DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-41 and Atm

DIOPT Version :10

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_011240687.1 Gene:Atm / 11920 MGIID:107202 Length:3077 Species:Mus musculus


Alignment Length:3053 Identity:636/3053 - (20%)
Similarity:1080/3053 - (35%) Gaps:985/3053 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 STQRKDMWKL---LYNHVNRNVS-------NFSGVYSVIEDILCQEPSLISCSLVRELHNKFQDT 56
            |:|:.|:.||   :::...|.:|       ||..:.::|:.           ||| ||..:|   
Mouse   473 SSQKSDLLKLWIKIWSITFRGISSGQTQTENFGLLEAIIQG-----------SLV-ELDREF--- 522

  Fly    57 FLLWLLNKLAKCLSESPDSSECINLQRKIL------------SSCCSNHPKLFERLVLAYV---- 105
               |.|...:.|...|| |..|:.|...|.            |.|.:|.....:..::.::    
Mouse   523 ---WKLFTGSACKPSSP-SVCCLTLALSICVVPDAIKMGTEQSVCEANRSFSVKESIMRWLLFYQ 583

  Fly   106 --EAIEET------------HLQLSSLDLGQLSNERKPAITVRIFRCDVECLQEFDPHCAIEDIK 156
              :.:|::            ||.:..:.:.......|.|  ::.|:...||.|    ||  ||.:
Mouse   584 LEDDLEDSTELPPILQSNFPHLVVEKILVSLTMKNSKAA--MKFFQSVPECEQ----HC--EDKE 640

  Fly   157 VP--LEQADMYAKS-------LLEVLQHA-----HHIGYATHGDIFSGSLHQALLILKECDMDTK 207
            .|  .|..:::.::       |..|.::|     ..:|::...:: ..||...||.|.|     :
Mouse   641 EPSFSEVEELFLQTTFDKMDFLTTVKEYAVEKFQSSVGFSVQQNL-KESLDHYLLGLSE-----Q 699

  Fly   208 LASLNYCHNVLRSQS---ASS------------WITNPDVGHYAQLTLEATAIMWSAVAKWLDMG 257
            |.| ||...:..|::   .||            .|...|..|.::|..:|.::|..|........
Mouse   700 LLS-NYSSEITSSETLVRCSSLLVGVLGCYCYMGIITEDEAHKSELFQKAKSLMQCAGESISLFK 763

  Fly   258 CMTRQELK------RLNITTKLLLEVLHMRARPAHHLGYLLLNEI-----LSLPTAIELDD--GL 309
            ..|.:|.:      .:::.|..|  .:|.:..|         |:|     |.|.|:..::|  .:
Mouse   764 NKTNEESRIGSLRNVMHLCTSCL--CIHTKHTP---------NKIASGFFLRLLTSKLMNDIADI 817

  Fly   310 LETLSSYIQGQLEHSVVP---------LEQLVHLQ---QLMLSHWHCHPTHLVPILALMGLKQTE 362
            .::|:|..:..|:|.|.|         .:.|:..:   ...||  ..:|...|......|..|  
Mouse   818 CKSLASCTKKPLDHGVHPGEDDEDGGGCDSLMEAEGPSSTGLS--TAYPASSVSDANDYGENQ-- 878

  Fly   363 MRSGVVQVLTQSLVEILKKEEVLSKDWQKLI-----------AILRGFKQLEKLILSQSQHKIAE 416
               ..|..::....:.|.|::.|..|..:.:           ...||.....||:|.        
Mouse   879 ---NAVGAMSPLAADYLSKQDHLLLDMLRFLGRSVTASQSHTVSFRGADIRRKLLLL-------- 932

  Fly   417 HEGHIDSSVL-AMLPLQCE----IIKVADTNWNNLSMQ-----LVELESKCSADRR--------- 462
                :|||:| .|.||...    ::|....|.::|.|:     |..|...||..||         
Mouse   933 ----LDSSILDLMKPLHLHMYLVLLKDLPGNEHSLPMEDVVELLQPLSLVCSLHRRDQDVCKTIL 993

  Fly   463 ----HI--HLEICSLLMQITFIR--HFLKTQ------TQHQLLAILQRHLKLSYLCAIRLETPSS 513
                ||  :|...|:.|:.|.|.  |||...      |:.:......|...:..|..:....|.|
Mouse   994 SNVLHIVTNLGQGSVDMESTRIAQGHFLTVMGAFWHLTKEKKCVFSVRMALVKCLQTLLEADPYS 1058

  Fly   514 ----VHTQMQSFYAQQYMRLFQSEETQEIFCSNLPQLYISGFIKP----------EQLMKALP-- 562
                ::.:.|.|...:....|.:::..::      ::..:|.:..          .:.:||||  
Mouse  1059 EWAILNVKGQDFPVNEAFSQFLADDHHQV------RMLAAGSVNRLFQDMRQGDFSRSLKALPLK 1117

  Fly   563 ----TINNRSGRAQV-IRLLLCSQPGKLSVFKVKDRIELYCPKCRPLPKKLPGIYLGKCKQQLPC 622
                :.||....|:. ||.|||....                     |..|..||..|       
Mouse  1118 FQQTSFNNAYTTAEAGIRGLLCDSQN---------------------PDLLDEIYNRK------- 1154

  Fly   623 PDFSSTNLEMIANDLLFYPDFECIAQHLDLLC-------FEPNVILGLLRETEALQKVSVKVIGQ 680
                |..|.|||..|...|  .|..|.|..||       .||:::      .:.|:|||      
Mouse  1155 ----SVLLMMIAVVLHCSP--VCEKQALFALCKSVKENRLEPHLV------KKVLEKVS------ 1201

  Fly   681 LVSAMRVRSPEFLEQLANLVLAAIKAMLAKPLTEQNVLQQRSMLNVLTAIAHMEDNEIWLFHWFK 745
              .:...||                                           :||          
Mouse  1202 --ESFGCRS-------------------------------------------LED---------- 1211

  Fly   746 MTFFFLVHTRSLVAQEAVLAATEMCASQGLQTIHLWNWYKRDALDLTVRLALNVYLLDGVRFTRS 810
               |.:.|...||.:...|..||                               |.|....|   
Mouse  1212 ---FMISHLDYLVLEWLNLQDTE-------------------------------YSLSSFPF--- 1239

  Fly   811 LRALTKMLGFTCVQEFTCKYHRLLTAMVLPHCIVNPLCKGVLVLIAKQMQKHIGTLFSISFLRIY 875
                 .:|.:|.:::|    :|....:::||.::......| ..||.|:||...:|....|.:|.
Mouse  1240 -----MLLNYTSIEDF----YRSCYKILIPHLVIRSHFDEV-KSIANQIQKCWKSLLVDCFPKIL 1294

  Fly   876 THV------------FLTEEPELANSCIELV--VSCTQSSLQQLMNADVKQTVAELLIYFNRNPT 926
            .|:            :::::.|.|....:.:  .......:.|:..:::.:.|.|||:       
Mouse  1295 VHILPYFAYEGTRDSYVSQKRETATKVYDTLKGEDFLGKQIDQVFISNLPEIVVELLM------- 1352

  Fly   927 FVMRSFQSLLQLSIGSLEELSSQTANA--EFANFIAERFLGVITYFESCL----SEPSFEKPLKE 985
                    .|..:..|.:..:||:|.|  :|:.: |...||.:...:..|    :.|.|...:.:
Mouse  1353 --------TLHETADSADSDASQSATALCDFSGY-AGLTLGELAVADGDLDPAPNPPYFPSHVIQ 1408

  Fly   986 ETLYSLGQIMRFVGSQHVTQFRFKIIAMLSFVHTLQEPRLQRIC---------------LKIWHI 1035
            .|       ..::.:.|.|:|: .|:.:||.:....:..|..||               |||:|:
Mouse  1409 AT-------FAYISNCHKTKFK-SILEILSKIPDSYQKILLAICEQAAETNNVFKKHRILKIYHL 1465

  Fly  1036 F---------------------------LHVVNVQE----------------------------- 1044
            |                           :|.:|.:.                             
Mouse  1466 FVSLLLKDIQSGLGGAWAFVLRDVIYTLIHYINKRSSHFTDVSLRSFSLCCDLLSRVCHTAVTQC 1530

  Fly  1045 ---LGPSLGRIVATLQPLLADNESVKQVNDLYEFIILRNASMLGTFITDLYFLDRMENVSPSIQK 1106
               |...|..||.||.||:...|..:||.||.:::::.|.......:| :..||...:       
Mouse  1531 KDALESHLHVIVGTLIPLVDYQEVQEQVLDLLKYLVIDNKDNKNLSVT-IKLLDPFPD------- 1587

  Fly  1107 CIRRHTAHLDLK-------------GLAEEENQ-------SP-PLV------DQLRFLQKHITDE 1144
                |....||:             .|.||.|.       :| ||.      |..|.|::| .|:
Mouse  1588 ----HVIFKDLRLTQQKIKYSGGPFSLLEEINHFLSVSAYNPLPLTRLEGLKDLRRQLEQH-KDQ 1647

  Fly  1145 CLQVRVYALQHLGDLFGRRRPKLNSTILSELPLEPMLEQIVNVL----MAGCQHDDSQLQMASAK 1205
            .|           ||....:......|:.:|        :|::|    ||..|..:.::..|..:
Mouse  1648 ML-----------DLLRASQDNPQDGIVVKL--------VVSLLQLSKMAVNQTGEREVLEAVGR 1693

  Fly  1206 CLGELGAIDASYLPSNYN--------FASPQHLPLNILSDDFAVLALTSLCRGYQFQQNTKHVDS 1262
            ||||:|.:|.|.:...:|        :..|:...|     .:.::.||:|       .||...| 
Mouse  1694 CLGEIGPLDFSTIAVQHNKDVSYTKAYGLPEDREL-----QWTLIMLTAL-------NNTLVED- 1745

  Fly  1263 FSLAIQETLAICGISPKEQKKVQ-------LWQSLPAR---MRQLMEPMLHSCYTCVHRPSTCLQ 1317
             |:.|:...|.|      .|.:.       .|::....   |...::|...|....:..|.:..:
Mouse  1746 -SVKIRSAAATC------LKNILATKIGHIFWENYKTSADPMLTYLQPFRTSRKKFLEVPRSVKE 1803

  Fly  1318 QPLFG---------SHYSHNYYEEWAFLWASRL-IDYLPSSG-RRHLLSSYKPCIKRDSNMLSTF 1371
            ..|.|         ...||:       :|...| ..:|.|.| ...:|...||..:..::.....
Mouse  1804 DVLEGLDAVNLWVPQSESHD-------IWIKTLTCAFLDSGGINSEILQLLKPMCEVKTDFCQML 1861

  Fly  1372 YPYILLHALLECTTEQ-----RNHIQEEFMAVLQANEESSSSVRGRQELGAIKENAFKQFESRKY 1431
            .||::...||:.|.|.     ..|::..|.:..:.:.::|.|        |...|:  ..||..:
Mouse  1862 LPYLIHDVLLQDTHESWRTLLSAHVRGFFTSCFKHSSQASRS--------ATPANS--DSESENF 1916

  Fly  1432 AAGIKPLASTLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGGKPPETIDSNYR 1496
                  |...|  |:|...:.:         .::|:|:|     |:.....|.......:|.|| 
Mouse  1917 ------LRCCL--DKKSQRTML---------AVVDYLRR-----QKRPSSGTAFDDAFWLDLNY- 1958

  Fly  1497 KIHEFLNLIPKLLVSRASYNCGEYARALSYLESY---------------LEEG-----------E 1535
                       |.|::.:.:|..:..||.|.|.|               .|||           :
Mouse  1959 -----------LEVAKVAQSCSAHFTALLYAEIYSDKKSTDEQEKRSPTFEEGSQGTTISSLSEK 2012

  Fly  1536 DKSQRLLEQFTFLVEVYGSLRDPDSVEGA---------VQVRSYDMSVT-QDILVNRLVERQQDM 1590
            .|.:..:.....|:|:|.|:.:|||:.|.         .::|:|:...| :..||...:|.....
Mouse  2013 SKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPLTRIRTYEHEATWEKALVTYDLETSISS 2077

  Fly  1591 ITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLIADGL-WQRLSDRYSDQC--FAECKSELL 1652
            .|....::.:...:...|:   :..||:           || ::|     .:.|  ..|.:.:..
Mouse  2078 STRQSGIIQALQNLGLSHI---LSVYLK-----------GLDYER-----REWCAELQELRYQAA 2123

  Fly  1653 WRLGSYDEMEELQSNWPAQCSQG-----------------CLKLRRPLTTRIEFDSLLDGMRESV 1700
            ||          ...|....|.|                 ||:.|       ||.:..:.:|.:.
Mouse  2124 WR----------NMQWGLCASAGQEVEGTSYHESLYNALQCLRNR-------EFSTFYESLRYAR 2171

  Fly  1701 LEELRSCSAVQQHSYANAYDAVLKLHLVHELHCSQELVEKLEQDRDEDNQEKLMKNYFDDWQYRL 1765
            ::|:...|.....|..:.|..:.:|..:.||..|.||..:...||  :..|...|     ||...
Mouse  2172 VKEVEELSKGSLESVYSLYPTLSRLQAIGELENSGELFSRSVTDR--ERSEAYWK-----WQKHS 2229

  Fly  1766 QIVQ-PQVRIQESIYSFRRNILAELQRRLTDRNH-------LLPHLK--TELARIWLNSAQINRN 1820
            |::: .....||.:.:.|..||..|.::..:|:.       |..||.  :.|||.:.|:....|.
Mouse  2230 QLLKDSDFSFQEPLMALRTVILETLVQKEMERSQGACSKDILTKHLVEFSVLARTFKNTQLPERA 2294

  Fly  1821 AGQLQRAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQ----------------LSI 1869
            ..::::....|...:|:.     :|.|::.|.|.:|.:|::.|::.                |.:
Mouse  2295 IFKIKQYNSAICGISEWH-----LEEAQVFWAKKEQSLALSILKQMIKKLDSSFKDKENDAGLKV 2354

  Fly  1870 MRSGC----------------------------------QGNVKQLAAEQRHLF-----FRGKYL 1895
            :.:.|                                  .||.::|...|...|     |.....
Mouse  2355 IYAECLRVCGSWLAETCLENPAVIMQTYLEKAVKVAGSYDGNSRELRNGQMKAFLSLARFSDTQY 2419

  Fly  1896 QAV--YSAESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEKI---LEARQGGKSEPTGEQD 1955
            |.:  |...|.......:||..:|.:.:.|:.:   :|..::..|:   ||..:........::.
Mouse  2420 QRIENYMKSSEFENKQTLLKRAKEEVGLLREHK---IQTNRYTVKVQRELELDECALRALREDRK 2481

  Fly  1956 DMLINVMVNYAKSLRYGSEH---VYQSMPRLISLWLDTTESSTNTEQVKK-------------MN 2004
            ..|...:.||...|..|.||   |:    ||.||||:.:..|.....:||             |.
Mouse  2482 RFLCKAVENYINCLLSGEEHDLWVF----RLCSLWLENSGVSEVNGMMKKDGMKISSYKFLPLMY 2542

  Fly  2005 DLLTNCCTALPTAV-FYTVYSQMLSR--LCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKS 2066
            .|.....|.:...: |:.|.:.::||  |.||.:.:|     :|:.|..|...:.|         
Mouse  2543 QLAARMGTKMTGGLGFHEVLNNLISRISLDHPHHTLF-----IILALANANKDEFL--------- 2593

  Fly  2067 AKAHRIKRCKLVLTDSRLQNSTFQKLLQDFNSLTERLMDLTNKEVTLDRTYKLSDLDTRL----- 2126
            :|....:|       ||:..||.::                |..:..|||    :..||:     
Mouse  2594 SKPETTRR-------SRITKSTSKE----------------NSHLDEDRT----EAATRIIHSIR 2631

  Fly  2127 SKLCKQPEFSQILLPFEKYMQPTLPLNSDSN----SSEGSHLPANQSTVNW-------FPYQQIY 2180
            ||.||..:..:.|.  :.|:   :..|.|::    ..:|.::||||.....       .|..:|.
Mouse  2632 SKRCKMVKDMEALC--DAYI---ILANMDASQWRAQRKGINIPANQPITKLKNLEDVVVPTMEIK 2691

  Fly  2181 I--SGFQESVLILRSAAKPKKLT--------IRC--SDGKDYDVLVKPKDDLRRDARLMEFNGLV 2233
            :  :|..|:::.::|.....:|.        |.|  ||||:...|||.:||||:||.:.:...:.
Mouse  2692 VDPTGEYENLVTIKSFKTEFRLAGGLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMC 2756

  Fly  2234 KRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLY--AQRRL---VMSTRQ 2293
            ...|.::...|:|:|.|.||.|:|.::..|::||...........:|..  |.||.   ..|..|
Mouse  2757 NTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEYLVNSEDGAHRRYRPNDFSANQ 2821

  Fly  2294 LQSLAVPLH-ESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGY 2357
            .|...:.:. :|.|.|.:.| ..:.....|||:.:..::|..|..|:|.|..|.|:||..|:|||
Mouse  2822 CQKKMMEVQKKSFEEKYDTF-MTICQNFEPVFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVGY 2885

  Fly  2358 ILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRK 2422
            ||||||||.:|||..|.:.:.||:|....|.||::||.||.|||||:.:::..||..||||.||:
Mouse  2886 ILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITGVEGVFRR 2950

  Fly  2423 CCEITLRLLKQESKTLMSILRPFVYD------------VGAQTRK-------------------- 2455
            |||.|:.:::...:||::|:...:||            :..|.|.                    
Mouse  2951 CCEKTMEVMRSSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDESDLHSTPNADDQECKQS 3015

  Fly  2456 -GAATAKITKDVQRIADRLQGHVKRQQANSIPLSTEGQVNFLINEATKVDNLASMYIGWGAFL 2517
             ........|..:|:..|||..:|..:..:: ||..||||.||.:|....||:.::.||.|::
Mouse  3016 LSDTDQSFNKVAERVLMRLQEKLKGVEEGTV-LSVGGQVNLLIQQAMDPKNLSRLFPGWKAWV 3077

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 31/182 (17%)
FAT 1653..1985 CDD:396714 81/421 (19%)
TEL1 <1946..2517 CDD:227365 183/656 (28%)
PIKKc_ATR 2181..2448 CDD:270625 100/284 (35%)
AtmXP_011240687.1 TAN 8..165 CDD:463317
FAT 2116..2510 CDD:396714 82/429 (19%)
PIKKc_ATM 2704..2983 CDD:270715 100/279 (36%)
FATC 3047..3076 CDD:460514 13/28 (46%)
Blue background indicates that the domain is not in the aligned region.

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