DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and age-1

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	NP_496462.2	Gene:	age-1 / 174762	WormBaseID:	WBGene00000090	Length:	1182	Species:	Caenorhabditis elegans

Alignment Length:	1272	Identity:	227/1272 - (17%)
Similarity:	405/1272 - (31%)	Gaps:	432/1272 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1296 QLMEPMLHSCYTCVHRPSTCLQQPLFGSHYSHNYYEEWAFLWASRLIDYLPSSGRRHLLSSYKP- 1359
            :|:.||....|:.  :|...:.:.|      :|:.|........:.:..|...|...:|..|:|
Worm   118 ELIAPMKWGTYSV--KPQDYVFRQL------NNFGEIEVIFNDDQPLSKLELHGTFPMLFLYQPD 174

  Fly  1360 CIKRDSNMLSTFYPYILLHAL---LECTTEQRNHIQEEFMAVLQANEESSSSVRGRQELGAIKEN 1421
            .|.||..::|.     :.|.|   |:...|..:....:|.|.|.|..:.:...||      ::..
Worm   175 GINRDKELMSD-----ISHCLGYSLDKLEESLDEELRQFRASLWARTKKTCLTRG------LEGT 228

  Fly  1422 AFKQFESRKYAAGIKPLASTLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGGK 1486
            :...|...:|..    :..:...|          |..|:.|..|.:...|.:....|:|
Worm   229 SHYAFPEEQYLC----VGESCPKD----------LESKVKAAKLSYQMFWRKRKAEING------ 273

  Fly  1487 PPETIDSNYRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFT----- 1546
                             :..|::..:..:|..|..::|  |.::|.|     .|.|:.:.
Worm   274 -----------------VCEKMMKIQIEFNPNETPKSL--LHTFLYE-----MRKLDVYDTDDPA 314

  Fly  1547 ---FLVEVYGS---LRDPDSVEGAVQVRSYDMSVTQDILVNR----LVERQQDMITSYEQLLSST 1601
               :.:::.|.   :.:||     |::.||| .|..::...|    :|.||..::..|   ....
Worm   315 DEGWFLQLAGRTTFVTNPD-----VKLTSYD-GVRSELESYRCPGFVVRRQSLVLKDY---CRPK 370

  Fly  1602 DQMQPDHVRA--------MIDAYLRDTPK--------------TAQLIADGLWQRLSDRYSDQCF 1644
            ...:|.:|||        ::...:..|||              ||.|....||
Worm   371 PLYEPHYVRAHERKLALDVLSVSIDSTPKQSKNSDMVMTDFRPTASLKQVSLW------------ 423

  Fly  1645 AECKSELLWR---LGSYDEMEELQSNWPAQCSQ----------GCLKLRRPLTTRIE-------- 1688
             :..:.|:.|   :..:|        :||....          |.|.|....||::.
Worm   424 -DLDANLMIRPVNISGFD--------FPADVDMYVRIEFSVYVGTLTLASKSTTKVNAQFAKWNK 479

  Fly  1689 ----FDSLLDGMRESVLEELRSCSAVQQHSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDEDN 1749
                ||..:..|..|                     |||.:.:::                   .
Worm   480 EMYTFDLYMKDMPPS---------------------AVLSIRVLY-------------------G 504

  Fly  1750 QEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQRRLTDRNHL-LPHLKTELARIWLN 1813
            :.||....|:.....:.:...:..:::..:.|                || .|......:||..|
Worm   505 KVKLKSEEFEVGWVNMSLTDWRDELRQGQFLF----------------HLWAPEPTANRSRIGEN 553

  Fly  1814 SAQINRNAGQLQRAQLYILKAAEY--------QPSGLFIERAKLLWQKGDQVMAMNYLE------ 1864
            .|:|..||.       ..::.:.|        |....::.:.:..|.:...:|..:|..
Worm   554 GARIGTNAA-------VTIEISSYGGRVRMPSQGQYTYLVKHRSTWTETLNIMGDDYESCIRDPG 611

  Fly  1865 -EQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSESC 1928
             ::|.::....:..:.....||||::...:|:|
Worm   612 YKKLQMLVKKHESGIVLEEDEQRHVWMWRRYIQ-------------------------------- 644

  Fly  1929 HVQMAQFLEKILEARQGGKSEPTGEQDDMLINVMVNYAKSLRYGSEHVYQSMPRLISLWLDTTES 1993
                              |.||     |:||                   .:..|..:|.|....
Worm   645 ------------------KQEP-----DLLI-------------------VLSELAFVWTDRENF 667

  Fly  1994 STNTEQVKKMN--------DLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVE 2050
            |.....::|..        .||...||   ..|......:.|:....||.....:|..:.....|
Worm   668 SELYVMLEKWKPPSVAAALTLLGKRCT---DRVIRKFAVEKLNEQLSPVTFHLFILPLIQALKYE 729

  Fly  2051 AYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQKLLQDFNSLTERLMDLTNKEV---- 2111
            ...|..:.|:|          :.|   .|.|.|:.:..|..|..:...|  |..||.::|.
Worm   730 PRAQSEVGMML----------LTR---ALCDYRIGHRLFWLLRAEIARL--RDCDLKSEEYRRIS 779

  Fly  2112 ---------------TLDRTYKLSDLDTRLSKLCKQPEFSQILLPFEKYMQPTLPLNSDSNSSEG 2161
                           .:.|...:.|..||:|.|.|.       :|.:   ..|:.|..:..|.
Worm   780 LLMEAYLRGNEEHIKIITRQVDMVDELTRISTLVKG-------MPKD---VATMKLRDELRSI-- 832

  Fly  2162 SHLPANQSTVNWFPYQQIYISG--FQESVLILRSAAKPKKLTIRCSDGKD------YDVLVKPKD 2218
            ||...|..:    |...:|..|  ..:..::|.||.:|..|..:..:.|.      ..::.|..|
Worm   833 SHKMENMDS----PLDPVYKLGEMIIDKAIVLGSAKRPLMLHWKNKNPKSDLHLPFCAMIFKNGD 893

  Fly  2219 DLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNL------------ 2271
            |||:|..:::    |...:.....|......:..|||||..|..|::|.:||.
Worm   894 DLRQDMLVLQ----VLEVMDNIWKAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQVGTGF 954

  Fly  2272 --ASYRSI---CMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQR 2331
              .:.|||   .||.:.:::..:...:.:|........||:|  :...|.:
Worm   955 MNTAVRSIDPSFMNKWIRKQCGIEDEKKKSKKDSTKNPIEKK--IDNTQAM-------------- 1003

  Fly  2332 FATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQG--ELLP 2394
                ..::|:.:.::.:....|:..||:|:.|||.:|::..| :|...|:||..:...|  :|..
Worm  1004 ----KKYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLMLTE-DGKYFHIDFGHILGHGKTKLGI 1063

  Fly  2395 YPEVVPFRLT-HNMIVAMGPLGVEGS------FRKCC 2424
            ..:..||.|| |.|.|......|:|:      |:..|
Worm  1064 QRDRQPFILTEHFMTVIRSGKSVDGNSHELQKFKTLC 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	49/372 (13%)
		PIKKc_ATR	2181..2448	CDD:270625	62/278 (22%)
		FATC	2486..2517	CDD:280430
age-1	NP_496462.2	PI3K_p85B	98..177	CDD:197539	13/66 (20%)
		PI3K_rbd	241..360	CDD:197540	28/164 (17%)
		C2_PI3K_like	420..574	CDD:176026	34/237 (14%)
		PI3Ka	606..798	CDD:214537	42/283 (15%)
		PKc_like	793..1181	CDD:304357	78/349 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900