DRSC/TRiP Functional Genomics Resources

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Protein Alignment mei-41 and atl-1

DIOPT Version :10

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:NP_505487.3 Gene:atl-1 / 179352 WormBaseID:WBGene00000226 Length:2531 Species:Caenorhabditis elegans


Alignment Length:2779 Identity:549/2779 - (19%)
Similarity:1004/2779 - (36%) Gaps:778/2779 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   208 LASLNY-CHNVLRSQSASSWITNPDVGHYAQLTLEATAIMWSAVAKWLD------MGCMTRQELK 265
            |.|:.: .|.:...|..||   ...:..:..:.....|.....:||..|      |..:|:|:.:
 Worm    62 LQSITFTLHLITEKQELSS---EEKIRLFQSVIASMCAFEDEELAKCFDRILSVLMISVTKQDPR 123

  Fly   266 RLNITTKLLLEVL-HMRARPAHHLGYLLLNEILSLPTAIELDDGLLETLSSYIQGQLEHSVVP-- 327
            ......:.||||: :....|:..|..|:..||.|   ||.|.      .|.:.:..|:.:::.  
 Worm   124 ETIYFLQGLLEVVKYCDVEPSSSLPQLITPEIAS---AISLG------ASGFFRYHLKWNIISTL 179

  Fly   328 ----LEQLVHLQQLMLSHWHCHPTHLVPILALMGLKQTEMRSGVVQVLTQSLVEILKKEEVLSKD 388
                ..:.||..:|:|...||.......:.....:.:..:|:|:.         |||.:::.:..
 Worm   180 FGENAGECVHFDELVLFWPHCRSQLEDKLKNDCSMTENCLRAGLT---------ILKYKKLHNSI 235

  Fly   389 WQKLIAILRGFKQLEKL-------------ILSQSQHKIAEHEGHIDSSVLAM------LPLQCE 434
            ..:.:.|...|.....|             :|::.||.:.:|     ..||.|      .|:|..
 Worm   236 LDQALFIDELFATFNSLTAKKSTNHMTFPKLLNEIQHFLQDH-----GKVLIMHKELRQKPVQWL 295

  Fly   435 II---KVADTN-----WNNLSMQLVELESKCSADRRHIHLEICSLLMQITF--IRHFLKTQTQH- 488
            ||   .:.|.|     ..|.|:.|::|.:  :.|.......:|....:|..  |:|.:  |:.| 
 Worm   296 IIYLELIDDANDKFGLLENFSLLLLDLST--NHDIHEFPARLCMTASEICMRRIKHSI--QSTHT 356

  Fly   489 ----QLLAILQRHLKLS-------YLC-AIRLETPSSVHT-----------QMQSFYAQQYMRLF 530
                ..|.||...|||:       :.| |..:|...|::.           .:|:.:.||:.:. 
 Worm   357 DCLADYLDILASLLKLARIQKLDIFQCFATEIEAHHSLNNPLWPRILRSLLSVQNPHCQQFCKK- 420

  Fly   531 QSEETQEIFCSNLPQLYISGFIKPEQLMKALPTI-----------NNRSGRAQVIRLLL--C--- 579
                    |..::.:|:|: .:..|.....|.::           ||..|..|:|..||  |   
 Worm   421 --------FVPSIDKLWIT-LLNGESSRATLNSLVIVTASCPFANNNDEGVKQIIPFLLIPCFQD 476

  Fly   580 -------------------SQPGKL-------SVFK--VKDRIELYCPKCRPLPKKLPGIYLGKC 616
                               |:|.:|       :|.:  ..:..:|....|....:|..|.|: ..
 Worm   477 FRDRVGSKWDNFRFIGLPKSEPSELINLERFTTVLERSTSESTKLRAVNCALQLEKKTGKYI-NL 540

  Fly   617 KQQLPCPDFSSTNLEMIAND----LLFYPD-FECIAQHLDL----LCFEPNVI--LGLLRETEAL 670
            ..::....||.:..:.|||.    :||..| .:.|...:.:    ||.:....  |.:|:..:.|
 Worm   541 VAEMSLAVFSKSQTDRIANSFEPLILFLTDNLQLINDFITILIAKLCEKQEFYSELTILKYFKTL 605

  Fly   671 QKV---------SVKVIGQLV-----SAMRVRSPEFLEQLANLVLAAIKAMLAKPLTEQNVLQQR 721
            ||:         |.|..|:..     |...|:..  .|.|:.|    ||.::|:    :|...|.
 Worm   606 QKLFCLAANGRNSCKKCGEECFVDPDSKENVKID--YESLSGL----IKGIVAR----RNTFSQE 660

  Fly   722 SMLNVLTAIAHMEDNEIWLFHWFKMTFFFLVHTRSLVAQ-EAVLAATEMCASQGLQT-IHLWNWY 784
            .:...|      :.:.:.|.|         |.::.:.:. .:::.|.::..|:.... ..:|...
 Worm   661 LIREFL------QTSRVMLLH---------VDSKGIASSFTSIIKALDIGFSENANAYFRVWELV 710

  Fly   785 --KRDALDLTVRLALNVYL-LDGVRFTRSLRALTKMLGFTCVQEFTCKYHRLLTAMVLPHCIVNP 846
              :.:|   ||...|.:|: |.|..|.        :||    .:...|.|..|:.          
 Worm   711 CCRSEA---TVEKKLQMYIPLIGRSFA--------LLG----DDAALKVHGFLSN---------- 750

  Fly   847 LCKGVLVLIAKQMQKHIGTLFSISFLRIYTHVFLTEEPELANSCIELVVSCTQSS--LQQLMNAD 909
                  ||.|:.......|||:.||          ....|.|..|:..||.|..:  .|.|:.|.
 Worm   751 ------VLSARLSSTVKATLFASSF----------AHSVLKNCEIDWNVSYTWKTQFSQCLIKAP 799

  Fly   910 VKQTVAELLIYFNRNPTFVMRSFQSLLQLSIGS------------LEE-----LSSQTANAEFAN 957
            |......|.|.|.|..|...|.|.:.|.....|            :.|     ||...::..|.|
 Worm   800 VGTCEEALQIMFKRYSTIFTRCFLNRLFFDASSAGAQKPSYDEHRIREITRCYLSHVLSDFNFPN 864

  Fly   958 ----------------------------------FIAERFLGVITYFESCLSEPS-------FEK 981
                                              ||.:..........|....||       ..|
 Worm   865 QKITFNMIRPSLLYWSLLSSARGINSKLTLSVIDFICQEMSAASVSMSSISPNPSDIRIVMIQRK 929

  Fly   982 PLKEETLYSLGQIMRFVGSQHVTQF--------RFKIIAMLSFVHTLQEPRLQRICLKIWHIFLH 1038
            .|..||...|.|.:.|..:::.|.|        .||...:.:.:.:.::           .:|:|
 Worm   930 SLITETFAQLVQFLAFENNRNTTSFWKFCSDHCDFKDEDIRTVISSYRK-----------QVFMH 983

  Fly  1039 --VVNVQEL----GPSLGRIVATLQPLLADNESVKQ------------VNDLYEFIILRNASMLG 1085
              :|:.:|.    .||:     .::.|.|..|::|:            .|:..||:.:     ..
 Worm   984 LLLVSAREFLNPRNPSM-----IVEQLRATYENIKKGEKFMISTAIETRNEGIEFLFI-----FR 1038

  Fly  1086 TFIT-DLYFLDR----------MENVSPS--------IQKCIRRHTAHLDLKGLAEEENQSP--P 1129
            |:.| |.|||.|          ::|:...        |...:|:...:||       ..||.  .
 Worm  1039 TYFTNDQYFLTREATAESFRILLQNMKQDFFDTNWYIILMTLRQIPLNLD-------STQSSWIS 1096

  Fly  1130 LVDQLRF------LQKHITDECLQVRVYALQHLGDLFGRRRPKLN-STILSELPLEPMLEQIVNV 1187
            .::|:.:      :.:.:||      :..:::...|..:...:|: ..::.::..:.|::::..:
 Worm  1097 FIEQINYSILRSNIWRILTD------ISRIENNDILIEKVWNRLSYDMVIDKISTDAMIKRVFWL 1155

  Fly  1188 LMAGCQ-HDDSQLQMASAKCLGELGAIDASYLPSNYNFASPQHLPLNILSDDFAVLALTSLCRGY 1251
            :....: ..|.:.:::.::.:.::......:         ||: |....:|:.|    :.:.|..
 Worm  1156 IPLEVEKRIDLKFEISKSRQIEDVLEFIRMF---------PQY-PSVQFADNLA----SKIERKT 1206

  Fly  1252 QFQQN-TKHVDSFSLAIQETLAICGISPKEQKKVQLWQSLP---------------------ARM 1294
            .:::. .|.:.|.|..:.:    |....::.|.:::.|.||                     ...
 Worm  1207 VYKEELPKLIGSLSRILPQ----CHSKREQNKIIKILQKLPIICSDLPDHNFIRWDTRFKFFCEP 1267

  Fly  1295 RQLMEPMLHSCYTCVHRPSTCLQQPLFGSHYSHNYYEEWAFLWASRLIDYLPSSGRRHLLSSYKP 1359
            |||.:.:|..|...|.                        .:..:..|:|:.    |.:...||.
 Worm  1268 RQLTQAVLEDCAGIVE------------------------VMTGTSKIEYVD----RTMCEIYKF 1304

  Fly  1360 CIKRDSN--MLSTFYPYILLHALLECTTEQRNHIQEEFMAVLQANEESSSSVRGRQELGAIKENA 1422
            ....:::  |.||......::|.:.|:.:     .|..|...:..:|.|        ||..:..:
 Worm  1305 FNPNEASPEMKSTLDGIKNMYAKMICSQK-----PEPSMIEQKTIDELS--------LGGSRRES 1356

  Fly  1423 FKQF---------ESRKYAAGIKPLASTLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLREW--- 1475
            |.::         |..:.|    ||:|.......:|:..:.:||.:....::...:..:.:|   
 Worm  1357 FSRWLTVIILKCAEMSEDA----PLSSLASIAHVDDTRFLSKLAMRFILTVIHMERDSVTQWILS 1417

  Fly  1476 -------QRIHGRSTGG-KPPET-----IDSNY-----------RKIHEFLNLIPKLLVS----- 1511
                   ...|.|.|.. :.|.:     .|..|           :||.|.:....|.::|     
 Worm  1418 TFEEALTNTNHRRLTNSDRGPASFVFYVFDFIYSYSSSEELRKKKKIWEKVISFWKSMMSWTFKD 1482

  Fly  1512 ----------RASYNCGEYARALSYLESYLEEGEDKSQRLLEQ------FTFLVEVYGSLRDPDS 1560
                      :.:...|...|.:.:||.::|:....|..:..:      || |:.:||.:.:.:.
 Worm  1483 ENGHGQPLIVKVAETFGMEKRCILWLEMFMEQKRKTSTEIESETEAAYYFT-LMNLYGRIHELNG 1546

  Fly  1561 VEGAVQVRSYDMSVTQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQ 1625
            |.||                             |.:|    .::|.|||...|            
 Worm  1547 VRGA-----------------------------YARL----SRIQIDHVYGKI------------ 1566

  Fly  1626 LIADGLWQRLSDRYSDQCFA------------ECKSELLWRLG--SYDEMEELQ----------- 1665
                .:.:...|..|..|||            |...:|:..|.  .|.::|..:           
 Worm  1567 ----SMREAFGDFNSAACFARMTGKGKPFNSTEAIQKLIDELNCLEYSQIERNEQEDYLNSLKTL 1627

  Fly  1666 SNW----------PAQCSQG---------CLKLRRPLTTRIEFDSLLDGMRESVLEELRSCSAVQ 1711
            |.|          |...|:.         .||:.|........::.::..:..|:|.|..|:...
 Worm  1628 SQWVNIDNDIGPSPHIFSRNIEYWATESTILKMIRNDERDEIVNNAIENAKSKVIERLSECAIGG 1692

  Fly  1712 QHSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDE------DNQEKLMKNYFDDWQYRLQIVQP 1770
            ..||..|...:::|..::      |:||......||      |..:.:.|. .||.:.::.|::|
 Worm  1693 SCSYEIATPFLVELQKLN------EIVELKNVSNDELSAFNSDFWKNIQKR-TDDSEQKISILEP 1750

  Fly  1771 QVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAA 1835
            .:|::.|:...|       .:.:|.|:.  .::::.:..:.|.||:|.|..|..:||||.::.|.
 Worm  1751 ILRVRRSMLDIR-------MQSMTGRDK--ENIRSRIVEVHLQSARIARLTGCFERAQLSLINAK 1806

  Fly  1836 EYQP--SGLFIERAKLLWQKGDQVMAMN----------------YLEEQLSI---MRSGCQGNVK 1879
            :..|  :.:.:|.|||..|..|::..|:                |.:.|.|:   ::...:..::
 Worm  1807 KVLPFENKIVLEEAKLQLQTSDELNGMSLLDSIISKNFGDLHTIYTDTQQSVNLDVQKSAKLKIE 1871

  Fly  1880 QLAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEK--ILEA 1942
            ....|.::||      .:|......|:........|.:......|...|........|.  :|:.
 Worm  1872 HYQEETKNLF------SSVQMLRISHMIKAGNTIGFDKVYHETTQLLQCFAHSGVMYEAAWLLDY 1930

  Fly  1943 RQGGKSEPTGEQDDMLINVMVNYAKSLRYGSEHVYQ--SMPRLISLWLDTTES-STNTEQVKKM- 2003
            ....|     |:...::.::..|.:..:|....|.|  ::.|:.||||..|.. ||:...|.|: 
 Worm  1931 LSNYK-----ERSKHVLPLLKAYKEVAKYEKNQVLQARAVERMTSLWLSNTRKISTHISSVPKLP 1990

  Fly  2004 ----NDLLTNCCT---ALPTAV-------FYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQ 2054
                :||..|..:   .:.||:       ||..|:.:...:.|...:|...::.::.:|:...|.
 Worm  1991 EGQISDLRQNIKSMNREIQTALEHIGWRAFYPAYAVLARHIDHQDEEVTRTIKQIMKQLILRMPH 2055

  Fly  2055 QSLW----MLLPHFKSAKAH------RIKR---CKLVLTD-----SRLQNSTFQKLLQDFNSLTE 2101
            |.:|    :|..:..|.|..      .:||   |.:.|.|     |.:.|:...|:..|...|:|
 Worm  2056 QCMWQSAYLLRQNIASVKEKYMEVLTEVKRKAPCYVTLIDQYDYASGVFNTVSGKVESDDCKLSE 2120

  Fly  2102 RLMDLTNKEVTLDRTYKLSDL--DTRLSKLCKQPEFSQILLPFEKYMQPTLPLNS--DSNSSEGS 2162
            ::..|  |.:..|:.|...:|  :.|:...||  ..|.|::|....:..::....  |....|..
 Worm  2121 KVDGL--KTMFRDKKYDPKELVMNRRVDCDCK--ILSGIMVPVRSVIDESVHDTEIRDDGFEESC 2181

  Fly  2163 HLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLM 2227
            |||           .:..|..|.:.|.:|.|..||..:.:....|:...::.|..|||.:|....
 Worm  2182 HLP-----------DRYLIHDFSDKVKVLHSNTKPVIIKLTTKTGRIVRLICKKDDDLSKDYHFT 2235

  Fly  2228 EFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTR 2292
            :...:....|.:|...|.:::...||:|:|..::.|::|::..:.|:......|..    :.|..
 Worm  2236 KMVEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLDKLMG----MTSGE 2296

  Fly  2293 QLQSLAV------PLHESIERK--REVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTV 2349
            .|:.|..      |:.:....|  |||..|..    |.|..:|.|.::.....|:.:|..:.::.
 Worm  2297 WLEKLKFWNTHMKPMGKEERTKYFREVACKNT----PVVMGKWFRIQYPEAGQWFASRKLFAKST 2357

  Fly  2350 AVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPL 2414
            ||||::|||.||||||.:| |.....|..:||||:.:||:||.|..||:||||||.|||..||.:
 Worm  2358 AVMSVIGYIFGLGDRHTKN-LMVHTTGKCIHVDFDMIFNKGETLGTPELVPFRLTQNMINGMGEV 2421

  Fly  2415 GVEGSFRKCCEITLRLLKQESKTLMSILRPFVYDVGAQTRKGAATAKITKDV------QRIADRL 2473
            .::|.||..||..||:.::.|..    :..::.|:........:..:..||.      :.::.||
 Worm  2422 ALDGEFRTVCEQALRVFRENSYE----IEKYIADLPNLVADFPSNKRAPKDFDMSEAKRLVSGRL 2482

  Fly  2474 QGHV---KRQQANSI--PLSTEGQVNFLINEATKVDNLASMYIGWGAFL 2517
            :|.:   |..::|.|  |:......:.||..||..:.|:.||:||.|.|
 Worm  2483 RGQIMTAKLYRSNPISHPMQVSQLASSLIELATSEEKLSEMYLGWMATL 2531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 24/159 (15%)
FAT 1653..1985 CDD:396714 73/394 (19%)
TEL1 <1946..2517 CDD:227365 165/629 (26%)
PIKKc_ATR 2181..2448 CDD:270625 85/274 (31%)
atl-1NP_505487.3 FAT 1627..>1873 CDD:396714 53/261 (20%)
PIKKc 2189..2458 CDD:270708 86/281 (31%)
FATC 2500..2529 CDD:460514 10/28 (36%)

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