DRSC/TRiP Functional Genomics Resources

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Protein Alignment mei-41 and Pik3c2g

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:NP_446375.1 Gene:Pik3c2g / 116720 RGDID:620231 Length:1505 Species:Rattus norvegicus


Alignment Length:1324 Identity:227/1324 - (17%)
Similarity:413/1324 - (31%) Gaps:507/1324 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  1418 IKENAFKQFESRKYAAGIKPLASTLVSDRK--------------------EDSSRVP-------- 1454
            |.|.|..:..:|||..|..|..|.|.....                    |..:.||        
  Rat   119 IHEGASWRNPTRKYHGGEDPRFSALTPSSTGLDKCHQQGQSGTEHCNYYVEPENNVPHHYSPYSM 183

  Fly  1455 ------RLAGKLCAELLD---------FLQRWLREWQRIHGRSTGGKPPETIDS---NYRKIHEF 1501
                  ...|...|:|::         ||.| ..|...:......|.|.|.:::   :.:.:..|
  Rat   184 DSIPDSEEKGSGDADLVEPSLVFSKDSFLPR-ASENMSVESTEPIGCPLEIVEAPQGSNKSLASF 247

  Fly  1502 LNLIPKLL----VSRASYNCGE-YARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSV 1561
            .|.:.|:.    .|..:.|.|: :|...:|           ..||.....|.|::        |.
  Rat   248 CNNVTKIRGLYHASDTNSNSGKIWAITTAY-----------PSRLFADTQFRVKI--------ST 293

  Fly  1562 EGAVQV------RSYDMSVTQDILVNRLVERQQDMITSYEQLLS---STDQMQPDHV-------- 1609
            :.:.|:      .:|   :.:|::...|:....:.::..|.|||   |.:.:|.||.        
  Rat   294 DNSAQLLLLKPPANY---LVKDLIAEILLLCANEQLSPKEYLLSICGSEEFLQTDHCLGSHKIFQ 355

  Fly  1610 --RAMIDAYL---RDTPKTAQLIADGLWQRLSDRYSDQCFAECKSELL-----WRLGSYDEMEEL 1664
              :::|..:|   ||||           .:||.:..|.......::||     |::.        
  Rat   356 KSKSVIQLHLQRSRDTP-----------GKLSRKRDDDRSRVHLNQLLEFTHIWKIS-------- 401

  Fly  1665 QSNWPAQCSQGCLKLRRPLTTRIEFDSLL---DGMRESVLEELRSCSAVQQHSYAN--------- 1717
                 .||....:|     :..:..:.||   :.:.|..|..:.||.......:.|         
  Rat   402 -----RQCLSTVMK-----SYNLHVEHLLKTQEDVEEKPLSSMFSCGRHPPQPHGNDIIEDVRNI 456

  Fly  1718 -----------AYDAVLKLHLVHELHCSQELVEKLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQ 1771
                       ..|||.:|.|:         :::..|:..: |.|...|.:.:            
  Rat   457 CSVLGCIETKQVSDAVKELTLI---------LQRPSQNFHQ-NSETSKKGFIE------------ 499

  Fly  1772 VRIQESIYSFRRNILAELQRRL------------TD-----------RNH--LLPHLKTELARI- 1810
                        |:.:||.|.|            ||           |:|  |..||...:..: 
  Rat   500 ------------NVTSELSRSLHQLVDVYCSSFCTDFRPARAPGGVSRDHAGLHSHLSFTVCSLH 552

  Fly  1811 -----------------WLN---------------------SAQINRN--------AGQLQRAQL 1829
                             ||.                     |..:|.|        ...|.|..:
  Rat   553 NVPETWAHSYKAFSFSCWLTYAGKKLCQVKSCRSLPVTKSFSFSVNWNEIINFPLEIKSLPRESM 617

  Fly  1830 YILKAAEYQPSGLF-IERAK-----LLW--------QK---GDQVMAMNYLEE-QLSIMRSG--- 1873
            .::|        || |:.|.     |.|        :|   |.::::|....| .:.:|..|   
  Rat   618 LVIK--------LFGIDSATHSANLLAWTCLPLFPKEKSPLGSRLLSMTLQSEPPIEMMAPGVWD 674

  Fly  1874 --------------------------------------CQGNVKQLAAEQ----------RHLFF 1890
                                                  |..::.:|:.:|          |:|:|
  Rat   675 GSQPTPLTLQIDFPAATWEYVKPETEENRTDHQEPPRECLKHIARLSQKQPPLLLSVEKRRYLWF 739

  Fly  1891 RGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQD 1955
            ...|                                 |:.:.:. |..:|.:..|        .|
  Rat   740 YRFY---------------------------------CNNENSS-LPLVLGSAPG--------WD 762

  Fly  1956 DMLINVMVNYAKSLRYGSEHVYQSMPRLISLWLDTTESSTNTEQVKK-MNDLLTNCCTALPTAVF 2019
            :..::.|  :|...|:...|..:::..|.|.:.|........:|:.. :.|.|.:|...|..||.
  Rat   763 EGTVSEM--HAVLRRWTFSHPLEALGLLTSRFPDQDIREVAVQQLDNFLTDELLDCLPQLVQAVK 825

  Fly  2020 Y--TVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDS 2082
            :  ::.|.::..|.|.......|...:...|.:|..:.       :|||.....:...:....::
  Rat   826 FEWSLESPLVELLLHRSLQSIRVAHRLFWLLRDAQGED-------YFKSWYQELLAALQFCAGEA 883

  Fly  2083 RLQN-STFQKLLQDFNSLTERL--------MDLTNKEV-TLDRTYKLSDLDTRLSKLCKQPEFSQ 2137
            .::. |..|||::....:.|::        .|:..||: :|:..:|  |:     |.|       
  Rat   884 LIEELSKEQKLVKLLGDIGEKVKSAGDAQRKDVLKKEIGSLEEFFK--DI-----KTC------- 934

  Fly  2138 ILLPFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGF-QESVLILRSAAKPKKLT 2201
                                     |||.|.:         :.:.|. :::.....|.|.|.|:|
  Rat   935 -------------------------HLPLNPA---------LCVKGIDRDACSYFTSNALPLKIT 965

  Fly  2202 IRCSD--GKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGL 2264
            ...::  ||:..|:.|..||||:|..:::...::.....|:....|..:    |..|...:..|.
  Rat   966 FINANPMGKNISVIFKAGDDLRQDMLVLQIIQVMDNVWLQEGLDMQMII----YGCLATGKAQGF 1026

  Fly  2265 VEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLR 2329
            :|.:|:..:...|.::              ..|..||.|:..:|                  |..
  Rat  1027 IEMVPDAVTLAKIHLH--------------SGLIGPLKENTIKK------------------WFS 1059

  Fly  2330 QRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLP 2394
            |.......:.:|...:..:.|...:|.:|||:.|||.:||:..: :|...|:||      |:.|.
  Rat  1060 QHNHLKEDYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTK-SGHMFHIDF------GKFLG 1117

  Fly  2395 YPEV--------VPFRLTHNM--IVAMGPLGVE--GSFRKCCEITLRLLKQESKTLMSILRPFVY 2447
            :.:.        .||..|..|  .:..|....:  ..|.:.|.....::::.|:.|:|:|...::
  Rat  1118 HAQTFGGIKRDRAPFIFTSEMEYFITEGGKNTQHFQDFVELCCRAYNIVRKHSQLLLSLLEMMLH 1182

  Fly  2448 DVGAQTRKGAATAKITKDVQRIAD 2471
             .|....:|....|...|..|..|
  Rat  1183 -AGLPELRGIEDLKYVHDNLRPQD 1205

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825
FAT 1653..1985 CDD:280429 69/495 (14%)
PIKKc_ATR 2181..2448 CDD:270625 58/281 (21%)
FATC 2486..2517 CDD:280430
Pik3c2gNP_446375.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
PI3K_rbd <310..368 CDD:295323 12/57 (21%)
C2A_PI3K_class_II 535..697 CDD:175979 25/169 (15%)
PI3Ka 712..879 CDD:294194 35/217 (16%)
PKc_like 886..1238 CDD:304357 81/412 (20%)
PX_domain 1267..1367 CDD:295365
C2 1389..1501 CDD:301316
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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