DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and rad3

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	NP_595357.1	Gene:	rad3 / 2540719	PomBaseID:	SPBC216.05	Length:	2386	Species:	Schizosaccharomyces pombe

Alignment Length:	2448	Identity:	594/2448 - (24%)
Similarity:	1013/2448 - (41%)	Gaps:	521/2448 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 LKRLNITTKLLLEVLHMRARPAHHLGYLLLNEILSLPTAIELDDGLLETLSSYIQGQLEHSVVPL 328
            |||::|....|.  ||:.:|                         :::||..:....:.|.:...
pombe   264 LKRISIGDSQLF--LHLHSR-------------------------IVQTLCCFSLNFIYHGLPIC 301

  Fly   329 EQLVHLQQLMLSHWHCHPTHLVPILALMGLKQT-EMRSGVVQVLTQSLVEILKKEEVLSKDWQKL 392
            |:..|:....::            |.|..||:| .:.:..:.:...||.       ||.|....|
pombe   302 EKSKHILMSSIN------------LTLGSLKKTYTVANTAISLFFLSLF-------VLPKTVAGL 347

  Fly   393 -----IAILRGFKQLEKL----------ILSQSQHKIAEHEGHIDSSVLAMLPLQCEIIKVADTN 442
                 :::|..||.||:|          ||.:.:::.:|    ||.:.|......| ..|:.:|.
pombe   348 FYPFGVSLLSDFKVLEQLEPDSDLKKAIILFKCRYQSSE----IDQTTLRAFGEIC-TGKLENTL 407

  Fly   443 WNNLSMQLVELESKCSADRRHIHLEICSLLMQITFIRHFLKTQTQHQLLAILQRHLKLSY----- 502
            ::|..:.|                          |:.|:|.....      |...||:.:
pombe   408 FSNSELNL--------------------------FLLHYLSLDND------LSNILKVDFQNGHN 440

  Fly   503 LCAI-------RLETPSSV--HTQMQSFYAQQYMRLFQSEETQE----IFCSNLPQLYISGFIKP 554
            :|..       .|:.||::  ..:|..:|:...:.:  ||:..:    :.|:::.:
pombe   441 ICTFAKWCINNNLDEPSNLKHFREMLDYYSSHNVTI--SEDDLKNFSLVLCTHVAK--------- 494

  Fly   555 EQLMKALPTINNRSGRAQVIRLL----------LCSQPGKLSVFKVKDRIELYCPKCRPLPKKLP 609
                     :|.::.  .:.|..          .|....:.|:||:... ||:|...     |.|
pombe   495 ---------VNEKTN--SIFRTYEVHGCEVCNSFCLLFDERSLFKIPYH-ELFCALL-----KNP 542

  Fly   610 GIYLGKCKQQLPCPDF-------SSTNLEMIANDLLFYPDFECIAQHLDLLCFEPNVILGLLRET 667
            .|.....||.|....|       |:.|.|                   .:|.....::..|...:
pombe   543 DIISSSVKQSLLLDGFFRWSQHCSNFNKE-------------------SMLSLREFIMKALASTS 588

  Fly   668 EALQKVSVKVIGQLVSAMRVRSP------EFLEQLANLVLAAIKAMLAKPLTEQNVLQQRSMLNV 726
            ..|:.|:.||:     .:.::.|      ||.::...|:...:|.:    ..|...:.:..:|:.
pombe   589 RCLRVVAAKVL-----PIFIKGPNNLDIVEFHKESKALIFNTLKIL----AVENTAILETVILSW 644

  Fly   727 LTAIAHMEDNEIWLFHWFKMTFFFLVHTRSLVAQEAVLAATEMCASQGLQTIHLWNWYKRDALDL 791
            ::....:|:.|:   |:..:.....|....:..|...|:|.:..||    |.|:..|........
pombe   645 ISLSRVVEEEEL---HFVLLEVISSVINSGIFYQGIGLSALQQIAS----TRHISVWQLLSPYWP 702

  Fly   792 TVRLALNVYLLDGVRFTRSLRALTKMLGFTCVQEFTCKYHRLLTAMVLPHCIVNPLCKGVLVLIA 856
            ||.:|    ::.|:....::.:|...|......:|..:    ..|..||..::.. .|.::|.||
pombe   703 TVSVA----IVQGMGKKPNIASLFAQLMNISEGDFLIR----TQAYTLPFLVLTK-NKALIVRIA 758

  Fly   857 KQMQKHIGTLFSISFLRIYTHVFLTEEPELANSCIELVVSCTQS----SLQQLMNAD-VKQTVAE 916
            :..|..:.||...:..:|...:..|:.|.|..|.:.|:...|..    .|..|:.:| :..||..
pombe   759 ELSQSDVATLCLTNMHKILASLLTTDHPNLEESVMLLLSLATSDFEKVDLTSLLRSDPISITVEL 823

  Fly   917 LLIYFNRNPTFVMRSFQSLLQLSIGSLEELSSQTANAE-------FANFIAERFLGVITYFESCL 974
            |.:|.|..|       ...::.::..:..:.||..|.|       ..:|.....||::..|.:.|
pombe   824 LQLYQNDVP-------HEKIENALRKVAMIVSQVVNDEDLSNKELLYDFFNNHILGILAEFSNIL 881

  Fly   975 SEPSFEKPLKE--ETLYSLGQIMRFVGSQHVTQFRFKIIAMLSFVHT-LQEPRLQRICLKIWHIF 1036
            ::...:..:.|  :|:..:.:::...|.    ..:..:..:||.:.: .|...|:...:|.|...
pombe   882 NDLKGKTSINEKIKTIVGIEKMLSLCGG----AVKLGLPQILSNLQSAFQNEHLRFYAIKAWFSL 942

  Fly  1037 LHVVNVQELGPSLGRIVATLQPLL--ADNESVKQVNDLYEFIILRNASMLGTFITDLYFLDRMEN 1099
            :......|.....|..:..|.||.  .:.:..:.|..:::||
pombe   943 ILATKEPEYSSIAGLSLVILPPLFPYLEPQEAELVIQIFDFI----------------------- 984

  Fly  1100 VSPSIQKCIR---------RHTAHLDLKGLAEE---ENQSPPLVDQLRFLQKHITDECLQVRVYA 1152
             |....||::         ..:|...||  |:|   ..|:.....:|:.:.|.:|:|...|....
pombe   985 -SSDTHKCLQGLKWAIPTSLDSACFSLK--AKEIFCSLQNEDFYSELQSIIKCLTNENEPVCYLG 1046

  Fly  1153 LQHLGDLFGRRRPKLNSTILSELPLEPMLEQIVNVLMAGC---QHDDSQLQMASAKCLGELGAID 1214
            ||.|...|..:..:|:.|:..::..| :|:|::..|:..|   ...:.|:...:||.||||||||
pombe  1047 LQKLELFFQAKVDELHDTLNLDISNE-VLDQLLRCLLDCCVKYASTNMQISYLAAKNLGELGAID 1110

  Fly  1215 ASYLPSNYNFASPQH-LPLNILSDDFA--------VLAL--TSLCRGYQFQQNTKHVDSFSLAIQ 1268
                ||.   |..|| :...::.|:|.        :|..  :.|...:....:||.....:.|:|
pombe  1111 ----PSR---AKAQHIIKETVVLDNFENGEESLKFILDFMQSQLIPAFLVTTDTKAQGFLAYALQ 1168

  Fly  1269 ETLAICGISPK--EQKK-----VQLWQSLPARMRQLMEPMLHSCYTCVHRPSTCLQQPLFGSHYS 1326
            |.|.:.|....  .:||     .:.|.|||...::::.|.|.|.|.....|...::.|::..:.:
pombe  1169 EFLKLGGFKSAVINKKKGLTVVTEHWMSLPDLSKRVLIPFLTSKYHLTPIPKIDIRYPIYKENVT 1233

  Fly  1327 HNYYEEWAFLWASRLIDYLPSSGRRHLLSSYKPCIK-RDSNMLSTFYPYILLHALLECTTEQRNH 1390
               ...|..|::.:|::|..|.....:.......:| ::.|:.....|:::|:.:|..:..:.|.
pombe  1234 ---IHTWMQLFSLKLMEYAHSQNAEKIFGICSKVVKDQEVNIPCFLLPFLVLNVILTESELEVNK 1295

  Fly  1391 IQEEFMAVL-QANEESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPLASTLVSDRKEDSSRVP 1454
            :.|||..|: |...:..:|| |:|...:..:..||
pombe  1296 VIEEFQLVINQPGPDGLNSV-GQQRYTSFVDVFFK------------------------------ 1329

  Fly  1455 RLAGKLCAELLDFLQRWL-----REWQ------RIHGRSTGGKPPETIDSNYRKIHEFLNLIPKL 1508
                     ::|:|.:||     |.|.      |...|....:...:.:|:..|:..||:..|..
pombe  1330 ---------IVDYLNKWLRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVESFLSRFPSK 1385

  Fly  1509 LVSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMS 1573
            .:...|.|||.:||||.|.|.::.........|...:..|.|:|..:.|||.:| ||.:..:|.|
pombe  1386 TLGIVSLNCGFHARALFYWEQHIRNATAPYAALESDYRVLQEIYAGIDDPDEIE-AVSLNFHDYS 1449

  Fly  1574 VTQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADGLWQRL--- 1635
            ..|.:|::.........::.||.::    |..|::.:|.|..       ...::..|.::.|
pombe  1450 FDQQLLLHENSGTWDSALSCYEIII----QKDPENKKAKIGL-------LNSMLQSGHYESLVLS 1503

  Fly  1636 ------SDRYSDQCFAECKSELLWRLGSYDEMEELQSNWPAQCSQGCL------KLRRPLTTRIE 1688
                  :|.:..........|..||..|.|.:::..|....:..:..|      .||:.     .
pombe  1504 LDSFIINDNHEYSKMLNLGIEASWRSLSIDSLKKCLSKSNLESFEAKLGSIFYQYLRKD-----S 1563

  Fly  1689 FDSLLDGMRESVLEELRSCSAVQQHSYANAYDAVLKLHLVHELHCSQE---LVEKLEQDRDEDNQ 1750
            |..|.:.::...::...:.:....||..:.||.:.|||.:::.....|   :|        .||.
pombe  1564 FAELTERLQPLYVDAATAIANTGAHSAYDCYDILSKLHAINDFSRIAETDGIV--------SDNL 1620

  Fly  1751 EKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTE----LARIW 1811
            :.:::.       ||..|.|..:.:..|.|                .||:.:.|.|    .|.|:
pombe  1621 DIVLRR-------RLSQVAPYGKFKHQILS----------------THLVGYEKFENTKKTAEIY 1662

  Fly  1812 LNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQG 1876
            |..|:|:|..||.|||...||||.:.......||.|:..|.:|....|::.|...|:       .
pombe  1663 LEIARISRKNGQFQRAFNAILKAMDLDKPLATIEHAQWWWHQGQHRKAISELNFSLN-------N 1720

  Fly  1877 NVKQLAAEQRHL----------FFRGK-YLQAV-YSAESMHLCADAVLKYFQEAIAVHRQSESCH 1929
            |:..|..|....          ..:|| :|:.. :..::..|....:..|:.:|:.::.:.|:.|
pombe  1721 NMFDLVDEHEERPKNRKETLGNPLKGKVFLKLTKWLGKAGQLGLKDLETYYHKAVEIYSECENTH 1785

  Fly  1930 VQMAQFLEKILEARQGGKSEPTGEQDDM-----LINVMVN-YAKSLRYGSEHVYQSMPRLISLWL 1988
            ..:......:.|..|   ..|..||.:.     |:..::| :.:||.||:.|:|:|||:|::|||
pombe  1786 YYLGHHRVLMYEEEQ---KLPVNEQSERFLSGELVTRIINEFGRSLYYGTNHIYESMPKLLTLWL 1847

  Fly  1989 DTTES------------------STNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVN 2035
            |....                  |:..:.::.||..:......:|...|....|||:||:|||.|
pombe  1848 DFGAEELRLSKDDGEKYFREHIISSRKKSLELMNSNVCRLSMKIPQYFFLVALSQMISRVCHPNN 1912

  Fly  2036 DVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLT---DSRLQNST---FQKLLQ 2094
            .|:.:|.::|..:|.:||.::||.|:...||....|..|.|.:|.   ..:|..|:   .:.|.|
pombe  1913 KVYKILEHIIANVVASYPGETLWQLMATIKSTSQKRSLRGKSILNVLHSRKLSMSSKVDIKALSQ 1977

  Fly  2095 DFNSLTERLMDLTNKEVTLDRTYKLSDLD-TRLSKLCKQPEFS---QILLPFEKYMQPTLPLNSD 2155
            ....:||:|::|.|..:. .::.|:|..| .|||       |.   .:::|.:.::..|||. .|
pombe  1978 SAILITEKLINLCNTRIN-SKSVKMSLKDHFRLS-------FDDPVDLVIPAKSFLDITLPA-KD 2033

  Fly  2156 SNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDL 2220
            :|  ..||.|        ||..|..:..|::.|.|:.|..||:|:.:|.:||..|..|.||||||
pombe  2034 AN--RASHYP--------FPKTQPTLLKFEDEVDIMNSLQKPRKVYVRGTDGNLYPFLCKPKDDL 2088

  Fly  2221 RRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQR 2285
            |:||||||||.|:.:.|.:|..|.:|.|.||||.|:|.|||||.:||:.:...:|.|.:..|.|:
pombe  2089 RKDARLMEFNNLICKILRKDQEANRRNLCIRTYVVIPLNEECGFIEWVNHTRPFREILLKSYRQK 2153

  Fly  2286 RLVMSTRQLQSLAVPLHESIERKR--EVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRT 2348
            .:.:|   .|.:.|.|..::....  ::|.|:::|..||||.||..:.|..|::|..:|..|.||
pombe  2154 NIPIS---YQEIKVDLDFALRSPNPGDIFEKKILPKFPPVFYEWFVESFPEPNNWVTSRQNYCRT 2215

  Fly  2349 VAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGP 2413
            :||||:|||:|||||||||||||.|..|:|:||||||||::|.....||.|||||||||:.||||
pombe  2216 LAVMSIVGYVLGLGDRHGENILFDEFTGEAIHVDFNCLFDKGLTFEKPEKVPFRLTHNMVDAMGP 2280

  Fly  2414 LGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYDVGAQ-TRKGAATAKITKDVQRIAD----RL 2473
            .|.||.|||..|||:|||:....||||:|..|::|...: .||.:::.....:...:.|    :.
pombe  2281 TGYEGGFRKASEITMRLLRSNQDTLMSVLESFLHDPLVEWNRKKSSSKYPNNEANEVLDIIRKKF 2345

  Fly  2474 QGHVKRQQANSIPLSTEGQVNFLINEATKVDNLASMYIGWGAF 2516
            ||.:   ...:||||.|||:..||..|....||..|||||.|:
pombe  2346 QGFM---PGETIPLSIEGQIQELIKSAVNPKNLVEMYIGWAAY 2385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825	18/107 (17%)
		FAT	1653..1985	CDD:280429	82/362 (23%)
		PIKKc_ATR	2181..2448	CDD:270625	135/268 (50%)
		FATC	2486..2517	CDD:280430	17/31 (55%)
rad3	NP_595357.1	TEL1	177..2386	CDD:227365	594/2448 (24%)
		UME	862..968	CDD:214825	19/109 (17%)
		PIKKc_ATR	2051..2322	CDD:270625	136/273 (50%)
		FATC	2355..2386	CDD:280430	17/31 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	260	1.000	Domainoid score	I371
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	530	1.000	Inparanoid score	I216
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004409
OrthoInspector	1	1.000	-	-		oto100660
orthoMCL	1	0.900	-	-		OOG6_102609
Panther	1	1.100	-	-	LDO	PTHR11139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2044
SonicParanoid	1	1.000	-	-		X3128
TreeFam	1	0.960	-	-
	12	11.850