Protein Alignment mei-41 and Pik3c2a

DIOPT Version :9

• Sequence 1: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Sequence 2: NP_001101970.1
• Gene: Pik3c2a / 361632
• RGDID: 1310389
• Length: 1687
• Species: Rattus norvegicus
• Alignment Length: 1113
• Identity: 200/1113 - (17%)
• Similarity: 375/1113 - (33%)
• Gaps: 367/1113 - (32%)

  Fly  1542 LEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVT---QDILVNRLVERQQDMITSYEQLLSSTDQ 1603
            |:..||........|..:..|..|.:..|...:.   ::::....||   :::.||...:....|
  Rat   507 LQLLTFSAMCQNLARTAEDDEAPVDLNKYLYQIEKPYKEVMTRHPVE---ELLDSYHYQVELALQ 568

  Fly  1604 MQPDHVRAMIDAYLRDTPKTAQLIADGLWQRLSDRYSDQCFAECKSEL-----LWRLGSYDEMEE 1663
            .:..| || ||..::...|....: ||:        ......|...:|     |.|..|.|....
  Rat   569 TENQH-RA-IDQVIKAVRKICSAL-DGV--------ETPAVTEAVKKLKRAVNLPRNKSADVTSL 622

  Fly  1664 LQSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLEELRSC-----------------SAVQ 1711
            ...:.....::|.|.|..|:  ::..|.|...:.:.:.....||                 :|.:
  Rat   623 SGGDTSKNSTRGSLNLENPV--QVSMDHLTAAIYDLLRLHTNSCKSSTVCPQGSRNIKEAWTATE 685

  Fly  1712 Q------------HSYANAYDAVLKLHLVHEL-HCSQELVEKLEQDRDEDNQEKLMKNYF--DDW 1761
            |            .::.:.|:   |.:|:..| |..::|.:.:     :..:....||:|  ..|
  Rat   686 QLQFTVYAAHGISSNWVSNYE---KYYLICSLSHNGKDLFKPI-----QSKKVGTYKNFFYLIKW 742

  Fly  1762 Q----YRLQIVQ-------------------------------PQV--RIQESIYSFRRNILAEL 1789
            .    :.:||.|                               |:.  ::..:::.|:|.:..
  Rat   743 DELIIFPIQISQLPLESVLHLTLFGVLNQSSGSSPDSNKQRKGPEALGKVSLTLFDFKRFLTC-- 805

  Fly  1790 QRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQ---PSGLFIERAKLLW 1851
                          .|:|..:| .|:..|...|.:.: :.|:::....|   ||..|
  Rat   806 --------------GTKLLYLW-TSSHTNSIPGAIPQ-KSYVMERIVLQVDFPSPAF-------- 846

  Fly  1852 QKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQAVYSAESMHLCAD--AVL-- 1912
               |.:.....::..:          ::|...|......:||.|..|:...|..|..:  |.|
  Rat   847 ---DIIYTSPQIDRNI----------IQQYKLEALENEIKGKLLDIVHRDSSFGLSKEDKAFLWE 898

  Fly  1913 -KYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQDDMLINVMVNYAKSLRYGSEHV 1976
             :|:            | ::....|.|||.:....|              ..|.||:  |...|.
  Rat   899 KRYY------------C-LKHPNCLPKILASAPNWK--------------WANLAKT--YSLLHQ 934

  Fly  1977 YQSMPRLISLWLDTTESSTNTEQVKKM---------NDLLTNCCTALPTAVFYTVYSQ------M 2026
            :..:..|.:  |:..::....::|:.:         :|.||:.......|:.|.:|..      :
  Rat   935 WPPLCPLAA--LELLDAKFADQEVRSLAVSWIEAISDDELTDLLPQFVQALKYEIYLNSSLVRFL 997

  Fly  2027 LSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQK 2091
            |||          .|.|:.|       ..||:.||              |..|.|:|. .|.::.
  Rat   998 LSR----------ALGNIQI-------AHSLYWLL--------------KDALHDTRF-GSRYEH 1030

  Fly  2092 LLQDFNSLTERLMDLTNKEV--TLDRTYKLSDLDTRLSKLCKQPEFSQILLPFEKYMQPT----- 2149
            :|       ..|:.:..|.:  .|.:..||..|...:::..:|...|...:..:|.|:..
  Rat  1031 VL-------GALLSVGGKGLREELSKQMKLVQLLGGVAEKVRQASGSARQVVLQKSMERVQSFFL 1088

  Fly  2150 -----LPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSD--G 2207
                 :||...        |.|.:..:              :|.....|.|.|.|:|:..:|  |
  Rat  1089 RNKCRVPLKPS--------LVAKELNI--------------KSCSFFSSNAMPLKVTMVNADPLG 1131

  Fly  2208 KDYDVLVKPKDDLRRDARLMEFNGLV-KRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNL 2271
            ::.:|:.|..:|||:|...::...:: |.:|.:...     |.:..:..|....:.|:||.:|..
  Rat  1132 EEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLD-----LRMVIFKCLSTGRDQGMVELVPAS 1191

  Fly  2272 ASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPH 2336
            .:.|.|.:. |.    |..:.:.:.||                           ||||:...:..
  Rat  1192 DTLRKIQVE-YG----VTGSFKDKPLA---------------------------EWLRKYNPSEE 1224

  Fly  2337 SWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPEV--- 2398
            .:.:|...:|.:.|...:..|:||:.|||.:||:. ...|...|:||      |:.|.:.::
  Rat  1225 EYEKASENFIYSCAGCCVATYVLGICDRHNDNIML-RSTGHMFHIDF------GKFLGHAQMFGS 1282

  Fly  2399 -----VPFRLTHNMIVAMGPLGVEGSFR------KCCEITLRLLKQESK---TLMSILRPFVYDV 2449
                 .||.||.:|...:.. |.:.:.|      .||: ...|:::::.   .|:|::.|
  Rat  1283 FKRDRAPFVLTSDMAYVING-GEKPTIRFQLFVDLCCQ-AYNLIRKQTNLFLNLLSLMIP----- 1340

  Fly  2450 GAQTRKGAATAKITKDVQRIADRLQGHVKRQQANSIPLSTEGQVNFLINE---------ATK--- 2502
                 .|.......:|::.:.|.||           |.:|:.:.......         |||
  Rat  1341 -----SGLPELTSIQDLKYVRDALQ-----------PQTTDAEATIFFTRLIESSLGSIATKFNF 1389

  Fly  2503 -VDNLASM 2509
             :.|||.:
  Rat  1390 FIHNLAQL 1397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	64/408 (16%)
		PIKKc_ATR	2181..2448	CDD:270625	62/286 (22%)
		FATC	2486..2517	CDD:280430	8/37 (22%)
Pik3c2a	NP_001101970.1	PI3K_rbd	411..514	CDD:279173	3/6 (50%)
		C2A_PI3K_class_II	678..850	CDD:175979	30/208 (14%)
		PI3Ka_II	871..1039	CDD:238441	46/237 (19%)
		PI3Kc_C2_alpha	1044..1396	CDD:270720	86/440 (20%)
		PX_PI3K_C2_alpha	1427..1535	CDD:132822
		C2B_PI3K_class_II	1561..1682	CDD:176027

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900