DRSC/TRiP Functional Genomics Resources

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Protein Alignment mei-41 and Pik3c2b

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_006249816.1 Gene:Pik3c2b / 289021 RGDID:1306541 Length:1633 Species:Rattus norvegicus


Alignment Length:1578 Identity:304/1578 - (19%)
Similarity:511/1578 - (32%) Gaps:477/1578 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1144 ECLQVRVYALQHLGDLFGRRRPKLNSTILSELPLEPMLEQIVNVLMAGCQHDDSQLQMAS----- 1203
            |.||:...||..|.......|.|.|:        ||.|          ...|:..|...|     
  Rat    28 EALQMEYDALSRLRHHKEESRAKQNT--------EPSL----------ISWDEPALDFYSKPAGR 74

  Fly  1204 ---AKCLGELGAIDASYLPSNYNFAS-PQHLPLNILSD---------------DFAVLALTSLCR 1249
               .|.|..|...|.:.   |||..| |:.||.:...|               |:.         
  Rat    75 RTELKLLRGLSGSDPTL---NYNSISPPEELPNSTSQDPQPGTDPWPKGSQSGDYL--------- 127

  Fly  1250 GYQFQQNTKHVDSFSLAIQETLAIC-GISPKE-QKKVQLWQSLPARMR-------QLMEPMLHSC 1305
             |.|..:.... |.|....:|...| .:||.. ..:|.:|.:.|...|       ::.:|...:.
  Rat   128 -YIFDGSDGRC-SLSPVSGDTDGSCKKLSPPPLPPRVSIWDAPPLPPRKGSPSPSKISQPDDINS 190

  Fly  1306 YTCVHRPSTCL---QQPLFGSHYSHNYYEEWAFLWASRLIDYLPS-SGRRHLLSS-----YKPCI 1361
            ::.|.:||..|   |.|..|.                     ||: .|:||:|.|     ....|
  Rat   191 FSLVEQPSDKLLGAQDPGEGE---------------------LPNGGGQRHVLGSVDYDGINDAI 234

  Fly  1362 KRDSNMLSTFYPYILLHALLECTTEQRNHIQEEFMAVLQANEESSSSVRGRQEL----------- 1415
            .| .|:.||:...||..|         ....:|....|..::::|.....|.:.           
  Rat   235 TR-LNLKSTYDSEILSDA---------TRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYT 289

  Fly  1416 --GAIKENAFKQFESRKYAAGIKPLASTL--------VSDRKEDSSRVPRLAGKLCAELLDFLQR 1470
              .|.::||......|..||.:.....|:        ||:.:::.      ....| .:||.   
  Rat   290 PRYANRKNATPGKNRRISAAPVSSRTHTVTNGHELFEVSEERDEE------VAAFC-HMLDI--- 344

  Fly  1471 WLREWQRIHGRSTGGKPPETIDSNYRKIHEFLNLIPKLLVSRA------SYNCGEYA-----RAL 1524
             ||........|..|....|:..:...:.:.:||...:|....      :.||....     :.|
  Rat   345 -LRTGSDTQDYSLTGCVWSTVTPSPEHLGDEVNLKVTVLCDSLREPLTFTCNCSSTVDLLIYQTL 408

  Fly  1525 SYLESYLEEGEDKSQRL----LEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQDILVNRLVE 1585
            .|....|.|.:.....|    ||:|.......|      |.|.....|.:|:::       ||..
  Rat   409 CYTHDELREVDVGDFVLKPCGLEEFLQNKHALG------SHEYIQHCRKFDINI-------RLQL 460

  Fly  1586 RQQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKT------------------AQLIADGLW 1632
            .:|..|.| :...:..|...|..:..:|....|...:|                  |.|:|:|.:
  Rat   461 MEQKAIRS-DLARTVNDDQSPSTLNYLIHLQERPVKQTISRQALSLLFDTYHNEVDAFLLAEGDF 524

  Fly  1633 QRLSDRYSDQCFAECKSELLWRLGSYD--EMEELQSNWPAQCSQGCLKLRRP---LTTRIEFDSL 1692
            ...:||......|.|.:     |.:.:  |:....:..|...|:...|:::.   ||.|...:.:
  Rat   525 PLKADRVVQSVKAICNA-----LAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLTVRENREKV 584

  Fly  1693 LDGMRESVLEELRSCSAVQQHSYANAYDAVLKLHLVHE--------------------------- 1730
            ::.:..::|:.:....:.....:..|.....|..||.|                           
  Rat   585 VEALTAAILDLVELYCSTFNADFQTAVPGSRKHDLVQEACHFSGALAFTVYGTHRIPIIWATSYE 649

  Fly  1731 ---LHCS-----QELVEKLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNIL- 1786
               |.||     :||...|:..|          .:|..:.:.|.|...|:.....:....|..| 
  Rat   650 EFYLSCSLSHGGKELCSPLQTRR----------AHFSKYLFHLIIWDQQICFPVQVNRLPRETLL 704

  Fly  1787 -----------------AELQRRLTDRNHLLPHLKTELARIWLNSAQIN-RNAGQLQRAQLYILK 1833
                             |..|:|:.:            |..|:.:...| |......|..|.:..
  Rat   705 CATLYALPIPPPGSSSEANKQKRVPE------------ALGWVTTPLFNFRQVLTCGRKLLGLWP 757

  Fly  1834 AAEYQPSGLFIERAKLLW------QKGDQVMAMNYLEEQLSIMRSGCQGN-------VKQLAAEQ 1885
            |.:        |.:...|      |....::.:::......|..:...|:       ...|..|.
  Rat   758 ATQ--------ENSSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREED 814

  Fly  1886 RHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSEP 1950
            :      :.|:.:...||::..:||..|...|      :...||.:::. |..:|      .|.|
  Rat   815 Q------RKLKDITQKESLYWLSDADKKQLWE------KRYYCHTEVSS-LPLVL------ASAP 860

  Fly  1951 TGE---QDDMLINVM----VNYAKSLRYGSEHVY---QSMPRLISLWLDTTESSTNTEQVKKMND 2005
            :.|   ..|:...:.    :|:..:|  |..|..   |.:.|:...|:.:...:       ::.|
  Rat   861 SWEWACLPDIYALLQQWTHMNHQDAL--GLLHATFPDQEVRRMAVQWIGSLSDA-------ELLD 916

  Fly  2006 LLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKL-VEAYPQQSLWMLLPHFKSAKA 2069
            .|.....||.    |..|      |..|:  |..:|:..|..| |..|   ..|:|         
  Rat   917 YLPQLVQALK----YECY------LDSPL--VRFLLKRAISDLRVTHY---FFWLL--------- 957

  Fly  2070 HRIKRCKLVLTDSRLQNSTFQKLLQDF-----NSLTERLMDLTNKEVTLDRTYKLSDLDTRLSKL 2129
                  |..|.||:. :..:|.||...     ..|.|..    |::..|..|         |:||
  Rat   958 ------KDSLKDSQF-SIRYQYLLAALLCCCGKGLREEF----NRQCWLVNT---------LAKL 1002

  Fly  2130 CKQ-----PEFSQ-ILLPFEKYMQPTLPLNSDSNSSEGS-HLPANQSTVNWFPYQQIYISGF-QE 2186
            .:|     |...| ||....:.::....||       || .||.:.|         :.:.|. ..
  Rat  1003 AQQVREATPSARQGILRAGLEEVRQFFALN-------GSCRLPLSPS---------LLVKGIVPR 1051

  Fly  2187 SVLILRSAAKPKKLTIRCSD--GKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLH 2249
            ......|.|.|.||..:..|  |::..|:.|..||||:|...::...::.:...|:. ...|.:.
  Rat  1052 DCSYFNSNAVPLKLAFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEG-LDMRMVI 1115

  Fly  2250 IRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTK 2314
            .|.::.   ....|:||.:||..:.|.|.:     ...|..:.:.:.||                
  Rat  1116 FRCFST---GRGKGMVEMIPNAETLRKIQV-----EHGVTGSFKDRPLA---------------- 1156

  Fly  2315 QLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAV 2379
                       :||::.......:.:|...:|.:.|...:..||||:.|||.:||:. :..|...
  Rat  1157 -----------DWLQKHNPGEDEYEKAVENFIYSCAGCCVATYILGICDRHNDNIML-KTTGHMF 1209

  Fly  2380 HVDFNCLFNQGELLPYPEV--------VPFRLTHNMIVAMGPLGVEGSFR------KCCEITLRL 2430
            |:||      |..|.:.::        .||..|.:|...:.. |.:.|.|      .||: ...|
  Rat  1210 HIDF------GRFLGHAQMFGNIKRDRAPFVFTSDMAYVING-GDKPSSRFHDFVDLCCQ-AYNL 1266

  Fly  2431 LKQESKTLMSILRPFVYDVGAQTRKGAATAKITKDVQRIADRLQGHVKRQQANSIPLSTEGQVNF 2495
            :::.:...:::|       |.....|.......:|::.:.|.|:  .:..:||:....|....:.
  Rat  1267 IRKHTHLFLNLL-------GLMLSCGIPELSDLEDLKYVYDALR--PQDTEANATTYFTRLIESS 1322

  Fly  2496 LINEATK----VDNLASM 2509
            |.:.|||    :.|||.|
  Rat  1323 LGSVATKLNFFIHNLAQM 1340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825
FAT 1653..1985 CDD:280429 65/413 (16%)
PIKKc_ATR 2181..2448 CDD:270625 59/283 (21%)
FATC 2486..2517 CDD:280430 9/28 (32%)
Pik3c2bXP_006249816.1 PI3K_rbd 363..465 CDD:395642 22/114 (19%)
C2A_PI3K_class_II 621..793 CDD:175979 28/201 (14%)
PI3Ka_II 812..980 CDD:238441 46/226 (20%)
PI3Kc_C2_beta 986..1339 CDD:119421 92/435 (21%)
PX_PI3K_C2_beta 1368..1476 CDD:132823
C2B_PI3K_class_II 1504..1626 CDD:176027
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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