Protein Alignment mei-41 and tor1

DIOPT Version :10

• Sequence 1: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Sequence 2: NP_596275.1
• Gene: tor1 / 2540473
• PomBaseID: SPBC30D10.10C
• Length: 2335
• Species: Schizosaccharomyces pombe
• Alignment Length: 2821
• Identity: 572/2821 - (20%)
• Similarity: 997/2821 - (35%)
• Gaps: 900/2821 - (31%)

  Fly    98 ERLVLAYVEAIEE----THLQLSSLDLGQLSNERKPAITVRIFRCDVECLQEFDPHCAIEDIKVP 158
            |.:.||..:.::|    :..:||...|.:.:|:    |..|||    |.:...|.|
pombe    12 ESIQLAAADQLKEFVHSSTKELSGESLARFNND----INRRIF----ELIHSHDSH--------- 59

  Fly   159 LEQADMYAKSLLEVLQHAHHIGYATHGDIFSGSLHQALLILKECDMDTKLASLNYCHNVLR-SQS 222
                                       :.|.|.|....||  |.:.:..:.:|:...|.|| :..
pombe    60 ---------------------------ERFGGILAIGKLI--EFESEGDVTNLSRYANYLRMTLP 95

  Fly   223 ASSW----ITNPDVGHYAQL--TLEATAIMWSA--VAKWLDMGCMTRQELKRLNITTKLLLEVLH 279
            ::.|    ::...:||.|..  ||.|..:.:..  ..:||.   ..|||.||:  ...|:::.|
pombe    96 STDWHSMELSAKVLGHLAASGGTLAAEFVEFEVQRAFEWLQ---GDRQEQKRM--AAILIIKAL- 154

  Fly   280 MRARPAHHLGYLLLNEIL-SLPTAIELDDGLL-ETLSSYIQGQLEHSVVPLEQLVHLQ---QLML 339
              |:.:..|.||.::||. :|.|.:.....|: ||.:..:...|: .|...|..|.||   :::|
pombe   155 --AQNSPTLVYLYISEIFQNLWTGLRDPKPLIRETAADALGASLD-VVCQREAKVQLQCFNEVLL 216

  Fly   340 SHWHCHPTHLVPILALMGLKQTEMRSGVVQVLTQSLVEILKKEEVLSKDWQKLIAILRGFKQLEK 404
            ...|             ||:|:.     |:.|..||:                     .:|:|
pombe   217 QAEH-------------GLRQSS-----VEYLHGSLL---------------------AYKEL-- 240

  Fly   405 LILSQSQHKIAEHEGHIDSSVLAMLPLQCEIIKVADTNWNNLSMQLVELESKCSADRRHIHLEIC 469
              ..:|...|.||.                      |.:.:|:::|.|        .|...:..|
pombe   241 --FEKSGSFIREHY----------------------TEFCDLALRLRE--------HRDNSIRRC 273

  Fly   470 SLLMQITFIRHFLKTQTQHQLLAILQRHLK--LSYLCA-IRLETPSSVHTQMQSFYAQQYMRLFQ 531
                 |.|:   |.|.:::......||:|.  :.||.: ||.:...|:     :|.|...:.:..
pombe   274 -----IVFL---LPTLSEYNPKKFQQRYLDSFMVYLLSHIRKDKEKSL-----AFEAIGRIAMAV 325

  Fly   532 SEETQEIFCSNLPQLYISGFIKPEQLMKALPTINNRSGRAQVIRLLLCSQPGKLSVFKVKDRIEL 596
            :|       :.:|  |:...:|                   |||..|.:        ||:::
pombe   326 NE-------AMIP--YLQNILK-------------------VIRDTLTA--------KVREK--- 351

  Fly   597 YCPKCRPLPKKLPGIYLGKCKQQLPCPDFSSTNLEMIANDLLFYPDFECI-----AQHLDLLCFE 656
                                           |..|.        |.||||     |..|:|| .:
pombe   352 -------------------------------TQYEK--------PVFECIGMLAAAVKLELL-ED 376

  Fly   657 PNVILGLLRETEALQKVSVKVIGQLVSAMRVRSPEFL----EQLANLVLAAIKAMLAKPLTEQNV 717
            ...:|||:...|    :||.:...||. |....|..|    |:|.|        |:::.||.:|.
pombe   377 SRSLLGLIFSCE----LSVHLRQALVK-MAENIPPLLAPIQERLLN--------MVSQILTGKNF 428

  Fly   718 ------LQQRSMLNVLTAIAHMEDNEIWLFHWFKMTFFFLVHTRSLVAQEAVLAATEMCASQGLQ 776
                  ....|..|:.:|   .|.::                 ||...:..:||         |:
pombe   429 EIRTNDTYTPSFTNIYSA---REPDQ-----------------RSKSTESIILA---------LE 464

  Fly   777 TIHLWNWYKRDALDLTVRLALNVYLLDGVRFTRSLRALTKMLGFTCVQEFT----CKYHRLLTAM 837
            |:..:|:.....:.......|: ||.:.....|...|.      ||.|.|.    |:....|...
pombe   465 TLGTFNFTGYSLISFIQESVLS-YLENDNSEIRIAAAR------TCCQVFARDPICRKTNPLAVE 522

  Fly   838 VLPHCIVNPLCKG-----------VLVLIAKQMQKHIGTLFSIS--FLRIYTHVFLTEE------ 883
            .:...:...|..|           ||.|:.::..:|:....:|.  |:.:...||...|
pombe   523 SVAEVLEKLLTLGIADSDPKIRETVLSLLDERFDRHLAHPDNIRCLFIALNDEVFSIREIAIIII 587

  Fly   884 ------------PELANSCIELVVSCTQSSLQQLMNADVKQTVAELL-IYFNRNPTFVMRSFQSL 935
                        |.|..:.|:|:     |.::...|:..|:..|:|| :..::..|.:....||:
pombe   588 GRLALYNPAHVMPSLRKTIIQLL-----SDMEYSGNSRQKEESAQLLKLLVSKARTLIKPYIQSI 647

  Fly   936 LQLSIGSLEELSSQTANAEFANFIAERFLGVITYFESCLSEPSFEKPLKEETLYSLGQIMRFV-- 998
            :.:.:....:.|...::|            :|:......|....:.|:...     |..|:.:
pombe   648 IHVILPKAADTSPGVSSA------------IISALGELASVEGEDMPVDVR-----GSFMKLILV 695

  Fly   999 --GSQHVTQFRFKIIAMLSFVHTLQEPRLQRICLKIWHIFLHVVNVQELGPSLGRIVATLQ---- 1057
              ..|..|   .|.:|.|..        |:::|.:..::   :....:..|.||.::..||
pombe   696 NLQDQSST---LKRLASLKC--------LRKLCGRSGYV---IQPYLDYPPLLGALIGILQSEQP 746

  Fly  1058 -PLLADNESVKQVNDLYEFIILRNASMLGTFITDLYFLDRMENVSPSIQKCIRRHTAH------- 1114
             |:..:              :||...:||..  |.|.....|.||..:|.  ..:.||
pombe   747 TPIRRE--------------VLRTLGVLGAL--DPYTYLTTEEVSDDLQS--SHNNAHGVPQISA 793

  Fly  1115 --------------LDLKGLAEEENQS-------------------------PPLVDQLRFLQKH 1140
                          :.|.|:.::.:.|                         |.:|.  .|||..
pombe   794 AQYPSLENYAMVAVVTLIGILKDSSLSMHHSSVVQAVMHICSQMGSKSTVFLPQVVP--TFLQVM 856

  Fly  1141 ITDECLQVRVYALQ--------------HLGDLFGRRRPKLNST-----ILSEL----------P 1176
            .:........|..|              ::.|:|...:....||     ::.||          .
pombe   857 QSLSASSAEFYFQQLTTLTSIIGPNIRDYVSDIFNLSKVFWESTTSLLLVILELIDAIAIALQDE 921

  Fly  1177 LEPMLEQIVNVLMAGCQHDDSQLQMASAKCLGELGAIDASYLPSNYNFASPQHLPLNILSDDF-- 1239
            .:..|.||::.::.....|::..:..|.|.|       .|::....|.....||.|.::...|
pombe   922 FKFYLPQILSCMLKAFSLDNTSSRSVSYKVL-------QSFVIFGSNIEEYMHLVLPVIIRSFER 979

  Fly  1240 ----------AVLALTSLCRGYQFQQNTKHVDSFSLAIQETLAICGISPKEQKKVQLWQSLPARM 1294
                      |:..:..|.:...|.      |..|..|...:.:.|.|..:.:.| :..:|.|.:
pombe   980 DTIPLGFRKSALKCIAQLFQSVNFS------DHASRIIHPLVRMLGKSNGDLRAV-IMDTLCAIV 1037

  Fly  1295 RQL------MEPMLHSCYTCVHRPSTCLQQPLFGSHYSHNYYEEWAFLWASRLI--DYLPSSGRR 1351
            .||      ..||::              :.|.....||..||    |..|||:  :.||   :.
pombe  1038 SQLGYDYSIFIPMVN--------------KVLVSHKISHPAYE----LLVSRLLKGEPLP---KD 1081

  Fly  1352 HLLSSYKPCIKRDSNMLSTFYPYILLHALLECTTEQRNHIQEEFM-------AVLQANEESSSSV 1409
            .::..:||  :..:...||                     |:|.:       |.|:|..|||..:
pombe  1082 VVVKEFKP--RPSTKPFST---------------------QDEVLTKLPVDQASLKAAWESSQKL 1123

  Fly  1410 R--------GRQELGAIKENAFKQFESRKYAAGI-KPLASTLV-------------SDRK----- 1447
            .        .|..:..:||:......|....||| .|||..|.             |::|
pombe  1124 TRDDWQDWIRRISIELLKESPSSALRSCSTLAGIYHPLARDLFNVSFLSCWDELTESNKKNLVKS 1188

  Fly  1448 -EDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGGKPPETIDSNYRKIHEFLNLIPKLLVS 1511
             |.:...|.::.::...||:..:...||             ..|:.            ||..::|
pombe  1189 IELAMNAPNISVEILQTLLNLAEYMERE-------------DHTLP------------IPIKVIS 1228

  Fly  1512 RASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQ-VRSYDMSVT 1575
            ..:..|..||:||.|.|....: |.|.:..:.....|:.:...|:..|:..|.:| .:.:.....
pombe  1229 AHASKCNVYAKALHYTELQFVQ-ETKEEVSISTIESLITINNHLQQSDAAVGMLQYTKEHKQFSL 1292

  Fly  1576 QDILVNRLVERQQDMITSYEQLLSSTDQMQPDHVRAMIDAY-LRDTPKTAQLIADGLWQRLSDRY 1639
            ::....:| .|..|.:.:||......|.....::..:...| |.|....::| |...|. .|::.
pombe  1293 KETWYEKL-HRWDDALAAYEHREREGDSSFEINIGKLRCYYALGDWDHLSEL-AQKAWV-TSEQE 1354

  Fly  1640 SDQCFAECKSELLWRLGSYDEMEELQSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGM-------- 1696
            ..:..|...:...|.||.::.:.|..|...          |.|...  ||.|.:..:
pombe  1355 HREAIAPLAAAAAWGLGQWNLISEYVSAMD----------RDPQDK--EFFSAISAVHLGQYNKA 1407

  Fly  1697 -------RESVLEELRSCSAVQQHSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDEDNQEKLM 1754
                   |:.::.:|   |::...||..||..::|..::.||   :|:::..:..:.|:|.:.|.
pombe  1408 YGHIERHRDILVNDL---SSIIGESYNRAYGIMVKSQMLSEL---EEIIDYKKNMQYENNLDSLK 1466

  Fly  1755 KNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSAQINR 1819
            |.    |:.||:..|..|.:..:...||..:|:             |....|:   |:..|.:.|
pombe  1467 KT----WRKRLEGCQKNVDVWHNTLRFRALVLS-------------PQDSPEM---WIKLADLCR 1511

  Fly  1820 NAGQLQRAQLYILKAAEYQPSGLF-IERAKL------------LWQKGDQVMAMNYLEEQLSIMR 1871
            .:.:|:.:...:.......||..: ::..||            ||....:.:|::.|||..|.:.
pombe  1512 RSDRLKLSNQCLTYLMGRDPSNAYPLDSLKLLNPHVVYTYLKYLWATDQKNIAVSELEEFTSYLS 1576

  Fly  1872 S--GCQ-GNVKQL---------AAEQRHLFFR-----GKYLQAVYSAESMHLCADAVLKYFQEAI 1919
            |  |.: |:..:|         ::|:|....|     ||:.:::..:.:.....|.:..||...:
pombe  1577 SKHGYKMGDSSKLVDILASSSVSSEERSFLARCFHKLGKWKKSLQDSVNQESVRDILNCYFYATL 1641

  Fly  1920 AVHRQSESCHVQMAQFLEKILEARQGGKSEPT--GEQDDMLINVMVNYAKSLRYGS----EHVYQ 1978
            ......::.|.......|.:      |..|.|  |...||....:|...|...:.|    ::..|
pombe  1642 FDKSWYKAWHSWALANFEVV------GYYEQTEHGVTQDMYEQYIVPAIKGFFHSSVLNQKNSLQ 1700

  Fly  1979 SMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRN 2043
            .:.||::||....|.|   :....:.:..:|    :|...:..|..|:::|:....:.|...:..
pombe  1701 DILRLLNLWFKFGEHS---DVAAAIVEGFSN----VPMDTWLEVIPQLIARIHTSSSSVRASVHQ 1758

  Fly  2044 VIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNS---------TFQKLLQD---- 2095
            ::..:...:||..::.|....||....:....|.:: ||.|.:|         ..|:|::.
pombe  1759 LLSDIGRVHPQALVYSLTVSSKSTNPQQKHSAKSIM-DSMLSHSDTLVRQALLVSQELIRVAILW 1822

  Fly  2096 ----FNSLTER------------LMDLTNK-EVTLDRTYKLSDLDTRLSKLCKQPEFSQILLPFE 2143
                :..|.|.            ::|:... ..||::.      .:.||::.....|...|....
pombe  1823 HELWYEGLEEASQAYFSDHDISLMIDIVKPLHETLEKG------PSTLSEISFAQTFGYDLRKAR 1881

  Fly  2144 KYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIY---------------------------- 2180
            .|.|..|        .:|.....|||   |..|.|::
pombe  1882 SYWQKFL--------QDGDPTELNQS---WDLYYQVFRRIQKQLPRIKHLELQYVSPKLLDACDL 1935

  Fly  2181 ----------------ISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEF 2229
                            ||.|..:..::.|..:|::|||..||||||..::|..:|||:|.|:|:.
pombe  1936 ELAVPGTYGHNKPVIRISHFHHTFEVISSKQRPRRLTIHGSDGKDYQYVLKGHEDLRQDERVMQL 2000

  Fly  2230 NGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPN----------LASYRSICMNLYAQ 2284
            .||....|..|:...:|||:|..|.|:|.:...||:.|:|:          ..|.|:|.:|| ..
pombe  2001 FGLCNTLLTTDSETFKRRLNIERYTVIPLSPNSGLLGWVPHSDTLHFLIKEFRSKRNILLNL-EH 2064

  Fly  2285 RRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQ----EWLRQRFATPHSWYEARNTY 2345
            |.::.......||      ::.:|.|||  :.|.|:...:.    .||:.|  :..:|.:.|.:|
pombe  2065 RMMLQMAPDCDSL------TLLQKLEVF--EYVMANTDGYDLYHVLWLKSR--SSEAWLDRRTSY 2119

  Fly  2346 IRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDF-NCLFNQGELLPYPEVVPFRLTHNMIV 2409
            .:::||||||||||||||||..|::....:|..:|:|| :|.........:||.:|||||..:|.
pombe  2120 TQSLAVMSMVGYILGLGDRHPSNLMMDRYSGKIIHIDFGDCFEVAMHREKFPEKIPFRLTRMLIN 2184

  Fly  2410 AMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYD------------VGAQT--------- 2453
            ||...|::|:::..||:.:|:|:..:::||::|..||||            .||.|
pombe  2185 AMEVSGIQGTYKITCELVMRVLRSNTESLMAVLEAFVYDPLINWRLMTKSSFGASTTLRPTSSSV 2249

  Fly  2454 -RKG------------AATAKIT---------KDVQ---RIADRLQG---HVKRQQANSIPLSTE 2490
             .||            ||.::..         :.:|   |::::|.|   .:|.|      |..:
pombe  2250 EEKGRSYTHRARHADYAALSETNGVNAEGLNERSIQVLKRVSNKLTGKDFDLKEQ------LPVK 2308

  Fly  2491 GQVNFLINEATKVDNLASMYIGWGAF 2516
            .||..||.:||..:||...|:||.:|
pombe  2309 AQVEKLIQQATAPENLCRCYVGWCSF 2334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825	18/113 (16%)
		FAT	1653..1985	CDD:396714	76/382 (20%)
		TEL1	<1946..2517	CDD:227365	180/715 (25%)
		PIKKc_ATR	2181..2448	CDD:270625	99/281 (35%)
tor1	NP_596275.1	HEAT_EZ	144..193	CDD:463906	14/53 (26%)
		TEL1	195..2335	CDD:227365	520/2584 (20%)
		HEAT repeat	527..553	CDD:293787	5/25 (20%)
		HEAT repeat	563..593	CDD:293787	5/29 (17%)
		HEAT repeat	601..631	CDD:293787	9/34 (26%)
		HEAT repeat	644..673	CDD:293787	5/40 (13%)