DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-41 and atl-1

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:NP_505487.3 Gene:atl-1 / 179352 WormBaseID:WBGene00000226 Length:2531 Species:Caenorhabditis elegans


Alignment Length:2779 Identity:549/2779 - (19%)
Similarity:1004/2779 - (36%) Gaps:778/2779 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   208 LASLNY-CHNVLRSQSASSWITNPDVGHYAQLTLEATAIMWSAVAKWLD------MGCMTRQELK 265
            |.|:.: .|.:...|..||   ...:..:..:.....|.....:||..|      |..:|:|:.:
 Worm    62 LQSITFTLHLITEKQELSS---EEKIRLFQSVIASMCAFEDEELAKCFDRILSVLMISVTKQDPR 123

  Fly   266 RLNITTKLLLEVL-HMRARPAHHLGYLLLNEILSLPTAIELDDGLLETLSSYIQGQLEHSVVP-- 327
            ......:.||||: :....|:..|..|:..||.|   ||.|.      .|.:.:..|:.:::.  
 Worm   124 ETIYFLQGLLEVVKYCDVEPSSSLPQLITPEIAS---AISLG------ASGFFRYHLKWNIISTL 179

  Fly   328 ----LEQLVHLQQLMLSHWHCHPTHLVPILALMGLKQTEMRSGVVQVLTQSLVEILKKEEVLSKD 388
                ..:.||..:|:|...||.......:.....:.:..:|:|:.         |||.:::.:..
 Worm   180 FGENAGECVHFDELVLFWPHCRSQLEDKLKNDCSMTENCLRAGLT---------ILKYKKLHNSI 235

  Fly   389 WQKLIAILRGFKQLEKL-------------ILSQSQHKIAEHEGHIDSSVLAM------LPLQCE 434
            ..:.:.|...|.....|             :|::.||.:.:|     ..||.|      .|:|..
 Worm   236 LDQALFIDELFATFNSLTAKKSTNHMTFPKLLNEIQHFLQDH-----GKVLIMHKELRQKPVQWL 295

  Fly   435 II---KVADTN-----WNNLSMQLVELESKCSADRRHIHLEICSLLMQITF--IRHFLKTQTQH- 488
            ||   .:.|.|     ..|.|:.|::|.:  :.|.......:|....:|..  |:|.:  |:.| 
 Worm   296 IIYLELIDDANDKFGLLENFSLLLLDLST--NHDIHEFPARLCMTASEICMRRIKHSI--QSTHT 356

  Fly   489 ----QLLAILQRHLKLS-------YLC-AIRLETPSSVHT-----------QMQSFYAQQYMRLF 530
                ..|.||...|||:       :.| |..:|...|::.           .:|:.:.||:.:. 
 Worm   357 DCLADYLDILASLLKLARIQKLDIFQCFATEIEAHHSLNNPLWPRILRSLLSVQNPHCQQFCKK- 420

  Fly   531 QSEETQEIFCSNLPQLYISGFIKPEQLMKALPTI-----------NNRSGRAQVIRLLL--C--- 579
                    |..::.:|:|: .:..|.....|.::           ||..|..|:|..||  |   
 Worm   421 --------FVPSIDKLWIT-LLNGESSRATLNSLVIVTASCPFANNNDEGVKQIIPFLLIPCFQD 476

  Fly   580 -------------------SQPGKL-------SVFK--VKDRIELYCPKCRPLPKKLPGIYLGKC 616
                               |:|.:|       :|.:  ..:..:|....|....:|..|.|: ..
 Worm   477 FRDRVGSKWDNFRFIGLPKSEPSELINLERFTTVLERSTSESTKLRAVNCALQLEKKTGKYI-NL 540

  Fly   617 KQQLPCPDFSSTNLEMIAND----LLFYPD-FECIAQHLDL----LCFEPNVI--LGLLRETEAL 670
            ..::....||.:..:.|||.    :||..| .:.|...:.:    ||.:....  |.:|:..:.|
 Worm   541 VAEMSLAVFSKSQTDRIANSFEPLILFLTDNLQLINDFITILIAKLCEKQEFYSELTILKYFKTL 605

  Fly   671 QKV---------SVKVIGQLV-----SAMRVRSPEFLEQLANLVLAAIKAMLAKPLTEQNVLQQR 721
            ||:         |.|..|:..     |...|:..  .|.|:.|    ||.::|:    :|...|.
 Worm   606 QKLFCLAANGRNSCKKCGEECFVDPDSKENVKID--YESLSGL----IKGIVAR----RNTFSQE 660

  Fly   722 SMLNVLTAIAHMEDNEIWLFHWFKMTFFFLVHTRSLVAQ-EAVLAATEMCASQGLQT-IHLWNWY 784
            .:...|      :.:.:.|.|         |.::.:.:. .:::.|.::..|:.... ..:|...
 Worm   661 LIREFL------QTSRVMLLH---------VDSKGIASSFTSIIKALDIGFSENANAYFRVWELV 710

  Fly   785 --KRDALDLTVRLALNVYL-LDGVRFTRSLRALTKMLGFTCVQEFTCKYHRLLTAMVLPHCIVNP 846
              :.:|   ||...|.:|: |.|..|.        :||    .:...|.|..|:.          
 Worm   711 CCRSEA---TVEKKLQMYIPLIGRSFA--------LLG----DDAALKVHGFLSN---------- 750

  Fly   847 LCKGVLVLIAKQMQKHIGTLFSISFLRIYTHVFLTEEPELANSCIELVVSCTQSS--LQQLMNAD 909
                  ||.|:.......|||:.||          ....|.|..|:..||.|..:  .|.|:.|.
 Worm   751 ------VLSARLSSTVKATLFASSF----------AHSVLKNCEIDWNVSYTWKTQFSQCLIKAP 799

  Fly   910 VKQTVAELLIYFNRNPTFVMRSFQSLLQLSIGS------------LEE-----LSSQTANAEFAN 957
            |......|.|.|.|..|...|.|.:.|.....|            :.|     ||...::..|.|
 Worm   800 VGTCEEALQIMFKRYSTIFTRCFLNRLFFDASSAGAQKPSYDEHRIREITRCYLSHVLSDFNFPN 864

  Fly   958 ----------------------------------FIAERFLGVITYFESCLSEPS-------FEK 981
                                              ||.:..........|....||       ..|
 Worm   865 QKITFNMIRPSLLYWSLLSSARGINSKLTLSVIDFICQEMSAASVSMSSISPNPSDIRIVMIQRK 929

  Fly   982 PLKEETLYSLGQIMRFVGSQHVTQF--------RFKIIAMLSFVHTLQEPRLQRICLKIWHIFLH 1038
            .|..||...|.|.:.|..:::.|.|        .||...:.:.:.:.::           .:|:|
 Worm   930 SLITETFAQLVQFLAFENNRNTTSFWKFCSDHCDFKDEDIRTVISSYRK-----------QVFMH 983

  Fly  1039 --VVNVQEL----GPSLGRIVATLQPLLADNESVKQ------------VNDLYEFIILRNASMLG 1085
              :|:.:|.    .||:     .::.|.|..|::|:            .|:..||:.:     ..
 Worm   984 LLLVSAREFLNPRNPSM-----IVEQLRATYENIKKGEKFMISTAIETRNEGIEFLFI-----FR 1038

  Fly  1086 TFIT-DLYFLDR----------MENVSPS--------IQKCIRRHTAHLDLKGLAEEENQSP--P 1129
            |:.| |.|||.|          ::|:...        |...:|:...:||       ..||.  .
 Worm  1039 TYFTNDQYFLTREATAESFRILLQNMKQDFFDTNWYIILMTLRQIPLNLD-------STQSSWIS 1096

  Fly  1130 LVDQLRF------LQKHITDECLQVRVYALQHLGDLFGRRRPKLN-STILSELPLEPMLEQIVNV 1187
            .::|:.:      :.:.:||      :..:::...|..:...:|: ..::.::..:.|::::..:
 Worm  1097 FIEQINYSILRSNIWRILTD------ISRIENNDILIEKVWNRLSYDMVIDKISTDAMIKRVFWL 1155

  Fly  1188 LMAGCQ-HDDSQLQMASAKCLGELGAIDASYLPSNYNFASPQHLPLNILSDDFAVLALTSLCRGY 1251
            :....: ..|.:.:::.::.:.::......:         ||: |....:|:.|    :.:.|..
 Worm  1156 IPLEVEKRIDLKFEISKSRQIEDVLEFIRMF---------PQY-PSVQFADNLA----SKIERKT 1206

  Fly  1252 QFQQN-TKHVDSFSLAIQETLAICGISPKEQKKVQLWQSLP---------------------ARM 1294
            .:::. .|.:.|.|..:.:    |....::.|.:::.|.||                     ...
 Worm  1207 VYKEELPKLIGSLSRILPQ----CHSKREQNKIIKILQKLPIICSDLPDHNFIRWDTRFKFFCEP 1267

  Fly  1295 RQLMEPMLHSCYTCVHRPSTCLQQPLFGSHYSHNYYEEWAFLWASRLIDYLPSSGRRHLLSSYKP 1359
            |||.:.:|..|...|.                        .:..:..|:|:.    |.:...||.
 Worm  1268 RQLTQAVLEDCAGIVE------------------------VMTGTSKIEYVD----RTMCEIYKF 1304

  Fly  1360 CIKRDSN--MLSTFYPYILLHALLECTTEQRNHIQEEFMAVLQANEESSSSVRGRQELGAIKENA 1422
            ....:::  |.||......::|.:.|:.:     .|..|...:..:|.|        ||..:..:
 Worm  1305 FNPNEASPEMKSTLDGIKNMYAKMICSQK-----PEPSMIEQKTIDELS--------LGGSRRES 1356

  Fly  1423 FKQF---------ESRKYAAGIKPLASTLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLREW--- 1475
            |.::         |..:.|    ||:|.......:|:..:.:||.:....::...:..:.:|   
 Worm  1357 FSRWLTVIILKCAEMSEDA----PLSSLASIAHVDDTRFLSKLAMRFILTVIHMERDSVTQWILS 1417

  Fly  1476 -------QRIHGRSTGG-KPPET-----IDSNY-----------RKIHEFLNLIPKLLVS----- 1511
                   ...|.|.|.. :.|.:     .|..|           :||.|.:....|.::|     
 Worm  1418 TFEEALTNTNHRRLTNSDRGPASFVFYVFDFIYSYSSSEELRKKKKIWEKVISFWKSMMSWTFKD 1482

  Fly  1512 ----------RASYNCGEYARALSYLESYLEEGEDKSQRLLEQ------FTFLVEVYGSLRDPDS 1560
                      :.:...|...|.:.:||.::|:....|..:..:      || |:.:||.:.:.:.
 Worm  1483 ENGHGQPLIVKVAETFGMEKRCILWLEMFMEQKRKTSTEIESETEAAYYFT-LMNLYGRIHELNG 1546

  Fly  1561 VEGAVQVRSYDMSVTQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQ 1625
            |.||                             |.:|    .::|.|||...|            
 Worm  1547 VRGA-----------------------------YARL----SRIQIDHVYGKI------------ 1566

  Fly  1626 LIADGLWQRLSDRYSDQCFA------------ECKSELLWRLG--SYDEMEELQ----------- 1665
                .:.:...|..|..|||            |...:|:..|.  .|.::|..:           
 Worm  1567 ----SMREAFGDFNSAACFARMTGKGKPFNSTEAIQKLIDELNCLEYSQIERNEQEDYLNSLKTL 1627

  Fly  1666 SNW----------PAQCSQG---------CLKLRRPLTTRIEFDSLLDGMRESVLEELRSCSAVQ 1711
            |.|          |...|:.         .||:.|........::.::..:..|:|.|..|:...
 Worm  1628 SQWVNIDNDIGPSPHIFSRNIEYWATESTILKMIRNDERDEIVNNAIENAKSKVIERLSECAIGG 1692

  Fly  1712 QHSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDE------DNQEKLMKNYFDDWQYRLQIVQP 1770
            ..||..|...:::|..::      |:||......||      |..:.:.|. .||.:.::.|::|
 Worm  1693 SCSYEIATPFLVELQKLN------EIVELKNVSNDELSAFNSDFWKNIQKR-TDDSEQKISILEP 1750

  Fly  1771 QVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAA 1835
            .:|::.|:...|       .:.:|.|:.  .::::.:..:.|.||:|.|..|..:||||.::.|.
 Worm  1751 ILRVRRSMLDIR-------MQSMTGRDK--ENIRSRIVEVHLQSARIARLTGCFERAQLSLINAK 1806

  Fly  1836 EYQP--SGLFIERAKLLWQKGDQVMAMN----------------YLEEQLSI---MRSGCQGNVK 1879
            :..|  :.:.:|.|||..|..|::..|:                |.:.|.|:   ::...:..::
 Worm  1807 KVLPFENKIVLEEAKLQLQTSDELNGMSLLDSIISKNFGDLHTIYTDTQQSVNLDVQKSAKLKIE 1871

  Fly  1880 QLAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEK--ILEA 1942
            ....|.::||      .:|......|:........|.:......|...|........|.  :|:.
 Worm  1872 HYQEETKNLF------SSVQMLRISHMIKAGNTIGFDKVYHETTQLLQCFAHSGVMYEAAWLLDY 1930

  Fly  1943 RQGGKSEPTGEQDDMLINVMVNYAKSLRYGSEHVYQ--SMPRLISLWLDTTES-STNTEQVKKM- 2003
            ....|     |:...::.::..|.:..:|....|.|  ::.|:.||||..|.. ||:...|.|: 
 Worm  1931 LSNYK-----ERSKHVLPLLKAYKEVAKYEKNQVLQARAVERMTSLWLSNTRKISTHISSVPKLP 1990

  Fly  2004 ----NDLLTNCCT---ALPTAV-------FYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQ 2054
                :||..|..:   .:.||:       ||..|:.:...:.|...:|...::.::.:|:...|.
 Worm  1991 EGQISDLRQNIKSMNREIQTALEHIGWRAFYPAYAVLARHIDHQDEEVTRTIKQIMKQLILRMPH 2055

  Fly  2055 QSLW----MLLPHFKSAKAH------RIKR---CKLVLTD-----SRLQNSTFQKLLQDFNSLTE 2101
            |.:|    :|..:..|.|..      .:||   |.:.|.|     |.:.|:...|:..|...|:|
 Worm  2056 QCMWQSAYLLRQNIASVKEKYMEVLTEVKRKAPCYVTLIDQYDYASGVFNTVSGKVESDDCKLSE 2120

  Fly  2102 RLMDLTNKEVTLDRTYKLSDL--DTRLSKLCKQPEFSQILLPFEKYMQPTLPLNS--DSNSSEGS 2162
            ::..|  |.:..|:.|...:|  :.|:...||  ..|.|::|....:..::....  |....|..
 Worm  2121 KVDGL--KTMFRDKKYDPKELVMNRRVDCDCK--ILSGIMVPVRSVIDESVHDTEIRDDGFEESC 2181

  Fly  2163 HLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLM 2227
            |||           .:..|..|.:.|.:|.|..||..:.:....|:...::.|..|||.:|....
 Worm  2182 HLP-----------DRYLIHDFSDKVKVLHSNTKPVIIKLTTKTGRIVRLICKKDDDLSKDYHFT 2235

  Fly  2228 EFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTR 2292
            :...:....|.:|...|.:::...||:|:|..::.|::|::..:.|:......|..    :.|..
 Worm  2236 KMVEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLDKLMG----MTSGE 2296

  Fly  2293 QLQSLAV------PLHESIERK--REVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTV 2349
            .|:.|..      |:.:....|  |||..|..    |.|..:|.|.::.....|:.:|..:.::.
 Worm  2297 WLEKLKFWNTHMKPMGKEERTKYFREVACKNT----PVVMGKWFRIQYPEAGQWFASRKLFAKST 2357

  Fly  2350 AVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPL 2414
            ||||::|||.||||||.:| |.....|..:||||:.:||:||.|..||:||||||.|||..||.:
 Worm  2358 AVMSVIGYIFGLGDRHTKN-LMVHTTGKCIHVDFDMIFNKGETLGTPELVPFRLTQNMINGMGEV 2421

  Fly  2415 GVEGSFRKCCEITLRLLKQESKTLMSILRPFVYDVGAQTRKGAATAKITKDV------QRIADRL 2473
            .::|.||..||..||:.::.|..    :..::.|:........:..:..||.      :.::.||
 Worm  2422 ALDGEFRTVCEQALRVFRENSYE----IEKYIADLPNLVADFPSNKRAPKDFDMSEAKRLVSGRL 2482

  Fly  2474 QGHV---KRQQANSI--PLSTEGQVNFLINEATKVDNLASMYIGWGAFL 2517
            :|.:   |..::|.|  |:......:.||..||..:.|:.||:||.|.|
 Worm  2483 RGQIMTAKLYRSNPISHPMQVSQLASSLIELATSEEKLSEMYLGWMATL 2531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 24/159 (15%)
FAT 1653..1985 CDD:280429 73/394 (19%)
PIKKc_ATR 2181..2448 CDD:270625 85/274 (31%)
FATC 2486..2517 CDD:280430 11/30 (37%)
atl-1NP_505487.3 FAT 1627..>1873 CDD:280429 53/261 (20%)
PIKKc 2189..2458 CDD:270708 86/281 (31%)
FATC 2500..2529 CDD:280430 10/28 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0.85977 Normalized mean entropy S4341
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D80538at2759
OrthoFinder 1 1.000 - - FOG0004409
OrthoInspector 1 1.000 - - oto18627
orthoMCL 1 0.900 - - OOG6_102609
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2044
SonicParanoid 1 1.000 - - X3128
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.800

Return to query results.
Submit another query.