DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-41 and Tor

DIOPT Version :10

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_061516349.1 Gene:Tor / 1278082 VectorBaseID:AGAMI1_003192 Length:2531 Species:Anopheles gambiae


Alignment Length:2865 Identity:562/2865 - (19%)
Similarity:986/2865 - (34%) Gaps:958/2865 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 WLLN---KLAKCLSESPDSSECINLQRKILSSCCSNHPKL--FERLVLAYVEAIEETHLQLSSLD 119
            |.:|   :..:||.::....:.:|...::       |..|  |..::.....|.|:.::||.||.
Mosquito   216 WHMNCYDQAFECLRDTVGREKNLNRDDRV-------HGALIVFNEILRCSHAAWEKKYMQLDSLP 273

  Fly   120 LGQ---LSNERKPAITVRIFRCDVECLQEFDPHCAIEDIKVPLEQADMYAKSLLEVLQHAHHIGY 181
            :.|   |.::|:........|..|..:::|..|.....:.        |:....:|:.....  :
Mosquito   274 VDQKRSLRSQREEEGRGFFPRIRVPFMEKFGNHSGQSSVS--------YSSRYYDVVTDMKF--F 328

  Fly   182 ATHGDIFSGSLHQALLILKECDMDTKLASLNYCHNVLRSQSASSWITNPDVGHYAQLTLEATAIM 246
            ..:..:...:|::||  :|| ..||      .|..||..:|:.|        .|...||      
Mosquito   329 RQNSSVQESALYRAL--VKE-KYDT------ICQAVLDQRSSKS--------PYVIQTL------ 370

  Fly   247 WSAVAKWLDMGCMTRQELKRLNITT--KLLLEVLHMRARPAH----HLGYLLLNEILSLPTAIEL 305
               :|.:..:....|:|..||::.|  ..||.:|..:.:..:    .|||:.:        |:|.
Mosquito   371 ---LAIFPRLAAFNREEFVRLHLRTVANYLLTLLRSKEKERNAAFVSLGYIAV--------AVEK 424

  Fly   306 DDGLLETLSSYIQGQLEHSVVPLEQL-----------VHLQQLMLSHWHCHPTHLVPILALMGLK 359
            :   :|..:..|. :|..|.:||:..           |.:..::|.|            ||.|..
Mosquito   425 E---IEPYTKRIM-ELIGSALPLKDTPNKRKAPVDPSVFMCVMLLGH------------ALKGGI 473

  Fly   360 QTEMRSGVVQVLTQSLVEILKKEEVLSKDWQKLIAILRGFKQLEKLILSQSQHKIAEHEGHIDSS 424
            ..|::..:..:|:..|.             ..||..||...:    .:.|:|.:|......|.|.
Mosquito   474 THEIKEIIAPMLSTGLS-------------PALIVCLRELCE----TVPQAQQEITAGLLKILSY 521

  Fly   425 VLAMLPLQCEIIKVADTNWNNLSMQLVELESKCSADRRHIH----------------LEICSLLM 473
            ||...||...|:..:.:..:...:..:|.:.:....::.:|                .|.||||.
Mosquito   522 VLMNRPLPQFIVPKSHSVVSPAFLSSLEQQPQSQPPQQQVHDTATIVLALQTLGKFSFEGCSLLQ 586

  Fly   474 QITFIR----HFLKTQTQHQLLAILQRHLKLSYLCAIRLETPSSVHTQMQSFYAQQYMRLFQ--- 531
               |::    |||.::.|.                 ||:|   :|||  .:|..:..::..:   
Mosquito   587 ---FVQRCADHFLNSEQQE-----------------IRIE---AVHT--CTFLLKLALQAAESNG 626

  Fly   532 ---SEETQEIFCSNLPQLYISGF--IKPEQLMKALPTINNRSGRAQVIRLLLCSQPGKLS----- 586
               ||...:...|.|.::.:.|.  :.|...::.|.:: :.|...|:      :||..||     
Mosquito   627 NDVSETLTQTLSSVLEKILVVGITDVDPAVRLRVLKSL-DESFDTQL------AQPWFLSSLLVT 684

  Fly   587 ----VFKVKDRIELYCPKCRPLPKKLPGIYLGKCKQQLPC---PDFSSTNLEMIANDLLFYPDFE 644
                ||::::               |..|.:|:.....|.   |....|.::::..         
Mosquito   685 IHDEVFEIRE---------------LAIIIIGRLSTINPAYVMPSLRKTMVQLLTE--------- 725

  Fly   645 CIAQHLDLLCFEPNVILGLLRETEALQKVSVKVIGQLVSAMRVRSPEFLEQLANLVLAAIKAMLA 709
              .:|           .|:.|..|.    |.:::..|:    |.:|..:......:|..:...|.
Mosquito   726 --LEH-----------SGVSRNKEQ----SARMLDHLI----VSTPRLVASYMRPILTILVPKLK 769

  Fly   710 KPLTEQNVLQQRSMLNVLTAIAHMEDNEIWLFHWFKMTFFFLVHTRSLVAQEAVLAATEMCASQG 774
            :|  :||   ...:||||.||..:.  |:...|          |.....:.|.:....:|.:..|
Mosquito   770 EP--DQN---PSVVLNVLRAIGDLA--EVIGGH----------HVLQKWSDELLQLLLDMLSDAG 817

  Fly   775 ---LQTIHLWNWYKRDALDLTVRLALNVY--LLD-GVRFTRSLRALTKMLGFTCVQEFTCKYHRL 833
               .:.:.||.:.:..:....|.:..|.|  |:| .:.|.::.:.|               |.|.
Mosquito   818 STEKRAVALWTFGQLVSATGQVVVPYNKYPNLIDILINFLKTEQQL---------------YVRR 867

  Fly   834 LTAMVLPHCIVNPLCKGVLVLIAKQMQKHIGTLFSISFLRIYTHVFLTEEPELANSCIELVVSCT 898
            .|..||          |:|                 ..|..|.|       ::....|:     :
Mosquito   868 ETIRVL----------GLL-----------------GALDPYKH-------KMNRGLID-----S 893

  Fly   899 QSSLQQLMNADVKQ------TVAELLIYFNRN-----PTFVMRSFQSLLQLSIGSLEELSSQTAN 952
            |:|...|::.|.|.      :.:|:||..:..     |..|:.:...:|:....|...||...| 
Mosquito   894 QTSANILISVDTKTDEHTDLSTSEMLINMSTQLDEYYPAVVISTLMKILRDPTLSNHHLSVVQA- 957

  Fly   953 AEFANFIAERFLGVITYFESCLSEPSFEKPLKEETLYSLGQIMRFVGSQHVTQ-----FRFKIIA 1012
                          ||:                 |..|||    ..|..:::|     .|..:.|
Mosquito   958 --------------ITF-----------------TFTSLG----IKGVPYLSQVLPCLLRNIVTA 987

  Fly  1013 MLSFVHTLQEPRLQRICLKIWHIFLHVVNVQELGPSLGRIVATLQPLLADNESVKQVNDLYEFII 1077
            .:|    |:|...|::...|..:..|::..                          ::|::|   
Mosquito   988 EMS----LKEYLFQQLSTLISIVKQHIIGF--------------------------MDDIFE--- 1019

  Fly  1078 LRNASMLGTFITDLYFLDRMENVSPSIQKCIRRHTAHLDLKG-------LAEEENQSPPLVDQLR 1135
                 ::.||.|                      |....:.|       .|...:..|.:::.:.
Mosquito  1020 -----LIKTFWT----------------------TGGAGVPGGGGSSSSTASAASLQPTIINLVE 1057

  Fly  1136 FLQKHITDECLQVRVYALQHLGDLFGRRRPKLNSTILSELPLEPMLEQIVNVLMAGCQHDDSQLQ 1200
            .:.  |...| :.:||                         |..::.||:.||:    ||.|:.:
Mosquito  1058 KIA--IALGC-EFKVY-------------------------LPQLMPQILRVLL----HDTSKDR 1090

  Fly  1201 MASAKCLGEL----GAIDASYL----PSNYNFASPQHLPLNILSDDFAVLALTSLCRGYQFQQNT 1257
            ..:.|.||.:    ..:| .||    |:......|..:|||:     ::.||.::  .|      
Mosquito  1091 AVTVKLLGAMRNFGNNLD-DYLHLIIPAIVKLFEPLDIPLNV-----SITALQTI--NY------ 1141

  Fly  1258 KHVDSFSLAIQETLAICGISPKEQKKVQLWQSLPARMRQLMEPMLHSCYTCVHRPSTCLQQPLFG 1322
                     :.|.|.....|.:                 ::.|::...                 
Mosquito  1142 ---------LAEVLDFTDFSSR-----------------IVHPLVRVL----------------- 1163

  Fly  1323 SHYSHNYYEEWAFLWASRLIDYLPSSGRRHLLSSYKPCIKRDSNMLSTFYPYILLHALLECTTEQ 1387
                 ::|.|...:..:.|...:...||::|:  :.|.:.|  .|:....|.:....||  |..|
Mosquito  1164 -----DFYPELRPVALTTLCSIMIQLGRKYLV--FVPLVNR--VMIKHKIPSVEYTKLL--TKLQ 1217

  Fly  1388 RNH---IQEEFMAVLQANEESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPLASTLVSDR--- 1446
            .|.   :.:|| .:.||...:       :|:....::..|     |:...:..|.:...::|   
Mosquito  1218 NNSTLAMDDEF-RIRQARNRN-------REISLPSDSTIK-----KFPVSMSDLEAMFKANRRVS 1269

  Fly  1447 KED--------------SSRVPRLAGKLCAELLDFLQRWLRE---------WQRI---------H 1479
            |:|              .|:.|.|  :.||.|.....:.|::         |..:         |
Mosquito  1270 KDDWLEWLRRLSIILLKESKNPAL--RSCATLAQNYPQLLKDLFNAAFVSCWSDLSEKLKQDLAH 1332

  Fly  1480 GRS---TGGKPPETIDSNYRKIHEF--------LNLIPKLLVSRASYNCGEYARALSYLESYLEE 1533
            ..:   |....|| |......:.||        |.:..|:|..|| ..|..||:||.|.|.....
Mosquito  1333 SLTQALTVQDLPE-ITQTVLNLAEFMEHCESYPLKIDSKILGERA-MECRAYAKALHYKEDEFHR 1395

  Fly  1534 GEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQDILVNRLVERQQDMITSYEQLL 1598
            .:|..|.|.|.   |:.:...|:..::.||.::......|..:::.|.   .|..:.:.|:||  
Mosquito  1396 TDDPPQSLFES---LILINNKLQQKEAAEGLLEYAGRHRSSAEEMKVQ---VRWYEKLHSWEQ-- 1452

  Fly  1599 SSTDQMQPDHVRAMIDAYLRDTPKTAQ--------LIADGLWQRL---SDRYSDQCFAECKSE-- 1650
                      .|::....|:..|...:        |.|.|.|..|   :.:..|...:|.:|:  
Mosquito  1453 ----------ARSLYSEKLKSNPNDLESRLGEMRCLEALGEWSALNAVTTQNWDALGSEGQSKAG 1507

  Fly  1651 -----LLWRLGSYDEMEELQSNWPAQCSQGCLKLRRPLTTRIE----FDSLLDGMRESVLEELRS 1706
                 ..|.|..:|.|.......|.....|.. .|..|....|    ..||:|..|:.:..||  
Mosquito  1508 RLAAAAAWGLQDWDGMHRFVRCIPEDTQDGAF-YRAVLAVHNEQYALAQSLIDSTRDLLDTEL-- 1569

  Fly  1707 CSAVQQHSYANAYDAVLKLHLVHELHCSQELVE-KLEQDRDEDNQ----EKLM--KNYFDDWQYR 1764
             :|:...||..||.|::.:.::.||   :|::: ||..:|.|..:    ::|:  :...:|||..
Mosquito  1570 -TAMAGESYERAYGAMVCVQMLAEL---EEVIQYKLIPERRETIKSMWWDRLLGGQRLVEDWQRV 1630

  Fly  1765 LQIVQPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQL 1829
            :|:                              |.|.....|..|.||..|.:.|..|.|:.::.
Mosquito  1631 IQV------------------------------HSLVLSPKEDIRTWLKFASLCRKNGSLKLSEK 1665

  Fly  1830 YILKAAEYQP-----SGLFIERAKLLWQKGDQVMAMNYLEE--------------QLSIMRSGCQ 1875
            .:....||.|     ..|.|::..:.:.....:....|.:|              |.....||. 
Mosquito  1666 TLTMLLEYDPMENLSEPLPIDKPHVTFAYTKHLHMAGYTKEAYDHLNRFVASFSPQAFTASSGA- 1729

  Fly  1876 GNVKQLAAEQRHLFFRGKYLQAVYSAESM-------HLCADAVLKYFQ----------------- 1916
            |....|..|.|.|..|......::.:.|.       ||....::.|.:                 
Mosquito  1730 GGQDDLKDENRRLLARCFLKLGMWQSSSTGGNLVKDHLINGILVCYSRATKHDPNWYKAWHNWAY 1794

  Fly  1917 ---EAIAVHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQDDMLINVMVNYA--------KSLR 1970
               |.:...:|.|..........|:                     |::.:||        :|:.
Mosquito  1795 MNFEVVQAKKQQEEYTKNPGSAAER---------------------NLIKHYAVPAVRGFFQSIN 1838

  Fly  1971 YGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVN 2035
            ....:..|...||::||.|..       |.:::.:.|......:....:..|..|:::|:..|.|
Mosquito  1839 LSQGNSLQDTLRLLTLWFDHA-------QYEEVYEALVEGMRVIDKNTWLQVIPQLIARIDTPRN 1896

  Fly  2036 DVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSA------KAHRI--KRCK---------LVLTD-- 2081
            .|..::..::.::.:.:||..::.|....|||      .||:|  ..|:         |::::  
Mosquito  1897 LVGQLINYLLTEIGKTHPQALVYPLTVASKSAPGTRKQAAHKILNNMCEHSNTLVNQVLLISEEL 1961

  Fly  2082 ------------------SRL----QN-----STFQKL---LQ---------DFNSLTERLMDLT 2107
                              |||    ||     :|.:.|   ||         .||....|  |||
Mosquito  1962 IRVAILWHEQWHEGLEEASRLYFGEQNVEGMFATLEPLHAMLQRGPQTLKESSFNQAYGR--DLT 2024

  Fly  2108 NKEVTLDRTYKLS----DLD----------TRLSKLCKQPEFSQILLPFE-KYMQP-TLPLNSDS 2156
            ..:... :.||.|    ||:          .|:|:...|      |...| :|:.| .|...:..
Mosquito  2025 EAQEWC-KHYKNSKNTRDLNQAWDLYYHVFRRISRQLVQ------LTSLELQYVSPKLLACRNLE 2082

  Fly  2157 NSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLR 2221
            .:..||:.|..         |.|.|:..:.::.|:.|..:|:||.||.|:||:|..|:|..:|||
Mosquito  2083 LAVPGSYTPGQ---------QLICIASIETNLTIISSKQRPRKLCIRGSNGKNYMFLLKGHEDLR 2138

  Fly  2222 RDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRR 2286
            :|.|:|:..|||...|..|....:|.|.|:.|||:|.:...||:.|:|:..:...:..:....::
Mosquito  2139 QDERVMQLFGLVNTLLLNDRDTFRRNLTIQRYAVIPLSTNSGLIGWVPHCDTLHKLIRDYRDSKK 2203

  Fly  2287 LVMSTRQLQSLAVPL---HESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRT 2348
            .:::......|.:..   |.::.:|.|||...|.........:.|..:..:...|::.|..|||:
Mosquito  2204 TMLNIEHRIMLRMAPDYDHLTVMQKVEVFEHALDQTKGDDLAKLLWLKSPSSEQWFDRRTNYIRS 2268

  Fly  2349 VAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELL-PYPEVVPFRLTHNMIVAMG 2412
            :||||||||||||||||..|::....:|..:|:||...|...... .:||.:|||||..:|.||.
Mosquito  2269 LAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLINAME 2333

  Fly  2413 PLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYD----------------------------- 2448
            ..|:||::|:.||..:.:|::...:||::|..||||                             
Mosquito  2334 VTGIEGTYRRTCESVMNVLRRNKDSLMAVLEAFVYDPLLNWRLLDSDRLRRSKNAGDMDSVSGSM 2398

  Fly  2449 --------------------------VGAQ-------------------TRKGAA---------- 2458
                                      .|.|                   :..|||          
Mosquito  2399 HEDSLLSYNARRDARLNELNATTGPAAGGQPSATVNVPSGGTTAAIPVPSASGAAVPPGGDAPDG 2463

  Fly  2459 ------------TAKITKDVQRIADRLQGHVKRQQANSIPLSTEGQVNFLINEATKVDNLASMYI 2511
                        ..|....|.|:.|:|.|   :....:.|::...|::.||.:||..:||...||
Mosquito  2464 NYPAMQNPVDVTNKKARAIVDRVKDKLTG---KDFGKAEPVAVNRQIDLLIQQATSNENLCQCYI 2525

  Fly  2512 GWGAF 2516
            ||..|
Mosquito  2526 GWCPF 2530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 16/109 (15%)
FAT 1653..1985 CDD:396714 74/396 (19%)
TEL1 <1946..2517 CDD:227365 181/753 (24%)
PIKKc_ATR 2181..2448 CDD:270625 93/270 (34%)
TorXP_061516349.1 None

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