Protein Alignment mei-41 and Pik3cg

DIOPT Version :9

• Sequence 1: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Sequence 2: NP_001139672.1
• Gene: Pik3cg / 30955
• MGIID: 1353576
• Length: 1102
• Species: Mus musculus
• Alignment Length: 1130
• Identity: 221/1130 - (19%)
• Similarity: 402/1130 - (35%)
• Gaps: 324/1130 - (28%)

  Fly  1472 LREWQRIHGRSTGGKPPETIDSNYRKIHEFLNLIP--------KLLVSRASYNCGEYARALSYLE 1528
            |..|:.:| :|.|            :||.....:|        |.|.|...|:..:.:..
Mouse   122 LHYWKLMH-KSPG------------QIHVVQRHVPSEETLAFQKQLTSLIGYDVTDISNV----- 168

  Fly  1529 SYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMS--VTQDILVNRLVERQQD-- 1589
             :.:|.|...:||:.  ..:.||.|  ||         .:.|.|.  ||...|.:.|.::..:
Mouse   169 -HDDELEFTRRRLVT--PRMAEVAG--RD---------AKLYAMHPWVTSKPLPDYLSKKIANNC 219

  Fly  1590 -MITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADGLWQRLSDRYSDQCFAECKSE--L 1651
             .|..:....|.|.::..|           |||.|   |....:.:::.:.|....:|.:||  .
Mouse   220 IFIVIHRGTTSQTIKVSAD-----------DTPGT---ILQSFFTKMAKKKSLMNISESQSEQDF 270

  Fly  1652 LWRLGSYDE-------MEELQSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLEELR---- 1705
            :.|:...||       ::..|  |..||          |....|...:||...:..|:|:|
Mouse   271 VLRVCGRDEYLVGETPLKNFQ--WVRQC----------LKNGDEIHLVLDTPPDPALDEVRKEEW 323

  Fly  1706 ----SCSAVQQHSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDEDNQEKLMKNYFD-DWQYRL 1765
                .|:.|      ..|...|.:|                   .:|::.....:.:| |.::|:
Mouse   324 PLVDDCTGV------TGYHEQLTIH-------------------GKDHESVFTVSLWDCDRKFRV 363

  Fly  1766 QI------VQPQ-----VRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSAQINR 1819
            :|      |.|:     |.::.:| ...:.:|.  |||.:.:    |..:..|..:||......:
Mouse   364 KIRGIDIPVLPRNTDLTVFVEANI-QHGQQVLC--QRRTSPK----PFAEEVLWNVWLEFGIKIK 421

  Fly  1820 N--AGQLQRAQLYIL-------KAAEYQPSGLFIERAKLLW-------------QKGDQVMAMNY 1862
            :  .|.|...|:|..       ||:...|......:|:||:             :.||.|:.|..
Mouse   422 DLPKGALLNLQIYCCKTPSLSSKASAETPGSESKGKAQLLYYVNLLLIDHRFLLRHGDYVLHMWQ 486

  Fly  1863 LEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIAV--HR-- 1923
            :        ||        .||::..|...|...|....:...:....:|..:...||:  ||
Mouse   487 I--------SG--------KAEEQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHRPT 535

  Fly  1924 ---QSESCHVQMAQFLEKILEARQGGKSEP----TGEQDDMLINVMVNYAK----------SLRY 1971
               :.:....:|...|.|.|||...  ::|    |.|..::|.:......|          |:::
Mouse   536 PDPEGDRVRAEMPNQLRKQLEAIIA--TDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKW 598

  Fly  1972 GSEHV----YQSMPRLISLW-------------LDTTESSTNTE--QVKKM-----NDLLTNCCT 2012
            |.:.:    ||.:.|. .:|             ||...|..|..  .|:|:     :|:|.....
Mouse   599 GQQEIVAKTYQLLARR-EIWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQ 662

  Fly  2013 ALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKL 2077
            .:....|...:...|:|        |.:.|.:..|.:..:   ..|.|               :.
Mouse   663 LVQAVKFEPYHDSALAR--------FLLKRGLRNKRIGHF---LFWFL---------------RS 701

  Fly  2078 VLTDSRLQNSTFQKLLQDF--NSLTERLMDLTNKEVTLDRTYKLSDLDTRLSKLCKQPEFSQILL 2140
            .:..||.....|..:|:.:  ...|..|.|.|.:...::...|:: :|.:.....|....||::.
Mouse   702 EIAQSRHYQQRFAVILEAYLRGCGTAMLQDFTQQVHVIEMLQKVT-IDIKSLSAEKYDVSSQVIS 765

  Fly  2141 PFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILR------SAAKPKK 2199
            ..::.::          |.:.|:||.:        ::..|..|.:...|::.      |..||..
Mouse   766 QLKQKLE----------SLQNSNLPES--------FRVPYDPGLKAGTLVIEKCKVMASKKKPLW 812

  Fly  2200 LTIRCSD-----GKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFN 2259
            |..:|:|     .:...::.|..||||:|..:::    :.|.:..........|.:..|..:...
Mouse   813 LEFKCADPTVLSNETIGIIFKHGDDLRQDMLILQ----ILRIMESIWETESLDLCLLPYGCISTG 873

  Fly  2260 EECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVF 2324
            ::.|::|.:.:..:...|      |:..|.:|...:.                         .|.
Mouse   874 DKIGMIEIVKDATTIAQI------QQSTVGNTGAFKD-------------------------EVL 907

  Fly  2325 QEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDF-NCLFN 2388
            ..||:::......:..|...::.:.|...:..::||:||||.:||:.:| .|:..|:|| :.|.|
Mouse   908 NHWLKEKCPIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMISE-TGNLFHIDFGHILGN 971

  Fly  2389 QGELLPY-PEVVPFRLTHNMIVAMGPLGVEGS--FRKCCEITLR--LLKQESKTLMSILRPFVYD 2448
            ....|.. .|.|||.||.:.:..||..|.:.|  |:|..::.:|  |..:....|:.||    :.
Mouse   972 YKSFLGINKERVPFVLTPDFLFVMGSSGKKTSPHFQKFQDVCVRAYLALRHHTNLLIIL----FS 1032

  Fly  2449 VGAQTRKGAATAKITKDVQRIADRL 2473
            :...|.....|:|  :|::.|.|.|
Mouse  1033 MMLMTGMPQLTSK--EDIEYIRDAL 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	78/405 (19%)
		PIKKc_ATR	2181..2448	CDD:270625	61/283 (22%)
		FATC	2486..2517	CDD:280430
Pik3cg	NP_001139672.1	PI3K_rbd	203..312	CDD:197540	27/134 (20%)
		C2_PI3K_class_I_gamma	350..527	CDD:176044	38/199 (19%)
		PI3Ka_I	549..725	CDD:238444	36/204 (18%)
		PI3Kc_IB_gamma	729..1095	CDD:270627	81/388 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900