DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TH1 and Nelfcd

DIOPT Version :9

Sequence 1:	NP_001285326.1	Gene:	TH1 / 32607	FlyBaseID:	FBgn0010416	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_001258183.1	Gene:	Nelfcd / 679203	RGDID:	1590753	Length:	591	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	316/576 - (54%)
Similarity:	438/576 - (76%)	Gaps:	9/576 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SGWQGRAKGQTNPEETL---EDNPQKTIQECLEKFLTPDYIMEPGIFTQLKRYFQSGGSPEEVIS 69
            |.|...|.|..:.||..   ||:.: ..||||.||.|.||||||.||..||||||:|||||.||.
  Rat    19 SEWGEEADGGQHQEEDSGEGEDDAE-VQQECLHKFSTRDYIMEPSIFNTLKRYFQAGGSPENVIQ 82

  Fly    70 MLSENYKAVAQMANLLAEWLILAGVKVTEVQAMVENHLKEMILKSFDPKKADTIFTEEGETPDWL 134
            :|||||.||||..||||||||..||:..:||..||||||.:::|.|||:|||:|||||||||.||
  Rat    83 LLSENYTAVAQTVNLLAEWLIQTGVEPVQVQETVENHLKSLLIKHFDPRKADSIFTEEGETPAWL 147

  Fly   135 TEMIDHYTWRSLIYRLAEEYPDCLMLNFTIKLISDAGFQSEITSISTAAQQIEVFSRVLKTSIVK 199
            .:||.|.|||.|.|:|||.:|||||||||:|||||||:|.||||:|||.||:|||||||:||:..
  Rat   148 EQMIAHTTWRDLFYKLAEAHPDCLMLNFTVKLISDAGYQGEITSVSTACQQLEVFSRVLRTSLAT 212

  Fly   200 FLN-NPDDVHGAIQECARMVCHGQHTYVYSQVLIQVLSQEQKGGFNMKRLSQEIIKYALQNNQNV 263
            .|: ..:::...:.|.|:|||||:|||:::|.::.||:||::||..::|::||:.::|.:...:.
  Rat   213 ILDGGEENLEKNLPEFAKMVCHGEHTYLFAQAMMSVLAQEEQGGSAVRRVAQEVQRFAQEKGHDA 277

  Fly   264 TPITMALNGSAVYPQACQALTSMLTRNTLNPADITVLFRNYSGSDPPPIDLIRNPQFLELLVDAL 328
            :.||:||..:|.||:|||||.:||:|..||||||||||:.::..||||::|||.|.||:|.:.:|
  Rat   278 SQITLALGTAASYPRACQALGAMLSRGALNPADITVLFKMFTSMDPPPVELIRVPAFLDLFMQSL 342

  Fly   329 FRSGVKINPEHKPKYMFLLAYASAVIDQPAKKRPMTERMLNKEELKSTIQAIEKAHTI-CNVDQG 392
            |:.|.|||.:||.||:.:||||::|::...|.:.::   :.|:|||||.:|:|..|.: ||.::|
  Rat   343 FKPGAKINQDHKHKYIHILAYAASVVETWKKNKRVS---IGKDELKSTSKAVETVHNLCCNENKG 404

  Fly   393 STELIAELQTLYNCIKYPVVGVGVIRWIENVVMEPSYFKLSTDSCPTHLAVLDEVAAVHPTLQQQ 457
            ::||:|||.|||.||::|||.:||::|::..|.||.||:|.||..|.|||:|||::..|..|..|
  Rat   405 ASELVAELSTLYQCIRFPVVAMGVLKWVDWTVSEPRYFQLQTDHTPVHLALLDEISTCHQLLHPQ 469

  Fly   458 ILFLLIRLFESKQDELEILVQLEMKKMILDRMVNLLTRGCVVPVLRYIKQCCAIEDTDISLIRYF 522
            :|.||::|||::..:|:::.|||:||.:|||||:||:||.|:||:.||::|....||||||||||
  Rat   470 VLQLLVKLFETEHSQLDVMEQLELKKTLLDRMVHLLSRGYVLPVVSYIRKCLEKLDTDISLIRYF 534

  Fly   523 VTEVLETITHPYSPEFVQLFLPMVENEEITGTMRGEGDNDPVSEFIVHCKAHYTTV 578
            |||||:.|..||:.:|||||||::||:.|.||::.||::|||:|||.|||:::..|
  Rat   535 VTEVLDVIAPPYTSDFVQLFLPILENDSIAGTIKAEGEHDPVTEFIAHCKSNFIVV 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TH1	NP_001285326.1	TH1	2..576	CDD:398497	315/572 (55%)
Nelfcd	NP_001258183.1	TH1	11..588	CDD:282684	315/572 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	579	1.000	Domainoid score	I206
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9496
Inparanoid	1	1.050	580	1.000	Inparanoid score	I985
OMA	1	1.010	-	-		QHG54582
OrthoDB	1	1.010	-	-		D1288184at2759
OrthoFinder	1	1.000	-	-		FOG0008383
OrthoInspector	1	1.000	-	-		oto95913
orthoMCL	1	0.900	-	-		OOG6_105505
Panther	1	1.100	-	-	LDO	PTHR12144
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6371
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980