DRSC/TRiP Functional Genomics Resources

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Protein Alignment mei-41 and atm

DIOPT Version :10

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_002664603.3 Gene:atm / 403064 ZFINID:ZDB-GENE-040809-1 Length:3091 Species:Danio rerio


Alignment Length:3059 Identity:593/3059 - (19%)
Similarity:1058/3059 - (34%) Gaps:1037/3059 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 KDMWKLLYNHVNRNVSNFSGVYSVIEDILCQEPSLIS----------CSLVRELHNK-------- 52
            ::.||:           |||.       :| :|||:|          ||:.:.:|::        
Zfish   523 REFWKV-----------FSGA-------VC-KPSLVSALSLTQALLKCSVPKSVHSRDATSVVLT 568

  Fly    53 --------FQDTFLLWLLNKLAKCLSESPDSSECINLQRKILSSCCSNH------------PKLF 97
                    .:|:.:.||:                :|.|.:.....|..|            |::.
Zfish   569 DAGGEPPSLRDSIISWLI----------------MNEQNEETEENCRPHLIISRDFPLYLIPRIV 617

  Fly    98 ERLVL------------------------------AYVEAIEETHLQLS----------SLDLGQ 122
            ..|.|                              |.::.:|...||.|          ::|...
Zfish   618 VSLTLKDSRAGLTFLMGSLKPDCFSPENSSLTETKATMDEVESLFLQFSFDEAHSSAGFTVDKDS 682

  Fly   123 LSNERKPAITVRIFRCDVECLQEFDPHCAIEDIKVPLEQADMYAKSLLEVLQHAHHIGYATHGDI 187
            :.:| ||..||                  |:.::..||.      |||.:.:..    :..:...
Zfish   683 VYSE-KPQFTV------------------IQALRSKLEH------SLLSIAEQL----FTCYSPD 718

  Fly   188 FSGSLHQALLILKECDMDTKLASLNYCHNVLRSQSASSWITNPDVGHYAQLTLEATAIM-----W 247
            .:.:.|:.  :|:...:...:.:...|..:|..:.|.          .:.|.|:|.|::     :
Zfish   719 STNTPHEC--VLRCVSLLIGVLAAYVCIGMLSEEQAC----------LSPLFLKAKALVHEFSHY 771

  Fly   248 SAVAK----------------WLDMGCMTRQEL--KRLNITTKLLLEVLHMRARPAHHLGYLLLN 294
            ::.||                .|...|:.|:|.  |...|:..|.::.|.:|          |||
Zfish   772 TSTAKSKLAENETLASVQSVMLLCSDCICRREKGDKMSTISRTLFMKTLPVR----------LLN 826

  Fly   295 EILSLPTAIELDDGLLETLSSYIQGQLEHSVVPLEQLVHLQQLMLSHWHCHPTHLVPILALMGLK 359
            ::..:...:..:.|..:|:           |:..|                     |:       
Zfish   827 DLCDMSKQLLSNSGKKDTI-----------VIESE---------------------PV------- 852

  Fly   360 QTEMRSGVVQVLTQSLVEILK----KEEVLSKDWQKLIAILRGFKQLEKLILSQSQHKIAEHEGH 420
              :|::..:||..|..:::.:    .:.:.|:.                   |||..:.|     
Zfish   853 --DMQTSRIQVDNQEEIDLFEDGDGTQHITSRP-------------------SQSNEEAA----- 891

  Fly   421 IDSSVLAMLPLQCEIIKVADTNWNNLSMQLVELESKCSADRRHIHLEICSLLMQITFIR------ 479
             ||..:.                          .:|.:....|:..:..:.|..:.|:.      
Zfish   892 -DSKFIT--------------------------GTKSALSEEHLSKQDLTFLSVLGFLSLCASSE 929

  Fly   480 -----HFLKTQTQHQLLAIL-------QRHLKLSYLCAIRLETPSSVHTQMQSFYAQQYMRLFQS 532
                 .|....||.:||.:|       ..||:: ||..:: :.|:.|    .|...:::..|.:.
Zfish   930 LNGGFSFKPLDTQRKLLKLLDLADFSQMLHLQM-YLSLLK-KLPAEV----ASLDPEEFNALLRP 988

  Fly   533 --------EETQEIFCSNLPQLYISGFIKPEQLMKALPTINNRSGRAQVIRLLLCSQPG------ 583
                    .:.||: ||.:             |...||:          ||.|..|..|      
Zfish   989 LADVCSLYRQDQEV-CSAI-------------LFSLLPS----------IRCLGLSSSGSEQEED 1029

  Fly   584 ----KLSVFKVKDRIELYCPKCRPLPKKLPGIYLGKCKQQLPCPDFSSTNLEMIANDLLFYPDFE 644
                |.|:.||   |..:|             :|||..:   |.  ||..:.:          .:
Zfish  1030 MADIKGSLLKV---ISGFC-------------FLGKSGK---CT--SSVRVAL----------RQ 1063

  Fly   645 CIAQHLDLLCFEPN---VILGLLRETEALQKVSVKVIGQ------LVSAMRVRSPEFLEQLANLV 700
            |:   |.||..:|.   .:|.|..|...:..|...::..      :::|:.|.| .||::..:  
Zfish  1064 CL---LALLEADPCCKWAVLTLREEELPVSAVLSSLLADSHQHVCMLTALSVES-LFLKKALH-- 1122

  Fly   701 LAAIKAMLAKPLTEQNVLQQRSMLNVLTAIAHMED-------NEIWLFHWFKMTFFFLVHTRSLV 758
             ::.|.||  ||..|....:...|.....|...::       :|.           |......|.
Zfish  1123 -SSRKMML--PLKNQQTAFENIYLKAQEGIRRQKNCPSEDLPDET-----------FNRRATLLK 1173

  Fly   759 AQEAVLAATEMCASQGLQTIHLWNWYKRDALDLTVRLALNVYLLDGVRFTRSLRALTKMLG---- 819
            :...|::.:.:|..|.|  ..|:..||.:.:|..:             ..:.||.::|.||    
Zfish  1174 SVSMVMSCSPVCEKQAL--FALFQSYKENGIDEQL-------------IKKVLRGISKSLGNRDH 1223

  Fly   820 ------------------------FT-----------CVQE--FTCKYHRLLTAMVLPHCIVNPL 847
                                    :|           |..|  |...||     :::||.:....
Zfish  1224 KSLINSHLYYLVAEWLNQKQSDSSYTLQSFPYALLDCCSLEEFFRSSYH-----VLIPHLVFLND 1283

  Fly   848 CKGVLVLIAKQMQKHIG----TLFSISFLRIY-------------THVFLTEEPELANSCIELVV 895
            .:||     |.:..|:|    .|.:..|.:|.             |||  .::.|.|:...:::.
Zfish  1284 FEGV-----KSIGDHLGQDWKQLLAKCFPKIMVNILPHFALAGQDTHV--AQQREKAHRVYDILK 1341

  Fly   896 SCT---QSSLQQLMNADVKQTVAELLIYFNR-------------------NPTFVM--------- 929
            :..   :..:..|:..::...|.|||:..:.                   ||.|..         
Zfish  1342 NSNCLGKQQIDSLICNNLPDIVVELLMTLHETAGDKGDLQKFTGELDPAPNPPFFSSYVIKATLD 1406

  Fly   930 ----------RSFQSLLQLSIGSLEEL-------SSQTANAEFANFIAERFLGVITYFESCLSEP 977
                      :|..::|..:..|::.:       :.:|.||    :...|.|.:...|.|.|.  
Zfish  1407 YLSKCHSANHKSLVAILSKTPMSIQRILVAVCQKADETTNA----YERHRILMMYHLFVSLLL-- 1465

  Fly   978 SFEKPLKEETLYSLGQIMRFVGSQHVTQFRFKIIAMLSFVH--TLQEPRLQRICLKIWHIFLHVV 1040
               |.:|:    .||....||       .|..|..::..::  :.|:..:....|.:....|.:|
Zfish  1466 ---KEVKD----GLGGAWAFV-------LRDIIYTLIHHINSRSSQQDEVSTRSLSLCCDLLSLV 1516

  Fly  1041 NV-------QELGPSLGRIVATLQPLLADNESV-KQVNDLYEFIILRNAS--MLGTFITDLYFLD 1095
            ..       ..|...|..||.||...:.:..:: :||..|..|:::.|..  ||...|..|....
Zfish  1517 CQTAVEYCDDALESHLQVIVGTLTAQVTEQSAISEQVLSLLRFLVMENPENRMLRKSIPLLEPFP 1581

  Fly  1096 RMENVSP--SIQKCIRRHTAHLDLKG-----LAEEENQSPPLV------DQLRFLQKHITDECLQ 1147
            ...|.:.  :.|..::..:....|:.     |:.....|.||.      |..|.|..|       
Zfish  1582 EQPNFAELRAAQHALKYSSGAFTLRQEIEHFLSVASCDSLPLARLEGLKDLKRQLHSH------- 1639

  Fly  1148 VRVYALQHLGDLFGRRRPKLNSTILSELPLEPMLEQIVNVL----MAGCQHDDSQLQMASAKCLG 1208
                 .|.:|.|.......|:|.||..|        ::|:|    :|........:..|:.:|||
Zfish  1640 -----KQQIGQLLKECHADLDSCILVNL--------VLNLLQLCKIAANHPGGGDIMKAAGRCLG 1691

  Fly  1209 ELGAIDASYLPSNYN----FASPQHLPLNILSDDFAVLALTSLCRGYQFQQNTKHVDSFSLAIQE 1269
            |||.:|.|.:..::.    :|....|..|: ...:..:.|.|:....     |.|    |:|:::
Zfish  1692 ELGPVDLSSIALHHGKDQLYARAAKLFHNV-PHQWIFIILNSMDNAL-----TNH----SIAVRQ 1746

  Fly  1270 TLAIC-------------GISPKEQKKVQLWQSLPARMRQLMEPMLHSCYTCVHR-----PSTCL 1316
            |..:|             |...|.::...|....|.|..:..||::....|...|     ....|
Zfish  1747 TAGLCIKDILATQSGIEFGEIHKSKRDPLLAYLNPFRSSKKREPIMAMDVTPESRDRLTSADLWL 1811

  Fly  1317 QQPLFGSHYSHNYYEEWAFLWASRLIDYLPSSGRRH--LLSSYKPC-IKRD--SNMLSTFYPYIL 1376
            .||        :.:::|.......|:|   |.|.|:  ||.:...| :|.|  ..||..|...||
Zfish  1812 MQP--------DGHKDWLKNLCMALLD---SGGVRNEALLLTRPLCEVKTDFCQRMLPLFVHDIL 1865

  Fly  1377 L-------HALLECTTEQRNHIQEEFMAVLQANEESSSSVRGRQELGAIKEN---AFKQFESRKY 1431
            |       ..||.      .|||..|.   |....|:.:.|....:.:...|   |..|.:..| 
Zfish  1866 LGDVDGSWRQLLS------THIQSFFS---QCRRPSTPTSRPTTPMLSDSGNTTDAANQCQIDK- 1920

  Fly  1432 AAGIKPLASTLVSDRKEDSSRVP--RLAGKLCAELLDFLQRWLREWQRIHGRSTGGKPPETIDSN 1494
             |.::.:.:.:...|::.....|  ...|.:|..  :|   ||                   |.|
Zfish  1921 -ASLRSMLAVIDHLRQQSRPLAPGSNEYGTVCDS--NF---WL-------------------DLN 1960

  Fly  1495 YRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEE--------------------GEDKSQ 1539
            |            |.|:.|:..|..:..||.|.|.|:::                    .||.||
Zfish  1961 Y------------LEVAGAAQMCSAHFTALLYSEIYVDKIRSNMEQNRRSQSRASRRITFEDNSQ 2013

  Fly  1540 ---------RLLEQFTF-----LVEVYGSLRDPDSVEGA---------VQVRSYDMS-------V 1574
                     |.||...|     |:|||..:.:|||:.|.         .::|:|:..       |
Zfish  2014 TLSVSNLNERSLEDSGFSLQDLLIEVYRCIGEPDSLYGCGGGKLTSPLTRIRTYEHEAMWEKALV 2078

  Fly  1575 TQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADGL-WQRLSDR 1638
            :.|:..|         :....:.:...:.:|...:.:::..||....|      ||: |      
Zfish  2079 SYDLHSN---------LPEVTRQIGIVEGLQNFGLCSILSTYLHGLEK------DGMEW------ 2122

  Fly  1639 YSDQCFAECKSELLWRLGSYD-EMEELQSNWPAQCSQGCLKLRRPLTTR--IEFDSLLDGMRESV 1700
              .....|.:.:..||...:| ::.|.........::......:.|..:  ..|:..|:..|...
Zfish  2123 --GPELRELRFQAAWRSTQWDCDLPERNEKLKPGINESLFNALQALRDKEFSLFEQTLNYARGRE 2185

  Fly  1701 LEEL--RSCSAVQQHSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDEDNQEKLMKNYFDDWQY 1763
            :|||  .|..||     ::.|.|:..|..:.||...:||..:...|..       :...:..||.
Zfish  2186 VEELCRGSLEAV-----SSLYPALCNLQRISELQSVEELFSRPVTDSS-------LNEVYRKWQQ 2238

  Fly  1764 RLQIV-QPQVRIQESIYSFRRNILAELQRRLTD---RNHLLPHLKTELARIWLNSAQINRNAG-- 1822
            ...:: .....:.|.:.:.|.:|...|....||   :|:|:....:.|..:    .::.|:||  
Zfish  2239 HSDLLTDSDFSLVEPVLALRSSIQEALISSETDPDRKNYLISTYSSHLMEL----CRLARSAGNT 2299

  Fly  1823 ---------------------------QLQRAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAM 1860
                                       ||:.||::.:|    :..||.:|..|.:..|.|.::.:
Zfish  2300 QLAERAVFHMKQHNLVMSGSGSSSWAWQLEEAQVFWVK----KEHGLALELLKQMIHKLDDLVCV 2360

  Fly  1861 --------------------------------NYLEEQLSIMRSGCQGNVKQLAAEQRHLFFR-G 1892
                                            ||||..:.::...|.|...:|.:::...:|. .
Zfish  2361 NPAVVPVYSECLRLCGSWLAESCLESPAVILENYLERAVEVIEEHCGGLKSKLQSQKTQAYFSLA 2425

  Fly  1893 KYLQAVYSA----------ESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGK 1947
            ::..|.|..          |:.|    |:|:..:|.:.:.|:.:..:.:....:::.||......
Zfish  2426 RFSDAQYQGIENYMKSSEFENKH----ALLEKAKEEVDLMRERKVNNNRYTVKVQRELELDVKAL 2486

  Fly  1948 SEPTGEQDDMLINVMVNYAKSLRYGSEH---VYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTN 2009
            :....:::..|:..:.||.:.|..|.||   |:    ||.||||:..:       ||.:||.:.:
Zfish  2487 ANLQADRNRFLLKAVENYIECLELGEEHDTWVF----RLASLWLENAD-------VKAVNDKMKS 2540

  Fly  2010 CCTALPTAVFYTVYSQMLSRLCHPVNDVFT--------VLRNVIIKLVEAYPQQSLWMLLPHFKS 2066
            ....:|:..|..:..|:.:|:...|:....        ||..:|.:....:|..:|:::|....:
Zfish  2541 GVKKIPSYKFLPLMYQLAARMGTKVSSSMASQDVGFHHVLNELICQSSVDHPHHTLFIILALVNA 2605

  Fly  2067 AKAHRIKRCKLVLTDSRLQNSTFQK---LLQDFNSLTERLMDLTNKEVTLDRTYKLSDLDTRLSK 2128
            .|.....|       ||...|:.::   |..:...:..:::|:..|:    |...:.|::    .
Zfish  2606 NKDDSFSR-------SRSSKSSARQPSPLDLERAEVARKIIDVVRKK----RAKMVKDIE----M 2655

  Fly  2129 LCKQPEFSQILLPFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYI---------SGF 2184
            ||.    :.|.|.:       :..:......:...:||.|..:.....:.:.|         ||.
Zfish  2656 LCN----AYITLAY-------MDASRHKTEKKAIPIPAEQPLMQIKDLEDVIIPTMDIKVDPSGR 2709

  Fly  2185 QESVLILRSAAK----------PKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQ 2239
            .|.|:.:||..:          ||.:....|||.....|||.:||||:||.:.:...:....|.:
Zfish  2710 YEDVVTVRSFKRHFHLAGGVNLPKIIDCEGSDGISRRQLVKGQDDLRQDAVMQQVFHMCSTLLQR 2774

  Fly  2240 DAPARQRRLHIRTYAVLPFNEECGLVEWL------------PNLASYRSI----CMNLYAQRRLV 2288
            :|..|:|:|:||.|.|:||::..|::||.            |...:::..    ..|:..:::::
Zfish  2775 NAETRKRKLNIRRYKVVPFSQRSGVLEWCSGTVPIGEFLVDPQKGAHKRFRPQDWANMLCRKKMM 2839

  Fly  2289 MSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMS 2353
            .:.|.          ....|.:.|| ::.....|||:.:..:||..|..|.|.|..|.|:||..|
Zfish  2840 EAQRM----------EFNDKLQAFT-EVCQNFRPVFRYFCMERFLDPAIWLERRLAYTRSVATSS 2893

  Fly  2354 MVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEG 2418
            :||||:||||||.:|||..|...:.||:|....|.||::||.||.|||||:.:::..||..||||
Zfish  2894 IVGYIVGLGDRHIQNILIDEQTSELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITGVEG 2958

  Fly  2419 SFRKCCEITLRLLKQESKTLMSILRPFVYDV--------------------------------GA 2451
            .||:|||.|:.:::...:.|::|:...:||.                                |.
Zfish  2959 VFRRCCEKTMEVMRSSQEALLTIVEVLLYDPLFDWTMNPLKAFYLQQHDEQAELNATLNPTPGGD 3023

  Fly  2452 QT---RKGAATAKITKDVQRIADRLQGHVKRQQANSIPLSTEGQVNFLINEATKVDNLASMYIGW 2513
            :.   ||.:.:....|..:|:..|||..:|..:..:: ||..||||.||.:|....||:.::.||
Zfish  3024 EIETHRKASDSQSFNKVAERVLLRLQEKLKGVEDGTV-LSVGGQVNLLIQQAMDPKNLSRLFPGW 3087

  Fly  2514 GAFL 2517
            .|::
Zfish  3088 QAWV 3091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 23/113 (20%)
FAT 1653..1985 CDD:396714 75/415 (18%)
TEL1 <1946..2517 CDD:227365 169/654 (26%)
PIKKc_ATR 2181..2448 CDD:270625 98/301 (33%)
atmXP_002664603.3 TAN 8..165 CDD:463317
FAT 2128..2525 CDD:396714 77/424 (18%)
TEL1 <2438..3090 CDD:227365 176/704 (25%)
PIKKc_ATM 2716..2995 CDD:270715 95/289 (33%)
Blue background indicates that the domain is not in the aligned region.

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