DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and Pik3c2b

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	NP_001092746.2	Gene:	Pik3c2b / 240752	MGIID:	2685045	Length:	1632	Species:	Mus musculus

Alignment Length:	1318	Identity:	236/1318 - (17%)
Similarity:	419/1318 - (31%)	Gaps:	451/1318 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1478 IHGRSTGGKPPETIDSNYRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRLL 1542
            |:..|:..:||:                 ||||::...            |..|.:|..:...|
Mouse   188 INSFSSAEQPPD-----------------KLLVAQDPE------------EGELPDGRGQGHTL- 222

  Fly  1543 EQFTFLVEVYGSLRDPDSVEGAV---QVRS-YDMSVTQDI----------------LVNRLVERQ 1587
                      ||: |.|.:..|:   .::| ||..::.|.                ...:.|.|.
Mouse   223 ----------GSV-DYDGINDAITRLNLKSTYDSEISSDATRGWKEGRGPLDFNKDTSGKPVARS 276

  Fly  1588 QDM-----ITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADG--LWQRLSDRYSDQCFA 1645
            :.|     ..:|....::.....|.:.|.:..|.:...|.|   :|:|  |:: :|:...::..|
Mouse   277 KTMPPQVPPRTYTSRYANRKNATPGNNRRISAAPVGSRPHT---VANGHELFE-VSEERDEEVAA 337

  Fly  1646 ECKSELLWRLGS----YD-----------EMEELQSNWPAQCSQGCLKLRRPLTTRIEFDSLLDG 1695
            .|....:.|.||    |.           ..|.|......:.:..|..||.|||......|.:|.
Mouse   338 FCHMLDILRTGSDIQDYSLTGCVWSTVTPSPEHLGDEVNLKVTVLCDSLREPLTFTCNCSSTVDL 402

  Fly  1696 MRESVL----EELRS----------CS---------AVQQH---SYANAYDAVLKLHLVHELHCS 1734
            :....|    :|||.          |.         |:..|   .|...:|..::|.|:.:....
Mouse   403 LIHQTLCYTHDELREVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDISIRLQLMEQKAIR 467

  Fly  1735 QELVEKLEQDRDEDN-------QEKLMKN---------YFD------------DWQYRLQI---- 1767
            .:|...:..|:....       ||:.:|.         .||            |..:.|:.
Mouse   468 SDLARTVNDDQSPSTLNYLIHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVV 532

  Fly  1768 -------------------------------VQPQVRIQESIYSFRRN---ILAELQRRLTDRNH 1798
                                           :||:::...|:.|.|.|   ::..|...:.|
Mouse   533 QSVKAICNALAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLSVRENREKVVEALTAAILD--- 594

  Fly  1799 LLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFI-----ERAKLLWQKGDQVM 1858
                    |..::.::...:.........:..:::.|.:.|..|..     .|..::|
Mouse   595 --------LVELYCSTFNADFQTAVPGSRKHDLVQEACHFPGALAFTVYGTHRIPIIW------- 644

  Fly  1859 AMNYLEEQLSIMRSGCQGNVKQLAA--EQRHLFFRGKYLQAVYSAESMHLCA-DAVLKYFQEAIA 1920
            |.:|.:..||...|  .|. |:|.:  :.|...| .|||        .||.. |..:.:..:...
Mouse   645 ATSYEDFYLSCSLS--HGG-KELCSPLQTRRAHF-SKYL--------FHLIIWDQQICFPVQVNR 697

  Fly  1921 VHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQDDMLINVMVNYAKSLRYGSEHVYQSMPRLIS 1985
            :.|::..|....|..:.....:.:..|.:...|....:...:.|:.:.|..|.        :|:.
Mouse   698 LPRETLLCATLYALPVPPPGGSSEANKQKRVPEALGWVTTPLFNFRQVLTCGR--------KLLG 754

  Fly  1986 LWLDTTES----------------------------------------------STNTEQVKKMN 2004
            ||..|.|:                                              |...|..:|:.
Mouse   755 LWPATQENSGARWSAPNFHQPDSVILQIDFPSSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLK 819

  Fly  2005 DL--------LTN------------CCTALPTAVFYTVYSQMLSRLCHPVNDVFTVL-------- 2041
            |:        ||:            |.|.:.:.......:......|.|  |::.:|
Mouse   820 DITQKESLYWLTDADKKQLWEKRYYCHTEVSSLPLVLASAPSWEWACLP--DIYALLQQWTHMNH 882

  Fly  2042 RNVIIKLVEAYPQQSL------WM----------LLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQ 2090
            ::.:..|...:|.|.:      |:          .||....|..:   .|.|   ||.|.....:
Mouse   883 QDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKY---ECYL---DSPLVRFLLK 941

  Fly  2091 KLLQD-------FNSLTERLMDLTNKEVTLDRTYKLSD------------------LDTRLSKLC 2130
            :.:.|       |..|.:.|.|   .:.::...|.|:.                  |...|:||.
Mouse   942 RAISDLRVTHYFFWLLKDSLKD---SQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNTLAKLA 1003

  Fly  2131 KQ-----PEFSQILL--PFEKYMQPTLPLNSDSNSSEGS-HLPANQSTVNWFPYQQIYISGF-QE 2186
            :|     |...|.:|  ..|:..| ...||       || .||.:.|         :.:.|. ..
Mouse  1004 QQVREATPSARQGILRVGLEEVKQ-FFALN-------GSCRLPLSPS---------LLVKGIVPR 1051

  Fly  2187 SVLILRSAAKPKKLTIRCSD--GKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLH 2249
            ......|.|.|.||..:..|  |::..|:.|..||||:|...::...::.:...|:. ...|.:.
Mouse  1052 DCSYFNSNAVPLKLAFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEG-LDMRMVI 1115

  Fly  2250 IRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTK 2314
            .|.::.   ....|:||.:||..:.|.|.:     ...|..:.:.:.||
Mouse  1116 FRCFST---GRGKGMVEMIPNAETLRKIQV-----EHGVTGSFKDRPLA---------------- 1156

  Fly  2315 QLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAV 2379
                       :||::.......:.:|...:|.:.|...:..||||:.|||.:||:. :..|...
Mouse  1157 -----------DWLQKHNPGEDEYEKAVENFIYSCAGCCVATYILGICDRHNDNIML-KTTGHMF 1209

  Fly  2380 HVDFNCLFNQGELLPYPEV--------VPFRLTHNMIVAMGPLGVEGSFR------KCCEITLRL 2430
            |:||      |..|.:.::        .||..|.:|...:.. |.:.|.|      .||: ...|
Mouse  1210 HIDF------GRFLGHAQMFGNIKRDRAPFVFTSDMAYVING-GDKPSSRFHDFVDLCCQ-AYNL 1266

  Fly  2431 LKQESKTLMSILRPFVYDVGAQTRKGAATAKITKDVQRIADRLQGHVKRQQANSIPLSTEGQVNF 2495
            :::.:...:::|       |.....|.......:|::.:.|.|:  .:..:||:....|....:.
Mouse  1267 IRKHTHLFLNLL-------GLMLSCGIPELSDLEDLKYVYDALR--PQDTEANATTYFTRLIESS 1322

  Fly  2496 LINEATK----VDNLASM 2509
            |.:.|||    :.|||.|
Mouse  1323 LGSVATKLNFFIHNLAQM 1340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	73/446 (16%)
		PIKKc_ATR	2181..2448	CDD:270625	59/283 (21%)
		FATC	2486..2517	CDD:280430	9/28 (32%)
Pik3c2b	NP_001092746.2	PI3K_rbd	363..465	CDD:366310	21/101 (21%)
		C2A_PI3K_class_II	621..793	CDD:175979	34/198 (17%)
		PI3Ka_II	812..980	CDD:238441	30/178 (17%)
		PI3Kc_C2_beta	986..1339	CDD:119421	90/423 (21%)
		PX_PI3K_C2_beta	1368..1476	CDD:132823
		C2B_PI3K_class_II	1504..1626	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900