DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-41 and pik3cb

DIOPT Version :9

Sequence 1:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster
Sequence 2:	XP_005157523.1	Gene:	pik3cb / 100002263	ZFINID:	ZDB-GENE-030131-1904	Length:	1080	Species:	Danio rerio

Alignment Length:	1319	Identity:	233/1319 - (17%)
Similarity:	416/1319 - (31%)	Gaps:	470/1319 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1336 LWASR--------LIDYLPSSG--------RRHLLSSYKPCIKRDSNMLSTFYPYILL------H 1378
            |||..        ::|:|..:|        |...:...|..:.:::..    ||...|      |
Zfish    11 LWAESGLDGDDQVMVDFLLPTGIYIQMEVPRESTIQHIKLLLWKEAQT----YPLFSLLGEMEGH 71

  Fly  1379 ALLECTTEQRNH--IQEE---------FMAVL--------QANEESSSSV-----RGRQELGAIK 1419
             :.||..:...|  :::|         |:.||        :|.....|.:     :|..||.|::
Zfish    72 -MFECVNQAAVHEELEDETRRLCDVRPFLPVLKLITRNCGRAERLLDSKIGVLIGKGLHELDALQ 135

  Fly  1420 ENAFKQFESR-----------------------KYA---------------AGIKPLASTLVSDR 1446
            :...|.|.|:                       .|:               .||  :..|:..|:
Zfish   136 DQEVKDFRSKMKRISEEKMQQMQMMSWGQWLRSSYSPQLDTSSLDNLIERHEGI--IKITMHYDQ 198

  Fly  1447 KEDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGGKPPETID--SNYRKIHEFLNLIPKLL 1509
            .:|::.:........:|::|..   |::||..||      |.|.|.  |||     .|.:..:|.
Zfish   199 SQDTASLKVSLNCTVSEVMDHA---LKKWQTTHG------PEEDIGARSNY-----VLRVSDRLE 249

  Fly  1510 VSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMSV 1574
            .....|...:|    .|:.:.|..||:.                                 .::|
Zfish   250 FLFEDYPLIQY----KYIRACLSTGENP---------------------------------HLTV 277

  Fly  1575 TQDILVNRLVERQQDMITSYEQLLSSTDQMQ-PDHVRAMIDAYLRDTPKTAQLIADGL------- 1631
            ....:|..:.|::...:.|.....:|...:. |...|       :.|.:|:.:.|..|
Zfish   278 VHFDIVKSMFEKEIATVGSVLARKTSNPPLPLPPKKR-------QTTVRTSSMSASQLPQQLHTC 335

  Fly  1632 -WQ-----RLSDRYSDQCFAECKSELLWRLGSYDEMEELQSNWPAQCSQGCLKLRRPLTTRIEFD 1690
             |:     |::...:::..||..:::..|.|.:...|.|...  |..::...:........:|||
Zfish   336 VWKVHSLFRINLVKANKVNAEDAAKIQVRAGLFHGTELLCKT--AVSNESSSRSEHVWNKTLEFD 398

  Fly  1691 -SLLDGMRESVLEELRSCSAV------------QQHSYANAYDAVLKLHLVHE------------ 1730
             .:.|..|.:     |.|.|:            .::::.|.|..:.|...||.
Zfish   399 IPVCDLPRMA-----RLCFAIYAVMDKVKKQRSTKNTHLNKYQTIRKAGKVHYPIAWVNTMVFDY 458

  Fly  1731 ----------LHCSQELVEKLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNI 1785
                      |||.....::||:..:...  .:..|.:.:....|.|..|:...|..::.....|
Zfish   459 RGQLKTGDIILHCWSSFPDELEEMLNPIG--TIQTNPYTENATELHISFPEYSTQPVVFPAFDKI 521

  Fly  1786 LAELQRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIERAK-L 1849
            |.:               ..|:|.. .:|..:.|..   ::..:.:.:..|..|.....|..| |
Zfish   522 LEK---------------AAEIAGA-SDSMSMGRGG---KKFYIELKEIMERDPLSQLCENEKDL 567

  Fly  1850 LWQKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKY 1914
            :|                 .:|..|:.|..|...         |.|.:|              |:
Zfish   568 IW-----------------TLRYDCRENFPQSLP---------KLLLSV--------------KW 592

  Fly  1915 FQEAIAVHRQSESCHVQMAQFLEKILE----------------------ARQGGKSEPTGEQDDM 1957
                        |.|..||| |:.:|:                      .|:...|......||.
Zfish   593 ------------SKHEDMAQ-LQALLQIWPKLSPRDALELLDFNYPDQYVREFAVSCLKDMSDDE 644

  Fly  1958 LINVMVNYAKSLRYGSEHVYQ-SMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYT 2021
            |:..::...:.|||  |..|. |:.|.:   |:..::|      :|:...|           |:.
Zfish   645 LLQYLLQLVQVLRY--EPYYDCSLSRFL---LERAQTS------RKIGHFL-----------FWH 687

  Fly  2022 VYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQN 2086
            :.|:|..    |...|...|      ::|||.:.    .:||.:..|
Zfish   688 LRSEMYM----PAVSVHFAL------ILEAYCRG----CIPHIEVLK------------------ 720

  Fly  2087 STFQKLLQDFNSLTERLMDLTNKEVTLDRTYKLSDLDTRLSKLCKQPEFSQILLPFEKYMQPTLP 2151
                           :.::..||...::...||..:.|:    .||....:.       |...|.
Zfish   721 ---------------KQVEALNKLKAVNELIKLGTIKTK----TKQAHLKEA-------MMSCLR 759

  Fly  2152 LNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQ-ESVLILRSAAKPKKLTI--RCSDGKDYDVL 2213
            ......:....|.|.|.:         |.::|.. |....:.|..||..:..  :...|:...::
Zfish   760 QTGFIETLSDLHSPLNPN---------ILLAGVSVEKCKYMDSKMKPLWIVYNNKLLGGETVGII 815

  Fly  2214 VKPKDDLRRD---ARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPN---LA 2272
            .|..||||:|   .::::...|:.:..:.|       |.|..|..|...:..||:|.:.:   :|
Zfish   816 FKNGDDLRQDMLTLQILKLMDLLWKEANLD-------LRIVPYGCLATGDHSGLIEVVSSADTIA 873

  Fly  2273 SYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHS 2337
            :.:....|:.|                         ...|.|.       ....||:.: .:..:
Zfish   874 NIQKTSSNMAA-------------------------AAAFNKD-------ALLNWLKDK-NSGDA 905

  Fly  2338 WYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLP-------- 2394
            ..:|...:..:.|...:..|:||:||||.:||: ....|...|:||      |.:|.
Zfish   906 LDKAIEEFTLSCAGYCVATYVLGIGDRHSDNIM-VRSTGQLFHIDF------GHILGNFKSKFGI 963

  Fly  2395 YPEVVPFRLTHNMI--VAMGPLGVE---GSFRKCCEITLRLLKQESKTLMSILRPFVYDVGAQTR 2454
            ..|.|||.|||:.|  :..|..|..   |:||:.||....:|::.....:::.       .....
Zfish   964 KRERVPFILTHDFIHVIQEGKTGNTEKFGNFRQYCEEAYMILRKNGNLFITLF-------ALMLT 1021

  Fly  2455 KGAATAKITKDVQRIADRL 2473
            .|.......||:|.:.|.|
Zfish  1022 AGLPELTSVKDIQYLKDSL 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	67/390 (17%)
		PIKKc_ATR	2181..2448	CDD:270625	61/288 (21%)
		FATC	2486..2517	CDD:280430
pik3cb	XP_005157523.1	PI3K_p85B	35..110	CDD:280372	13/79 (16%)
		PI3K_rbd	176..281	CDD:295323	27/157 (17%)
		C2_PI3K_class_I_beta_delta	334..511	CDD:176075	31/185 (17%)
		PI3Ka	548..713	CDD:294194	46/253 (18%)
		PKc_like	716..1077	CDD:304357	81/432 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900