Protein Alignment mei-41 and Y75B8A.24

DIOPT Version :9

• Sequence 1: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Sequence 2: NP_499596.2
• Gene: Y75B8A.24 / 176653
• WormBaseID: WBGene00013557
• Length: 2106
• Species: Caenorhabditis elegans
• Alignment Length: 2593
• Identity: 469/2593 - (18%)
• Similarity: 822/2593 - (31%)
• Gaps: 907/2593 - (34%)

  Fly   194 QALLILKECDMDTKLASLNYCHNVLRSQSASSWITNPDVGHYAQLTLEATAIMWSAVAKWLDMGC 258
            |.|.|....:.:|||:.:   .|:|.............:.|..:.:|       .|:|.:|
 Worm    13 QCLAICIAQNENTKLSQI---FNLLALDDKEEQFEAQPLSHNVRCSL-------IAIANYL---- 63

  Fly   259 MTRQELKRLNITTKLLLEVLHMRARPAHHLGYLLLNEILSLPTAIELDDGLLETLSSYIQGQLEH 323
                               ||...:.|..|..:||..:::||....:|||||.          :.
 Worm    64 -------------------LHSHGQHADELVPMLLRALIALPHMKWIDDGLLN----------KS 99

  Fly   324 SVVPLEQLVHLQQLMLSHWHCHPTHLVPILALMGLKQTEMRSGVVQVL---TQSLVEILKKEEVL 385
            ..:|:::....         |..|.|..:.|.:...:.::.|.....|   ..|:.::|:.:|.|
 Worm   100 DKIPIQEQFSF---------CFNTSLSDLAAHLPRFRQQIVSAQADALACAVSSIYDVLEDQESL 155

  Fly   386 SKDWQKLIAILRGFKQLEKLILSQSQHKIAEHEGHIDSSVLAML-PL------QCEIIKVADTNW 443
            ..::..:|.::     ...|.|.:|   |.......|:.::::: ||      :|:....||..
 Worm   156 EHNYSHVIKLM-----CYALGLLRS---IGRFSADYDTPLISLIFPLPVDETKKCKGAGGADIK- 211

  Fly   444 NNLSMQLVELESKCSADRRHIHLEICSLLMQITFIRHFLKTQTQHQLLAILQRHLKLSYLCAIRL 508
            :.:|......::.|.|....      .||:            |..:...:::.:.||.
 Worm   212 HRISSDEFTFDTSCDASSSD------PLLL------------TDSKSSRLIRMYNKLG------- 251

  Fly   509 ETPSSVHTQMQSFYAQQY---MRLFQSEETQEIFCSNLPQLYISGFIKPEQLMKALPTINNR--S 568
                      .||....|   ::|..|.|..|....::.:|..|.|      :::|..|:..  |
 Worm   252 ----------ASFLLNNYTGGLKLTMSSEDLEKLFDSVQRLMDSKF------LESLDEISGEIFS 300

  Fly   569 GRAQVIRLLLCSQPGKLSVFKVKDRIELYCPKCRPLPKKLPGIYLGKCKQQLPCPDFSSTNLEMI 633
            |.:.|          |.:.:|....|...|  |..|.|.:.|.|..|         .|..|.|..
 Worm   301 GGSGV----------KRNPYKSMSEITNLC--CLTLLKDVLGPYSVK---------NSDKNQENC 344

  Fly   634 ANDLL----FYPDFECIAQHLDLLCFEPNVILGLLRETEALQKVSVKVIGQLVSAMRVRSPEFLE 694
            .|.|.    ..|..|..|:.:.:  |....:..|..|..:||..|...:...||..::.......
 Worm   345 GNSLQEASPSSPISEKFAKEISI--FSKTALSKLDAELSSLQHSSESSLSTEVSRQKLNIQSATV 407

  Fly   695 QLANLVLAAIKAMLAKPL------------TEQNVLQQRSMLNVLTAIAHMEDNEIWLFHWFKMT 747
            .|..:..|||..|.|..:            |::.::.|..:  .|.||:.|..
 Worm   408 CLQLIAWAAIDDMDADAICTEIIVRLFANQTQKTIISQLPL--YLKAISSMAT------------ 458

  Fly   748 FFFLVHTRSLVAQEAVLAATEMCASQGLQTIHLWNWYKRDALDLTVRLALNVYLLDGVRFTRSLR 812
               |......||..||:        |.||...|      :...:..:||.:..|..|
 Worm   459 ---LAEKFPAVATTAVI--------QNLQRFLL------EPAPMLTKLASDSTLERG-------- 498

  Fly   813 ALTKMLGFTCVQEFTCKYHRLLTAMVLPHC-----IVNPLCKGVLVLIAKQMQKHIGTLFSISFL 872
               |..|                 .|:.|.     :::.:.|..|.|.|
 Worm   499 ---KSAG-----------------DVIQHSKSSNNLIDAITKRKLSLDA---------------- 527

  Fly   873 RIYTHVFLTEEPELANSCIELVVSCTQSSLQQLMNAD-VKQTVA----ELLIYFNRNPTFVM--- 929
                         |.||.|:.:....:||::  |.:| |:|.:|    :|.:..|.| .||:
 Worm   528 -------------LRNSAIKAICRALKSSIR--MESDSVQQCLAGLSTKLFVCSNAN-NFVVSLV 576

  Fly   930 --RSFQSLLQLSIGSLE-------ELSSQTANAEFANFIAERFLGVITYFESCLSEPSFEKPLKE 985
              .:.|:|..:.:|.::       |:..|.....|||..::..:.:|    .||:|
 Worm   577 CENAIQTLGGIGVGLVDSTAVEVPEMVVQIYLQRFANPPSQLDVTMI----RCLAE--------- 628

  Fly   986 ETLYSLGQIMRFVGSQHVTQFRFKIIAMLSFVHTLQEPRLQRICLKIWHIFLHVVNVQELGPSLG 1050
                     |...|::.:.:..:|:..              :||::                |..
 Worm   629 ---------MWIAGARSIYENVWKLFT--------------QICIE----------------SSN 654

  Fly  1051 RIVATLQPLLADNESVKQVNDLYEFIILRNASMLGTFITDLYFLDRMENVSPSIQKCIRRHTAHL 1115
            |:.:.     .:|||    ||                       .|..:||.::...:.|..|
 Worm   655 RVYSQ-----GNNES----ND-----------------------QRYTHVSLAVDVAMSRMAA-- 685

  Fly  1116 DLKGLAEEENQSPPLVDQLR-FLQ-----KHITDECLQVRVYALQHLGDLFGRRRPKLNSTILSE 1174
               |:|.|:::...||..|. |:|     :.:.::..:..|......|:| |...||:.|.:...
 Worm   686 ---GVANEDDKMTLLVRLLELFVQLGIEGRRVGEKVSKSTVKMSTSAGNL-GVLMPKIASLLRRM 746

  Fly  1175 LPLEPMLEQIVNVL--------MAGCQHDDSQL------------------QMASAKCLGELGAI 1213
            .|:.....::.::.        :.|...:.|.|                  .:|:.....||  |
 Worm   747 QPISEPTTKLRSLFRDFWFYCTVLGFDVESSSLWPEEWYNAVCETATKTPVLIATENLRSEL--I 809

  Fly  1214 DASYLPSNYNFASPQHL------------------PLNILSDDFAVLALTSLCRGYQFQQ----N 1256
            |.:.:.|  :..|||.|                  || |...|||  ..|.|...::.:.    :
 Worm   810 DNAAIRS--DSISPQELQEMRNTVLAELSHQAEAVPL-INRFDFA--NCTYLLSVHRMETMRLIH 869

  Fly  1257 TKHVDSFSLAIQETLAICGISPKEQKKVQ--LWQSLPARMRQLMEPMLHSCYTCVHRPSTCLQQP 1319
            ..|||:||...:.      |..|..:|.:  ||..:.|...::   .|..|...:.|...  .:|
 Worm   870 ANHVDAFSSFFKY------IEDKTMRKDKSGLWTCMLAAAPRI---FLEWCEKMMKRRDN--DEP 923

  Fly  1320 LFGSHYSHNYYEEWAFLWASRLIDYLPSSGRRHLLSSYKPCIKRDSNMLSTFYPYIL-----LHA 1379
                       .|.|.:|.::.:.:..:...|.:......|:   |.::..| ||:|     |..
 Worm   924 -----------TEEALVWHAQFLLFKFNHHLREVRKVADACL---SQLVKAF-PYLLWNTKVLTT 973

  Fly  1380 LLECTTEQRNHIQEEFMAVLQANEESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPLASTLVS 1444
            :|....|..:::|::     ....|...::.|   .|..........|.|:             |
 Worm   974 ILRLLQELEDNLQKD-----PTCREPQFTIEG---FGGWTIQLQDSIEGRR-------------S 1017

  Fly  1445 DRKEDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGGKPPETIDSNYRKIHEFLNLIPKLL 1509
            ..|:.|.||        .::|....||               .|.:..||              |
 Worm  1018 VVKDFSMRV--------KQILKEALRW---------------APASTHSN--------------L 1045

  Fly  1510 VSRASYNCGEYARALSYLESYLEEGEDKS----QRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSY 1570
            :...|....|...|:........||..||    ..|.::..:|.:|.|.|.
 Worm  1046 LEYVSKFGSERDAAMQLAIDATSEGSGKSGSYLTSLYKRSNYLGQVKGMLA-------------- 1096

  Fly  1571 DMSVTQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTP-KTAQLIADGLW-- 1632
             .:::.||          |.:|:..||:   |:::.|..||....  :|.. :.|.|:...|:
 Worm  1097 -TTLSGDI----------DQVTAENQLI---DRLEKDFQRACKSG--KDMEMEQAVLLLTALFVS 1145

  Fly  1633 -QRLSDR------------YSDQCFAECKSELLWRLGSYDEMEELQSNWPAQC------------ 1672
             :.|::|            :::...:.|.....|.|.:..|...|..:..|:.
 Worm  1146 LRSLNERILSLLVRTPLLNFTESTVSLCTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGLF 1210

  Fly  1673 -------SQGCLKLRRPLTTR--------IEF-----DSLLDGMRE--SVLEELRSCSAVQQHSY 1715
                   |..|.||.||..:.        |||     |......||  .|||.:
 Worm  1211 EKEVVGGSPLCQKLERPPPSANFRPHREWIEFIGERCDVASYSSREQLDVLEMM----------- 1264

  Fly  1716 ANAYDAVLKLHL-VHELH----CSQELVEKLEQDRDEDNQE-----------KLMKNYFDDWQYR 1764
               :...|..|: ...||    ||..........::..||.           :|:.......|..
 Worm  1265 ---FSQTLSAHIGTGHLHGSTACSNPASLAGPSRKETINQVTRGIEAVGVRFRLLSCVLGMVQQD 1326

  Fly  1765 LQIVQP-QVRIQESIYS--FRRNILA-----ELQRRLTDRNHLL----PHLKTE--------LAR 1809
            ..:::| .|.|::.:||  |....:|     :.:.||.:...||    .|||.:        ||:
 Worm  1327 ACLLRPTNVLIRQRVYSCAFHYFTIAPQGPTQPEERLREDIRLLTRFFEHLKNDKHYMQKEALAK 1391

  Fly  1810 ---------------------IWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIERAKLLWQK 1853
                                 :.::...:...|.......|.:..:..| .:.|.:...|.:...
 Worm  1392 TDKNLVMSSTMSQMQTNFEKSLLISGTPVTATAAGTPNTSLMLPPSTNY-ANTLTLSSQKSMAAT 1455

  Fly  1854 GDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQAVYSAESMHLCADAV--LKYFQ 1916
            ...:.:...:|.:|||..   ...:|.. .:||::.              |.|.|:.:  |..:.
 Worm  1456 SASIRSGKSIETKLSIEE---DRRIKTW-MKQRNML--------------MLLVANEIERLSAWL 1502

  Fly  1917 EAIAVHRQSESCHVQMAQFLE-KILEAR-QGGKSEPTGEQDDMLINV-----------------M 1962
            ..:|:  ..|.|.:...:||. ...:|: .||:.....||..:..::                 :
 Worm  1503 HPLAL--AQEDCALDSEEFLRGAFTQAKATGGEKNIWREQAQLAWDISPELAIQLPSRFRGSPEL 1565

  Fly  1963 VNYAKSLRYGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLT--NCCTALPTAVFYTVYSQ 2025
            |.|...|..|.......:|..:.|:|.   :.:...:...|:.:||  .|...:       ..|.
 Worm  1566 VKYVDVLVRGQPEPVAHIPEALPLFLG---NGSTVFETSDMSHVLTWARCSPVM-------ALSL 1620

  Fly  2026 MLSRL--CHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAH-----------------R 2071
            :..|:  .||::..:.|      :::.:|....|.:.:|....|..:                 :
 Worm  1621 LTPRIYPMHPISMQYAV------RVLRSYSADELLLYIPQIVQAVRYDTMGYISELIIWLAGHSQ 1679

  Fly  2072 IKRCKLV-------LTDSRLQ----------NSTFQKLLQDFNSLTERLMDLTNKEVTLDRTYKL 2119
            :...:|:       .||...:          |...||:|........|..         :..:||
 Worm  1680 LLSHQLIWNMQTNMFTDEESKVKDPVLFEALNDIMQKILSQLEGAARRFH---------EAEFKL 1735

  Fly  2120 SDLDTRLSKLCKQPEFSQILLPFEK---YMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYI 2181
            ....|.:|...|         ||.|   ..:..|...:|......::||:|
 Worm  1736 FHQLTAISGTIK---------PFPKGDARKKACLKALADVKIETITYLPSN-------------- 1777

  Fly  2182 SGFQESVLI---------LRSAAKPKKL----TIRCS---------------DGK----DYDVLV 2214
               .|:||:         ::||||...|    ..||.               .||    |.:.|.
 Worm  1778 ---PEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIGLQAQSEHGGKTTEADLEELK 1839

  Fly  2215 KPK--------------DDLRRDARLMEFNGLVKR-YLHQDAPARQRRLHIRTYAVLPFNEECGL 2264
            |.:              ||:|:|...::...|:|. :.....|.|     :..|.|:..:..||:
 Worm  1840 KVQDSRVCWQAAIFKVGDDVRQDMLALQLMQLMKNVWAGLGLPVR-----VFPYRVVATSPGCGV 1899

  Fly  2265 VEWLPNLASY----RSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQ 2325
            :|.:||..|.    |.....||                           |.|..|........||
 Worm  1900 IECVPNSKSRDQLGRQTDFGLY---------------------------EYFKTQYGDESSETFQ 1937

  Fly  2326 EWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQ- 2389
                          |||..::|::|..|:..::|.:.|||..||:. :.:|..:|:||..:|..
 Worm  1938 --------------EARRNFVRSMAAYSVFSFLLQIKDRHNGNIMI-DLDGHIIHIDFGFMFESS 1987

  Fly  2390 --GELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRK---CCEITLRLLKQESKTLMSIL 2442
              |.|...|:   |:|:..|:..||.......||:   .|......::...|:.:|::
 Worm  1988 PGGNLGFEPD---FKLSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLV 2042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825	14/104 (13%)
		FAT	1653..1985	CDD:280429	77/443 (17%)
		PIKKc_ATR	2181..2448	CDD:270625	69/319 (22%)
		FATC	2486..2517	CDD:280430
Y75B8A.24	NP_499596.2	PI4Ka	1544..1720	CDD:238443	27/191 (14%)
		PI4Kc_III_alpha	1781..2105	CDD:270711	68/312 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900