DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and Atr

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	NP_063917.1	Gene:	Atr / 245000	MGIID:	108028	Length:	2641	Species:	Mus musculus

Alignment Length:	2806	Identity:	721/2806 - (25%)
Similarity:	1230/2806 - (43%)	Gaps:	622/2806 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLYNHVNRN-----------VSNFSGVYSVIEDILCQEPS-----------LISCSLVRELHNKF 53
            |:|.| .||           ||.|  :..:.|.:.|.:|:           .|..:|:..|.:..
Mouse   159 LIYLH-KRNAVGEVMEWPVVVSRF--LSRLDEHMGCLQPAPLQFMNVQNVEFIEVTLLMVLIHIV 220

  Fly    54 QDTF------LLWLLNKLAKCLSESPDSSECINLQR---KILSSCCSNHPKLFE----------R 99
            ...|      |||.:.              |..|:.   ||.|...|...:|||          .
Mouse   221 PTVFFRRQELLLWQIG--------------CALLEHGSPKIRSLAISLLTELFELGGLPAQPAST 271

  Fly   100 LVLAYVEAIEETHLQLSSLDLGQLSNERKP--AITVRIFRCDVECLQEFDP---HCAIEDIKVPL 159
            ....::|.::    .|..:|..||....:|  .:...:|..:.|..:..:|   :..:|.:.|..
Mouse   272 FFSLFLELLQ----HLVGMDADQLKLYEEPLSKLLKTLFPFEAEAYRNIEPVYLNVLLEKLSVMF 332

  Fly   160 E-------QADMYAKSLLEVLQHAHHIGYATHGDIFSGSLHQALLILKECDMDTKLASLNYCH-- 215
            |       ::|:...:|..:||:     :.|    |..:.:::.|.::      |:...|.|.
Mouse   333 EDRVLMRLKSDLLKAALCHLLQY-----FLT----FVPAGYESALQVR------KVYVTNICRAL 382

  Fly   216 -NVLRSQSASSWITNPDVGHYAQLTLEATAIMWSAVAKWLDMGCMTRQE----------LKRLNI 269
             :.|..|....::..|   .||.|.:|:..|:..       :.|..:||          .||..:
Mouse   383 VDALGVQKHVGYLLGP---FYAALKMESKEIIER-------IQCQAQQENLSGNNDEVSPKRRKL 437

  Fly   270 TTKLLL---------EVLHMRARPAHHLGYLLLNEILSLPTAIELDDGLLETLSSYIQGQLEHSV 325
            ::.|..         |::|:.......|..:|..:..||..::|..     ||.:.:...||...
Mouse   438 SSSLSSYKKPSRQPEEIIHVDMDKKSILWNVLKQKAESLQISLECG-----TLKNSVAEALEGIT 497

  Fly   326 VPLEQLVHLQQLMLSHW---------HCHPTHLVPILALMGLKQTEMRSGVVQVLTQSLVEILKK 381
            |.| ||..|..:..||.         |.|.                                .||
Mouse   498 VVL-QLTALCTVHCSHQDMDGHNVKDHQHK--------------------------------YKK 529

  Fly   382 EEVLSKDWQKLIAILRGFKQLEKLILSQSQHKIAEHEGHIDSSVLAMLPLQCEIIKVADTNWNNL 446
            :..:...|..|....:..|....|:  :|..|: |.|..|||           ::::.|.
Mouse   530 KPPVVVTWMSLDFYTKVLKSCRSLL--ESVQKL-ELELVIDS-----------MVRICDA----- 575

  Fly   447 SMQLVELESKCSADRRHIHLEICSL--------------LMQITFIRHFL----------KTQTQ 487
               |:.::.| |:.:.|:..|:|.:              |...||..:.|          ..|.|
Mouse   576 ---LMYMQVK-SSFKDHVLEELCGMLSLPWIYSYSDDNSLKMTTFATNLLPLSQRVWDSYSPQAQ 636

  Fly   488 HQ---LLAILQRHLKLSYLCAIRLETPSSVHTQMQSFYAQQYMRLFQSEETQEIFCSNLPQLYI- 548
            .:   ||.:..|.:.|.:..|:......|.|..:::...:.:..|...:.:    |:.:|::.:
Mouse   637 SKCVFLLTLFPRRIFLEWRTAVYNWALKSSHEVIRASCVKGFFILLHQQNS----CNQIPKMLVD 697

  Fly   549 -----SGFIKPEQLMKALPTINNRSGRAQVIRLLLCSQPGKL----SVFKVKDRIELY------- 597
                 |..:|.|              .|.|:..|:|:..|..    ||....:.::|:
Mouse   698 RVKDDSDMVKKE--------------FASVLGQLVCTLHGMFYLSSSVEPCFEHMDLFSKNLKAT 748

  Fly   598 ----CPK-------CRPLPKKLPGIYLGKCKQQLPCPDFSSTNLEMIANDLLFYPDFECIAQHLD 651
                |..       |:|        :|....:..|.|           ..|.|..:...:.:|||
Mouse   749 SQHECSSSQVKASTCKP--------FLFLLTKNTPSP-----------VKLAFIDNLHHLCKHLD 794

  Fly   652 LLCFEPNVILGLLRETEALQKVSVKVIGQLVSAMRVRSPEFLEQLANLVLAAIKAMLAKPLTEQN 716
               |:.:.     ||.:|       |:|.|::.|  ..|:...::|  ....||.:|....:|..
Mouse   795 ---FQEDE-----REVKA-------VLGTLLNLM--EDPDKDVRIA--FSGNIKYILESLNSEDG 840

  Fly   717 VLQQRSMLNVLTAIAHME---DNEIWLFHWFKMTF-----------------FFLVH-TRSLVAQ 760
            .:::..:|.:..|..|.:   :||:      |.|.                 |.|:| ...|:::
Mouse   841 FVKELFVLRMKEAYTHAQIARNNEL------KDTLILTTGDIGRAAKGDLIPFALLHLLHCLLSK 899

  Fly   761 EAVL---AATEMCASQGLQTIHLWNW---YKRDALDLTV-------------------------- 793
            .|.:   |.||:.|....:::.|.|:   ||:......|
Mouse   900 SASVSGAAYTEIRALVAAKSVKLQNFFSQYKKPICQFLVESLHSSQMTALPSAPCQSSEIRKQDV 964

  Fly   794 ----RLALNVYLLDGVRFTRSLRALTKMLGFTCVQEFTCKYHRLLTAMVLPHCI--VNPLCKGVL 852
                .:|||           :|..:..:..|..:..|..:..::|    ||...  .:|....::
Mouse   965 AHHREMALN-----------TLSEIANVFDFPDLNRFLTRTLQVL----LPDLAAKASPAASALI 1014

  Fly   853 VLIAKQMQKHIGTLFSISFLRIYTHVFLTEEPELANSCIELVVSCTQSSLQQLMNADVKQTVAEL 917
            ..:.||:......:...:|..|::|               ||.||::..|::.::....:|..||
Mouse  1015 RTLGKQLNVSRREILINNFKYIFSH---------------LVCSCSKDELERALHYLKNETEIEL 1064

  Fly   918 LIYFNRNPTFVMRSFQSL---LQLSIG--------SLEELSSQTANAE-------------FANF 958
                   .:.:.:.||.|   |.|.||        .|..|:|..::.:             .|::
Mouse  1065 -------GSLLRQDFQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDITSPELMADY 1122

  Fly   959 IAERFLGVITYFESCLSEPSFEKPLKEETLYSLGQIMRFVGSQHVTQFRFKIIAM----LSFVHT 1019
            :..:.||::.:|...|...|.....|:..|.||..:|:.:|.:||:..|.|::..    |.|...
Mouse  1123 LQPKLLGILAFFNMQLLSSSVGIEDKKMALTSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDD 1187

  Fly  1020 LQEPRLQRICLKIWHIFLHVVNVQELGPSLGRIVATLQPLLADNESVKQVNDLYEFIILRNASML 1084
            ..|     :|.:.|..|:..::...|||.|..::..|.||:  :...|:...::.::|:.|...:
Mouse  1188 FPE-----LCCRAWDCFVRCLDHAYLGPLLSHVIVALLPLI--HMQPKETAAIFHYLIIENRDAV 1245

  Fly  1085 GTFITDLYFL---DRMENVSPSIQKCIRRHTAHLDLKGLAEEENQSPPLVDQLRFLQKHITDECL 1146
            ..|:.::|||   ..:|.:...:|:             ..:|.:::..|...|:...|.|..|.:
Mouse  1246 QDFLHEIYFLPDHPELEKIKAVLQE-------------YRKETSETTDLQTTLQLSMKAIQHENV 1297

  Fly  1147 QVRVYALQHLGDLFGRRRPKLNSTILSELPLEPMLEQIVNVLMAGCQHDDSQLQMASAKCLGELG 1211
            .||::||..|.:...:.:.||.........:||::.|:|.|::.|||..:||.::...:||||||
Mouse  1298 DVRIHALTSLKETLYKNQEKLIKYATDSETVEPVISQLVTVILKGCQDANSQARLLCGECLGELG 1362

  Fly  1212 AIDASYLPSNYNFASPQ------HLPLNILSDDFAVLALTSLCRGY-QFQQNTKHVDSFSLAIQE 1269
            |||    |...:|::.:      .....:....||...|..|.|.| .:..|::..||.:.||||
Mouse  1363 AID----PGRLDFSTTETQGKDFTFVTGVEDLSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQE 1423

  Fly  1270 TLAI--CGISPKEQKKVQLWQSLPARMRQLMEPMLHSCYTCVHRPS--TCLQQPLFGSHYSHNYY 1330
            .|:|  |..........|||:..|..:|:::||.|::.|....:.:  :.:.:|::.|...:| :
Mouse  1424 LLSIYDCREMQSNGPGYQLWKRFPEHVREILEPHLNTRYKSSQKSTDWSGVTKPIYLSKLGNN-F 1487

  Fly  1331 EEWAFLWASRLIDYLPSSGRRHLLSSYKPC----IKRDSNMLSTFYPYILLHALLECTTEQRNHI 1391
            .||:..||.    ||.:..|.:|.|....|    :|.|..:.....|:||::.||.|..|.:..:
Mouse  1488 AEWSSSWAG----YLITKVRDNLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEV 1548

  Fly  1392 QEEFMAVLQANEESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPLASTLVSDRKEDSSRVPRL 1456
            ..|.||||:.:|:.:.|.                                     ::.:|.:.:|
Mouse  1549 YAEIMAVLKHDEQHAIST-------------------------------------QDSASDLCQL 1576

  Fly  1457 AGKLCAELLDFLQRWLR-EWQRIH------GRSTGGKPPETIDS----NYRKIHEFLNLIPKLLV 1510
            :.:....:||.|.:|.| ::|.::      .:..|||..:.:.:    :|:.:..||:|||:..:
Mouse  1577 STQTVFSVLDHLTQWARHKFQALNAEKLAQNKPKGGKVNKILSNVNFEDYQSVTRFLDLIPQDTL 1641

  Fly  1511 SRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVT 1575
            :.||:....|.||:.:.||::.|   |.|.:.:...||.::|.::.:||.|.|...:|..:.|:.
Mouse  1642 AVASFRSKAYTRAVMHFESFITE---KKQNIQKHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLK 1703

  Fly  1576 QDILVNRLVERQQDMITSYEQLLSSTDQMQPDH-------VRAMIDAYLRDTPKTAQLIADGLWQ 1633
            :.||.:..:...:|....|::.:    |::||.       |::|:......|..|.   .:|:..
Mouse  1704 EQILEHESIGLLRDATACYDRAI----QLEPDQIIHYHGVVKSMLGLGQLSTVITQ---VNGVHA 1761

  Fly  1634 RLSDRYSDQCFAECKSELLWRLGSYDEMEEL------QSNWPAQCSQGCLKLRRPLTTRIEFDSL 1692
            ..|: ::|: ....:.|..|:|..:|.:|..      .:.|..:..|..|..::..||.. :|:|
Mouse  1762 NRSE-WTDE-LNTYRVEAAWKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDTTTF-YDTL 1823

  Fly  1693 LDGMRESVLEELRSCSAVQQHSYANAYDAVLKLHLVHEL-HCSQELVEKLEQDRDEDNQEKLMKN 1756
            .....|.::.  .|.::.::.||...|:.:::||::.|| |..:.|..|  ...|..|::.|
Mouse  1824 KLVRAEQIVP--LSAASFERGSYQRGYEFIVRLHMLCELEHSLKPLFRK--SPGDSCNEDSL--- 1881

  Fly  1757 YFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSAQINRNA 1821
               :|..||::.|...|.:|.|.:.||.:|: |.:|        |.....:...||.||::.|.|
Mouse  1882 ---NWGARLEMTQNSYRAKEPILALRRALLS-LNKR--------PDYNEMVGECWLQSARVARKA 1934

  Fly  1822 GQLQRAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQR 1886
            |..|.|...:|.|.|.:.:.|::||||.||.|||...|:..|::.:.:    |....|. .:|.:
Mouse  1935 GHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGVEL----CFPENKS-PSESK 1994

  Fly  1887 HLFFRGK--YLQAVYSAESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSE 1949
            |:...|:  .|...:..|:.:..::||:|.:::......:.|..|..:|::.:|::......|.|
Mouse  1995 HMLIHGRATLLVGRFMEETANFESNAVMKKYKDVTLFLPEWEDGHFYLAKYYDKLMPMVTDNKME 2059

  Fly  1950 PTGEQDDMLINVMVNYAKSLRYGSEHVYQSMPRLISLWLDTTESSTNTEQ------------VKK 2002
               :|.|::..:::::.:||:||::.:||||||::|||||....:...|:            :.|
Mouse  2060 ---KQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLSLWLDFGAKAYEWEKGGRSDRLQMRNDLAK 2121

  Fly  2003 MNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSA 2067
            :|.:||.....|....|.|.:||::||:||..::||.||..:|.|:..|||||::||:....||:
Mouse  2122 INSVLTEHTNRLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSS 2186

  Fly  2068 KAHRIKRCKLVLTDSRLQNSTFQKLLQDFNSLTERLMDLTNKEVT-LDRTYKLSDLDTRLSKLCK 2131
            ...|:.|||.:||.:.....:.:|.:.|...||::|::|.||.|. .:.|..:|.....|.:|.:
Mouse  2187 YPMRVNRCKEILTKAIHMKKSLEKFVGDATRLTDKLLELCNKSVDGSNSTLSMSTHFKMLKRLVE 2251

  Fly  2132 QPEFSQILLPFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAK 2196
            .|.||:||:|.:..|.||||      |..|:|  ||...   ||....|::||.:.|.||.|..|
Mouse  2252 DPTFSEILIPLQSVMIPTLP------SVLGAH--ANHDP---FPGHWAYLAGFDDVVEILSSLQK 2305

  Fly  2197 PKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEE 2261
            |||::::.||||.|.::.|||||||:|.||||||.|:.:.|.:||.:|:|.||||||||:|.|:|
Mouse  2306 PKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLNDE 2370

  Fly  2262 CGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQE 2326
            ||::||:.|.|..|.|...:|.::.:.|:.::|:...:|...::..|.:||.:.|:|.|||||.|
Mouse  2371 CGIIEWVNNTAGLRPILTKIYKEKGVYMTGKELRQCMLPKSAALSEKLKVFQELLLPRHPPVFHE 2435

  Fly  2327 WLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGE 2391
            |..:.|..|.|||.:|:.|.|:.||||||||||||||||||||||....|:.||||||||||:||
Mouse  2436 WFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGE 2500

  Fly  2392 LLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYD---VGAQT 2453
            ....||:|||||||||:..|||:|.||.||:.||:||||::.:.:.|||:|:.|::|   ..::.
Mouse  2501 TFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTLRLMRDQREPLMSVLKTFLHDPLVEWSKP 2565

  Fly  2454 RKGAATA-----------KITKDVQRIADRLQGHVK-RQQANSIPLSTEGQVNFLINEATKVDNL 2506
            .||.:.|           |....|..|..||||.:| |.:...:|||.||.|::||.|||..:.|
Mouse  2566 VKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLL 2630

  Fly  2507 ASMYIGWGAFL 2517
            ..||:||..::
Mouse  2631 CQMYLGWTPYM 2641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825	28/108 (26%)
		FAT	1653..1985	CDD:280429	91/340 (27%)
		PIKKc_ATR	2181..2448	CDD:270625	143/266 (54%)
		FATC	2486..2517	CDD:280430	16/30 (53%)
Atr	NP_063917.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..447		3/23 (13%)
		HEAT repeat	690..720	CDD:293787	7/43 (16%)
		HEAT repeat	729..788	CDD:293787	11/77 (14%)
		HEAT 1	799..835		12/51 (24%)
		HEAT repeat	802..837	CDD:293787	10/45 (22%)
		UME	1119..1225	CDD:214825	29/112 (26%)
		HEAT 2	1329..1365		17/35 (49%)
		NR_LBD	1529..>1607	CDD:299703	22/114 (19%)
		FAT	1771..2092	CDD:280429	92/348 (26%)
		TEL1	<2123..2641	CDD:227365	237/528 (45%)
		PIKKc_ATR	2290..2564	CDD:270625	144/273 (53%)
		FATC	2610..2641	CDD:280430	16/30 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835675
Domainoid	1	1.000	291	1.000	Domainoid score	I1537
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	781	1.000	Inparanoid score	I524
Isobase	1	0.950	-	0.85977	Normalized mean entropy	S4341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10493at33208
OrthoFinder	1	1.000	-	-		FOG0004409
OrthoInspector	1	1.000	-	-		oto92328
orthoMCL	1	0.900	-	-		OOG6_102609
Panther	1	1.100	-	-	LDO	PTHR11139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2044
SonicParanoid	1	1.000	-	-		X3128
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.740