Protein Alignment mei-41 and Pi3K59F

DIOPT Version :9

• Sequence 1: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Sequence 2: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Alignment Length: 1148
• Identity: 212/1148 - (18%)
• Similarity: 378/1148 - (32%)
• Gaps: 423/1148 - (36%)

  Fly  1396 MAVLQANEESSSSVRGRQELGAI-KENAFKQ----------------FESRKYAAGIKPLASTLV 1443
            :.:|..:....::|.|...:... |:..|:|                |.||....|
  Fly   109 LTILDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKG--------- 164

  Fly  1444 SDRKEDS-SRVPRLAGKLC-------AELLDFLQR-WLREWQRIHGRSTGGKPPETIDSNYRKIH 1499
               ||.| |::.|| |||.       .:.:|:|.| ..||             .|.|:...:::.
  Fly   165 ---KESSKSQMQRL-GKLAKKHRNGQVQKVDWLDRLTFRE-------------IEVINEREKRMS 212

  Fly  1500 EFLNLI---PKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSV 1561
            :::.|:   |.::|.      ..|..|:.|.|   .||:.|.:  |.....||.|      |||
  Fly   213 DYMFLMIEFPAIVVD------DMYNYAVVYFE---PEGDVKYK--LPAKPKLVSV------PDS- 259

  Fly  1562 EGAVQVRSYDMSVTQDILVNRLVERQQDMITSYEQL-LSSTDQMQPDHVRAMIDAYLRDTPKTAQ 1625
                           :|.:..||||:...:...|:. :|..|......:|..:...:...|.|..
  Fly   260 ---------------EIQMENLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYV 309

  Fly  1626 LIA---DGLWQ----RLSDRYSDQCFAECKSELLWRLGSYDEMEE---LQSNWPAQCSQGCLKLR 1680
            |.:   |.:|:    ..|.:.:...|.:|   :.|:|  .||:.:   :.:||.....:..|:|.
  Fly   310 LSSEEQDLVWKFRFYLSSHKKALTKFLKC---INWKL--EDEVTQALWMLANWAPMDVEDALELL 369

  Fly  1681 RPLTTRIEFDSLLDGMRESVLEELRSCSAVQQHSYANAYDAVLKLHLVHELHCSQELVEKLEQDR 1745
            .|..|.                       .|...||                     |.:|.|..
  Fly   370 SPTFTH-----------------------PQVRKYA---------------------VSRLAQAP 390

  Fly  1746 DEDNQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHL------K 1804
            |||    |:       .|.||:||                    ..:..|..|:: ||      :
  Fly   391 DED----LL-------LYLLQLVQ--------------------ALKYEDPRHIV-HLHGCIFPE 423

  Fly  1805 TELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSI 1869
            .::.|..|:.                         :|..::::.|               ..||.
  Fly   424 RDVVRSILDD-------------------------NGSLLDQSSL---------------SDLSA 448

  Fly  1870 MRSGCQGNVKQLAAEQRHLFFRGKYLQAVYSAESMHL-CADAVLKYFQEAIAVHRQSESCHVQMA 1933
            ..||..|:|  :.|.||    ....|.|:.|.:|:.. .|.......|.::|:...|
  Fly   449 TSSGLHGSV--IPANQR----AASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPS-------- 499

  Fly  1934 QFLEKILEARQGGKSEPTGEQDDMLINVMVNYAKSLRYGSEHVYQSMPRLISLWLDTTESSTNTE 1998
                  ..|..|..|.|.....:.|:     .|:.:.:|      |:|..:..:
  Fly   500 ------APATPGSSSLPCDSNSNALM-----LAEGISFG------SVPANLCTF----------- 536

  Fly  1999 QVKKMNDLLTNCCTALPTAVFYTVY-------SQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQS 2056
                   |:...||....|.::..|       .:.:.:.....:|::.::..:.:|::|    ..
  Fly   537 -------LIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLE----NG 590

  Fly  2057 LWMLLPHFKSAKAHR------IKRCKLVLTDSRLQN---STFQKLLQDFNSLTERLMDLTNKEVT 2112
            .:.|...|.:.:..|      :|..|||..:...:|   ..|||||.:.:...   ::.||
  Fly   591 NFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFK---VNFTN---- 648

  Fly  2113 LDRTYKLSDLDTRLSKLCKQPEFSQILLPF--EKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFP 2175
                                  |..|..|.  |.|:...:|:.:.
  Fly   649 ----------------------FEPIPFPLDPEIYITKIVPMRTS-------------------- 671

  Fly  2176 YQQIYISGFQESVLILRSAAKPKKLTIRCSDG-KDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQ 2239
                          :.:||..|.|||...|.. .:|..:.|..||||:|..:::...|:.:.|.:
  Fly   672 --------------LFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRR 722

  Fly  2240 DAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHES 2304
            :    ...|.:..|.||..:.:.|.::::.:..                            :.|.
  Fly   723 E----NLDLKLTPYKVLATSSKHGFLQYVDSCT----------------------------VAEV 755

  Fly  2305 IERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWY----EARNTYIRTVAVMSMVGYILGLGDRH 2365
            :.|:..:             ..:.|:.....:..|    |..:|||::.|...::.|:||:||||
  Fly   756 LAREGNI-------------HNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRH 807

  Fly  2366 GENILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVE--GSFRKCCEITL 2428
            .:|:|... ||...|:||..:..:.   |.|...|.:|:..|:.|||.:..|  ..|||.|....
  Fly   808 LDNLLLTT-NGKLFHIDFGYILGRD---PKPMPPPMKLSKEMVEAMGGISSEHHHEFRKQCYTAY 868

  Fly  2429 RLLKQESKTLMSI----LRPFVYDVGAQTRKGAATAKITKDVQ 2467
            ..|::.:..::::    :...|.|:..:..|  |..|:.:::|
  Fly   869 LHLRRHANVMLNLFSLMVDATVPDIALEPDK--AVKKVEENLQ 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	59/341 (17%)
		PIKKc_ATR	2181..2448	CDD:270625	59/277 (21%)
		FATC	2486..2517	CDD:280430
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	19/89 (21%)
		PI3Ka_III	284..561	CDD:238442	74/446 (17%)
		PI3Kc_III	601..945	CDD:270628	83/423 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900