg

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_021330656.1 Gene:pik3cg / 406598 ZFINID:ZDB-GENE-040426-2532 Length:1113 Species:Danio rerio


Alignment Length:1224 Identity:221/1224 - (18%)
Similarity:437/1224 - (35%) Gaps:327/1224 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1400 QANEESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPLASTLVSDRKEDSSRVPRLAGKLCAEL 1464
            ||:::....|  |:|....:....|.|.|.. |..::.:|...|......:|:.           
Zfish    19 QASDDEPPVV--RREENKRRRRRMKAFTSAS-AVSMEHIAVEFVLPTTNKNSKT----------- 69

  Fly  1465 LDFLQ-----RWLREWQRI---HGRSTGGKPPETIDSN--------YRKIHEFLNLIPKLLVSRA 1513
            ||.||     .|..|..::   |...|....||.....        |:|...:..:..|..|.: 
Zfish    70 LDTLQLDVTGNWTVEQVKVQLWHRAVTSKLCPEFYQKYSPDYCILLYQKKGNWYEIYDKQQVFQ- 133

  Fly  1514 SYNCGEYARALS------YLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDM 1572
            :.:|..|.:||.      :|....:..||.    |:...||..:.|                ||:
Zfish   134 TLDCIRYWKALRKDVGKIHLVVRQQPAEDS----LQYQRFLNHLIG----------------YDV 178

  Fly  1573 SVTQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADGLWQRLSD 1637
            :...::..:.|...::.::|..:..||..|    .::.:| |.::..||....|::     ::|:
Zfish   179 TDVSNVHDDELEFTRRKLLTPRKIELSDRD----PNLYSM-DPWMTTTPMPEYLLS-----KISN 233

  Fly  1638 RYSDQCFAECKSELLWRLGSYDEMEELQ---SNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRES 1699
            .:           :|..:......:.::   .:.|.|..|.       ...:|.....|.|:.|.
Zfish   234 NH-----------ILMVIHKETTSQTIKVSIDDTPVQVLQS-------FFAKITNKRALLGISED 280

  Fly  1700 VLEE---LRSCSAVQQHSYANAYDAVLKLHLV-------HELHC--------SQELVEKLEQDRD 1746
            |.|.   ||.|.. :::.|.|  :|:...|.:       .|:|.        .|::|:|.:..:.
Zfish   281 VSESDFVLRVCGR-EEYLYGN--NAIKDFHWIRQCLKNGEEIHLVLEHPPNPEQDVVQKEDWSQV 342

  Fly  1747 ED------NQEKLMKNYFDD--------W----QYRLQIVQPQV----RIQESIYSFRRNILAEL 1789
            :|      ..|:|.....|.        |    ::|::|:...:    |..|.|.....:|....
Zfish   343 DDCTGVAGTHEQLTITEKDHEKVFTISLWDCNRKFRVKILGIDIPVLPRNSELIVFVEASIFHGQ 407

  Fly  1790 QRRLTDRNHLLPHLKTELARIWLN--------------SAQINRNAGQLQRAQLYILKAAE---- 1836
            |....:|....|..:..:...||.              |.|::....|.|.:     |..|    
Zfish   408 QLLAQERTSSKPFTEEVIWNTWLEFNIKIKDLPKGARLSLQVSCGKAQTQTS-----KETECKNK 467

  Fly  1837 ----YQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQA 1897
                |..:.|.::...|| ::|:.::.|..:.|:                :|........|...|
Zfish   468 SRLLYYVNLLLVDHRSLL-RQGEFILHMWKMPEK----------------SEDNSSVNADKLTSA 515

  Fly  1898 VYSAESMHLCADAVLKYFQEAIAVHRQSESCHV-------QMAQFLEKILEARQGGKSEP----T 1951
            ....::..:....:|..:...:|:.:..:|..:       :|...|.|..|  |...::|    |
Zfish   516 TNPDKNNSMAVAILLDKYCYPVALPKSKDSPDIEGERGQREMPNHLRKQFE--QIIATDPLHPLT 578

  Fly  1952 GEQDDMLIN----------VMVNYAKSLRYGSEHVYQSMPRLI---SLW----LDT--------- 1990
            .|..::|.:          ....:..|:::|.:........|:   ::|    ||.         
Zfish   579 SEDKELLWHFRQECMRDPKAYPKFLSSVKWGKQEAVAITHYLLERSTIWDRSVLDVGLVLQLLDC 643

  Fly  1991 --TESSTNTEQVKKM-----NDLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKL 2048
              ::.:..|..|:|:     :|:|......:....|...:...|:|        |.:.|.:..|.
Zfish   644 HFSDENVRTIAVRKLETLGDDDVLRYLLQLVQAVKFEPYHDSALAR--------FLLKRALRSKR 700

  Fly  2049 VEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQKLLQDFN---SLTERLMDLTN-- 2108
            :..:   ..|.|  ..:.|::...::...|:.::.|:... :::||||.   .:||.|..:..  
Zfish   701 IGHF---LFWFL--RSEIAQSMHYQQRYAVILEAYLRGCG-EEMLQDFRKQVEITEALQKVAREI 759

  Fly  2109 KEVTLDRTYKLS-----DLDTRLSKLCKQPEFSQIL-LPFEKYMQPTLP-LNSDSNSSEGSHLPA 2166
            |:::.:: |.:|     .|..:|..|       |:| || :.:..|..| |.:.:...|...:.|
Zfish   760 KQISAEK-YDISAQVVFQLRQKLEGL-------QVLGLP-DSFKVPYDPGLRAGALVIEQCKVMA 815

  Fly  2167 NQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNG 2231
            ::....|..:::                |.|..|:   ||  ...::.|..||||:|..:::...
Zfish   816 SKKKPLWLQFKR----------------ADPTTLS---SD--TIGIIFKDGDDLRQDMLILQILL 859

  Fly  2232 LVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQS 2296
            :::.....::    ..|.:..|..:....:.|::|.:.:..:..:|      |:..|.:|...:.
Zfish   860 IMESIWELES----LDLSLLPYGCISTGNKIGMIEIVKDATTIANI------QQSTVGNTGAFKD 914

  Fly  2297 LAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGL 2361
                                     .:..:|||::........:|.:.::.:.....:..|:||:
Zfish   915 -------------------------EILSQWLREKCVNEDKHQQAVDRFVFSCGGYCVATYVLGI 954

  Fly  2362 GDRHGENILFAEGNGDAVHVDF-NCLFNQGELLPY-PEVVPFRLTHNMIVAMGPLGVEGS----- 2419
            ||||.:||:..| .|:..|:|| :.|.|....|.. .|.|||.||.:.:..||..|.:.|     
Zfish   955 GDRHNDNIMITE-TGNLFHIDFGHILGNYKSFLGISKERVPFVLTPDFLYLMGTTGKKSSPNFLQ 1018

  Fly  2420 FRKCCEITLRLLKQESKTLMSILRPFVYDVGAQTRKGAATAKITKDVQRIADRL 2473
            |:..|......|:..:..|:     .::.:...|.....|:|  :|::.|.:.|
Zfish  1019 FQNVCLKAYLALRHHTNLLI-----ILFSMMLMTGMPQLTSK--EDIEYIREAL 1065

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825
FAT 1653..1985 CDD:280429 68/420 (16%)
PIKKc_ATR 2181..2448 CDD:270625 54/273 (20%)
FATC 2486..2517 CDD:280430
pik3cgXP_021330656.1 PI3K_rbd 221..327 CDD:307097 23/131 (18%)
C2_PI3K_class_I_gamma 366..537 CDD:176044 29/192 (15%)
PI3Ka_I 559..735 CDD:238444 30/190 (16%)
PI3Kc_IB_gamma 739..1105 CDD:270627 83/400 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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