DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-41 and mtor

DIOPT Version :9

Sequence 1:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster
Sequence 2:XP_031761369.1 Gene:mtor / 100491970 XenbaseID:XB-GENE-993118 Length:2532 Species:Xenopus tropicalis


Alignment Length:2894 Identity:548/2894 - (18%)
Similarity:996/2894 - (34%) Gaps:908/2894 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 VECLQEFDPHCAIEDIKVPLEQADMYAKSLLEVLQHAHHI-GYATHGDIF---SGSLHQALLILK 200
            ::..::...:...|..:|..|:|..:...|      .|.| .:.:..|:.   .|.|....||..
 Frog    29 IKAAKDLQHYVTTELREVSQEEATQFYDEL------NHFIFEFVSSSDVSERKGGILAIVSLIGV 87

  Fly   201 ECDMDTKLASL-NYCHNVLRSQSASSWITNPDVGHYAQLTLEATAIMWSA-VAKWLDMGCMTRQE 263
            |....|:::.. ||..|:|.|       ::|.|...|...:...|:.... .|::::.      |
 Frog    88 EGGNATRISRFANYLRNLLPS-------SDPGVMEMASKAMGRLAMAGDTFTAEYVEF------E 139

  Fly   264 LKRLNITTKLLLEVLHM-RARPAHHLGYLLLNEI-LSLPTAIELDDGLLETLSSYIQGQLEHSVV 326
            :||       .||.|.. |.....|...|:|.|: :|.||             .:.|     .|.
 Frog   140 VKR-------ALEWLGADRNEGRRHAAVLVLRELAVSAPT-------------FFFQ-----QVQ 179

  Fly   327 PLEQLVHLQQLMLSHWHCHPTHLVPILALMGLKQTEMRSGVVQVLTQSLVEILKKEEVLSKDWQK 391
            |.     ...:..:.|.               .:..:|.|.|..|...|:...::|   .|:.||
 Frog   180 PF-----FDNIFFAVWD---------------PKQAIREGAVAALRACLILTTQRE---PKELQK 221

  Fly   392 LIAILRGFKQLEKLILSQSQHKIAEHEG-HIDSSVLAMLPLQCEIIKVADTNWNNLSMQLVELES 455
            .:...:.:::.|:    .....:::.:| :.|..:...|.:..|:::::......|..::.|:  
 Frog   222 PLWYRQTYEEAER----GFDETLSKEKGMNRDDRIHGALLIINELVRISSMEGERLREEMEEI-- 280

  Fly   456 KCSADRRHIHLEICSLLM-------QITFIRHFLKTQTQ--HQLLAILQ---------------- 495
               ..::.:|.:.|..||       .||....|...|.|  :.||::|.                
 Frog   281 ---TQQQMVHDKHCKDLMTFGLKPRHITPFASFQSVQPQPSNALLSLLGYTGQQGILGYGAAPMP 342

  Fly   496 -----------RHL---KLSYLCAIRLETPSSVHTQMQSFYAQQYMRLFQSEETQEIFCSNLPQL 546
                       |.|   |...:|...|:..||.:..:|........||          .:..|..
 Frog   343 DKTTLVESRACRELVEEKFDQICRWVLKCRSSKNPLIQMTILNVLPRL----------AAFRPSA 397

  Fly   547 YISGFIKPEQLMKALPTINNRSGRAQVIRLLLCSQPGKLSVFKVKDRIELYCPKCRPLPKKLPGI 611
            :.:....|:.:...|..:.....|....:.|     |.:|| .|:..|.||.||           
 Frog   398 FTADLYLPDTMSHLLSCVRKEKERTVAFQAL-----GLISV-AVRSEIRLYLPK----------- 445

  Fly   612 YLGKCKQQLPCPDFSSTNLEMIANDLLFYPDFECIAQHL---------DLLCFEPNVILGLLRET 667
            .|...|..||..||:....:.|..|...:.....:|:.:         :||  ||.:.:||....
 Frog   446 ILEHVKAALPPKDFAHKRQKSIQVDATVFTCISMLARSMGPSIQQDIKELL--EPMLSVGLSPAL 508

  Fly   668 EALQKVSVKVIGQLVSAMRVRSPEFLEQLANLVLAAIKAMLAKPLTEQNV---LQQRSMLNVLTA 729
            .|:.....:.|.||...::    :.|.::.:|||      :.|||....:   |.|:.....||.
 Frog   509 TAVLYDLSRHIPQLKKDIQ----DGLLKMLSLVL------MHKPLRHPGMPKGLAQQLSSPSLTN 563

  Fly   730 IAHMED-NEIWLFHWFKMTFFFLVHTRSLVAQEAVLAATEMCASQGLQTIHLWNWYKRDALDLTV 793
            |..:.| ..|.|......||.|..|:.:...:.        ||...|.:.|  ...:.:|.....
 Frog   564 IPEISDVGSITLALRTLGTFEFEGHSLTQFVRH--------CADHFLNSEH--KEIRMEAARTCS 618

  Fly   794 RLAL-NVYLLDG---VRFTRSLRALTKMLGFTCVQEFTCKYHRLLTAMV------LPHCIVNPLC 848
            ||.. ::.||.|   |..| :::.:..:||            :||...:      :.:|      
 Frog   619 RLLTPSIQLLSGHGHVSQT-AVQVVADVLG------------KLLVVGITDPDPDIRYC------ 664

  Fly   849 KGVLVLIAKQMQKHIGTLFSIS--FLRIYTHVFLTEE------------------PELANSCIEL 893
              ||..:.::...|:....::.  |:.:...||...|                  |.|....|::
 Frog   665 --VLASLDERFDTHLAQAENLQALFVALNDEVFEIRELAICTIGRLSSMNPAFVMPFLRKMLIQI 727

  Fly   894 VVSCTQSSLQQLMNADVKQTVAELLIYFNRNPTFVMRSFQS------LLQL-------------- 938
            :.....|.:.:     .|:..|.:|.:...|...::|.:..      :|:|              
 Frog   728 LTELEHSGVGR-----NKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLRDPDPNPGVVTNVL 787

  Fly   939 -SIGSLEELSSQTANAEFANFIAERFLGVITYFE--SCLSEPSFEKPLKEETLYSLGQIMRFVG- 999
             :||.|    :|.:..|...::.|.|..::...:  |.|::       ::..|::|||::...| 
 Frog   788 ATIGEL----AQVSGLEMRKWMDELFPIIMDMLQDSSLLAK-------RQVALWTLGQLVASTGY 841

  Fly  1000 -SQHVTQFRFKIIAMLSFVHTLQEPRLQRICLKIWHI------FLHVVNVQELGPSLGRIVATLQ 1057
             .:...::...:..:|:|:.|.|...::|..:::..:      :.|.||:..:..|......:|.
 Frog   842 VVEPYRKYPSLLEVLLNFLKTEQNQGIRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASALSLS 906

  Fly  1058 PLLADNESVK-------------QVNDLYEFI-------ILRNASMLG---------TFI---TD 1090
            ...|:.:|..             .:::.|..:       |||:.|:..         |||   ..
 Frog   907 ESKANQDSADYSTSEMLVNMGNLPLDEFYPAVSVVTLMRILRDQSLSNHHTMVVQAITFIFKSLG 971

  Fly  1091 LYFLDRMENVSPSIQKCIRRHTAHLDLKGLAEEENQSPP----------LVDQL----RFLQKHI 1141
            |..:..:..|.|:....||     |....:.|....||.          :..||    .|::.||
 Frog   972 LKCVQFLPQVMPTFLSAIR-----LCDNNMRESHQPSPQKRTSLMSPQFMFQQLGMLVGFVRSHI 1031

  Fly  1142 ---TDECLQVRVYALQHLGDLFGRRRPKLNSTILSELPLEPM-----------LEQIVNVLMAGC 1192
               .||     ::||  :.|.:....| :.|||:  |.:|.:           |.|::..::...
 Frog  1032 RPYMDE-----IFAL--IKDYWTMNNP-IQSTII--LLIEQIVLSLGGEFKLYLPQLIPHMLRVF 1086

  Fly  1193 QHDDSQLQMASAKCLGELGAIDASYLPSNYNFASPQHLPLNILSDDFAVLALTSLCRGY------ 1251
            .||.|..:..:.|.|..:....|:.                   ||:..|.|..:.:.:      
 Frog  1087 MHDSSVGRSVTIKLLNAIQMFGANL-------------------DDYLHLLLPPIVKLFDAPDSP 1132

  Fly  1252 ------------QFQQNTKHVDSFSLAIQETLAICGISPKEQKKVQLWQSLPARMRQLME----- 1299
                        :..::....|..|..|...:....:||  ..::....:|.:.:.||.:     
 Frog  1133 MPARKVALETVDRLTESLDFTDYASRIIHPIVRTLDMSP--DLRITAMDTLSSLVFQLGKKYHIF 1195

  Fly  1300 -PM----------LHSCYTCVHRPSTCL-----------QQPLFGSHYSH--------------- 1327
             ||          ||..|..:    ||.           :.||...|.:.               
 Frog  1196 IPMVNKVLQKHRILHQRYEVL----TCRILKGYTLADEEEDPLIYQHKAQRGNLSETASAPLDAG 1256

  Fly  1328 ----------NYYEEWA----------FLWASRL-IDYLPSSGRRHLLS------SYKPCIKRDS 1365
                      |..:.|.          ..|..|| ::.|..|....|.|      :|.| :.|| 
 Frog  1257 PMKKLHVSTTNLQKAWGAARRVSKDDWLEWLRRLSVELLKDSSSPALRSCWSLAQAYNP-LARD- 1319

  Fly  1366 NMLSTFYPYILLHALLECTTEQRNHIQEEFMAVLQANEESSSSVRGRQELGAIKENAFKQFESRK 1430
                     :...|.|.|.:|.....|:|.:..:              ||....::         
 Frog  1320 ---------LFNAAFLSCWSELNEDQQDELIRSI--------------ELALTSQD--------- 1352

  Fly  1431 YAAGIKPLASTLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGGKPPETIDSNY 1495
                |..:..||::                   |.:|::           .|..|..|...|:..
 Frog  1353 ----IAEVTQTLLN-------------------LAEFME-----------HSDKGPLPLRDDNGV 1383

  Fly  1496 RKIHEFLNLIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDS 1560
                       .||..||| .|..||:||.|.|...::|  .|..:||.   |:.:...|:.|::
 Frog  1384 -----------VLLGERAS-KCRAYAKALHYKELEFQKG--PSPAILES---LISINNKLQQPEA 1431

  Fly  1561 VEGAVQ--VRSYDMSVTQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKT 1623
            ..|.::  ::.|.....|.....:|.| .:|.:.:|::.:    ::..|....::.       :.
 Frog  1432 ASGVLEFAMKHYGEMEIQATWYEKLHE-WEDALVAYDKKI----EVNKDDSELILG-------RM 1484

  Fly  1624 AQLIADGLWQRLSDRYSDQC--------------FAECKSELLWRLGSYDEMEELQSNWPAQCSQ 1674
            ..|.|.|.|.:|    ..||              .|...:...|.|..:|.|||.....|.....
 Frog  1485 RCLEALGEWGQL----HQQCCENWTNVNEDARAKMARMAAAAAWGLEQWDSMEEYTCLIPRDTHD 1545

  Fly  1675 GCLKLRRPLTTRIEFDSL----LDGMRESVLEELRSCSAVQQHSYANAYDAVLKLHLVHELHCSQ 1735
            |.. .|..|....:..||    :|..|:.:..||   :|:...||:.||.|::...::.||   :
 Frog  1546 GAF-YRAVLALHQDLFSLAQQCIDKARDMLDAEL---TAMAGESYSRAYGAMVTCQMLSEL---E 1603

  Fly  1736 ELVE-KLEQDRDEDNQEKLMKNYFD----------DWQYRLQIVQPQVRIQESIYSFRRNILAEL 1789
            |::: ||..:|    :|.:.:.::|          ||| ::.:||..|                 
 Frog  1604 EVIQYKLVPER----REIIRQTWWDRLQGCQRIVEDWQ-KILMVQSLV----------------- 1646

  Fly  1790 QRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIER-------- 1846
                     :.||   |..|.||..|.:...:|:|..:...::......|:   :|.        
 Frog  1647 ---------VSPH---EDMRTWLKYASLCSKSGRLALSHKTLVMLLGVDPA---LESDQPLPTAH 1696

  Fly  1847 -------AKLLWQKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQAVY----- 1899
                   .|.:|:...::.|..::::.::.|    |...:.:|.:.:|.....|.:...:     
 Frog  1697 PQVTYAYMKYMWKSTRKIEAFQHMQKFVNNM----QLQAQHVADDPQHKQELQKLMARCFLKLGE 1757

  Fly  1900 ---SAESMHLCA-DAVLKYFQEAIA-VHRQSESCHVQMAQFLEKILEAR---------------- 1943
               :.:.::.|. ..||:|:..|.. .|...::.|.......|.:|..:                
 Frog  1758 WQLNLQGINECTIPCVLEYYSAATEHDHNWYKAWHAWAVMNFEAVLHFKHQNHPRDEKKVRHPST 1822

  Fly  1944 -----QGGKSEPTGEQDD--------------------MLINV--MVNYAKSLRYGSEHVYQSMP 1981
                 :|.:||..||.:|                    :|..|  :..:.:|:.....:..|...
 Frog  1823 ASAPPEGSESESEGESNDNSPVSSPVQKKPSEDISHTLLLYTVPAVQGFFRSISLSRGNNLQDTL 1887

  Fly  1982 RLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVII 2046
            |:::||.|       ......:|:.|......:....:..|..|:::|:..|...|..::..::.
 Frog  1888 RVLTLWFD-------YGHWPDVNEALVEGIKTIQIDTWLQVIPQLIARIDTPRALVGRLIHQLLT 1945

  Fly  2047 KLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQKLLQDFNSLTERLMDL----- 2106
            .:...:||..::.|....||....|......:|.:....::|   |:|....::|.|:.:     
 Frog  1946 DIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNT---LVQQAMMVSEELIRVAILWH 2007

  Fly  2107 ---------------------------------------TNKEVTLDRTY--------------- 2117
                                                   |.||.:.::.|               
 Frog  2008 EMWHEGLEEASRLYFGERNVKGMFAVLDPLHAMMERGPQTLKETSFNQAYGRDLMEAQDWCRKYM 2072

  Fly  2118 ---KLSDLD----------TRLSKLCKQPEFSQILLPFEKYMQPTLPLNSDSNSSEGSHLPANQS 2169
               .:.||.          .|:||  :.|:.:.:.|   :|:.|.|.:..|...:.......||.
 Frog  2073 KSGNVKDLTQAWDLYYHVFRRISK--QLPQLTSLEL---QYVSPKLLMCRDLELAVPGTYDPNQP 2132

  Fly  2170 TVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVK 2234
            .:.        |.....|:.::.|..:|:|||:..|:|.::..|:|..:|||:|.|:|:..|||.
 Frog  2133 IIR--------IQSIAPSLQVITSKQRPRKLTLMGSNGHEFMFLLKGHEDLRQDERVMQLFGLVN 2189

  Fly  2235 RYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAV 2299
            ..|..|..:.::.|.|:.|||:|.:...||:.|:|:..:..::..:...:::::::......|.:
 Frog  2190 TLLANDPASLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRM 2254

  Fly  2300 PL---HESIERKREVF------------TKQLVPAHPPVFQEWLRQRFATPHS--WYEARNTYIR 2347
            ..   |.::.:|.|||            .|.|          ||:    :|.|  |::.|..|.|
 Frog  2255 APDYDHLTLMQKVEVFEHAVNNTAGDDLAKLL----------WLK----SPSSEVWFDRRTNYTR 2305

  Fly  2348 TVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELL-PYPEVVPFRLTHNMIVAM 2411
            ::||||||||||||||||..|::....:|..:|:||...|...... .:||.:|||||..:..||
 Frog  2306 SLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAM 2370

  Fly  2412 GPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYD---------------------------- 2448
            ...|::|::|..|...:.:|::...::|::|..||||                            
 Frog  2371 EVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNIKGNKRSRTRTDSYSAG 2435

  Fly  2449 ----------VGAQTRK---------------------GAATAKITKDVQRIADRLQGHVKRQQA 2482
                      :|....|                     .|...|..:.:.|:.|:|.|   |..:
 Frog  2436 QSGEIMETVELGETAHKKTGSTVPESIHTFIGDGLVQPEALNKKAIQIINRVRDKLTG---RDFS 2497

  Fly  2483 NSIPLSTEGQVNFLINEATKVDNLASMYIGWGAF 2516
            :...|....||..||.:||..:||...||||..|
 Frog  2498 HEETLDVATQVELLIKQATSHENLCQCYIGWCPF 2531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-41NP_523369.2 UME 955..1060 CDD:214825 19/114 (17%)
FAT 1653..1985 CDD:280429 75/414 (18%)
PIKKc_ATR 2181..2448 CDD:270625 88/284 (31%)
FATC 2486..2517 CDD:280430 14/31 (45%)
mtorXP_031761369.1 TEL1 346..2532 CDD:227365 478/2501 (19%)
HEAT repeat 597..619 CDD:293787 5/23 (22%)
HEAT repeat 645..671 CDD:293787 7/45 (16%)
HEAT repeat 681..711 CDD:293787 4/29 (14%)
HEAT repeat 719..749 CDD:293787 6/34 (18%)
HEAT repeat 762..793 CDD:293787 4/30 (13%)
HEAT repeat 805..835 CDD:293787 7/36 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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