DRSC/TRiP Functional Genomics Resources

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Protein Alignment mei-41 and Pik3cd

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_006538704.1 Gene:Pik3cd / 18707 MGIID:1098211 Length:1074 Species:Mus musculus


Alignment Length:1233 Identity:240/1233 - (19%)
Similarity:408/1233 - (33%) Gaps:431/1233 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1502 LNLIPKLLVSRASYNCGEYARALSYLESYL----------EEGEDKSQRLLEQFTFLVEVYGSLR 1556
            |:.|.::|..||.|.  .....||..|:|:          :|.||:.:||.:...||.       
Mouse    42 LSTIKQVLWHRAQYE--PLFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLP------- 97

  Fly  1557 DPDSVEGAVQVRSYDMSVTQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTP 1621
                                   |.|||.|:.|.:   ::|::|                     
Mouse    98 -----------------------VLRLVAREGDRV---KKLINS--------------------- 115

  Fly  1622 KTAQLIADGL--WQRLSD-----------RYSDQCFAECKSELLWRLGSYDEMEELQSNWPAQCS 1673
            :.:.||..||  :..|.|           ::.::..|. :.:|.|       :|.||.::|.|..
Mouse   116 QISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAH-RQQLGW-------VEWLQYSFPLQLE 172

  Fly  1674 -------QGCLKL-RRPLTTRIEFDSLLDGMRESVLEELRSCSAVQQHSYANAYDAVLKLHLVHE 1730
                   .|.|:: .|.|...::|    :|..||...::            :..|..|.|     
Mouse   173 PSARGWRAGLLRVSNRALLVNVKF----EGSEESFTFQV------------STKDMPLAL----- 216

  Fly  1731 LHCS---------QELVEKLEQDRDEDN--QEKLMKNY-FDDWQYRLQIVQPQVRIQESIYSFRR 1783
            :.|:         |.|||:.|:...:.|  .|.|..|| ...:||                    
Mouse   217 MACALRKKATVFRQPLVEQPEEYALQVNGRHEYLYGNYPLCHFQY-------------------- 261

  Fly  1784 NILAELQRRLTDRNHL-LPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIERA 1847
             |.:.|...||.  || :.|..:.||   :...|.| .|.|:|:.:.........:||.:     
Mouse   262 -ICSCLHSGLTP--HLTMVHSSSILA---MRDEQSN-PAPQVQKPRAKPPPIPAKKPSSV----- 314

  Fly  1848 KLLWQKGDQVMAMNYLEEQLSI-MRSGCQGNV--KQLAAEQRHLFFRGKYLQAVYSAESMHLCAD 1909
             .||.          ||:..|| :..|.:.|.  :.....|..||...:.|....|:..:::|::
Mouse   315 -SLWS----------LEQPFSIELIEGRKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSE 368

  Fly  1910 AVLKY---FQEAIA-VHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQDDMLINVMV-NYAKSL 1969
            .|.|.   |..::. :.|.:..|....| .:||..:||...|.....:......|:|: :|...|
Mouse   369 PVWKQRLEFDISVCDLPRMARLCFALYA-VVEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQL 432

  Fly  1970 RYGSEHVYQ--SMPRLISLWLD---TTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLS- 2028
            :.|...:|.  |:|......|:   |...:.|||....:...|..   ..|..|::....::|. 
Mouse   433 KTGERCLYMWPSVPDEKGELLNPAGTVRGNPNTESAAALVIYLPE---VAPHPVYFPALEKILEL 494

  Fly  2029 --------------------------------------RLCHPVNDVF--TVLRNVIIK------ 2047
                                                  ::.|.|.:.|  .:.|.:::.      
Mouse   495 GRHGERGRITEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHE 559

  Fly  2048 -------------------LVEAYP------QQSLWML-----LPHFKSAK------------AH 2070
                               .|.|:|      .|.|::|     ||...:.:            :.
Mouse   560 DVAQVSREGGSGRQPRGRWTVPAHPYLTTKLSQMLYLLCSWPELPVLSALELLDFSFPDCYVGSF 624

  Fly  2071 RIKRCKLVLTDSRLQNSTFQKLLQ-----DFNS-----LTERLMD--LTNKEVTLDRTYKL-SDL 2122
            .||..: .|||..|    ||.|||     .:.|     ||:.|:.  |.|:::.....:.| |::
Mouse   625 AIKSLR-KLTDDEL----FQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSEM 684

  Fly  2123 DT--------------------RLSKLCKQPEFSQILLPFEKYMQPTLPLNSDSNSSEGSHLPAN 2167
            ..                    .:..|.||.|....|.....:::.:....:...:.|..|:...
Mouse   685 HVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTKEMMHMCMR 749

  Fly  2168 QSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIR-CS-------DGK---------------- 2208
            |.|             :.|::..|:|...|..|... ||       |.|                
Mouse   750 QET-------------YMEALSHLQSPLDPSTLLEEVCSVEQCTFMDSKMKPLWIMYSSEEAGSA 801

  Fly  2209 -DYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIR--TYAVLPFNEECGLVEWLPN 2270
             :..::.|..||||:|...::...|:      |...:|..|.:|  .|..||..:..||:|    
Mouse   802 GNVGIIFKNGDDLRQDMLTLQMIQLM------DVLWKQEGLDLRMTPYGCLPTGDRTGLIE---- 856

  Fly  2271 LASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATP 2335
                            :|:.:..:.:  :.|::|.......|.|.       ....||:.:  .|
Mouse   857 ----------------VVLHSDTIAN--IQLNKSNMAATAAFNKD-------ALLNWLKSK--NP 894

  Fly  2336 -HSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLP----- 2394
             .:...|...:..:.|...:..|:||:||||.:||:..| :|...|:||      |..|.     
Mouse   895 GEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRE-SGQLFHIDF------GHFLGNFKTK 952

  Fly  2395 ---YPEVVPFRLTHNMIVAMGPLGVEGS-----FRKCCEITLRLLKQESKTLMSILRPFVYDVGA 2451
               ..|.|||.||::.:..:.......|     ||..||....:|::....       |::....
Mouse   953 FGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLL-------FLHLFAL 1010

  Fly  2452 QTRKGAATAKITKDVQRIADRLQ---------GHVKRQQANSIPLSTEGQVNFLINEATKVDN 2505
            ....|......:||:|.:.|.|.         .|.:.:...::..|.:.:||:|.:..:| ||
Mouse  1011 MRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSK-DN 1072

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825
FAT 1653..1985 CDD:280429 79/362 (22%)
PIKKc_ATR 2181..2448 CDD:270625 65/307 (21%)
FATC 2486..2517 CDD:280430 7/20 (35%)
Pik3cdXP_006538704.1 PI3K_p85B 32..107 CDD:396665 22/96 (23%)
PI3K_rbd 182..281 CDD:395642 30/142 (21%)
C2_PI3K_class_I_beta_delta 314..481 CDD:176075 39/186 (21%)
PI3Ka 504..713 CDD:214537 32/213 (15%)
PI3Kc_IA_delta 705..1072 CDD:270718 86/431 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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