DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-41 and mei-41

DIOPT Version :10

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_061514646.1 Gene:mei-41 / 1280291 VectorBaseID:AGAMI1_011692 Length:2656 Species:Anopheles gambiae


Alignment Length:2844 Identity:894/2844 - (31%)
Similarity:1380/2844 - (48%) Gaps:536/2844 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 KDMWKLLY----NHVNRNVSNFSGVYSVIE-DILCQEPSLISCSLVRELHN---KFQDTFLLWLL 62
            :.|||.|.    :.|:.:..:...:.|:|. ||...:|.|...:|:.|...   :..:.:|::.:
Mosquito    15 ESMWKTLIITFTDIVHDHEPHLEKILSMIRTDITYDDPGLFPKTLLNEAERHRCRCSNYWLMYQI 79

  Fly    63 NKLAKCLSESPDSSECINLQRKILSSCCSNHPKLFERLVLAYVEAIEETHLQLSSLD-----LGQ 122
            .::|...:....|....:||::|:.:              :|   |::..|.|.:..     |.|
Mosquito    80 LRIASLETYESISGSYTSLQKEIIKA--------------SY---IKQRWLALDTFREFIKLLNQ 127

  Fly   123 LSNERK---PAITV-----------------------RIFRC---DVECLQEFDPHCAIEDIKVP 158
            :::.:|   .|||.                       .:.||   .:.||     |...|.|.:.
Mosquito   128 MNDFKKGCPEAITTFYDAFQNVTAQGKQYFCEKIEIKSMARCRLVRLHCL-----HTLSEAISML 187

  Fly   159 LEQADMYAKSLLEVLQHAHHIGYATHGDIFSGSLHQALLILKECDMDTKLASLNYCHNVLRSQSA 223
            ..|.|      :|.:|....|.......:..|::.:..:.:        :...||..:|::.:|.
Mosquito   188 TNQQD------VESIQVVKEITCTVLKTLSVGNIEEKRISI--------IFFQNYFKHVVQERSG 238

  Fly   224 SSWITNP--------------DVGHYAQL------------------TLEATAIMWSAV-AKWLD 255
            |..:.|.              |..|.|.|                  |.:.:...|..| .||:|
Mosquito   239 SYPLYNMFNMINLLDVSLMGYDTWHSAMLMNRREVEYFVDTSTELFSTHQRSHQSWPVVPRKWID 303

  Fly   256 -----MGC-----------MTRQELKRLNITTKLLLEVLHMRARP-AHHLGYLLLNEILSLPTAI 303
                 :.|           :.::..::||.|...||:.|    :| ..|.|| :...|.....::
Mosquito   304 KILTVLLCTSLQPEQKVENLEKRHQEKLNQTLMALLQKL----KPELMHTGY-VPESINWFGASM 363

  Fly   304 ELDDGLLETLSSYIQGQLEHSV-------VPLEQLV----------------------------- 332
            :|||.|:..:...|.....:||       |.||..|                             
Mosquito   364 KLDDHLVTQIVKQINNARYNSVNKKQPTSVHLESAVWAIFLVNINKNSKLLKRALNMANKMDFKL 428

  Fly   333 HLQQLMLSHWHCHPTHL----------------VP-ILALMGLKQTEMRSGVVQVLTQSLVEILK 380
            |.|....|.   ..|.|                || ::.|.|.:|.::.:.||.|          
Mosquito   429 HAQMPFCSE---GDTELKNQQFFFFESKLELLQVPSLVELFGSRQMDLINAVVSV---------- 480

  Fly   381 KEEVLSKDWQKLIAILRGFKQLEKLILSQSQHKIAEHEGHIDSSVLAMLPLQCEIIKVADTNWN- 444
               :|..|.               |:|:|:|.:        :...:...|.:.       .||| 
Mosquito   481 ---ILINDC---------------LLLNQNQQR--------NLFQILFAPFEA-------NNWNG 512

  Fly   445 ----------NLSMQLVE--LESKCSADRRHIHLEI--CSLLMQITFIRHFLKTQTQHQLLAILQ 495
                      .:..:|.:  ||..|.....::|.|:  |.:..::|.:..|: ..|:|. .||.|
Mosquito   513 DVNQRYSWDTQMDNELCQHALEQLCKLRTNNLHSEVVSCCIKKKLTSLLTFI-ANTEHG-YAIKQ 575

  Fly   496 RHLKLSYLCAIRLETPSSVHTQMQSFYAQQYMRLFQSEETQEIFCS---NLPQLYISGFIKPEQL 557
                                |.:.||              |::..|   ||..|:      ...|
Mosquito   576 --------------------TLVHSF--------------QQLILSSKINLFDLF------ENVL 600

  Fly   558 MKALPTINNRSGRAQVI---RLLLCSQPGKLSVFKV----KDRIELYCPKCR---PLPKKLPGIY 612
            :..|.|||..:..|.::   .|..|.:...::.|:|    :.:....|.:|.   .....|...|
Mosquito   601 VPLLSTINGDAALADIVGVFSLFCCLRSDCIASFRVFQISETKRSFQCRECNNRTVSTTHLEDYY 665

  Fly   613 LGKCKQQLPCP---------------DFSSTNLEMIANDLLFYPDF-ECIAQHLDLLCFEPNVIL 661
            :....:||...               ..|.||.|   ..||...:| .|..:||.|...:..:..
Mosquito   666 IQTSSEQLMAQGKSINIDSHLRAFLLKISHTNEE---TTLLAMTNFLPCALKHLPLFMIDGEIES 727

  Fly   662 GLLR-----ETEALQKVS--VKVIGQLVSAMRVRSPEFLEQL-----ANLVLAAIKAMLAKPLTE 714
            ..:|     ..:..|:::  :..|.|::||..|..|...|.|     ..|:.|:...::.|....
Mosquito   728 CWIRLFGSNTAKVGQQLTEHIYAILQILSAYLVNKPGRYENLLTSMMEQLLSASRMCIMTKTTYA 792

  Fly   715 QNVLQQRSMLNVLTAIAHME------DNEIWLFHWFKMTFFFLVHTRSLVAQEAVLAATEMCASQ 773
            :.::..|.:...|.|.:|:.      |.:..|||..::..:.|:|..|.|..||.:..|||||.|
Mosquito   793 EQIIVVRMVAEFLNANSHIALRWKLIDVKETLFHCVRIMIYLLMHPESHVTHEASIVITEMCARQ 857

  Fly   774 GLQTIHLWNWYKRDALDLTVRLALNVYLLDGVRFTRSLRALTKMLGFTCVQEFTCKYHRLLTAMV 838
            .:....:.:||:.|.:.|.:.:|::.|:|.|:...:|:..::.........:|..|:::.:.||:
Mosquito   858 DISPNKVLSWYRHDIIKLMMSIAVSNYILAGITLHQSISIVSYTFESRDPVDFVGKHYKTIMAML 922

  Fly   839 LPHCIVNPLCKGVLVLIAKQMQKHIGTLFSISFLRIYTHVFLTEEPELANSCIELVVSCTQSSLQ 903
            ||.|:.:..|:.:|..||..::|.:..|.|.|||.|||::|::|..|:.|.|||.::..|.:|..
Mosquito   923 LPWCLRSSKCEYLLREIAVIVRKDLVALLSTSFLTIYTYLFISESVEVTNKCIEYIMRITGNSFF 987

  Fly   904 QLMNADVKQTVAELLIYFNRNPTFVMRSFQSLLQLSIGSLEELSSQTANAEFANFIAERFLGVIT 968
            .|:::|:|:||:|:|||::.||..||.:|:|||     |.:..:.:.:....|.:||||||||:.
Mosquito   988 HLLHSDIKRTVSEVLIYYHINPECVMHAFRSLL-----SKDSDNDEVSTTRIAEYIAERFLGVLA 1047

  Fly   969 YFESCLSEPSFEKPLKEETLYSLGQIMRFVGSQHVTQFRFKIIAMLSFVHTLQEP-RLQRICLKI 1032
            ..|:.|..|..||.||...|.|||.|:|.:|.:|:|.||||:||:|.....|.|. .|.:.|:..
Mosquito  1048 NLEATLVNPDGEKFLKRLALLSLGDIIRLLGGEHITPFRFKVIAVLRTALALPEGLALAKHCVNT 1112

  Fly  1033 WHIFLHVVNVQELGPSLGRIVATLQPLLADNESVKQ-VNDLYEFIILRNASMLGTFITDLYFLDR 1096
            |.||:..|:|::||..|..|..||:||:   ::.|: :..::.::::.|.|:||..:.||:|::.
Mosquito  1113 WRIFVCTVDVRQLGSLLSTIFVTLEPLI---DTYKEDIGYIFRYLVIENNSLLGNSLCDLFFIED 1174

  Fly  1097 MENVSPSIQKCI-RRHTAHLDLKGLAEEENQSPPLVDQLRFLQKHITDECLQVRVYALQHLGDLF 1160
             .||:.:|:|.: .|...:.|       |..|...|.:|..|.:|...|.|:||.||..:|..|.
Mosquito  1175 -TNVAENIKKIVASRIPKYYD-------EIGSDQFVTRLEELIRHSNHENLKVRAYAFSYLCRLC 1231

  Fly  1161 GRRRPKLNSTILSE---LPLEPMLEQIVNVLMAGCQHDDSQLQMASAKCLGELGAIDASYLPSNY 1222
            ...|.:||..||.:   :.| .::..:|..|..|....|..||..:|:|||||||:..|:||.||
Mosquito  1232 EHGRAELNEAILGQHQSISL-TIIATMVETLTRGLSEQDVILQQRAAECLGELGALAPSHLPPNY 1295

  Fly  1223 -----NFASPQHLPLNILSDDFAVLALTSLCRGYQFQQNTKHVDSFSLAIQETLAICGISPKEQK 1282
                 .||      |:|.||.||::||..|||.||.|:::|.||||||||||.|...|:||:..|
Mosquito  1296 APTGIGFA------LSIHSDCFAIIALRELCRAYQRQKDSKFVDSFSLAIQEILNERGVSPEADK 1354

  Fly  1283 KVQLWQSLPARMRQLMEPMLHSCYTCVHRPS-TCLQQPLF---GSHYSHNYYEEWAFLWASRLID 1343
            |.::|:::|.|:|.:|||:|.||||.|.|.| |.:..|:|   ||  ||    ||.:.||.::|:
Mosquito  1355 KREIWETIPERLRPIMEPLLTSCYTTVSRASQTAVAHPVFNNVGS--SH----EWCYQWACQMIE 1413

  Fly  1344 YLPSSGRRHLLSSYKPCIKRDSNMLSTFYPYILLHALLECT-TEQRNHIQEEFMAVLQ---ANEE 1404
            .:..:..|:||.::||.::.|...|....||||||:||.|. .::|..|.||..||..   |..|
Mosquito  1414 NITVNSTRNLLRAFKPSLRCDRGTLMLMLPYILLHSLLLCEGNDKRQFIVEELHAVFNGAIAYCE 1478

  Fly  1405 SSSSVRGRQELGAIKENAFKQFESRKYAAGIKPLASTLVSDRKEDSSRVPRLAGKLCAE----LL 1465
            |.|::.     .|.:.|.....|:.. |.|   |...:..:|.:.|.:...|.   ||:    |.
Mosquito  1479 SFSTIP-----AANRANDKVDIETTS-ANG---LIVCMTQERHDTSGKELALQ---CAKYAFGLF 1531

  Fly  1466 DFLQRWLREWQRIHGRSTGGKPPETIDSNYRKIHEFLNLIPKLLVSRASYNCGEYARALSYLESY 1530
            |||:||.|::  :...:|..|.......|:..:..|||.....|:::.::.|.||||||.|:|..
Mosquito  1532 DFLERWKRQY--LKDVTTKDKDLHNYQHNFVVVSTFLNNFDSNLLAQVNFKCHEYARALQYVEHS 1594

  Fly  1531 LEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQDILVNRLVERQQDMITSYE 1595
            | .|||||.:|.::.:||.|:|..|.|.|||||.:.:::.:.::.:.||.:....|.|:.:..||
Mosquito  1595 L-NGEDKSIKLQKKLSFLCELYSHLGDTDSVEGVIALKATEPTLHELILYHNATGRLQEAVACYE 1658

  Fly  1596 QLLSST--DQMQP--DHVRAMIDAYLR-DTPKTAQLIADGLWQRLSDRYSDQCFAECKSELLWRL 1655
            :||..|  ::..|  :.:.:||:.||| |.|:||.|:|:.|..|..|....:...:.::|.|:||
Mosquito  1659 RLLQLTNIEEQYPSLNFLNSMIECYLRLDHPETALLLAESLLVRFHDTALHKSLLDIQAEPLYRL 1723

  Fly  1656 GSYDEMEEL----------------QSNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLEEL 1704
            |.::|:|||                ..:|...|....::.|:|...|  |.|.:...|..|.:  
Mosquito  1724 GRFEELEELLLQRRADQLSGAIDGESRHWGVICGSLIIEFRQPDYAR--FCSEIQRARMYVFQ-- 1784

  Fly  1705 RSCSA--------VQQHSYANAYDAVLKLHLVHEL----HCSQELVEKLEQDRDED--------- 1748
            .|||.        .|..:|.|.||.|||||::.|.    |....|....:..|:::         
Mosquito  1785 GSCSKRSSSRSLDEQLGTYENRYDQVLKLHIIQEFAKCGHIMHTLRTLQKGQRNDELITASTVIV 1849

  Fly  1749 NQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQRRLTDRN----------HLLPHL 1803
            :.:||:.|    ...||:::||.....|.|.|.||.:|.|::|.:.:.|          :.|.||
Mosquito  1850 DLQKLVTN----MNARLEVLQPNAATIEPILSLRRILLKEMRRTIDEINWEKIDDDENVNRLRHL 1910

  Fly  1804 KTE-LARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQL 1867
            ..: :.::|:.|.::...|...|:|.||||.|..|:|..|||:.|||||.:.|...|:..||..|
Mosquito  1911 VDQTIGQLWMKSTELASRANMYQQALLYILHAESYRPPDLFIKNAKLLWDRRDITGALKVLERGL 1975

  Fly  1868 S-----IMRSGCQGN-VKQLAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSE 1926
            :     :..|....| :|....|.|.:...||.|.|.|:||:.::.|....:||:||:.::.:||
Mosquito  1976 NEILGDVPVSSVDNNHIKTTPKEIRLIQAEGKRLIATYNAEASNISATLNRRYFKEAVDMNPESE 2040

  Fly  1927 SCHVQMAQFLEKILEARQGGKSEPTGEQD-----DMLINVMVNYAKSLRYGSEHVYQSMPRLISL 1986
            ...||:||:::|:.      .|.|..||:     :||..||..|.||:.|||.::||||||::|:
Mosquito  2041 VALVQLAQYVDKLY------SSCPAVEQNSANCWEMLFEVMKCYGKSMMYGSNYIYQSMPRVLSI 2099

  Fly  1987 WLDTTE---------SSTNTEQVKK----MNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVF 2038
            |||:|.         :||:....:|    ||.|.:.....|....|:|.:||::||:.||..:.|
Mosquito  2100 WLDSTANTIPKSSEGTSTSLNMARKIAQSMNKLASKFKDTLSPYFFFTAFSQLISRVAHPSQETF 2164

  Fly  2039 TVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSR-LQNSTFQKLLQDFNSLTER 2102
            .:|:.:|:||:..||||:|||:|..:||:...|::||..:..|.: ||....|||::|||.|.||
Mosquito  2165 IILKAIIVKLLLYYPQQTLWMILSVYKSSYTIRVRRCVEIFNDRQLLQVENMQKLIKDFNGLAER 2229

  Fly  2103 LMDLTNKEVTLD----RTYKLSD-----LDTRLSKLCKQPEFSQILLPFEKYMQPTLPLNSDSNS 2158
            |::|||||:..:    |..||::     |...|.||.....||.||:|.|:.:|..|..|:..|.
Mosquito  2230 LIELTNKEIPGNPGGIRHSKLANVTVSILVKALPKLLADKNFSNILIPIERCIQLVLNKNTGMNF 2294

  Fly  2159 SEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRD 2223
            ..             :|...|||:|..|.|.:|.|..||:|:::|..:||.|.:::|||||||:|
Mosquito  2295 QP-------------YPTNAIYIAGISEEVTVLHSLQKPRKISLRGHNGKLYTMMMKPKDDLRKD 2346

  Fly  2224 ARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLV 2288
            .||||||.:||:||.||..|:.||||||||||||.|||||::||:.||.::|.|....|.||.|.
Mosquito  2347 FRLMEFNAVVKQYLSQDPDAKFRRLHIRTYAVLPLNEECGIIEWISNLNTFRGIVCTYYKQRGLG 2411

  Fly  2289 MSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMS 2353
            |:.::|::......|.:.:||..|...|||.|||:|.||.|..|..||:|::||::||:|.||:|
Mosquito  2412 MTAKELRNFNYERTEPLAKKRHAFETILVPRHPPLFSEWFRDCFPNPHNWFQARSSYIKTTAVIS 2476

  Fly  2354 MVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEG 2418
            ||||||||||||||||||...|||.||||||||||:||....||:|||||||||:.|||||||||
Mosquito  2477 MVGYILGLGDRHGENILFDSTNGDTVHVDFNCLFNRGETFTVPELVPFRLTHNMVDAMGPLGVEG 2541

  Fly  2419 SFRKCCEITLRLLKQESKTLMSILRPFVYD-----------VGAQTRKGA----ATAKITKDVQR 2468
            .:|:||||.||:|:..:.|.||:|:|||||           .|..:::.:    ...:...:|..
Mosquito  2542 LYRRCCEIVLRILQTHASTFMSVLKPFVYDPMVSWSKITFAQGESSQRDSYLERTDPQAMHNVLN 2606

  Fly  2469 IADRLQGHVK-RQQANSIPLSTEGQVNFLINEATKVDNLASMYIGWGAF 2516
            |.:||:|:|| ..:.:..|||.|||||.||.|||.:||||.|||||..:
Mosquito  2607 IEERLKGYVKVNGKLSHNPLSIEGQVNHLIKEATDIDNLAQMYIGWSGY 2655

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 48/105 (46%)
FAT 1653..1985 CDD:396714 121/390 (31%)
TEL1 <1946..2517 CDD:227365 285/615 (46%)
PIKKc_ATR 2181..2448 CDD:270625 157/266 (59%)
mei-41XP_061514646.1 None

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