DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-41 and let-363

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:NP_491549.2 Gene:let-363 / 172167 WormBaseID:WBGene00002583 Length:2695 Species:Caenorhabditis elegans


Alignment Length:3000 Identity:572/3000 - (19%)
Similarity:1038/3000 - (34%) Gaps:1013/3000 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 KLLYNHVNRNVS-------------NFSGVYSVIEDILCQEPSL---------ISCSLV--RELH 50
            :|..:|::|.::             .|..:::.:.|   :.|::         :..::|  ||..
 Worm   215 RLAASHLSRELALATPTAFFLRVNLFFKYIFNAVRD---KNPAVRIAGIDALHVVLTIVSQREAK 276

  Fly    51 NKFQDTFLLWLLNKLAKCLSESPDSSECINLQR-----KILSSCCSNHPKLFERLVLAYVEAIEE 110
            ||.:     |......:.|...|:.|:..:|.|     .||:.......:.||.:.....:.|::
 Worm   277 NKTE-----WFKKCFDEALEGQPNPSQKDDLDRWHAVALILNELLRISDQRFELIRCESSQFIKQ 336

  Fly   111 THLQ------------------LSSLDLGQLSNERKPAITVRIFRCDVECLQEFDPHCAIEDIKV 157
            ..|:                  :.|:...:|..||.|.|        ::|:::.          :
 Worm   337 KFLKEDEEEGVEWLVLTKQQTIVESVTARKLVLERFPKI--------LDCVRQI----------I 383

  Fly   158 PL--------EQADMYAKSLLEVLQHAHHIGYATHGDIFSGSLHQALLILKECDMDTKLASLNYC 214
            ||        :|:.:|..::|.                   .|...:....:||...:..|.:..
 Worm   384 PLANKTSSTKQQSSIYLNTVLM-------------------QLLPRICAFPQCDRTFQTISFDTS 429

  Fly   215 HNVLRSQSASS------WITNPDVGHYAQLTLEATAIMWSAVAKWLDMGCMTRQELKRLNITTKL 273
            ..:|:..:.::      .::||||  :|....:..:.:.:|:.|..:...:.       |..|.|
 Worm   430 FTILQRNAVAAPAIGMMMLSNPDV--HATHIEKTISFISAAIKKTTNSDVLD-------NYFTFL 485

  Fly   274 LLEVLHMRARPAHHLGYLLLNEILSLPTAIELDDGLLETLSSYIQGQLEHSVVPLEQLVHLQQLM 338
            .|.|      .|:|                       |.:::.|:     :::|     .|..:.
 Worm   486 FLFV------DAYH-----------------------EQVTTQIK-----AIIP-----QLMDIT 511

  Fly   339 LSHWHCHPTHLVPILALMGLKQTEMR--------SGVVQVLTQSLV--------------EILKK 381
            ||.      .|..:|.::.::..::|        :.|.|.||.||:              .||:|
 Worm   512 LSR------SLANVLKMIMMRIPKLRLNVQDGVMASVYQTLTGSLIPPKSEPIGRPASPKAILQK 570

  Fly   382 EEVLSKDWQKLIA---ILRGFKQLEKLILSQSQHKIAEHEGHIDSSV--LAMLPLQCEIIKVADT 441
            .|...|:.|:::.   :|..| ...:..|.:....:|::....|:..  ||.:...||::     
 Worm   571 AETDPKELQRIVLAVDVLGEF-YFSRGALQRIMQYVADYYLTADNVEIRLAAVSSCCEMV----- 629

  Fly   442 NWNNLSMQLVELESKCSADRRHIHLEICSLLMQITFIRHFLKTQTQHQLLAILQRHLKLSYLCAI 506
                  :..|.:..|.::|:|:      |||..|..:                     |..:|::
 Worm   630 ------VPFVGVYKKVTSDKRN------SLLQTIYGV---------------------LRAVCSV 661

  Fly   507 RLETPSSVHTQMQSFYAQQYMRLFQSEETQEIFC-SNLPQLYISGFIKPEQLMKALPTINNRSGR 570
             :.....|..:|                 |.|.| ..:|:.:::...:||.|......:::....
 Worm   662 -IVNDQDVRVRM-----------------QVISCFGQMPRPFLAHLAQPEMLEVQFMALHDEKLE 708

  Fly   571 AQVIRLLLCSQPGKLSVFKVKDRIELYCPKCRPLPKKLPGIYLGKCKQQLPCPDFSSTNLEMIAN 635
            .|...:.|..:..:|:                      |.:.|.:.:..|               
 Worm   709 MQQACVTLLGRLAELN----------------------PALVLPRLRLML--------------- 736

  Fly   636 DLLFYPDFECIAQHLDLLCFEPNVILGLLRETEA-LQKVSVKVIGQLVSAMRVRSPEFLEQLANL 699
                   .|.::|              :.:..:| |::.|.|:|.||..    :||:|:......
 Worm   737 -------LETLSQ--------------MQQSGQARLEQHSAKMIAQLAK----QSPKFMRPYVGS 776

  Fly   700 VLAAIKAMLAKPLTEQNVLQ-QRSMLNVLTAIAHMEDNEIWLFHWFKMTFFFLVH----TRSLVA 759
            ::.   ||:.|...:|...: ...:||.::.||.:...||  ....|..|..|.|    :.||..
 Worm   777 LMI---AMIPKLRNDQKYAEVTAQVLNAVSEIAVIGGAEI--VKNLKPLFEKLTHMINDSSSLHK 836

  Fly   760 QEAVLAAT-EMCASQGLQTIHLWNWYKRD---ALDLTVRLALNVYLLDGVRFTRSLRALTKMLG- 819
            :||.|.|. .:|.|    |.::.:.| ||   .||..:|: |...:.:.:|     |...|.|| 
 Worm   837 REAALRAIGGICRS----TAYVVDPY-RDYPSLLDDLLRI-LKTVMSNTMR-----REAIKTLGI 890

  Fly   820 -----------FT-CVQEFTCKYHRLLTAMVLP--------------------HCIVNPLCKGV- 851
                       || .||..|.    :.||:.||                    .|.:......: 
 Worm   891 LGAIDPYTHKVFTGSVQSSTA----ISTALSLPISETDSKDPRQDIIHWFNYEKCTLEEFYPAIT 951

  Fly   852 ---LVLIAK--------QMQKHIGTLF-SISFLR-IYTHVFLTEEPELANSCIELVVSCTQSS-- 901
               |:|:.:        ::.:.|.|:| |:..:. :||...:   |.|    ||:....|:||  
 Worm   952 IANLMLMMQDEDSQSYAEIAQAIVTIFRSLGDMAPLYTEQVI---PRL----IEVCRRATESSNR 1009

  Fly   902 -------LQQLMN--ADVKQTVAELLIYFNRNPTFVMRSFQ---SLLQLSIGSLEELSSQTANAE 954
                   ||||.|  |.:::..|.   |.....|.:..:::   |:..:.|..|.::.:...| :
 Worm  1010 ANLREFFLQQLANFVAIIRKHAAP---YMPAIFTIIADAWKEDISVKMVVIEVLTDMGTAIGN-D 1070

  Fly   955 FANFIAERFLGVITYFESCL-SEPSFEKPLKEETLYSLGQIMRFVGSQH-----------VTQFR 1007
            |:.:..|    :|.|..:.| ::.:.|:.|..:.:.|:.::...: .||           :..|.
 Worm  1071 FSKYTGE----LIPYLLTVLQTDKTKERVLTVKVMESIQKLTHCI-VQHLHLVLPPLLIILDDFS 1130

  Fly  1008 FKI----IAMLSFVHTLQE-------PRLQRICLKIWHIFLHVVNVQELGPSLGRIVATLQPLLA 1061
            .|:    .|:.:.:|..|:       ||:    ::.||   |.::..|:...|         ||.
 Worm  1131 LKLSIRNTALSTVLHMTQQVDVSAYAPRM----MQSWH---HNISTAEMRDKL---------LLL 1179

  Fly  1062 DNESVKQVNDLYEFI------------------------ILRNASMLGTFITDLYFLDRMENVS- 1101
            ..|.:||:...::..                        :.:.|.|....:|...|.....|:. 
 Worm  1180 LIEIIKQLGKFFDIFKRGVDQKLRDYNLDKSVHYEQYRKLAQRAQMSRDVLTSSVFAGSNGNIQY 1244

  Fly  1102 PSIQKCIRRHT----AHLDL----------KGLAEEENQSPPLVDQLRF-LQKHITDECLQVRVY 1151
            .|.|..:|...    |:.||          .|.:.::|:.    |..|: :::.|::|.      
 Worm  1245 SSTQAGMRGQANNVYANNDLHERLMNGSIDSGASRQDNRD----DYYRYGVEEKISEEV------ 1299

  Fly  1152 ALQHLGDLFGRRRPKLNSTI---LSELPLEPMLEQIVN--VLMAGCQHD-----DSQLQMASAKC 1206
                         ||:..|.   .|||....:.:|.:|  .||...:::     |..||......
 Worm  1300 -------------PKVAPTTARPTSELVTVQITKQRLNKDALMPQWKNENLTSKDEWLQWLMKIR 1351

  Fly  1207 LGELGAIDASYLPSNYNFASPQHLPLNILSDDFAVLALTSLCRGYQFQQNTKHVDSFSLAIQETL 1271
            :|.|          .|. :||.....:.|.|....||.......  |......:||   .:|..|
 Worm  1352 IGFL----------TYG-SSPSLRAASSLGDQHPHLARDLFPAA--FMSVWTELDS---DVQNDL 1400

  Fly  1272 AICGISPKEQKKVQLWQSLPARMRQLMEPMLHSCYTCVHRPSTCLQQPLFGSHYSHNYYEEW--- 1333
            ..|           |.:::...:.:|::.:|:......|.....|  |:     ||:....|   
 Worm  1401 TSC-----------LLRAISTGIPELIQTILNLAEFMDHSEKGPL--PI-----SHDVLGRWAEQ 1447

  Fly  1334 --AFLWASRLIDYLPSSGRRHLLSSYK--PCIKRDSNMLSTFYPYILLHALLEC----TTEQRNH 1390
              ||..|.|                ||  ..:|:..:|.:||...:.|.. .:|    |...:.:
 Worm  1448 TKAFAKACR----------------YKEMSVLKKSGSMQTTFTRKVKLEP-NDCQSLITYANKLN 1495

  Fly  1391 IQEEFMAVLQANE--ESSSSVRGR---------QELGAIKENAFKQFESRKYAAGIKPLASTLVS 1444
            :|||...|::..|  |.:..:|||         :.|||.      :.|.:|.::    ..:..|.
 Worm  1496 VQEEAAGVVRYAERNEMNFQMRGRWYEKLNEWEKALGAY------ELEEKKKSS----CPNLQVY 1550

  Fly  1445 DRKED--------SSRVPRLAGKLCAELLDFLQRWLREWQRIHGRST------GGKPPETIDS-N 1494
            |.|:.        ::...|:....|.|.|.       .|..::.:|.      |.:.....|. |
 Worm  1551 DEKDHLMTPEEAATAEEARMHEMRCLEALG-------RWDELNSKSVVWADQRGNRNDSVRDEIN 1608

  Fly  1495 YRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEEGED----------------KSQRLLE 1543
            .:::...:.:|    .:|.::....:.|...|:....|..:|                |:..|:|
 Worm  1609 KKQLDHKMAVI----AARGAWAVDNWERMADYVSVISENTQDGAMLRAVVAVHNDENTKAMGLIE 1669

  Fly  1544 QFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQDILVNRLVERQQDMITSYEQLLSSTDQMQPDH 1608
            :...::         ||...|:...||:.:....:.|.::.|.::.:  .|        :.:|:.
 Worm  1670 KVREMI---------DSELTAMANESYERAYIPMVSVQQMAELEEAI--EY--------KTRPER 1715

  Fly  1609 VRAMIDAYLRDTPKTAQLIADGL---------WQRLSDRYSDQCFAECKSELLWR--LGSYDEME 1662
                       .|:.|.|.:..|         ||||               ::.|  :.|..||.
 Worm  1716 -----------RPRIALLWSRRLQGCRRNVEQWQRL---------------IMLRGLVLSPQEMH 1754

  Fly  1663 ELQSNWPAQC-SQGCLKLRRPLTTRIEFDSLLDGMRESVLEELRSCSAVQQHSYANA-YDAVLKL 1725
            .|:..:.:.| .||                 .:.|..:||.||.|..|......|.| :|..|.:
 Worm  1755 PLRVKFSSMCRKQG-----------------KNSMSRAVLRELLSLPANSDLVRAKAPFDKPLLV 1802

  Fly  1726 HLVHELHCSQELVEKLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQ 1790
                     ..|.::|.||..:|...:.:::..:.|..|:..:.                     
 Worm  1803 ---------LALAKQLYQDDHKDEAIRALEDLANHWNKRINPIP--------------------- 1837

  Fly  1791 RRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIERAKLLWQKGD 1855
             :.|.| .|:|....|.|||   .|::             :||..|:       ...|.......
 Worm  1838 -KATGR-ELIPPSTKEPARI---CAKV-------------LLKLGEW-------TELKSKTSNNM 1877

  Fly  1856 QVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIA 1920
            ||..::::.:|:|......:....:..|.:..:.:   |.||.......|       |.:.:..:
 Worm  1878 QVGELSFVRQQVSPQYRTKESRTPETIAFENTINY---YQQATQYDPGWH-------KVWHKLAS 1932

  Fly  1921 VH---------------------RQSESCHV-----------------QMAQF------LEKILE 1941
            .|                     :|.:..|:                 |.|.|      |..|::
 Worm  1933 THFYAVCRERPHPTTVISPPQQPQQPKKMHIPPVTRATSPPPPAQKSPQPAPFHSITEPLSVIID 1997

  Fly  1942 -----------------ARQGGKS---------------EPTGEQDDML-----INVMVNYAKSL 1969
                             |.....|               .|:...::.|     .:.:..:||:|
 Worm  1998 YPVPPPLGSLVGLPPMPAYLSSNSSLPPQHHHVSPLSNDSPSNSAENKLYLKHAAHAVRCFAKAL 2062

  Fly  1970 RYGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDL---LTNCCTALPTAVFYTVYSQMLSRLC 2031
            ........:...||:.||.|..:.        |..|:   ||.....||...:.....|:::||.
 Worm  2063 MCSPGSRLEDTLRLMQLWFDHGDD--------KDQDVYFALTETIFDLPVTTWLEAIPQLMARLD 2119

  Fly  2032 HP--VNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQKLLQ 2094
            .|  ...|..||| |:.::....||..::.|....:|...||.|....||......:|   ||::
 Worm  2120 CPDDQKSVQLVLR-VLCEIARHRPQAVIYALTVASRSKDVHRSKNAGTVLEKMMEYHS---KLVR 2180

  Fly  2095 DFNSLTERLMDL----------------------TNKEVTLDRTYKLSDL-----DTRLSKLCKQ 2132
            :.:.:||.|:..                      .|.:...|....::||     .|.:.:...|
 Worm  2181 EASLVTEELVRCAILWHEQWHDALDDASRVYFHDNNVQAMFDALRNMNDLMQKGAPTTMKEHSFQ 2245

  Fly  2133 PEFSQILLPFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIY----------------- 2180
            ..:|..|....:|:|        :..|.|:....||:   |..|..::                 
 Worm  2246 QTYSSDLKEAGRYVQ--------AFESSGNVKDLNQA---WEIYCSVFKKLRDQLATLNSLDLVY 2299

  Fly  2181 ---------------------------ISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKD 2218
                                       |..|...:.::.|..:|:|:.||.|:|.||..|:|..:
 Worm  2300 VSPNLVSAKDLELVVPGTYDPSAPIVSIQSFSSKMNVITSKQRPRKMVIRGSNGLDYQFLLKGHE 2364

  Fly  2219 DLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYA 2283
            |.|:|.|:|:..|||...|..::...:|.|.|:.|:::..:::.||:.|:||..:..:: :..|.
 Worm  2365 DPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHTL-VKEYR 2428

  Fly  2284 QRR----LVMSTRQLQSLAVPL-HESIERKREVFTKQLVPAHPPVFQE--WLRQRFATPHS--WY 2339
            :::    |.:..:.||.|::.. |.::.:|.::|...|........:.  ||:    :|.|  |:
 Worm  2429 EKKAKIPLSIEHKTLQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWLK----SPSSEVWF 2489

  Fly  2340 EARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELL-PYPEVVPFRL 2403
            :.|..|.|:||.||||||||||||||..|::.....|..||:||...|....|. .:||.|||||
 Worm  2490 DRRTNYTRSVACMSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPFRL 2554

  Fly  2404 THNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYDVGAQTR------KGAATAKI 2462
            |..:|.||...|::|.:....|..|::|:...::|:::|..||||.....|      |...|.|.
 Worm  2555 TRMLINAMEVTGLDGVYNYTAERVLKMLRTNQESLLAVLEAFVYDPVINWRLVEGMKKDPKTRKD 2619

  Fly  2463 TKDVQRIA----------DRLQGHVKRQQANSIPLSTEG-----------QVNFLINEATKVDNL 2506
            |...|.:|          |.:...:||:...:..:.|:|           |:..|..:||...||
 Worm  2620 TGGRQNMAGAVLPSSSTTDSIMETIKRKLDGTEFVHTDGSTPPEPLQVTEQLAMLTEQATSPLNL 2684

  Fly  2507 ASMYIGWGAF 2516
            ...||||..|
 Worm  2685 CQSYIGWCPF 2694

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 22/127 (17%)
FAT 1653..1985 CDD:280429 66/416 (16%)
PIKKc_ATR 2181..2448 CDD:270625 92/276 (33%)
FATC 2486..2517 CDD:280430 12/41 (29%)
let-363NP_491549.2 HEAT repeat 654..683 CDD:293787 7/67 (10%)
TEL1 683..2695 CDD:227365 471/2375 (20%)
HEAT repeat 693..722 CDD:293787 4/28 (14%)
HEAT repeat 731..764 CDD:293787 10/68 (15%)
HEAT repeat 774..805 CDD:293787 6/33 (18%)
HEAT repeat 819..854 CDD:293787 12/38 (32%)
DUF3385 854..1028 CDD:288698 43/191 (23%)
HEAT repeat 863..887 CDD:293787 6/29 (21%)
Extensin_2 1970..2032 CDD:252669 7/61 (11%)
Rapamycin_bind 2188..2286 CDD:285924 17/108 (16%)
PIKKc_TOR 2327..2606 CDD:270713 94/283 (33%)
FATC 2664..2695 CDD:280430 10/30 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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