DRSC/TRiP Functional Genomics Resources

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Protein Alignment mei-41 and Pik3cd

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_038966422.1 Gene:Pik3cd / 366508 RGDID:1310990 Length:1048 Species:Rattus norvegicus


Alignment Length:1215 Identity:237/1215 - (19%)
Similarity:402/1215 - (33%) Gaps:421/1215 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1502 LNLIPKLLVSRASYNCGEYARALSYLESYL----------EEGEDKSQRLLEQFTFLVEVYGSLR 1556
            |:.|.::|..||.|.  .:...||..|:|:          :|.||:.:||.:...||.       
  Rat    42 LSTIKQVLWHRAQYE--PFFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLP------- 97

  Fly  1557 DPDSVEGAVQVRSYDMSVTQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTP 1621
                                   |.|||.|:.|.:   ::|::|                     
  Rat    98 -----------------------VLRLVAREGDRV---KKLINS--------------------- 115

  Fly  1622 KTAQLIADGL--WQRLSD-----------RYSDQCFAECKSELLWRLGSYDEMEELQSNWPAQCS 1673
            :.:.||..||  :..|.|           ::.::..|. :.:|.|       :|.||.::|.|..
  Rat   116 QISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAH-RQQLGW-------VEWLQYSFPLQLE 172

  Fly  1674 -------QGCLKL-RRPLTTRIEFDSLLDGMRESVLEELRSCSAVQQHSYANAYDAVLKLHLVHE 1730
                   .|.|.: .|||...::|    :|..||...::            :..|..|.|     
  Rat   173 PSARGWRAGLLHVSNRPLLVNVKF----EGSEESFTFQV------------STKDMPLAL----- 216

  Fly  1731 LHCS---------QELVEKLEQDRDEDN--QEKLMKNY-FDDWQYRLQIVQPQVRIQESIYSFRR 1783
            :.|:         |.|||:.|:...:.|  .|.|..:| ...:||                    
  Rat   217 MACALRKKATVFRQPLVERPEEYALQVNGRHEYLYGSYPLCHFQY-------------------- 261

  Fly  1784 NILAELQRRLTDRNHL-LPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIERA 1847
             |.:.|...||.  || :.|..:.||   :...|.| .|.|:|:.::........:||.:     
  Rat   262 -ICSCLHSGLTP--HLTMVHSSSILA---MRDEQSN-PAPQVQKPRVKPPPIPAKKPSSV----- 314

  Fly  1848 KLLWQKGDQVMAMNYLEEQLSI-MRSGCQGNV--KQLAAEQRHLFFRGKYLQAVYSAESMHLCAD 1909
             .||.          ||:...| :..|.:.|.  :.....|..||...:.|....|:..:::|::
  Rat   315 -SLWS----------LEQPFCIELIEGRKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSE 368

  Fly  1910 AVLKY---FQEAIA-VHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQDDMLINVMV-NYAKSL 1969
            .|.|.   |..:|. :.|.:..|....| .:||..:||...|.....:......|:|: :|...|
  Rat   369 PVWKQRLEFDISICDLPRMARLCFALYA-VVEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQL 432

  Fly  1970 RYGSEHVYQSMPRLISLW-------------LDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYT 2021
            :.|...:|        :|             ..|...:.|||....:...|..   ..|..|::.
  Rat   433 KTGERCLY--------MWPSVPDEKGELMNPAGTVRGNPNTESAAALVIYLPE---VAPHPVYFP 486

  Fly  2022 VYSQMLSRLCHPVNDVFT-----VLRNVIIK--------------------LVEAYPQ------- 2054
            ...::|....|......|     .||.::.:                    :.|.:|:       
  Rat   487 ALEKILELGRHGERGRITEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQEHFPEALARLLL 551

  Fly  2055 --------------QSLWML-----LPHFKSAK------------AHRIKRCKLVLTDSRLQNST 2088
                          |.|::|     ||...:.:            :..||..: .|||..|    
  Rat   552 VTKWNKHEDVAQLSQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLR-KLTDDEL---- 611

  Fly  2089 FQKLLQ-----DFNS-----LTERLMD--LTNKEVTLDRTYKL-SDLDT---------------- 2124
            ||.|||     .:.|     ||:.|:.  |.|:::.....:.| |::..                
  Rat   612 FQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCR 676

  Fly  2125 ----RLSKLCKQPEFSQILLPFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQ 2185
                .:..|.||.|....|.....:::.:....:...:.|..|:...|.|             :.
  Rat   677 GSTHHMKVLMKQGEALSKLKALNDFVKASSQKTTKPQTKEMMHMCMRQET-------------YM 728

  Fly  2186 ESVLILRSAAKP--------------------KKLTIRCSDGK-----DYDVLVKPKDDLRRDAR 2225
            |::..|:|...|                    |.|.|..|..|     ...::.|..||||:|..
  Rat   729 EALSHLQSPLDPSTLLEEVCSVEQCTFMDSKMKPLWIMYSSEKAGGAGSVGIIFKNGDDLRQDML 793

  Fly  2226 LMEFNGLVKRYLHQDAPARQRRLHIR--TYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLV 2288
            .::...|:      |...:|..|.:|  .|..||..:..||:|                    :|
  Rat   794 TLQMIQLM------DFLWKQEGLDLRMTPYGCLPTGDRTGLIE--------------------VV 832

  Fly  2289 MSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATP-HSWYEARNTYIRTVAVM 2352
            :.:..:.:  :.|::|.......|.|.       ....||:.:  .| .:...|...:..:.|..
  Rat   833 LHSDTIAN--IQLNKSNMAATAAFNKD-------ALLNWLKSK--NPGEALDRAIEEFTLSCAGY 886

  Fly  2353 SMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLP--------YPEVVPFRLTHNMIV 2409
            .:..|:||:||||.:||:..| :|...|:||      |..|.        ..|.|||.||::.:.
  Rat   887 CVATYVLGIGDRHSDNIMIRE-SGQLFHIDF------GHFLGNFKTKFGINRERVPFILTYDFVH 944

  Fly  2410 AMGPLGVEGS-----FRKCCEITLRLLKQESKTLMSILRPFVYDVGAQTRKGAATAKITKDVQRI 2469
            .:.......|     ||..||....:|::....       |::........|......:||:|.:
  Rat   945 VIQQGKTNNSEKFERFRGYCERAYTILRRHGLL-------FLHLFALMRAAGLPELSCSKDIQYL 1002

  Fly  2470 ADRLQ---------GHVKRQQANSIPLSTEGQVNFLINEATKVDN 2505
            .|.|.         .|.:.:...::..|.:.:||:|.:..:| ||
  Rat  1003 KDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSK-DN 1046

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825
FAT 1653..1985 CDD:280429 77/360 (21%)
PIKKc_ATR 2181..2448 CDD:270625 65/307 (21%)
FATC 2486..2517 CDD:280430 7/20 (35%)
Pik3cdXP_038966422.1 PI3K_p85B 32..107 CDD:396665 22/96 (23%)
PI3K_rbd 182..281 CDD:395642 30/142 (21%)
C2_PI3K_class_I_beta_delta 314..481 CDD:176075 37/194 (19%)
PI3Ka 504..687 CDD:214537 30/187 (16%)
PI3Kc_IA_delta 679..1046 CDD:270718 86/431 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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