DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and nonC

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster

Alignment Length:	2350	Identity:	440/2350 - (18%)
Similarity:	772/2350 - (32%)	Gaps:	855/2350 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   755 RSLVAQEAVLAATEMCASQGLQTIHLWNWYKRDALDLTVRLALN--------VYLLDGVRFTRS- 810
            |.|:.:.....:.|:|:.                ||..||..:|        |::||.:.....
  Fly   136 RRLINENNPTVSLELCSK----------------LDQAVRTPINMGYMTCSFVWILDNMLTLYKQ 184

  Fly   811 -----LRALTKMLG---------FTCVQEFTCKYHRLLTAMVLPHCIVNPLCKGVLVLIAKQMQK 861
                 |...:|.||         :...:||..|.::                      .:|:|||
  Fly   185 CPPPVLEECSKTLGLIGFINRKSYPIYEEFIVKNYK----------------------SSKRMQK 227

  Fly   862 HI-----GTLFSISFLRIYTHVFLTEEPELANSCIELVVSCTQSSLQQLMNADVKQTVAELLIYF 921
            ::     .||...:...::.:.             :.::...:..|:...:||:...|:..|:.|
  Fly   228 YMIMALRATLSCDTKCELHMYA-------------DKIMLLLKDFLENAESADIFIVVSNTLVQF 279

  Fly   922 NRN--PTFVMRSFQSLL------QLSIGSLEELSSQTANA------------EFANFIAERFLGV 966
            ..:  .||... |..::      ||..|...:|.:..|..            :|:..:.::|:..
  Fly   280 AASYAETFECH-FTDVVDIVIGWQLEAGQPTDLKTHCAQVLEQLTPFFSKQIDFSYGLLDQFVED 343

  Fly   967 ITYFESCLSEPSFEKPLKEETLYSLGQIMRFVGSQHVTQFRFKIIAMLSFVHTLQEPRLQRICLK 1031
            ||..|.  .||:       .|...:|   .|||:                .:||.:      ||.
  Fly   344 ITTLEE--GEPA-------NTAERVG---AFVGA----------------FNTLLK------CLA 374

  Fly  1032 IWHIFLHVVNVQ-ELGPSLGRIVATLQPLLADNESVKQVNDLYEFIILRNASMLGTFITDLYFLD 1095
            ...||:.:...: .:..::..::..:..|..:.|::..:|:|....:|.|.:.|...:.:...||
  Fly   375 RMQIFVGMPTCECIVKMAVDHLIKIMPTLHLNTEALVNINELICICLLNNFTGLDPILLEQVLLD 439

  Fly  1096 RMENV--SPSIQK--------C-IRRHTAHLDLKGLAEEENQSPPLVDQLR-------------- 1135
            :::.:  ...:|:        | :||..|.| ...|.....||.|.:.::|
  Fly   440 QVKRMISLTELQRQSVLYLLLCTVRRLRARL-TPSLVHFIFQSNPYMTKVRLRSPGETSYKLLLR 503

  Fly  1136 ------------FLQ---KHITDE---CLQ-------------VRVYALQHLGDLFGRRRPKLNS 1169
                        .||   |::.|:   ||:             ..|..:.||..|  ....|..|
  Fly   504 TCQETLLIRNVPLLQQAYKYLVDDIDACLEKLLITAPRSKARKASVLLVFHLSAL--AALAKQTS 566

  Fly  1170 TILSELPLEPMLEQIVNVLMAGCQHDD----SQLQMASAKCLGELGAIDASYLPSNYNFASPQHL 1230
            :|:.....:|   .|:.:|:..|:..:    |:...|.....|.|    ..:..:|:||.:.
  Fly   567 SIIGMYACKP---SILELLLTNCRAHELKFWSKYPAAQQAIFGLL----VVHCQANHNFRTN--- 621

  Fly  1231 PLNILSDDFAVLALTSLCRGYQFQ-QNTK-HVDSFSLAIQETLAICG----ISPKEQKKVQLW-Q 1288
                          :||.|..:.. :||. ..:||:..::...::.|    ::|:..:.:..| |
  Fly   622 --------------SSLLRDQELSAENTSPTANSFASILRFLDSVLGQAHQLAPQNLRVLLQWIQ 672

  Fly  1289 SLPARMRQLMEPMLHS------CYTCVHRPS--------TCLQQPL-FGSHYSHNYYEEWAFLWA 1338
            .|....|:.::.::..      |.......|        .|:|..| :|               .
  Fly   673 MLLRECREKIDLLMEQENFRGICRNIAATASKLVPLESAACIQTVLDYG---------------L 722

  Fly  1339 SRLIDYLPSSGRRHLLSSYKPCIKRDSNMLSTFY--PYILLHALLECTTEQRNHIQEEFMAVLQA 1401
            .||..| |.     ||..|:....:...||||.|  ||..::|.|..      |:      .|..
  Fly   723 ERLEKY-PK-----LLILYRDTALQQLQMLSTNYHAPYFQIYAQLPL------HL------TLTG 769

  Fly  1402 NEESSSSVRGRQ---------ELGAIKENAFKQFESRKYAAGIKPLASTLV-------------- 1443
            .|.|...:..|:         :..|:::|.|:.|..|..    ||...:|:
  Fly   770 GESSMPGMASRRVSVWQQRISQYSAVRDNVFRDFFDRVQ----KPEQDSLIHCLRELFVRSCQVA 830

  Fly  1444 --SDRKEDSSRVPRLAGKLCAELLDF-LQRWLREWQRIHGRSTGGKPPET--------------- 1490
              .:|:.:.|:..:...:|....|.| ..|:..: ||:  |:|.|||.||
  Fly   831 PQDERQMNLSQCTKRCQRLAIAWLQFEAARYCVD-QRL--RTTVGKPQETFLGFEAIIMRHARLL 892

  Fly  1491 ----------------------IDSNYRKIHEFLNLIPKLLVSRASYNCGEYAR----------- 1522
                                  :.||...:..||:.:.||:     ||..|.:.
  Fly   893 SGCAKEIERSALDDLSLEELLSMQSNLSLLLGFLDALEKLI-----YNAAEGSAFALRPPEKQVA 952

  Fly  1523 ---------------------------------ALSYLESYLEEGEDKSQRLLEQFTFLVEVYGS 1554
                                             .:.|.:..|...:.:.....:...::.....|
  Fly   953 AFFRLNNPTCQSWFNRIRIGVVIIAMHVQQPELVIRYAQQILVNSKTQDPTYSQAIVYMAWSLVS 1017

  Fly  1555 LRDPDSVEG------AVQVRSYD-MSVTQDILVNRLVERQQDMITSYEQLLSSTD---QMQPDHV 1609
            .::.||:.|      ....:||. :....|    :...:::..:..|..:|:..:   :::| |.
  Fly  1018 CQEADSLRGLRLWARGKSCKSYKWLKYAAD----QAAGKRESALAGYRTILAEKELQSELEP-HT 1077

  Fly  1610 RAMIDAYLRDTPKTAQLIAD-GLWQRLSDRYSDQCFAECKSEL-------------LWRL----- 1655
            |..:      ..:..|.:.| |.|.:|.:....|.......||             |.||
  Fly  1078 RQFV------VSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNPFLQRSNVEVNALERLLAKSE 1136

  Fly  1656 ----------GSYDEMEELQSNWPAQCSQGCLKLR--------RPLTTRIEFDSLLDG------- 1695
                      |.:.::....|||....|...|..|        |..|..|....||:.
  Fly  1137 ESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSERASFSSIHMRQRTEDIVLHKLLEDRCVPDQA 1201

  Fly  1696 -------MRESVLE---ELRSCSAVQQHSYANAYDAVLKLHLV------HEL------------- 1731
                   .|:|:|.   :.|||.           :..|..|:|      .||
  Fly  1202 KNLLDTQWRDSLLNPSFDQRSCK-----------ELTLLRHIVQGVSGGQELSLLPVSSGRCQNR 1255

  Fly  1732 ---------------------HCSQELVEKLEQD-----RDEDN---QEKLMKNYFDDWQYRLQI 1767
                                 ||:....|.|..|     |:|.|   .|.|:..:|.
  Fly  1256 SKFISSAILMRCLAWTQLLRQHCAPGSWETLCLDAAAAAREEGNLQLAETLLTQFFG-------- 1312

  Fly  1768 VQPQVRIQESIYSFRRNILAELQRRLTDRNHLLP--HLKTE---------------LARIWLNSA 1815
             ||...| .:::|..:.:..:....|...:.|:.  ||:.:               .|.:.||
  Fly  1313 -QPIGEI-AALFSLEQGVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSSIDVCAALCLN-- 1373

  Fly  1816 QINRNAGQLQRAQLYILKAAEY----QPSGLFIERAKLLWQKGDQV------------MAMNYLE 1864
             |.::..|.......:|..|::    ..:||...::.:|.|..||:            :|:...|
  Fly  1374 -IQKSNNQPAAGADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLPECPLTCDSSQPLAIPQAE 1437

  Fly  1865 EQLSIMRSGC----QGNVKQLAAEQRHLFFRGK-------------------------------- 1893
            ..::.:...|    ....:.|.|.....:..||
  Fly  1438 RMVARLVHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALDIPQPLESEKL 1502

  Fly  1894 --YLQAVYS----AESMHLC-----------------------------ADAVLKYFQEAIA--- 1920
              .|||:.:    |..:.:|                             .||:|:.::.|||
  Fly  1503 DELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLTFLADKTPEALDAILQIWRRAIANTY 1567

  Fly  1921 -VHRQSESCHVQMAQFLEKILEARQG-GKSEPTGEQDDMLINVMVNYAKSLRYGSEHVYQSMPRL 1983
             .::.:...:.|...|       :.| |..:|.||.       :|:..:.|.....::..:..||
  Fly  1568 DYYKDAARSYFQYLSF-------KSGSGPEKPEGEG-------VVSQRERLHVDDSNLVTTTLRL 1618

  Fly  1984 ISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKL 2048
            :.|.:         :....:.::|.......|.|.:..:..|:.|||.|....|...:.:::.:|
  Fly  1619 LRLIV---------KHASGLQEVLEQGLHTTPIAPWKVIIPQLFSRLNHHEPYVRKSVCDLLCRL 1674

  Fly  2049 VEAYPQQSLW-------------------------------MLLPHFKSAKAHRIKRCKLVLTDS 2082
            .::.||..::                               .||..........::..||::.:.
  Fly  1675 AKSRPQLVIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSKQAPEAVQHVKLMVKEL 1739

  Fly  2083 R-----LQNSTFQKLLQDFNSLTERLMDLT-----------NKEVTLDRTYKLSDLDTRLSKLCK 2131
            |     ........|...:|:...|:..|.           |....:.|...|:||:..::...:
  Fly  1740 RRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNVWRPQLLADLEALVAVTSR 1804

  Fly  2132 QPEFSQILLPFEKYMQPTLPLNSD----------------------SNSSEGSHLPANQSTVNWF 2174
            .|| :.....|.|.....:.|..|                      ||...||.......:::
  Fly  1805 PPE-TTYERSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQLYHILQSNMIRGSGSTLKMQSIS-- 1866

  Fly  2175 PY---------------------QQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKD 2218
            |.                     .|:||...:.||.:|.:..||||:....|:|:.|..|.|..:
  Fly  1867 PVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGME 1931

  Fly  2219 DLRRDARLMEFNGLVKRYL--HQDAPAR--QRRLHIRTYAVLPFNEECGLVEWL----PNLASYR 2275
            ||..|.|:|:|..:....:  ..|||..  .|..|   |:|:|...:.||:.|:    |..|.|:
  Fly  1932 DLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHH---YSVIPLGPQSGLISWVDGVTPVFALYK 1993

  Fly  2276 SICMNLYAQRR-LVMSTRQLQSLA-VPLHESIERKREVFTKQLVP---------AHPPVFQEW-- 2327
            .     :.||| .|.......::| ||     .|..::|..:|.|         :.|.  ::|
  Fly  1994 K-----WQQRRSQVAGNAGAGAVANVP-----RRFTDLFYNKLSPLLAKHNMQVSDPR--RQWPI 2046

  Fly  2328 ---------LRQRFATPHS------WYEARNT---------YIRTVAVMSMVGYILGLGDRHGEN 2368
                     |.|.  ||:.      |.:|.|.         ::|.::||||:||::||||||.:|
  Fly  2047 SVLLQVLDELSQE--TPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDN 2109

  Fly  2369 ILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQ 2433
            :|...|:||.||:|:|..|.:|..|..||.||||||.|::.|||..|:||.||..||..|:::::
  Fly  2110 VLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRK 2174

  Fly  2434 ESKTLMSILRPFVYDV--------GAQTRKGAATAKITKDVQRIAD----------RLQGHVKRQ 2480
            |.:||:::|..||||.        .||..:.:..||:    |..||          .|:.| |:.
  Fly  2175 ERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLNAKL----QESADGGGAGGLGVGDLKYH-KKD 2234

  Fly  2481 QANSIPLSTE 2490
            :....||.::
  Fly  2235 KNKGKPLDSD 2244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825	18/105 (17%)
		FAT	1653..1985	CDD:280429	86/528 (16%)
		PIKKc_ATR	2181..2448	CDD:270625	104/311 (33%)
		FATC	2486..2517	CDD:280430	2/4 (50%)
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	108/648 (17%)
		Rapamycin_bind	1738..1845	CDD:285924	16/107 (15%)
		PIKKc_SMG1	1894..2196	CDD:270714	106/318 (33%)
		FATC	3189..3217	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464453
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11139
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930