DRSC/TRiP Functional Genomics Resources

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Protein Alignment mei-41 and pik3cd

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:NP_957493.1 Gene:pik3cd / 394174 ZFINID:ZDB-GENE-040426-1128 Length:1039 Species:Danio rerio


Alignment Length:1182 Identity:226/1182 - (19%)
Similarity:390/1182 - (32%) Gaps:403/1182 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1523 ALSYLESYL----------EEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQD 1577
            |||..::|:          ||.||:.:||.:...||..:....|:.|.||..:        .|| 
Zfish    61 ALSDPDAYVFTCINMTAEREELEDEQRRLCDVRPFLPILRLVAREGDRVEKLI--------TTQ- 116

  Fly  1578 ILVNRLVERQQDMITSYEQLLSSTDQMQPDH--------VRAMID--AYLRDT-PKTAQLIADGL 1631
              :|:|:.:......|           |.:|        :||..:  ||||.| |          
Zfish   117 --INQLIGKGHHEFDS-----------QKNHELNEFRTKMRAFCEEHAYLRQTLP---------- 158

  Fly  1632 WQRLSDRYSDQCFAECKSELLWRLGSYDEMEELQSNWPAQ---CS----QGCLKLRRPLTTRIEF 1689
            |.:                  |          ::.|:|..   ||    .|..:..:.:...::|
Zfish   159 WDK------------------W----------MEYNFPCDLEPCSSVTQSGKSRSIKKIFVNVKF 195

  Fly  1690 DSLLDGMRESVLEELRSCSAVQQHSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDEDNQEKLM 1754
                :|..|:.:        :||.  ......|||.:.:.:   ...:...::|::.||      
Zfish   196 ----EGSEETFV--------LQQD--PQDLPVVLKRNALRK---KSTVFRSVKQEKPED------ 237

  Fly  1755 KNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQRRLTD-RNHLLPHL-KTELARIWLNSAQI 1817
                    |.||:.:.    .|.||.  :..|.:.:...|. ...|.||| ....:.|.....:.
Zfish   238 --------YSLQVNER----WEFIYG--KYPLCQFKYIFTCLHGGLTPHLTMVHYSSIVKYQEEQ 288

  Fly  1818 NRNAGQLQRAQLYILKAAEYQPSGLFIERAKL--LWQKGDQVMAMNYLEEQLSI-MRSGCQGNVK 1879
            :..:.|:.|::      |:.:|..|.::|...  ||.          ::|...| :..|.:.|..
Zfish   289 SGLSNQVSRSR------AQSKPPPLPLKRQNTCSLWS----------IQEPFYIYLLQGSRVNAD 337

  Fly  1880 Q--LAAEQRHLFFRGKYLQAVYSAESMHLCADAV----LKYFQEAIAVHRQSESCHVQMAQFLEK 1938
            :  ....|..||...:.|..|.::..:.:|.|.|    |.:......:.|.|..|..     |..
Zfish   338 EGMKLVVQAGLFHGSELLCKVVTSNEVSVCFDPVWDQKLVFDINVSDLPRMSRLCFA-----LYG 397

  Fly  1939 ILEARQGGKSEPTGEQDDML------INVMV-NYAKSLRYG--SEHVYQSMP----RLISLWLDT 1990
            ::|..   |..||.:::...      :|.|| :|...|:.|  |...:.|:|    .|::. :.|
Zfish   398 VIEKT---KKRPTKKKNKRADCPLAWVNTMVFDYKDQLKTGEFSLSTWPSVPDDKGDLLNP-MGT 458

  Fly  1991 TESSTNTEQ--------------------VKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVN 2035
            .|.:.|.:.                    ::|:|:|..|....:.|...:    |.|..:....|
Zfish   459 VEKNPNIDSTAGLLIRFPNIRPHPLYYPPIEKLNELGPNGEKVIATKEEH----QKLKEIVDNKN 519

  Fly  2036 D----------VFTVLRNVIIKLVEAYPQQSL-------------------WMLLPHFKSAKAHR 2071
            .          ::.:...:.:|..|:.|:..|                   |..||     ..|.
Zfish   520 STEFFEDEKEPLWKLREELRLKYPESLPKLLLITKWNKHEDVAQMVGLLQKWPELP-----ALHA 579

  Fly  2072 IK----------------RCKLVLTDSRLQNSTFQKLLQ-----DFNS-----LTERLMD--LTN 2108
            ::                ||...|.|.:|    ||.|||     .:.|     ||..|::  |.|
Zfish   580 LELLDYSFPDPHVRFFTIRCLRKLPDDKL----FQYLLQLVQVLKYESYLDCDLTSFLLERALAN 640

  Fly  2109 KEV------TLDRTYKLSDLDTR---------------LSKLCKQPEFSQILLPFEKYMQPTLPL 2152
            |::      .|.....:..:..|               :..|.||.|....:.....:::.....
Zfish   641 KKIGHFLFWHLRSEMHVPSVSLRFGLILEAYCRGSIFHIKSLMKQNEALNKMKALNDFVKSASQK 705

  Fly  2153 NSDSNSSEGSHLPANQSTVNWFPYQQI---YISGFQESVLI----------LRSAAKPKKLTIRC 2204
            .:...::|...:...|.|     |.:.   .:|....|:::          :.|..||..|..: 
Zfish   706 ATRIQTTEDMKVCIKQET-----YMEALSDVVSPLSPSIILCELCADKCKFMDSKMKPLWLMYK- 764

  Fly  2205 SDGKDYD---VLVKPKDDLRRDARLMEF----------NGLVKRYLHQDAPARQRRLHIRTYAVL 2256
               ..||   ::.|..||||:|...::.          .||              .|.::.|..|
Zfish   765 ---SKYDSVGIIFKNGDDLRQDMLTLQMIQIMDILWKTEGL--------------DLRMQPYGCL 812

  Fly  2257 PFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHP 2321
            ....:.||:|.:.|..:..:|..|                      .|.......|.|.      
Zfish   813 STGNKTGLIEVVKNSDTIANIQRN----------------------NSNSAATAAFNKD------ 849

  Fly  2322 PVFQEWLRQRFATP-HSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNC 2385
             ....||:.:  .| ....:|...:..:.|...:..|:||:||||.:||:..| :|...|:||  
Zfish   850 -ALLNWLKSK--NPGDKLDQAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRE-SGQLFHIDF-- 908

  Fly  2386 LFNQGELLP--------YPEVVPFRLTHNMIVAMGPLGVEGS-----FRKCCEITLRLLKQESKT 2437
                |..|.        ..|.|||.||::.:..:.......|     ||.|||...::|.:.. |
Zfish   909 ----GHFLGNFKSKFGINRERVPFILTYDFVHVIQEGRTNNSEKFERFRVCCEQAYKILCRNG-T 968

  Fly  2438 LMSILRPFVYDVGAQTRKGAATAKITKDVQRIADRLQGHVKRQQA---------NSIPLSTEGQV 2493
            |      ||.........|......:||:|.:.|.|......::|         .::..|.:.:|
Zfish   969 L------FVNLFALMKAAGLPELNSSKDIQYLKDSLALGKSEEEALKNFKVKFNEALRESWKTKV 1027

  Fly  2494 NFLINEATKVDN 2505
            |::::...| ||
Zfish  1028 NWMMHTFAK-DN 1038

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825
FAT 1653..1985 CDD:280429 69/362 (19%)
PIKKc_ATR 2181..2448 CDD:270625 66/303 (22%)
FATC 2486..2517 CDD:280430 6/20 (30%)
pik3cdNP_957493.1 PI3K_p85B 32..107 CDD:280372 13/45 (29%)
PI3K_rbd 188..280 CDD:295323 23/128 (18%)
C2_PI3K_class_I_beta_delta 315..481 CDD:176075 36/184 (20%)
PI3Ka_I 505..676 CDD:238444 30/183 (16%)
PI3Kc_IA_delta 676..1038 CDD:270718 85/430 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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